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On the Extension of the Three-Term Recurrence Relation to Probabilities Distributions without Moments
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作者 Habib Rebei Anis Riahi 《Journal of Applied Mathematics and Physics》 2018年第3期588-601,共14页
In this paper, we extend the three-term recurrence relation for orthogonal polynomials associated with a probability distribution having a finite moment of all orders to a class of orthogonal functions associated with... In this paper, we extend the three-term recurrence relation for orthogonal polynomials associated with a probability distribution having a finite moment of all orders to a class of orthogonal functions associated with an infinitely divisible probability distribution &#181;?having a finite moments of order less or equal to four. An explicit expression of these functions will be given in term of the Lévy-Khintchine function of the measure?&#181;. 展开更多
关键词 three-term recurrence relation Quantum Decomposition of Random Variables WITHOUT MOMENTS Lévy-Khintchine Function
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General calculation formulas and recurrence relations of radial matrix elements for relativistic n-dimensional hydrogen atom of spin S=0 被引量:1
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作者 CHENChang-yuan LUFa-lin SUNDong-sheng 《原子与分子物理学报》 CAS CSCD 北大核心 2004年第3期432-440,共9页
In this paper, the general calculation formulas of radial matrix elements for relativistic n-dimensional hydrogen atom of spin S=0 are obtained, and the recurrence relation of different power order radial matrix eleme... In this paper, the general calculation formulas of radial matrix elements for relativistic n-dimensional hydrogen atom of spin S=0 are obtained, and the recurrence relation of different power order radial matrix elements are also derived. 展开更多
关键词 n-dimensional hydrogen atom-type potential Klein-Cordon equation Radial matrix dements GENERAL calculation FORMULAS recurrence relations
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Convergence analysis for the Secant method based on new recurrence relations 被引量:1
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作者 BI Wei-hong REN Hong-min WU Qing-biao 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2008年第4期447-454,共8页
A new convergence theorem for the Secant method in Banach spaces based on new recurrence relations is established for approximating a solution of a nonlinear operator equation. It is assumed that the divided differenc... A new convergence theorem for the Secant method in Banach spaces based on new recurrence relations is established for approximating a solution of a nonlinear operator equation. It is assumed that the divided difference of order one of the nonlinear operator is Lipschitz continuous. The convergence conditions differ from some existing ones and are easily satisfied. The results of the paper are justified by numerical examples that cannot be handled by earlier works. 展开更多
关键词 Secant method Banach space recurrence relation semilocal convergence Lipschitz continuous divided difference
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Explicit Relations of Physical Potentials Through Generalized Hypervirial and Kramers' Recurrence Relations
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作者 孙国华 董世海 《Communications in Theoretical Physics》 SCIE CAS CSCD 2015年第6期682-686,共5页
