The frequent failures of small-diameter vascular grafts(SDVGs)mainly result from thrombosis and insufficient endothelialization.Despite recent biochemical modification strategies aiming to enhance long-term patency,th...The frequent failures of small-diameter vascular grafts(SDVGs)mainly result from thrombosis and insufficient endothelialization.Despite recent biochemical modification strategies aiming to enhance long-term patency,the challenges of suppressing thrombosis and promoting rapid endothelialization persist.We thus designed a biomimetic three-layer flexible vascular graft scaffold.This scaffold precisely replicates the nonlinear mechanical responses of vascular tissues and promotes vascular regeneration by minimizing the mechanical mismatch between the graft and the host.The biomimetic flexible SDVG scaffold comprises a screwed inner layer,a middle fabric layer,and a Polyethylene terephthalate(PET)helical coil.It shows excellent bending resistance and resilience,reducing thrombosis formation caused by impaired blood flow during bending.Moreover,this scaffold notably improves the adhesion,spreading,proliferation,and elongation of endothelial cells,facilitating luminal remodeling and maintaining long-term patency through its intimal topography.In vivo studies demonstrate that the endothelial layer forms within three months of implantation,ensuring long-term patency.By three months after implantation,both the endothelial and smooth muscle layers are regenerated,developing hierarchical microstructures and compositions similar to those of native vessels.The biomimetic flexible vascular graft with screwed structures exhibits excellent bending resistance and enhanced vascular remodeling,thereby promoting blood vessel regeneration and showing strong potential for clinical translation.展开更多
At present,smart substations use the IEC61850 standard based on the architectural framework of three layers and two networks to realize information digitization and advanced applications.Although the smart substation ...At present,smart substations use the IEC61850 standard based on the architectural framework of three layers and two networks to realize information digitization and advanced applications.Although the smart substation offers many improvements in design,equipment manufacturing,and construction,the intelligent devices used in smart substations are costly,and are also difficult to maintain since they are dispersed within a single unit.Functionality optimization and device integration,thus,have become important issues in smart substation development.This paper presents an integrated solution and implementation process for a smart substation system.In the process layer,an integrated intelligence component is developed that functions both as an intelligent terminal and a merging unit.In the bay layer,an integrated station-area protection measurement and control master device is designed to achieve such functions as protection,monitoring,control,fault recorder,and power quality monitoring.Finally,in the station control layer,an integrated information platform is established to bring together various system functions and to promote interactive sharing.Integration technology improves the economy and practicality of the smart substation,especially in a distribution power grid.展开更多
基金supported by the National Key Research and Development Program of China(No.2023YFC2412402)the Key Research and Development Program of Hubei Province(No.2022ACA002).
文摘The frequent failures of small-diameter vascular grafts(SDVGs)mainly result from thrombosis and insufficient endothelialization.Despite recent biochemical modification strategies aiming to enhance long-term patency,the challenges of suppressing thrombosis and promoting rapid endothelialization persist.We thus designed a biomimetic three-layer flexible vascular graft scaffold.This scaffold precisely replicates the nonlinear mechanical responses of vascular tissues and promotes vascular regeneration by minimizing the mechanical mismatch between the graft and the host.The biomimetic flexible SDVG scaffold comprises a screwed inner layer,a middle fabric layer,and a Polyethylene terephthalate(PET)helical coil.It shows excellent bending resistance and resilience,reducing thrombosis formation caused by impaired blood flow during bending.Moreover,this scaffold notably improves the adhesion,spreading,proliferation,and elongation of endothelial cells,facilitating luminal remodeling and maintaining long-term patency through its intimal topography.In vivo studies demonstrate that the endothelial layer forms within three months of implantation,ensuring long-term patency.By three months after implantation,both the endothelial and smooth muscle layers are regenerated,developing hierarchical microstructures and compositions similar to those of native vessels.The biomimetic flexible vascular graft with screwed structures exhibits excellent bending resistance and enhanced vascular remodeling,thereby promoting blood vessel regeneration and showing strong potential for clinical translation.
基金supported in part by the research program of State Grid Corporation of China under Grant PD71-15-036.
文摘At present,smart substations use the IEC61850 standard based on the architectural framework of three layers and two networks to realize information digitization and advanced applications.Although the smart substation offers many improvements in design,equipment manufacturing,and construction,the intelligent devices used in smart substations are costly,and are also difficult to maintain since they are dispersed within a single unit.Functionality optimization and device integration,thus,have become important issues in smart substation development.This paper presents an integrated solution and implementation process for a smart substation system.In the process layer,an integrated intelligence component is developed that functions both as an intelligent terminal and a merging unit.In the bay layer,an integrated station-area protection measurement and control master device is designed to achieve such functions as protection,monitoring,control,fault recorder,and power quality monitoring.Finally,in the station control layer,an integrated information platform is established to bring together various system functions and to promote interactive sharing.Integration technology improves the economy and practicality of the smart substation,especially in a distribution power grid.
