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Finite-Time Expected Present Value of Operating Costs until Ruin in a Two-Dimensional Risk Model with Periodic Observation
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作者 TENG Ye XIE Jiayi ZHANG Zhimin 《应用概率统计》 北大核心 2025年第5期748-765,共18页
This paper investigates ruin,capital injection,and dividends for a two-dimensional risk model.The model posits that surplus levels of insurance companies are governed by a perturbed composite Poisson risk model.This m... This paper investigates ruin,capital injection,and dividends for a two-dimensional risk model.The model posits that surplus levels of insurance companies are governed by a perturbed composite Poisson risk model.This model introduces a dependence between the two surplus levels,present in both the associated perturbations and the claims resulting from common shocks.Critical levels of capital injection and dividends are established for each of the two risks.The surplus levels are observed discretely at fixed intervals,guiding decisions on capital injection,dividends,and ruin at these junctures.This study employs a two-dimensional Fourier cosine series expansion method to approximate the finite time expected discounted operating cost until ruin.The ensuing approximation error is also quantified.The validity and accuracy of the method are corroborated through numerical examples.Furthermore,the research delves into the optimal capital allocation problem. 展开更多
关键词 two-dimensional risk model Fourier cosine expansion capital injection DIVIDEND
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An interactive framework integrating segment anything model and structure-from-motion for three-dimensional discontinuity identification in rock masses
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作者 Jiawei Wang Jun Zheng +4 位作者 Jie Hu Xiaojin Gong Qing Lü Ju Han Jialiang Sun 《International Journal of Mining Science and Technology》 2025年第10期1695-1711,共17页
The identification of rock mass discontinuities is critical for rock mass characterization.While high-resolution digital outcrop models(DOMs)are widely used,current digital methods struggle to generalize across divers... The identification of rock mass discontinuities is critical for rock mass characterization.While high-resolution digital outcrop models(DOMs)are widely used,current digital methods struggle to generalize across diverse geological settings.Large-scale models(LSMs),with vast parameter spaces and extensive training datasets,excel in solving complex visual problems.This study explores the potential of using one such LSM,Segment anything model(SAM),to identify facet-type discontinuities across several outcrops via interactive prompting.The findings demonstrate that SAM effectively segments two-dimensional(2D)discontinuities,with its generalization capability validated on a dataset of 2426 identified discontinuities across 170 outcrops.The model achieves 0.78 mean IoU and 0.86 average precision using 11-point prompts.To extend to three dimensions(3D),a framework integrating SAM with Structure-from-Motion(SfM)was proposed.By utilizing the inherent but often overlooked relationship between image pixels and point clouds in SfM,the identification process was simplified and generalized across photogrammetric devices.Benchmark studies showed that the framework achieved 0.91 average precision,identifying 87 discontinuities in Dataset-3D.The results confirm its high precision and efficiency,making it a valuable tool for data annotation.The proposed method offers a practical solution for geological investigations. 展开更多
关键词 Rock Mass DISCONTINUITY Digital outcrop model(DOM) Point clouds Large-scale model(LSM) Foundation model(FM)
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Three-Dimensional Prospectivity Modeling of Jinshan Ag-Au Deposit,Southern China by Weights-of-Evidence
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作者 Fan Xiao Qiuming Cheng +1 位作者 Weisheng Hou Frederik P.Agterberg 《Journal of Earth Science》 2025年第5期2038-2057,共20页
To comprehensively utilize the valuable geological map,exploration profile,borehole,and geochemical logging data and the knowledge on the formation of the Jinshan Ag-Au deposit for forecasting the exploration targets ... To comprehensively utilize the valuable geological map,exploration profile,borehole,and geochemical logging data and the knowledge on the formation of the Jinshan Ag-Au deposit for forecasting the exploration targets of concealed ore bodies,three-dimensional Mineral Prospectivity Modeling(MPM)of the deposit has been conducted using the weights-of-evidence(WofE)method.Conditional independence between evidence layers was tested,and the outline results using the prediction-volume(P-V)and Student's t-statistic methods for delineating favorable mineralization areas from continuous posterior probability map were critically compared.Four exploration targets delineated ultimately by the Student's t-statistic method for the discovery of minable ore bodies in each of the target areas were discussed in detail.The main conclusions include:(1)three-dimensional modeling of a deposit using multi-source reconnaissance data is useful for MPM in interpreting their relationships with known ore bodies;(2)WofE modeling can be used as a straightforward tool for integrating deposit model and reconnaissance data in MPM;(3)the Student's t-statistic method is more applicable in binarizing the continuous prospectivity map for exploration targeting than the PV approach;and(4)two target areas within high potential to find undiscovered ore bodies were diagnosed to guide future near-mine exploration activities of the Jinshan deposit. 展开更多