Based on a Hamfltonian identity, we study one-dimensional generalized hypervirial theorem, Blanchardlike (non-diagonal case) and Kramers' (diagonal case) recurrence relations for arbitrary x^k which is independen... Based on a Hamfltonian identity, we study one-dimensional generalized hypervirial theorem, Blanchardlike (non-diagonal case) and Kramers' (diagonal case) recurrence relations for arbitrary x^k which is independent of the central potential V(x). Some significant results in diagonal case are obtained for special k in xk (k ≥2). In particular, we find the orthogonal relation 〈n1|n2〉 = δh1,n2 (k = 0), 〈n1[V'(x)|n2〉 = (En1-En2)^2〈n1|x|n2〉 (k = 1), En = (n|V'(x)x/2|n〉 + (n|V(x)|n〉 (k = 2) and -4En(n|x|n) ~ 〈n|V'(x)x^2|n〉 + 4〈n|V(x)x|n〉 =0 (k=3). The latter two formulas can be used directly to calculate the energy levels. We present useYul explicit relations for some well known physical potentials without requiring the energy spectra of quantum system. 展开更多
关键词 Hamiltonian identity hypervirial relations Kramers' recurrence relation physical potentials
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A General Solution for a Class of Non-Homogeneous Recurrence Relations with Two Indices
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作者 YU Chang’an 《Wuhan University Journal of Natural Sciences》 CAS 2010年第4期287-291,共5页
In this paper,we present the formula of a solution for a class of recurrence relations with two indices by applying iteration and induction according to the principle of solving algebraic equa-tions.It provides a conc... In this paper,we present the formula of a solution for a class of recurrence relations with two indices by applying iteration and induction according to the principle of solving algebraic equa-tions.It provides a concrete model to solve the concerned prob-lems with modern computing tools. 展开更多
关键词 two indices non-homogeneous recurrence relation formula of general solution
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Temporal pattern of resolution/recurrence of choroidal neovascularization during bevacizumab therapy for wet age-related macular degeneration 被引量:5
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作者 Haiyan Wang Giulio Barteselli +4 位作者 William R.Freeman Su Na Lee Jay Chhablani Sharif El-Emam Lingyun Cheng 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2013年第5期600-605,共6页
AIMTo characterize temporal pattern of resolution and recurrence of naive choroidal neovascularization (CNV) secondary to wet age-related macular degeneration (AMD) treated with intravitreal bevacizumab on as needed r... AIMTo characterize temporal pattern of resolution and recurrence of naive choroidal neovascularization (CNV) secondary to wet age-related macular degeneration (AMD) treated with intravitreal bevacizumab on as needed regimen, and to analyze baseline risk factors for CNV resolution or recurrence. 展开更多
关键词 BEVACIZUMAB age-related macular degeneration recurrence anti-vascular endothelial growth factor therapy
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Estimating the Recurrence Periods of Earthquake Data in Turkey 被引量:1
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作者 Hande Konsuk Serpil Aktas 《Open Journal of Earthquake Research》 2013年第1期21-25,共5页
