Atrial fibrillation （AF）, the most commonly encountered arrhythmia in clinical practice, is associated with a 2-fold increase in total cardiovascular mortality, as well as the potential for substantial morbidity, in...Atrial fibrillation （AF）, the most commonly encountered arrhythmia in clinical practice, is associated with a 2-fold increase in total cardiovascular mortality, as well as the potential for substantial morbidity, including stroke, congestive heart failure, and cardiomyopathy. Its incidence and prevalence are increasing, and it represents a growing clinical and economic burden. Owing to relative inefficacy and side effects of current pharmacological and non-pharmacological therapy for AF, it remains a great challenge to improve primary and secondary AF prevention strategies to reduce this potentially enormous health burden.展开更多
CAS scientists recently discovered that activation of a protein called β2-adrenergic receptor may lead to the abnormal formation of the amyloid plaques, which are believed to be the hallmark and primary cause of Alzh...CAS scientists recently discovered that activation of a protein called β2-adrenergic receptor may lead to the abnormal formation of the amyloid plaques, which are believed to be the hallmark and primary cause of Alzheimer's disease.展开更多
Hunan Province is one of the high incidence areas of nasopharyngeal carcinoma (NPC) in China and ranks the fourth after Guangdong, Guangxi and Fujian. Consequently, the pathogenesis of NPC has been the focus of our st...Hunan Province is one of the high incidence areas of nasopharyngeal carcinoma (NPC) in China and ranks the fourth after Guangdong, Guangxi and Fujian. Consequently, the pathogenesis of NPC has been the focus of our study for many years. Induction of experimental NPC by chemical carcinogens began from 1972. Later, NPC in rats was successfully induced by nitroso compounds, especially N, N’-dinitroso-piperazine (DNPZ) which possesses relative organospecificity and is able to induce squamous cell carcinoma of nasopharynx in rats even by subcutaneous injection. NPC induced in rats is slightly different from the NPC of human due to species difference: it often developed as well-dif-展开更多
Rheumatoid arthritis (RA) is a common type of autoimmune disease in clinic. Patients mainly present with systemic and chronic arthropathy. The human digestive tract hosts trillions of symbiotic bacteria, which play an...Rheumatoid arthritis (RA) is a common type of autoimmune disease in clinic. Patients mainly present with systemic and chronic arthropathy. The human digestive tract hosts trillions of symbiotic bacteria, which play an important role in the development, maturation and functional maintenance of the host immune system. Intestinal microflora disorder can affect local and systemic immune system and is closely related to the occurrence of various diseases. Recently, intestinal microbes have been found to play an important role in RA development. The following is a review of the impact of intestinal flora disturbance on RA.展开更多
Objective To investigate the level of antisperm antibodies （ASA） in infertile men with absolute immotile sperm （AIS）. Methods Thirteen men with AIS were enrolled into this study. Sperm immotility of ejaculates fro...Objective To investigate the level of antisperm antibodies （ASA） in infertile men with absolute immotile sperm （AIS）. Methods Thirteen men with AIS were enrolled into this study. Sperm immotility of ejaculates from these infertile men was proven by two or three consecutive semen analyses. Sperm vitality was assessed by the eosin exclusion. Serum and seminal plasma were screened by the indirect immunobead test （IBT） for ASA tYpe IgG and IgA according to the WHO laboratory manual.Results Semen samples from these patients showed ejaculate volume, pH, and sperm count in the normal range. Sperm vitality, sperm concentration, and sperm abnormal forms in these cases were 40.2 ±11.1%, 45.0 ±11.9× 10^6/ml, and 97.8 ±1.4%, respectively. No ease had the positive or sub-positive level of ASA type IgG and IgA in samples of both serum and seminal plasma. Conclusion ASA is not associated with the pathogenesis of AIS-associated infertility.展开更多
文摘Atrial fibrillation （AF）, the most commonly encountered arrhythmia in clinical practice, is associated with a 2-fold increase in total cardiovascular mortality, as well as the potential for substantial morbidity, including stroke, congestive heart failure, and cardiomyopathy. Its incidence and prevalence are increasing, and it represents a growing clinical and economic burden. Owing to relative inefficacy and side effects of current pharmacological and non-pharmacological therapy for AF, it remains a great challenge to improve primary and secondary AF prevention strategies to reduce this potentially enormous health burden.
文摘CAS scientists recently discovered that activation of a protein called β2-adrenergic receptor may lead to the abnormal formation of the amyloid plaques, which are believed to be the hallmark and primary cause of Alzheimer's disease.
文摘Hunan Province is one of the high incidence areas of nasopharyngeal carcinoma (NPC) in China and ranks the fourth after Guangdong, Guangxi and Fujian. Consequently, the pathogenesis of NPC has been the focus of our study for many years. Induction of experimental NPC by chemical carcinogens began from 1972. Later, NPC in rats was successfully induced by nitroso compounds, especially N, N’-dinitroso-piperazine (DNPZ) which possesses relative organospecificity and is able to induce squamous cell carcinoma of nasopharynx in rats even by subcutaneous injection. NPC induced in rats is slightly different from the NPC of human due to species difference: it often developed as well-dif-
文摘Rheumatoid arthritis (RA) is a common type of autoimmune disease in clinic. Patients mainly present with systemic and chronic arthropathy. The human digestive tract hosts trillions of symbiotic bacteria, which play an important role in the development, maturation and functional maintenance of the host immune system. Intestinal microflora disorder can affect local and systemic immune system and is closely related to the occurrence of various diseases. Recently, intestinal microbes have been found to play an important role in RA development. The following is a review of the impact of intestinal flora disturbance on RA.
文摘Objective To investigate the level of antisperm antibodies （ASA） in infertile men with absolute immotile sperm （AIS）. Methods Thirteen men with AIS were enrolled into this study. Sperm immotility of ejaculates from these infertile men was proven by two or three consecutive semen analyses. Sperm vitality was assessed by the eosin exclusion. Serum and seminal plasma were screened by the indirect immunobead test （IBT） for ASA tYpe IgG and IgA according to the WHO laboratory manual.Results Semen samples from these patients showed ejaculate volume, pH, and sperm count in the normal range. Sperm vitality, sperm concentration, and sperm abnormal forms in these cases were 40.2 ±11.1%, 45.0 ±11.9× 10^6/ml, and 97.8 ±1.4%, respectively. No ease had the positive or sub-positive level of ASA type IgG and IgA in samples of both serum and seminal plasma. Conclusion ASA is not associated with the pathogenesis of AIS-associated infertility.