关键词 three-dimensional modeling mineral prospectivity mapping exploration targeting WEIGHTS-OF-EVIDENCE C-V fractal model Jinshan Ag-Au deposit mineral deposits economic geology
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The detection of keratoconus using a three-dimensional corneal model derived from anterior segment optical coherence tomography
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作者 Sang Ngoc Tran Isa S.K.Mohammed +1 位作者 Zeshan Tariq Wuqaas M.Munir 《Annals of Eye Science》 2025年第3期73-82,共10页
Background:Traditional imaging approaches to keratoconus(KCN)have thus far failed to produce a standardized approach for diagnosis.While many diagnostic modalities and metrics exist,none have proven robust enough to b... Background:Traditional imaging approaches to keratoconus(KCN)have thus far failed to produce a standardized approach for diagnosis.While many diagnostic modalities and metrics exist,none have proven robust enough to be considered a gold standard.This study aims to introduce novel metrics to differentiate between KCN and healthy corneas using three-dimensional(3D)measurements of surface area and volume.Methods:This retrospective observational study examined KCN patients along with healthy control patients between the ages of 20 and 79 years old at the University of Maryland,Baltimore.The selected patients underwent a nine-line raster scan anterior segment optical coherence tomography(AS-OCT).ImageJ was used to determine the central 6 mm of each image and each corneal image was then divided into six 1 mm segments.Free-D software was then used to render the nine different images into a 3D model to calculate corneal surface area and volume.A two-tailed Mann-Whitney test was used to assess statistical significance when comparing these subsets.Results:Thirty-three eyes with KCN,along with 33 healthy control,were enrolled.There were statistically significant differences between the healthy and KCN groups in the metric of anterior corneal surface area(13.927 vs.13.991 mm^(2),P=0.046),posterior corneal surface area(14.045 vs.14.173 mm^(2),P<0.001),and volume(8.430 vs.7.773 mm3,P<0.001)within the central 6 mm.Conclusions:3D corneal models derived from AS-OCT can be used to measure anterior corneal surface area,posterior corneal surface area,and corneal volume.All three parameters are statistically different between corneas with KCN and healthy corneas.Further study and application of these parameters may yield new methodologies for the detection of KCN. 展开更多
关键词 CORNEA ECTASIA keratoconus(KCN) anterior segment optical coherence tomography(AS-OCT) three-dimensional model(3D model)
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Development of a Two-Dimensional Hydrodynamic Model to Simulate Rip Currents in the Bai Dai-Cam Ranh Coast, Vietnam
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作者 Ngo Nam Thinh Nguyen Thi Bay 《Journal of Environmental & Earth Sciences》 2025年第4期203-216,共14页
Rip currents are a significant threat to swimmers worldwide,responsible for numerous drowning incidents each year.In Vietnam,Bai Dai Beach in Cam Ranh Bay,Khanh Hoa Province,has experienced an increase in drowning eve... Rip currents are a significant threat to swimmers worldwide,responsible for numerous drowning incidents each year.In Vietnam,Bai Dai Beach in Cam Ranh Bay,Khanh Hoa Province,has experienced an increase in drowning events due to rip currents in recent years.To address this issue,a comprehensive study was conducted based on developing a depth-averaged 2D hydrodynamic model to simulate rip currents in the Bai Dai-Cam Ranh coast.The HYDIST-2D numerical model was applied to simulate the rip current evolution in space and time for the study area.The results showed that the HYDIST-2D numerical model can accurately predict the location,magnitude,and microstructure of rip currents,including rip current speed,width,and length.The simulation results revealed that the rip current speed is greater during the low tide phase,with an average speed of 0.5 m s^(-1),while during high tide,the rip current speed is lower,around 0.1–0.8 m s^(-1).The width and length of the rip current also vary with the tide phase,with a wider and longer rip current observed during the low tide phase.The results also showed that the rip current speed and microstructure are influenced by the wave features,tide current,and bathymetry of the study area.The present study provides valuable insights into the dynamics of rip currents in the Bai Dai-Cam Ranh coast.The findings can be used to support the management of bathing activities and provide early warnings for potential risks associated with rip currents. 展开更多
