Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory damage.The expression of the C-C motif chemokine ligand...Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory damage.The expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after injury.Recent studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for treatment.This review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord injury.Additionally,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis.This review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted drugs.Nevertheless,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis.This review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.展开更多
This paper reviews the advances in research of co-pathogenesis and clinical treatment of ankylosing spondylitis(AS)and inflammatory bowel disease(IBD),in order to offer ideal therapeutic effects for comorbid patients ...This paper reviews the advances in research of co-pathogenesis and clinical treatment of ankylosing spondylitis(AS)and inflammatory bowel disease(IBD),in order to offer ideal therapeutic effects for comorbid patients and to provide new ideas for clinical practice.展开更多
Objective: this experiment briefly analyzes the understanding and treatment of ankle sprain in the department of orthopedics and traumatology of traditional Chinese medicine. Methods: five years from May 2020 to May 2...Objective: this experiment briefly analyzes the understanding and treatment of ankle sprain in the department of orthopedics and traumatology of traditional Chinese medicine. Methods: five years from May 2020 to May 2021 were selected as the time points, and the years from 2020 to 2021 were recent years. Therefore, the research results are more time-sensitive and referential. From the patients received in the hospital during this period of time, 68 cases of study subjects with medication standard were selected and randomly divided into the control group and the experimental group with 34 patients in each group. The patients in the control group were treated with traditional Chinese medicine, while the patients in the experimental group were treated with massage. After the experiment, the therapeutic effect, recovery time of ankle sprain and patients' satisfaction with the treatment were compared between the two groups. Results: the effective rate of treatment in the experimental group was as high as 94.1%, while that in the control group was only 82.3%, the difference was statistically significant (p < 0.05). In addition, the patients in the experimental group were 94.1% satisfied with the treatment, while the patients in the control group were 79.4% satisfied with the treatment. The patients in the experimental group were more satisfied with the treatment. Conclusion: according to the results of the experiment, it can be seen that the therapeutic effect of the traditional Chinese medicine massage combined with traditional Chinese medicine application is better than the conventional treatment, which can not only shorten the treatment time, speed up the recovery of the patients, but also increase the satisfaction of the patients.展开更多
Since the first hematopoietic stem cell transplantation(HSCT)in 1956,HSCT has served as a cellular-level transplantation treatment that has cured tens of thousands of patients with hematologic diseases.[1]HSCT primari...Since the first hematopoietic stem cell transplantation(HSCT)in 1956,HSCT has served as a cellular-level transplantation treatment that has cured tens of thousands of patients with hematologic diseases.[1]HSCT primarily eradicates leukemia cells through myeloablative conditioning chemotherapy and the graft-versus-leukemia(GVL)effect,with subsequent developments such as donor lymphocyte infusion(DLI)and microtransplantation emerging as additional therapeutic methods.展开更多
基金supported by the National Natural Science Foundation of China(Key Program),No.11932013the National Natural Science Foundation of China(General Program),No.82272255+2 种基金Armed Police Force High-Level Science and Technology Personnel ProjectThe Armed Police Force Focuses on Supporting Scientific and Technological Innovation TeamsKey Project of Tianjin Science and Technology Plan,No.20JCZDJC00570(all to XC)。
文摘Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory damage.The expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after injury.Recent studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for treatment.This review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord injury.Additionally,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis.This review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted drugs.Nevertheless,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis.This review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.
文摘This paper reviews the advances in research of co-pathogenesis and clinical treatment of ankylosing spondylitis(AS)and inflammatory bowel disease(IBD),in order to offer ideal therapeutic effects for comorbid patients and to provide new ideas for clinical practice.
文摘Objective: this experiment briefly analyzes the understanding and treatment of ankle sprain in the department of orthopedics and traumatology of traditional Chinese medicine. Methods: five years from May 2020 to May 2021 were selected as the time points, and the years from 2020 to 2021 were recent years. Therefore, the research results are more time-sensitive and referential. From the patients received in the hospital during this period of time, 68 cases of study subjects with medication standard were selected and randomly divided into the control group and the experimental group with 34 patients in each group. The patients in the control group were treated with traditional Chinese medicine, while the patients in the experimental group were treated with massage. After the experiment, the therapeutic effect, recovery time of ankle sprain and patients' satisfaction with the treatment were compared between the two groups. Results: the effective rate of treatment in the experimental group was as high as 94.1%, while that in the control group was only 82.3%, the difference was statistically significant (p < 0.05). In addition, the patients in the experimental group were 94.1% satisfied with the treatment, while the patients in the control group were 79.4% satisfied with the treatment. The patients in the experimental group were more satisfied with the treatment. Conclusion: according to the results of the experiment, it can be seen that the therapeutic effect of the traditional Chinese medicine massage combined with traditional Chinese medicine application is better than the conventional treatment, which can not only shorten the treatment time, speed up the recovery of the patients, but also increase the satisfaction of the patients.
基金supported by grants from the National Natural Science Foundation of China(No.82341201)the National Key R&D Program of China(Nos.2022YFA1103300 and 2022YFA1103304)+1 种基金the Chongqing Municipal Natural Science Foundation General Project(No.2024NSCQ-MSX3299)the Special Project for Talent Construction in Xinqiao Hospital(No.2022XKRC001).
文摘Since the first hematopoietic stem cell transplantation(HSCT)in 1956,HSCT has served as a cellular-level transplantation treatment that has cured tens of thousands of patients with hematologic diseases.[1]HSCT primarily eradicates leukemia cells through myeloablative conditioning chemotherapy and the graft-versus-leukemia(GVL)effect,with subsequent developments such as donor lymphocyte infusion(DLI)and microtransplantation emerging as additional therapeutic methods.