In this paper, the 231 earthquake data of magnitude 5 and higher, between north (39.00o-42.00o) and east (26.00o-45.00o) coordinates in Turkey from July 12, 1900 to October 23, 2011 are statistically analyzed. The pro... In this paper, the 231 earthquake data of magnitude 5 and higher, between north (39.00o-42.00o) and east (26.00o-45.00o) coordinates in Turkey from July 12, 1900 to October 23, 2011 are statistically analyzed. The probability density function and cumulative function of the magnitude are derived. It is shown that magnitude random variable is distrib-uted as the exponential distribution. The recurrence periods is also calculated. Recurrence period is estimatedapproxi-matelytwo times a year for an earthquake having magnitude 5.2. Using the Gutenberg-Richter function, the relation between magnitude and frequency is represented. 展开更多
关键词 EARTHQUAKE recurrence Estimation Gutenberg-Richter relation
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On Relations for Moments of Generalized Order Statistics for Lindley–Weibull Distribution
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作者 Faten A.Momen khan Saman Hanif Shahbaz Muhammad Qaiser Shahbaz 《Computer Systems Science & Engineering》 SCIE EI 2022年第4期197-208,共12页
Moments of generalized order statistics appear in several areas of science and engineering.These moments are useful in studying properties of the random variables which are arranged in increasing order of importance,f... Moments of generalized order statistics appear in several areas of science and engineering.These moments are useful in studying properties of the random variables which are arranged in increasing order of importance,for example,time to failure of a computer system.The computation of these moments is sometimes very tedious and hence some algorithms are required.One algorithm is to use a recursive method of computation of these moments and is very useful as it provides the basis to compute higher moments of generalized order statistics from the corresponding lower-order moments.Generalized order statistics pro-vides several models of ordered data as a special case.The moments of general-ized order statistics also provide moments of order statistics and record values as a special case.In this research,the recurrence relations for single,product,inverse and ratio moments of generalized order statistics will be obtained for Lindley–Weibull distribution.These relations will be helpful for obtained moments of gen-eralized order statistics from Lindley–Weibull distribution recursively.Special cases of the recurrence relations will also be obtained.Some characterizations of the distribution will also be obtained by using moments of generalized order statistics.These relations for moments and characterizations can be used in differ-ent areas of computer sciences where data is arranged in increasing order. 展开更多
关键词 Generalized order statistics Lindley–Weibull distribution recurrence relations MOMENTS
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老年性黄斑变性患者抗VEGF治疗后视力恢复的影响因素及复发的危险因素分析探究
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作者 吴觉艺 赖碧秀 林映竑 《临床和实验医学杂志》 2026年第1期82-86,共5页