关键词 HYDIST model SWIMMERS RIP Hydrodynamic Factors Breaking Waves
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Integrating three-dimensional printing and bioprinting technologies to develop a stretchable in vitro model of the human airway
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作者 Junned Chan Julian Gonzalez Rubio +7 位作者 Oscar O’Dwyer Lancaster-Jones Yashasvi Verma Charlotte Büchter Stefan Jockenhoevel Laura De Laporte Mirko Trilling Anja Lena Thiebes Daniela Duarte Campos 《Bio-Design and Manufacturing》 2025年第4期595-608,I0033-I0041,共23页
The global demand for in vitro respiratory airway models has surged due to the coronavirus disease 2019(COVID-19)pandemic.Current state-of-the-art models use polymer membranes to separate epithelial cells from other c... The global demand for in vitro respiratory airway models has surged due to the coronavirus disease 2019(COVID-19)pandemic.Current state-of-the-art models use polymer membranes to separate epithelial cells from other cell types,creating a nonphysiological barrier.In this study,we applied three-dimensional(3D)printing and bioprinting to develop an in vitro model where endothelial and epithelial cells were in direct contact,mimicking their natural arrangement.This proof-ofconcept model includes a culture chamber,with an endothelial bioink printed and perfused through an epithelial channel.In silico simulations of the air velocity within the channel revealed shear stress values ranging from 0.13 to 0.39 Pa,aligning with the desired in vivo shear stress observed in the bronchi regions(0.1–0.4 Pa).Biomechanical movements during resting breathing were mimicked by incorporating a textile mesh positioned away from the cell–cell interface.The epithelial channel demonstrated a capacity for compression and expansion of up to−14.7%and+6.4%,respectively.Microscopic images showed that the epithelial cells formed a uniform monolayer within the lumen of the channel close to the bioprinted endothelial cells.Our novel model offers a valuable tool for future research into respiratory diseases and potential treatments under conditions closely mimicking those in the lung. 展开更多
关键词 Airway-on-a-chip In vitro model BIOPRINTING HYDROGEL Tissue engineering Lung
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Exploring Electric Vehicle Purchases and Residential Choices in a Two-Dimensional Monocentric City:An Agent-Based Microeconomic Model
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作者 Chao Shu Yue Bao +1 位作者 Ziyou Gao Zaihan Gao 《Engineering》 2025年第3期316-330,共15页
Vehicle electrification,an important method for reducing carbon emissions from road transport,has been promoted globally.In this study,we analyze how individuals adapt to this transition in transportation and its subs... Vehicle electrification,an important method for reducing carbon emissions from road transport,has been promoted globally.In this study,we analyze how individuals adapt to this transition in transportation and its subsequent impact on urban structure.Considering the varying travel costs associated with electric and fuel vehicles,we analyze the dynamic choices of households concerning house locations and vehicle types in a two-dimensional monocentric city.A spatial equilibrium is developed to model the interactions between urban density,vehicle age and vehicle type.An agent-based microeconomic residential choice model dynamically coupled with a house rent market is developed to analyze household choices of home locations and vehicle energy types,considering vehicle ages and competition for public charging piles.Key findings from our proposed models show that the proportion of electric vehicles(EVs)peaks at over 50%by the end of the first scrappage period,accompanied by more than a 40%increase in commuting distance and time compared to the scenario with only fuel vehicles.Simulation experiments on a theoretical grid indicate that heterogeneity-induced residential segregation can lead to urban sprawl and congestion.Furthermore,households with EVs tend to be located farther from the city center,and an increase in EV ownership contributes to urban expansion.Our study provides insights into how individuals adapt to EV transitions and the resulting impacts on home locations and land use changes.It offers a novel perspective on the dynamic interactions between EV adoption and urban development. 展开更多
关键词 Electric vehicles Two-dimensional monocentric city Agent-based model Residential segregation
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Magnetization-resolved density of states and mixed-order transition in the two-dimensional random bond Ising model:an entropic sampling study
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作者 Yi Liu Ding Wang +2 位作者 Xin Wang Dao-Xin Yao Lei-Han Tang 《Communications in Theoretical Physics》 2025年第12期167-177,共11页
Systems with quenched disorder possess complex energy landscapes that are challenging to explore under conventional Monte Carlo methods.In this work,we implement an efficient entropy sampling scheme for accurate compu... Systems with quenched disorder possess complex energy landscapes that are challenging to explore under conventional Monte Carlo methods.In this work,we implement an efficient entropy sampling scheme for accurate computation of the entropy function in low-energy regions.The method is applied to the two-dimensional±J random-bond Ising model,where frustration is controlled by the fraction p of ferromagnetic bonds.We investigate the low-temperature paramagnetic–ferromagnetic phase boundary below the multicritical point at T_(N)=0.9530(4),P_(N)=0.89078(8),as well as the zerotemperature ferromagnetic–spin-glass transition.Finite-size scaling analysis reveals that the phase boundary for T<T_(N) exhibits reentrant behavior.By analyzing the evolution of the magnetizationresolved density of states g(E,M)and ground-state spin configurations against increasing frustration,we provide strong evidence that the zero-temperature transition is a mixed-order.Finite-size scaling conducted on the spin-glass side supports the validity of β=0,whereβis the magnetization exponent,with a correlation length exponentν=1.50(8).Our results provide new insights into the nature of the ferromagnetic-to-spin-glass phase transition in an extensively degenerate ground state. 展开更多
关键词 random bond Ising model entropic sampling mixed-order transition
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Practical Application of the Multi-Dimensional Interactive Teaching Model in College English
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作者 Bo Sun 《Journal of Contemporary Educational Research》 2025年第10期106-111,共6页
The multi-dimensional interactive teaching model significantly enhances the effectiveness of college English instruction by emphasizing dynamic engagement between teachers and students,as well as among students themse... The multi-dimensional interactive teaching model significantly enhances the effectiveness of college English instruction by emphasizing dynamic engagement between teachers and students,as well as among students themselves.This paper explores practical strategies for implementing this model,focusing on four key aspects:deepening teachers’understanding of the model through continuous learning,innovating interactive methods such as questioning techniques and practical activities,leveraging modern technology to integrate resources and track learning progress,and establishing a communication platform that centers on student participation.By adopting these approaches,the model fosters a student-centered classroom environment,improves comprehensive English application skills,and optimizes overall teaching quality. 展开更多
关键词 Multi-dimensional interactive teaching model Student-centered approach Teacher-student interaction
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Evaluation of three-dimensional structure modeling of key enzymes in endogenous catabolism of polyamines
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作者 GUO Baolin XUE Qian +1 位作者 WANG Bing ZHAO Yuan 《化学研究》 2025年第3期268-277,共10页
The acetylpolyamine oxidase(APAO),spermine oxidase(SMO),and spermidine/spermine N1-acetyltransferase(SSAT)are pivotal enzymes in polyamine metabolism,exerting direct influence on polyamine homeostasis regulation.Dysfu... The acetylpolyamine oxidase(APAO),spermine oxidase(SMO),and spermidine/spermine N1-acetyltransferase(SSAT)are pivotal enzymes in polyamine metabolism,exerting direct influence on polyamine homeostasis regulation.Dysfunctions in these enzymes are intricately linked to inflammatory diseases and cancers.Establishing their three-dimensional structures is essential for exploring enzymatic catalytic mechanisms and designing inhibitors at the atomic level.This article primarily assesses the precision of AlphaFold2 and molecular dynamics simulations in determining the three-dimensional structures of these enzymes,utilizing protein conformation rationality assessment,residue correlation matrix,and other techniques.This provides robust models for subsequent polyamine catabolic metabolism calculations and offers valuable insights for modeling proteins that have yet to acquire crystal structures. 展开更多
关键词 AlphaFold2 molecular dynamics simulation polyamine metabolism ENZYME structure modeling
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Quantum phase transitions with eigen microstate approach in one-dimensional transverse-field Ising model
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作者 Zhongshan Su Yuan Jiang +5 位作者 Gaoke Hu Yue-Hua Su Liangsheng Li Wen-Long You Maoxin Liu Xiaosong Chen 《Chinese Physics B》 2025年第8期652-657,共6页
We propose an eigen microstate approach(EMA)for analyzing quantum phase transitions in quantum many-body systems,introducing a novel framework that does not require prior knowledge of an order parameter.Using the tran... We propose an eigen microstate approach(EMA)for analyzing quantum phase transitions in quantum many-body systems,introducing a novel framework that does not require prior knowledge of an order parameter.Using the transversefield Ising model(TFIM)as a case study,we demonstrate the effectiveness of EMA by identifying key features of the phase transition through the scaling behavior of eigenvalues and the structure of associated eigen microstates.Our results reveal substantial changes in the ground state of the TFIM as it undergoes a phase transition,as reflected in the behavior of specific componentsξ_(i)^((k))within the eigen microstates.This method is expected to be applicable to other quantum systems where predefining an order parameter is challenging. 展开更多