目的探讨湿性老年性黄斑变性(wAMD)患者抗血管内皮生长因子(VEGF)治疗后视力恢复的影响因素及复发的独立危险因素。方法回顾性纳入2022年1月至2024年3月在福建省漳州市医院接受抗VEGF治疗的150例wAMD患者,根据治疗后12个月基线最佳矫正... 目的探讨湿性老年性黄斑变性(wAMD)患者抗血管内皮生长因子(VEGF)治疗后视力恢复的影响因素及复发的独立危险因素。方法回顾性纳入2022年1月至2024年3月在福建省漳州市医院接受抗VEGF治疗的150例wAMD患者,根据治疗后12个月基线最佳矫正视力(BCVA)改善幅度分为视力恢复组(n=65)、视力稳定组(n=58)及无反应组(n=27)。收集并比较3组患者的临床资料[性别、年龄、病程、高血压、糖尿病病史、吸烟史、BCVA、脉络膜新生血管(CNV)类型、中心视网膜厚度(CRT)、黄斑容积、视网膜椭圆体区(IS/OS)完整性缺失及外界膜连续性、视网膜内液(IRF)、视网膜下液(SRF)、外层视网膜管状结构(ORT)]、抗VEGF药物类型、注射频次等,筛选影响视力恢复的因素,并采用Pearson相关性分析各指标与视力恢复的相关性。随访13个月,按复发情况将wAMD患者分为复发组(n=62)、未复发组(n=88)。采用单因素及Cox比例风险回归模型分析复发的独立危险因素。结果视力恢复组、视力稳定组与无反应组患者在年龄、基线BCVA、CNV类型、CRT、黄斑容积、IS/OS完整性缺失、外界膜连续性、IRF、ORT存在、注射频次方面比较,差异均有统计学意义(P<0.05);3组在性别构成比、病程、高血压史、糖尿病史、吸烟史、SRF方面比较,差异均无统计意义(P>0.05)。Pearson相关性分析结果显示,IS/OS完整性缺失和外界膜连续性缺失与视力恢复均呈显著负相关(r=-0.623、-0.528,P<0.001)。Cox比例风险回归模型分析结果表明,基线SRF存在、黄斑容积增大及频繁注射均是wAMD复发的独立危险因素(HR=2.08,P=0.007;HR=1.32,P=0.029;HR=1.82,P=0.033)。结论老年性黄斑变性患者抗VEGF治疗后IS/OS完整性缺失及外界膜连续性缺失影响患者视力恢复,基线SRF存在、黄斑容积增大及频繁注射是复发的独立危险因素。 展开更多
关键词 老年性黄斑变性 抗血管内皮生长因子治疗 视力恢复 复发 危险因素
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肾癌术后复发免疫治疗并发多器官功能障碍综合征分析并文献复习
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作者 冉玉格 张荣三 +2 位作者 王康华 刘宽 苏雷 《临床误诊误治》 2026年第6期42-46,共5页
目的 探讨肾癌术后复发患者免疫治疗相关不良反应(irAEs)的临床特点、诊断及治疗措施等,为irAEs的早期识别、诊断、治疗及预防等提供参考。方法 回顾性分析2025年收治的1例肾癌术后复发经免疫治疗并发irAEs患者的临床资料及诊疗经过,并... 目的 探讨肾癌术后复发患者免疫治疗相关不良反应(irAEs)的临床特点、诊断及治疗措施等,为irAEs的早期识别、诊断、治疗及预防等提供参考。方法 回顾性分析2025年收治的1例肾癌术后复发经免疫治疗并发irAEs患者的临床资料及诊疗经过,并查阅相关文献进行分析。结果 1例肾癌患者行腹腔镜机器人辅助操作联合腹腔镜左肾根治性切除术后3年无明显诱因出现腰痛,伴右侧下肢放射痛、活动受限。经相关检查后考虑左肾癌术后骨转移、腹膜后淋巴结转移。经多学科讨论后建议免疫治疗联合靶向治疗+局部骨转移放疗。遂给予舒尼替尼联合特瑞普利单抗治疗。特瑞普利单抗免疫治疗后10 d出现恶心、呕吐、伴发热等症状,综合实验室检查结果考虑:免疫性肝损伤G3级、急性肾损伤2期、血小板减少症G4级、低钠血症,诊断为多器官功能障碍综合征。经多学科会诊给予相应治疗后好转,病情平稳后开始行骨转移瘤放疗,治疗3周,共12次,患者腰痛症状完全缓解,肝肾功能恢复正常,血常规恢复正常,继续靶向治疗。结论 肿瘤irAEs可能涉及各个器官系统,对不同系统、不同级别不良反应的及时识别、诊断与有效的治疗可取得较好效果,改善患者预后。 展开更多
关键词 肾癌 术后复发 特瑞普利单抗 免疫治疗相关不良反应 免疫性肝损伤 血小板减少症 糖皮质激素
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索立德吉治疗局部晚期基底细胞癌8例临床分析
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作者 许国康 蔡梅 《中华皮肤科杂志》 北大核心 2026年第2期166-169,共4页
目的探讨索立德吉治疗局部晚期基底细胞癌(laBCC)的临床疗效、安全性。方法本研究为病例系列研究,回顾分析2024年3月至2025年1月在云南大学附属医院接受索立德吉(200 mg/d)治疗的8例laBCC患者的临床资料,评估疗效、肿瘤缓解率和不良事... 目的探讨索立德吉治疗局部晚期基底细胞癌(laBCC)的临床疗效、安全性。方法本研究为病例系列研究,回顾分析2024年3月至2025年1月在云南大学附属医院接受索立德吉(200 mg/d)治疗的8例laBCC患者的临床资料,评估疗效、肿瘤缓解率和不良事件。结果8例laBCC患者,男3例,女5例,中位年龄74岁,病程(9.13±6.02)年。8例治疗后肿瘤均缩小,缩小率为2.33%~100.00%。5例肿瘤缩小率≥30%,其中2例临床表现为肿瘤完全消退(1例经病理证实完全缓解)。另3例肿瘤缩小率欠佳者,因肿瘤体积缩小、厚度减薄获得手术机会。所有患者均经历不良事件,肌酸激酶升高最为常见(6/6例,最高达3级),其次为脱发(3/8例)、味觉减退(2/8例)和肌肉痉挛(1/8例)。多数不良事件通过调整剂量或暂停用药可得到缓解。结论索立德吉治疗laBCC有效,但需密切监测肌酸激酶升高等不良反应。 展开更多
关键词 基底细胞 肿瘤复发 局部 索立德吉 治疗结果 药物相关性副作用和不良反应
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SPRED2蛋白表达与肝细胞癌患者临床病理特征、术后复发的关系
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作者 张娟 孙丽 《临床研究》 2026年第3期120-124,共5页
目的探讨肝细胞癌(HCC)组织中Sprouty相关蛋白2(SPRED2)表达与HCC患者临床病理特征、术后复发的关系。方法选取2018年1月至2020年1月在商丘市立医院行手术治疗的122例HCC患者,122例患者中,2例失访,其余120例患者均完成随访。按照HCC组... 目的探讨肝细胞癌(HCC)组织中Sprouty相关蛋白2(SPRED2)表达与HCC患者临床病理特征、术后复发的关系。方法选取2018年1月至2020年1月在商丘市立医院行手术治疗的122例HCC患者,122例患者中,2例失访,其余120例患者均完成随访。按照HCC组织及癌旁组织中SPRED2蛋白表达检测结果,将HCC患者分为SPRED2蛋白表达阳性组(n=16)和SPRED2蛋白表达阴性组(n=104),分析HCC患者癌组织SPRED2蛋白表达与临床病理特征的关系。根据有无术后复发分为复发组(45例)和未复发组(75例),以Cox模型分析术后复发影响因素,基于这些影响因素开展生存分析。结果随访期间失访2例,复发45例(37.50%),未复发75例(62.50%);HCC组织中SPRED2蛋白阳性表达率为13.33%,低于癌旁组织(61.67%),差异有统计学意义(P<0.05);SPRED2蛋白阳性组甲胎蛋白(AFP)>400 ng/mL患者少于≤400 ng/mL患者,TNM分期Ⅲ/Ⅳ期患者少于Ⅰ/Ⅱ期患者,有门静脉癌栓患者少于无门静脉癌栓患者,低/未分化患者少于高/中分化患者,差异均有统计学意义(P<0.05);多因素Cox回归分析显示,AFP>400 ng/mL、TNM分期Ⅲ/Ⅳ期、门静脉癌栓、低/未分化及SPRED2蛋白阳性是HCC患者术后复发的影响因素(P<0.05);AFP>400 ng/mL、TNMⅢ/Ⅳ期、门静脉癌栓、低/未分化患者术后复发率高于AFP≤400 ng/mL、TNMⅠ/Ⅱ期、无门静脉癌栓、高/中分化患者,差异均有统计学意义(P<0.05),SPRED2蛋白阳性表达患者的术后复发率低于阴性表达患者,差异有统计学意义(P<0.05)。结论HCC组织中SPRED2蛋白表达低于癌旁组织,HCC患者癌组织SPRED2蛋白表达不仅与临床病理特征有关,还是术后复发的影响因素。 展开更多