关键词 eigen microstate approach quantum phase transition transverse-field Ising model
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Three-dimensional geothermal reservoir model using the magnetotelluric method in medium and deep strata of Yishu fault zone,Rizhao Section
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作者 Du Wenlong Zhou Xingyu +5 位作者 Sun Yuanbin Wang Shidang Zhang Dabin Wang Chen Zhang Jinwei Ding Renwei 《Applied Geophysics》 2025年第4期1369-1379,1500,共12页
The Yishu fault zone in Shandong Province,China,exhibits favorable conditions for medium-and high-temperature geothermal storage.However,its geothermal occurrence patterns and heat storage model remain unclear.Recogni... The Yishu fault zone in Shandong Province,China,exhibits favorable conditions for medium-and high-temperature geothermal storage.However,its geothermal occurrence patterns and heat storage model remain unclear.Recognizing the importance of deep heat sources and heat channels in unraveling the formation mechanisms of medium-and high-temperature geothermal systems,we conducted a magnetotelluric survey along the Yishu fault zone,which contained 10 survey lines and 119 usable points.Using two-dimensional and three-dimensional nonlinear conjugate gradient inversion,the deep electrical structure was obtained,and the three-dimensional geothermal reservoir model in the study area was constructed for the first time.The results show that the deep low-resistance anomaly in the Yishu fault zone moves upward through the channel with slightly higher resistivity,forming a relatively low-resistance layer and a low-resistance layer in the shallow part,corresponding to the heat source,thermal conduction fault,heat reservoir,and overburden layer,respectively.The fault structure primarily controls regional geothermal anomalies,influencing atmospheric precipitation,surface water infiltration,and geothermal water migration pathways.The results of this study have a certain guiding significance for the study of the formation mechanism and distribution law of geothermal resources in the middle and deep strata of the Yishu fault zone.Additionally,the results provide valuable insights for the exploration and assessment of geothermal resources in the area. 展开更多
关键词 Yishu fault zone magnetotelluric sounding geothermal model heat flow channel
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Dynamical structure factor and a new method to measure the pairing gap in two-dimensional attractive Fermi-Hubbard model
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作者 Huaisong Zhao Feng Yuan +1 位作者 Tianxing Ma Peng Zou 《Chinese Physics B》 2025年第11期195-203,共9页
The measurement of the pairing gap is crucial for investigating the physical properties of superconductors or superfluids.We propose a strategy to measure the pairing gap through the dynamical excitations.With the ran... The measurement of the pairing gap is crucial for investigating the physical properties of superconductors or superfluids.We propose a strategy to measure the pairing gap through the dynamical excitations.With the random phase approximation(RPA),we study the dynamical excitations of a two-dimensional attractive Fermi-Hubbard model by calculating its dynamical structure factor.Two distinct collective modes emerge:a Goldstone phonon mode at transferred momentum q=[0,0]and a roton mode at q=[p,p].The roton mode exhibits a sharp molecular peak in the low-energy regime.Notably,the area under the roton molecular peak scales with the square of the pairing gap,which holds even in three-dimensional and spin-orbit coupled(SOC)optical lattices.This finding suggests an experimental approach to measure the pairing gap in lattice systems by analyzing the dynamical structure factor at q=[p,p]. 展开更多
关键词 attractive Fermi-Hubbard model SUPERFLUID dynamical excitations roton mode pairing gap measurement
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Mixed integer programming modeling for the satellite three-dimensional component assignment and layout optimization problem
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作者 Yufeng XIA Xianqi CHEN +3 位作者 Zhijia LIU Weien ZHOU Wen YAO Zhongneng ZHANG 《Chinese Journal of Aeronautics》 2025年第6期427-447,共21页
Satellite Component Layout Optimization(SCLO) is crucial in satellite system design.This paper proposes a novel Satellite Three-Dimensional Component Assignment and Layout Optimization(3D-SCALO) problem tailored to en... Satellite Component Layout Optimization(SCLO) is crucial in satellite system design.This paper proposes a novel Satellite Three-Dimensional Component Assignment and Layout Optimization(3D-SCALO) problem tailored to engineering requirements, aiming to optimize satellite heat dissipation while considering constraints on static stability, 3D geometric relationships between components, and special component positions. The 3D-SCALO problem is a challenging bilevel combinatorial optimization task, involving the optimization of discrete component assignment variables in the outer layer and continuous component position variables in the inner layer,with both influencing each other. To address this issue, first, a Mixed Integer Programming(MIP) model is proposed, which reformulates the original bilevel problem into a single-level optimization problem, enabling the exploration of a more comprehensive optimization space while avoiding iterative nested optimization. Then, to model the 3D geometric relationships between components within the MIP framework, a linearized 3D Phi-function method is proposed, which handles non-overlapping and safety distance constraints between cuboid components in an explicit and effective way. Subsequently, the Finite-Rectangle Method(FRM) is proposed to manage 3D geometric constraints for complex-shaped components by approximating them with a finite set of cuboids, extending the applicability of the geometric modeling approach. Finally, the feasibility and effectiveness of the proposed MIP model are demonstrated through two numerical examples"and a real-world engineering case, which confirms its suitability for complex-shaped components and real engineering applications. 展开更多
关键词 Mixed integer programming modeling Three-dimensional component assignment Layout optimization Phi-function Finite-rectangle method
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A stack-scale three-dimensional model to analyze the operation process of redox flow batteries
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作者 Haoyao Rao Lyuming Pan +14 位作者 Fan Yang Honghao Qi Xiaoqian Xu Xiangchi Liu Yifei Zhu Can Yang Jia Liu Jiayou Ren Qinping Jian Changxiang He Yubai Li Puiki Leung Yuan Lei Wenjia Li Lei Wei 《Materials Reports(Energy)》 2025年第4期91-100,共10页
Long-duration energy storage has become critical for renewable energy integration.While redox flow batteries,especially vanadium-based systems,are scaling up in capacity,their performance at the stack level remains in... Long-duration energy storage has become critical for renewable energy integration.While redox flow batteries,especially vanadium-based systems,are scaling up in capacity,their performance at the stack level remains insufficiently optimized,demanding more profound mechanistic studies and engineering refinements.To address the difficulties in resolving the flow inhomogeneity at the stack scale,this study establishes a multi-physics field coupling model and analyzes the pressure distributions,flow rate differences,active substance concentration,and electrochemical characteristics.The results show that the uneven cell pressure distribution is a key factor affecting the consistency of the system performance,and the increase in the flow rate improves the reactant homogeneity,with both the average concentration and the uniformity factor increasing with the flow rate.In contrast,high current densities lead to an increased imbalance between electrochemical depletion and reactant replenishment,resulting in a significant decrease in reactant concentration in the under-ribs region.In addition,a higher flow rate can expand the high-current-density region where the stack operates efficiently.This study provides a theoretical basis for optimizing the design of the stack components. 展开更多
关键词 Redox flow battery Numerical modeling Uniformity factor Mass transport Pump-based voltage efficiency
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Generalized Functional Linear Models:Efficient Modeling for High-dimensional Correlated Mixture Exposures
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作者 Bingsong Zhang Haibin Yu +11 位作者 Xin Peng Haiyi Yan Siran Li Shutong Luo Renhuizi Wei Zhujiang Zhou Yalin Kuang Yihuan Zheng Chulan Ou Linhua Liu Yuehua Hu Jindong Ni 《Biomedical and Environmental Sciences》 2025年第8期961-976,共16页
Objective Humans are exposed to complex mixtures of environmental chemicals and other factors that can affect their health.Analysis of these mixture exposures presents several key challenges for environmental epidemio... Objective Humans are exposed to complex mixtures of environmental chemicals and other factors that can affect their health.Analysis of these mixture exposures presents several key challenges for environmental epidemiology and risk assessment,including high dimensionality,correlated exposure,and subtle individual effects.Methods We proposed a novel statistical approach,the generalized functional linear model(GFLM),to analyze the health effects of exposure mixtures.GFLM treats the effect of mixture exposures as a smooth function by reordering exposures based on specific mechanisms and capturing internal correlations to provide a meaningful estimation and interpretation.The robustness and efficiency was evaluated under various scenarios through extensive simulation