关键词 肝细胞癌 Sprouty相关蛋白2 临床病理特征 复发
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卡度尼利单抗对复发性/晚期宫颈癌患者T淋巴细胞亚群水平细胞增殖凋亡相关蛋白的影响
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作者 柏家英 杨英捷 李凤虎 《河北医学》 2026年第2期335-341,共7页
目的:评价卡度尼利单抗对复发性/晚期宫颈癌患者免疫功能、细胞增殖凋亡相关蛋白的影响。方法:选择2022年10月至2024年5月本院48例复发性/晚期宫颈癌患者,均接受以卡度尼利单抗为基础的疗法。随访统计患者疗效、不良反应、生存率,观察... 目的:评价卡度尼利单抗对复发性/晚期宫颈癌患者免疫功能、细胞增殖凋亡相关蛋白的影响。方法:选择2022年10月至2024年5月本院48例复发性/晚期宫颈癌患者,均接受以卡度尼利单抗为基础的疗法。随访统计患者疗效、不良反应、生存率,观察患者治疗前、治疗后的细胞免疫功能、血清肿瘤标志物[鳞状细胞癌抗原(SCCA)、癌胚抗原(CEA)、糖类抗原125(CA125)、细胞角蛋白19片段(CYERA21-1)]、细胞增殖/凋亡相关蛋白表达[肿瘤蛋白P53(P53)、Bcl-2相关X蛋白(Bax)、程序性细胞凋亡因子5(PDCD5)、表皮生长因子受体(EGFR)、细胞质胸苷激酶(TK1)]、生活质量[宫颈癌生存质量评估量表(FACT-Cx)评分]变化。结果:48例复发性/晚期宫颈癌患者ORR为68.75%(33/48),DCR为81.25%(39/48);与治疗前相比,患者治疗后CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)升高,差异有统计学意义(P<0.05);与治疗前相比SCCA、CEA、CA125、CYERA21-1水平降低,差异有统计学意义(P<0.05);与治疗前相比,治疗后患者血清P53、Bax、PDCD5表达升高,EGFR、TK1表达降低,差异有统计学意义(P<0.05);与治疗前相比,治疗后患者FACT-Cx量表5个维度评分升高,差异有统计学意义(P<0.05);随访1年,OS率为81.25%(39/48),中位随访时间为11.354个月(95%CI:10.920~11.788);48例复发性/晚期宫颈癌患者3~4级不良反应发生率为58.33%(28/48),1~2级不良反应经相应处理后逐渐缓解。结论:以卡度尼利单抗为基础的治疗方案可改善复发性/晚期宫颈癌患者细胞免疫功能,降低血清肿瘤标志物水平,调节细胞增殖/凋亡相关蛋白表达,患者生存率较高,且整体安全性良好。 展开更多
关键词 复发性/晚期宫颈癌 卡度尼利单抗 免疫功能 细胞增殖凋亡相关蛋白
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首发精神分裂症患者血清核因子E2相关因子2、G72蛋白与氧化应激和复发风险的关系研究
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作者 金青青 金程程 +1 位作者 黄云卓 陈杰 《临床精神医学杂志》 2026年第1期52-55,共4页
目的:探讨首发精神分裂症(first-episode schizophrenia,FES)患者血清核因子E2相关因子2(nuclear factor E2-related factor 2,Nrf2)、G72蛋白与氧化应激和复发风险的关系。方法:检测FES患者(FES组,n=175)与健康者(对照组,n=85)血清Nrf2... 目的:探讨首发精神分裂症(first-episode schizophrenia,FES)患者血清核因子E2相关因子2(nuclear factor E2-related factor 2,Nrf2)、G72蛋白与氧化应激和复发风险的关系。方法:检测FES患者(FES组,n=175)与健康者(对照组,n=85)血清Nrf2、G72蛋白及氧化应激指标。分析Nrf2、G72与氧化应激指标的关系及对FES复发的预测价值。结果:FES患者的血清Nrf2与丙二醛(malondialdehyde,MDA)、一氧化氮(nitric oxide,NO)水平呈负相关,与G72呈正相关(P均<0.05),Nrf2与超氧化物歧化酶(superoxide dismutase,SOD)水平呈正相关,与G72呈负相关(P均<0.05);Logistic回归结果显示,G72蛋白高水平是FES患者复发的危险因素,Nrf2高水平是保护因素(P均<0.05)。受试者工作特征(receiver operating characteristic,ROC)结果显示,血清Nrf2、G72蛋白联合预测FES患者复发的曲线下面积(area under curve,AUC)为0.828。结论:血清Nrf2、G72蛋白水平与FES患者的氧化应激指标关系密切,且二者联合检测对FES复发具有较高的预测价值。 展开更多
关键词 首发精神分裂症 核因子E2相关因子2 G72蛋白 氧化应激 复发风险
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尖锐湿疣皮损组织中Smac、HIF-1α、ATG5表达与患者临床病理特征及复发关系研究
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作者 甘剑 孙健 《陕西医学杂志》 2026年第2期268-272,共5页
目的:探讨尖锐湿疣(CA)皮损组织中第二个线粒体衍生半胱天冬氨酸蛋白酶激活剂(Smac)、缺氧诱导因子-1α(HIF-1α)、自噬相关基因5(ATG5)表达与患者临床病理特征和复发的关系。方法:选取98例CA患者为CA组,选同期非皮肤病、因其他原因切... 目的:探讨尖锐湿疣(CA)皮损组织中第二个线粒体衍生半胱天冬氨酸蛋白酶激活剂(Smac)、缺氧诱导因子-1α(HIF-1α)、自噬相关基因5(ATG5)表达与患者临床病理特征和复发的关系。方法:选取98例CA患者为CA组,选同期非皮肤病、因其他原因切除外生殖器正常皮肤组织的志愿者85例为对照组。免疫组织化学染色法检测组织中Smac、HIF-1α、ATG5蛋白表达。随访6个月,记录复发情况。以四格表法分析皮损组织Smac、HIF-1α、ATG5蛋白表达对CA患者复发的预测价值。结果:与对照组正常皮肤组织比较,CA组皮损组织中Smac、ATG5蛋白阳性表达率降低,HIF-1α阳性表达率升高(均P<0.05)。不同病程CA患者Smac、HIF-1α、ATG5蛋白阳性表达率比较差异无统计学意义(均P>0.05)。不同病变范围、疣体数目、尿道受累、HPV感染类型患者皮损组织Smac、HIF-1α、ATG5蛋白阳性表达率比较差异有统计学意义(均P<0.05)。随访6个月,98例CA患者复发40例,未复发58例。Smac蛋白阳性患者复发率10.53%低于Smac阴性患者48.10%,HIF-1α蛋白阳性患者复发率87.65%高于HIF-1α阴性患者11.76%,ATG5蛋白阳性患者复发率11.54%低于ATG5阴性患者50.00%(均P<0.05)。皮损组织Smac、HIF-1α、ATG5蛋白表达联合预测CA患者复发的敏感度92.50%、特异度91.38%、阳性预测值88.10%、阴性预测值91.38%、准确率91.84%,高于单独指标预测(均P<0.05)。结论:Smac、HIF-1α、ATG5在CA皮损组织中异常表达,与临床病理特征及复发风险有关,三者联合对CA患者复发具有一定预测价值。 展开更多