studies.Results We applied the GFLM to two datasets from the National Health and Nutrition Examination Survey(NHANES).In the first application,we examined the effects of 37 nutrients on BMI(2011–2016 cycles).The GFLM identified a significant mixture effect,with fiber and fat emerging as the nutrients with the greatest negative and positive effects on BMI,respectively.For the second application,we investigated the association between four pre-and perfluoroalkyl substances(PFAS)and gout risk(2007–2018 cycles).Unlike traditional methods,the GFLM indicated no significant association,demonstrating its robustness to multicollinearity.Conclusion GFLM framework is a powerful tool for mixture exposure analysis,offering improved handling of correlated exposures and interpretable results.It demonstrates robust performance across various scenarios and real-world applications,advancing our understanding of complex environmental exposures and their health impacts on environmental epidemiology and toxicology. 展开更多
关键词 Mixture exposure modeling Functional data analysis High-dimensional data Correlated exposures Environmental epidemiology
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Implementation of the Actuator Disc Approach in Modeling Three-Dimensional Full-Sized Tidal Turbines and Flow Interactions in an Idealized Channel
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作者 Anas Abdul RAHMAN Vengatesan VENUGOPAL 《China Ocean Engineering》 2025年第3期504-517,共14页
A numerical investigation on the effectiveness of the actuator disc method in producing the interactions of multiple tidal stream devices via the 3D-RANS finite element model Telemac3D is explored. The methodology for... A numerical investigation on the effectiveness of the actuator disc method in producing the interactions of multiple tidal stream devices via the 3D-RANS finite element model Telemac3D is explored. The methodology for the implementation of the source term to represent an array of 20 m rotor diameter turbines deployed in an idealized channel is reviewed and discussed in detail. Flow interactions between multiple turbines are investigated for a single row arrangement with only two turbines and a two row arrangement containing three turbines. The results demonstrate that the non-hydrostatic solver shows better agreement when validated against published experimental data. Notably,the mesh density at the device location can strongly influence the simulated thrust from the disc. Although the actuator disc model can generally replicate the wake interactions well, the results indicate that it cannot accurately characterize the flow for regions with high turbulences. While a model setup with the largest lateral spacing(1.5D) demonstrates excellent agreement with the experimental data, the 0.5D model(smallest gap) deviates by up to 25%. These findings demonstrate the effectiveness of the applied source term in reproducing the wake profile, which is comparable with the published data, and highlight the inherent nature of the RANS and actuator disc models. 展开更多
关键词 velocity deficit wake characteristics device spacing non-hydrostatic model Telemac3D tidal turbine
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Thermodynamics of classical one-dimensional generalized nonlinear Klein-Gordon lattice model
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作者 Hu-Wei Jia Ning-Hua Tong 《Chinese Physics B》 2025年第8期381-396,共16页
We study the thermodynamic properties of the classical one-dimensional generalized nonlinear Klein-Gordon lattice model(n≥2)by using the cluster variation method with linear response theory.The results of this method... We study the thermodynamic properties of the classical one-dimensional generalized nonlinear Klein-Gordon lattice model(n≥2)by using the cluster variation method with linear response theory.The results of this method are exact in the thermodynamic limit.We present the single-site reduced densityρ^((1))(z),averages such as(z^(2)),<|z^(n)|>,and<(z_(1)-z_(2))^(2)>,the specific heat C_(v),and the static correlation functions.We analyze the scaling behavior of these quantities and obtain the exact scaling powers at the low and high temperatures.Using these results,we gauge the accuracy of the projective truncation approximation for theφ^(4)lattice model. 展开更多
关键词 cluster variation method linear response theory one-dimensional generalized nonlinear Klein-Gordon lattice model
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Construction of complex three-dimensional vascularized liver tissue model in vitro based on a biphasic cell-laden embedding medium
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作者 Weikang Lv Haoran Yu +7 位作者 Abdellah Aazmi Tuya Naren Wanli Cheng Mengfei Yu Zhen Wang Xiaobin Xu Huayong Yang Liang Ma 《International Journal of Extreme Manufacturing》 2025年第3期304-319,共16页
Constructing an in vitro vascularized liver tissue model that closely simulates the human liver is crucial for promoting cell proliferation,mimicking physiological heterogeneous structures,and recreating the cellular ... Constructing an in vitro vascularized liver tissue model that closely simulates the human liver is crucial for promoting cell proliferation,mimicking physiological heterogeneous structures,and recreating the cellular microenvironment.However,the layer-by-layer printing method is significantly constrained by the rheological properties of the bioink,making it challenging to form complex three-dimensional vascular structures in low-viscosity soft materials.To overcome this limitation,we developed a cross-linkable biphasic embedding medium by mixing low-viscosity biomaterials with gelatin microgel.This medium possesses yield stress and self-healing properties,facilitating efficient and continuous three-dimensional shaping of sacrificial ink within it.By adjusting the printing speed,we controlled the filament diameter,achieving a range from 250μm to 1000μm,and ensuring precise control over ink deposition locations and filament shapes.Using the in situ endothelialization method,we constructed complex vascular structures and ensured close adhesion between hepatocytes and endothelial cells.In vitro experiments demonstrated that the vascularized liver tissue model exhibited enhanced protein synthesis and metabolic function compared to mixed liver tissue.We also investigated the impact of varying vascular densities on liver tissue function.Transcriptome sequencing revealed that liver tissues with higher vascular density exhibited upregulated gene expression in metabolic and angiogenesis-related pathways.In summary,this method is adaptable to various materials,allowing the rheological properties of the supporting bath and the tissue's porosity to be modified using microgels,thus enabling precise regulation of the liver tissue microenvironment.Additionally,it facilitates the rapid construction of three-dimensional vascular structures within liver tissue.The resulting vascularized liver tissue model exhibits enhanced biological functionality,opening new opportunities for biomedical applications. 展开更多
关键词 3D bioprinting biphasic cell-laden medium sacrificial embedded printing vascularized liver tissue model
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Dynamic Modeling of the Three-Dimensional Seated Human Body for High-Speed Train Ride Comfort Analysis
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作者 Hanwen Xu Xinbiao Xiao +4 位作者 Xiaoqing Dong Jian Han Peng Chen Qin Hu Xuesong Jin 《Chinese Journal of Mechanical Engineering》 2025年第5期478-507,共30页
Typically,seat or floor acceleration is used to evaluate the ride comfort of a high-speed train.However,the dynamic performance of the human body significantly differs from that of the floor.Therefore,using the car bo... Typically,seat or floor acceleration is used to evaluate the ride comfort of a high-speed train.However,the dynamic performance of the human body significantly differs from that of the floor.Therefore,using the car body floor and seat accelerations to calculate the ride comfort index of a high-speed train may not reflect the true feelings of passengers.In this study,a 3D human-seat-vehicle-track coupling model was established to investigate the ride comfort of highspeed train passengers.The seated human model,which considers the longitudinal,lateral,vertical,pitching,yawing,and rolling motions,comprises the head,upper torso,lower torso,pelvis,thighs,and shanks.The model parameters were determined using multi-axis excitation measurement data based on a genetic algorithm.Subsequently,the applicability of the small-angle assumption and natural modes of the human model is analyzed.Using the coupling system model,the vibration characteristics of the human-seat interaction surface were analyzed.The ride comfort of the high-speed train and human body dynamic performance were analyzed under normal conditions,track geometric irregularities and train meeting conditions.The results showed that the passenger seats in the front and rear rows adjacent to the window had a higher acceleration value than the others.The human backrest and seat pad connection points have higher vibration amplitudes than the car body floor in the human-sensitive frequency range,indicating that using the acceleration values on the floor may underestimate the discomfort of passengers.The ride comfort of high-speed trains diminishes in the presence of track geometric irregularities and when trains pass each other.When the excitation frequency of track geometry irregularities approached the natural frequency of the human-seat-vehicle system,ride comfort in high-speed trains decreased significantly.Moreover,using seat acceleration to evaluate passenger ride comfort overlooks the vibration characteristics of the human body.The transient aerodynamic force generated when the train meets can cause a larger car body roll and lateral motion at 2 Hz,which,in turn,decreases the passenger ride comfort.This study presents a detailed human-seat-vehicle-track coupling system that can reflect a passenger’s dynamic performance under complex operating conditions. 展开更多
关键词 Seated human body High-speed train Ride comfort 3D Human body-seat-vehicle-track coupling coupled model
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