关键词 尖锐湿疣 第二个线粒体衍生半胱天冬氨酸蛋白酶激活剂 缺氧诱导因子-1α 自噬相关基因5 临床病理特征 复发
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血清可溶性B7-H3和Dickkopf相关蛋白1对早期胃癌患者内镜黏膜下剥离术后复发的预测价值
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作者 尼力帕尔·阿不都吾甫尔 麦合木提江·吾斯曼 管亚茹 《中国内镜杂志》 2026年第3期65-71,共7页
目的探究血清可溶性B7-H3(sB7-H3)和Dickkopf相关蛋白1(DKK1)对早期胃癌(EGC)患者内镜黏膜下剥离术(ESD)后复发的预测价值。方法选取2021年12月-2023年12月于该院接受ESD治疗的EGC患者133例作为EGC组,选取同期体检健康者133例作为对照组... 目的探究血清可溶性B7-H3(sB7-H3)和Dickkopf相关蛋白1(DKK1)对早期胃癌(EGC)患者内镜黏膜下剥离术(ESD)后复发的预测价值。方法选取2021年12月-2023年12月于该院接受ESD治疗的EGC患者133例作为EGC组,选取同期体检健康者133例作为对照组,比较两组血清sB7-H3和DKK1表达水平。根据ESD后是否复发,进一步将患者分为复发组和未复发组,采用多因素Logistic回归模型,分析影响EGC患者ESD后复发的独立危险因素;并绘制受试者操作特征曲线(ROC curve),分析血清sB7-H3和DKK1对EGC患者ESD后复发的预测价值。结果EGC组血清sB7-H3和DKK1水平明显高于对照组,差异均有统计学意义(P<0.05)。复发组血清sB7-H3和DKK1水平明显高于未复发组,差异均有统计学意义(P<0.05)。多因素Logistic回归分析显示,浸润深度为黏膜下(OR=4.228,95%CI:1.874~9.537)、血清sB7-H3水平高(OR=4.925,95%CI:1.999~12.133)和DKK1水平高(OR=5.262,95%CI:1.933~14.326)是影响EGC患者ESD后复发的独立危险因素(P<0.05)。ROC curve显示,血清sB7-H3和DKK1联合检测,预测EGC患者ESD后复发的AUC为0.878(95%CI:0.810~0.928),明显大于血清sB7-H3和DKK1单独检测的AUC(Z=2.61,P=0.009;Z=2.75,P=0.006)。结论血清sB7-H3和DKK1水平升高是影响EGC患者ESD后复发的独立危险因素。两者联合检测,预测EGC患者ESD后复发,具有较高的临床应用价值。 展开更多
关键词 早期胃癌(EGC) 内镜黏膜下剥离术(ESD) 可溶性B7-H3(sB7-H3) Dickkopf相关蛋白1(DKK1) 复发
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Management of recurrent rectal cancer:A population based study in greater Amsterdam 被引量:19
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作者 Roel Bakx Otto Visser +3 位作者 Judith Josso Sybren Meijer J Frederik M Slors J Jan B van Lanschot 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第39期6018-6023,共6页
AIM: To analyze, retrospectively in a populationbased study, the management and survival of patients with recurrent rectal cancer initially treated with a macroscopically radical resection obtained with total mesorec... AIM: To analyze, retrospectively in a populationbased study, the management and survival of patients with recurrent rectal cancer initially treated with a macroscopically radical resection obtained with total mesorectal excision (TME). METHODS: All rectal carcinomas diagnosed during 1998 to 2000 and initially treated with a macroscopically radical resection (632 patients) were selected from the Amsterdam Cancer Registry. For patients with recurrent disease, information on treatment of the recurrence was collected from the medical records. RESULTS: Local recurrence with or without clinically apparent distant dissemination occurred in 62 patients (10%). Thirty-two patients had an isolated local recurrence. Ten of these 32 patients (31%) underwent radical re-resection and experienced the highest survival (three quarters survived for at least 3 years). Eight patients (25%) underwent non-radical surgery (median survival 24 rno), seven patients (22%) were treated with radio- and/or chemotherapy without surgery (median survival 15 mo) and seven patients (22%) only received best supportive care (median survival 5 too). Distant dissemination occurred in 124 patients (20%) of whom 30 patients also had a local recurrence. The majority (54%) of these patients were treated with radio- and/or chemotherapy without surgery (median survival 15 mo). Twenty-seven percent of these patients only received best supportive care (median survival 6 mo), while 16% underwent surgery for their recurrence. Survival was best in the latter group (median survival 32 mo). CONCLUSION: Although treatment options and survival are limited in case of recurrent rectal cancer after radical local resection obtained with TME, patients can benefit from additional treatment, especially if a radical resection is feasible. 展开更多
关键词 Rectal cancer Total mesorectal excision Local recurrence relative survival
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Clinical and echocardiographic analysis of patients suffering from recurrent takotsubo cardiomyopathy 被引量:1
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作者 Ibrahim El-Battrawy Uzair Ansari +14 位作者 Michael Behnes Dennis Hillenbrand Katja Schramm Darius Haghi Ursula Hoffmann Theano Papavassiliu Elif Elmas Christian Fasmer Tobias Becher Stefan Baumann Christina Dosch Felix Heggemann Jurgen Kuschyk Martin Borggrefe Ibrahim Akin 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2016年第11期888-893,共6页
Background Recurrence of takotsubo cardiomyopathy (TTC) is a well-known complication. However, current literature lists only a few isolated cases. We aimed to determine the incidence and clinical significance of rec... Background Recurrence of takotsubo cardiomyopathy (TTC) is a well-known complication. However, current literature lists only a few isolated cases. We aimed to determine the incidence and clinical significance of recurrent TTC. Methods & Results Our institutional database constituted a collective of 114 patients diagnosed with TTC since 2003. Close follow-up of these patients revealed a recurrence of TTC in seven of these (6.1%). The time interval between the index event and its recurrence varied between six months and six years. Arterial hypertension was more revealed in the recurrence group of TTC compared to non-recurrence group, (P = 0.02). Chronic obstructive pulmo- nary disease and/or asthma was more diagnosed in the recurrence group, (P = 0.04). Clinical events like fight ventficular involvement, TTC related complications such as life-threatening arrhythmias, pulmonary congestion and in hospital death were observed more frequently in the recurrent episode. Over a mean follow-up of one year the mortality rate was similar in both groups. Conclusions Recurrence of TTC within six years after index event is not an uncommon phenomenon. In the event of right ventricular involvement in the relapse phase, it might be associated with a higher complication rate. TTC recurrence should be the first differential diagnosis in patients with a past history of TTC. 展开更多
关键词 Biventricular takotsubo cardiomyopathy recurrent takotsubo cardiomyopathy Takotsubo cardiomyopathy related complication
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A clinicopathological study on IgG4-related ophthalmic disease 被引量:1
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作者 Yuka Suimon Satoru Kase +2 位作者 Kan Ishijima Hiromi Kanno-Okada Susumu Ishida 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2018年第9期1539-1544,共6页
AIM: To investigate clinicopathological features of immunoglobulin G4-related ophthalmic disease(IgG4-ROD), and analyze the recurrence rates following systemic corticosteroid administration.METHODS: We retrospecti... AIM: To investigate clinicopathological features of immunoglobulin G4-related ophthalmic disease(IgG4-ROD), and analyze the recurrence rates following systemic corticosteroid administration.METHODS: We retrospectively searched clinical features, laboratory and histological findings based on the medical records of 21 patients with IgG4-ROD. All the patients examined in this study underwent surgical resection in the ocular adnexal lesions and underwent histological evaluation. This study further investigated clinical and histopathological features of 15 patients who received systemic corticosteroid after the resection.RESULTS: The mean age of the patients consisting of 7 males(33%) and 14 females(67%) was 61y. Fourteen patients were diagnosed as definitive, and 2 and 5 patients were probable and possible IgG4-ROD, respectively. Eyelid swelling was an initial symptom in 11 patients(52%) who did not show systemic involvements at a diagnosis. Fifteen patients received systemic corticosteroid administration, and all showed remission of inflammation. Among them, 10 patients did not recur, whereas 5 patients(33%) recurred during tapering. There were no significant difference between patients with or without recurrence in clinicopathological features.CONCLUSION: In this study, female patients are more predominant in IgG4-ROD. While inflammation recurs in one-third of patients, this study do not identify factors associated with recurrence after systemic corticosteroid administration. 展开更多
关键词 IgG4-related ophthalmic disease CORTICOSTEROID HISTOPATHOLOGY recurrence
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Complement-mediated renal diseases after kidney transplantation-current diagnostic and therapeutic options in de novo and recurrent diseases 被引量:1
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作者 Fedaey Abbas Mohsen El Kossi +3 位作者 Jon Jin Kim Ihab Sakr Shaheen Ajay Sharma Ahmed Halawa 《World Journal of Transplantation》 2018年第6期203-219,共17页
For decades, kidney diseases related to inappropriate complement activity, such as atypical hemolytic uremic syndrome and C3 glomerulopathy(a subtype of membranoproliferative glomerulonephritis), have mostly been comp... For decades, kidney diseases related to inappropriate complement activity, such as atypical hemolytic uremic syndrome and C3 glomerulopathy(a subtype of membranoproliferative glomerulonephritis), have mostly been complicated by worsened prognoses and rapid progression to end-stage renal failure. Alternative complement pathway dysregulation, whether congenital or acquired, is well-recognized as the main driver of the disease process in these patients. The list of triggers include: surgery, infection, immunologic factors, pregnancy and medications. The advent of complement activation blockade, however, revolutionized the clinical course and outcome of these diseases, rendering transplantation a viable option for patients who were previously considered as non-transplantable cases.Several less-costly therapeutic lines and likely better efficacy and safety profiles are currently underway. In view of the challenging nature of diagnosing these diseases and the long-term cost implications, a multidisciplinary approach including the nephrologist, renal pathologist and the genetic laboratory is required to help improve overall care of these patients and draw the optimum therapeutic plan. 展开更多
关键词 Complement-related DISEASES KIDNEY TRANSPLANTATION De novo recurrENT DISEASES
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