非霍奇金淋巴瘤(non-Hodgkin lymphoma,NHL)是临床上较为常见的血液系统恶性肿瘤,而弥漫性大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)是临床上最为常见的NHL。据研究报道,DLBCL在西方国家占成人NHL的30%~40%,而在我国所占比...非霍奇金淋巴瘤(non-Hodgkin lymphoma,NHL)是临床上较为常见的血液系统恶性肿瘤,而弥漫性大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)是临床上最为常见的NHL。据研究报道,DLBCL在西方国家占成人NHL的30%~40%,而在我国所占比例高达60%。展开更多
CD4 T helper(Th) cell differentiation into distinct T cell subsets is critical to the normal function of the immune system. Until recently,the paradigm held that na?ve T cells differentiated into distinct subsets unde...CD4 T helper(Th) cell differentiation into distinct T cell subsets is critical to the normal function of the immune system. Until recently,the paradigm held that na?ve T cells differentiated into distinct subsets under the guidance of environmental cues(e.g.,cytokines) and that once polarized,these cells were committed to a particular functional state. However,the existence of transdifferentiated T cell populations,which express signature transcription factors and cytokines associated with more than one Th subset,challenges the immutability of T helper subsets and suggests that plasticity is a feature of multifaceted immune responses. How this process impacts immune dysregulation in diseases such as inflammatory bowel diseases(IBD) and the machinery that underlies this process is far from fully understood. Interleukin(IL)-17 secreting helper T(Th17) cells have been heavily implicated in tissue-specific immune pathology including murine models of IBD,human Crohn's disease and ulcerative colitis. Plasticity within this subset is suggested by the existence of IL-17 secreting cells,which,can also secrete interferon-γ,the signature cytokine for Th1 cells or,can co-express the anti-inflammatory transcription factor forkhead box p3,a signature transcription factor of regulatory T cells. In this review we mainly discuss evidence for Th17 plasticity,mechanisms,which govern it,and highlight the potential to therapeutically target this process in human IBD.展开更多
This study creates and combines the general maneuver libraries for fixed-wing aircraft to implement tactical maneuvers.First,the generalized maneuver libraries are established by analyzing the characteristics of tacti...This study creates and combines the general maneuver libraries for fixed-wing aircraft to implement tactical maneuvers.First,the generalized maneuver libraries are established by analyzing the characteristics of tactical maneuvers required in battlefields.The 7th order polynomial is applied to both the creation of the maneuver libraries and the generation of the trajectories or flight paths for modal inputs.To track the desired trajectory,we design the Attitude Command Attitude Hold(ACAH)system and the Rate Command Rate Hold(RCRH)system using Model Following Controller(MFC).Moreover,the Line-of-Sight(LOS)guidance law is designed.In particular,the CONDUIT~?is employed to optimize the gains so that the control systems meet the aircraft Handling Qualities(HQ)criteria.Finally,flight simulations are performed for the longitudinal loop,immelmann-turn,and climb-slalom-descent maneuvers to verify that tactical aggressive maneuvers are realizable via the combination of maneuver libraries.This study can contribute to the development of flight techniques for aircraft tactical maneuvers and to the revision of air force operational manuals.展开更多
The 7th National Symposium on Coastal Engineering was held in Zhuhai, China, fromNovember 13th to 16th, 1993, co-sponsored by —Chinese Ocean Engineering Society —Harbour Engineering Committee, Chinese Society of Civ...The 7th National Symposium on Coastal Engineering was held in Zhuhai, China, fromNovember 13th to 16th, 1993, co-sponsored by —Chinese Ocean Engineering Society —Harbour Engineering Committee, Chinese Society of Civil Engineering —Harbour and Waterway Committee, Chinese Society of Hydraulic Engineering —Coast and Estuary Committee, Chinese Ocean and Limnology Society —Guangdong Ocean and Limnology Society —Guandong Society of Oceanograph展开更多
The 7th International Conference on Asian and Pacific Coasts （APAC2013） will be held in Bali, Indonesia in September 2013. The aim of the conference is to promote scientific advancement, technological progress, info...The 7th International Conference on Asian and Pacific Coasts （APAC2013） will be held in Bali, Indonesia in September 2013. The aim of the conference is to promote scientific advancement, technological progress, information exchange, and cooperation among engineers and researchers in coastal, port, and ocean engineering and other related fields展开更多
Background: We retrospectively identified prognostic factors in patients with Stage III colon cancer and considered the effectiveness of postoperative adjuvant chemotherapy based on these prognostic factors. Methods: ...Background: We retrospectively identified prognostic factors in patients with Stage III colon cancer and considered the effectiveness of postoperative adjuvant chemotherapy based on these prognostic factors. Methods: Two hundred and thirty four patients with lymph node metastases who underwent curative surgery for colon cancer between 1999 and 2005 were enrolled in the present study. Firstly, clinicopathological factors and survival data, were analyzed to determine prognostic factors related to cancer-specific survival. Secondly, we examined the effectiveness of postoperative adjuvant chemotherapy based upon these prognostic factors. Results: The multivariate analysis revealed that differentiation (P = 0.03, Hazard ratio = 2.50), lymphatic invasion (P = 0.02, Hazard ratio = 3.23) and the TNM classification, 7th?edition (P = 0.04, Hazard ratio = 1.94) were found to be significant independent prognostic factors. Among the patients classified as TNM IIIA, the recurrence-free survival rates were extremely good. Among the patients classified as IIIB and IIIC, there was no significant difference between the patients with and without postoperative adjuvant chemotherapy. Conclusion: The present study suggests that the patients with Stage IIIA colon cancer may not require postoperative adjuvant chemotherapy. The addition of oxaliplatin to 5-FU should be considered for the patients with Stage IIIB and IIIC colon cancer, for whom the prognoses are far from satisfactory.展开更多
文摘非霍奇金淋巴瘤(non-Hodgkin lymphoma,NHL)是临床上较为常见的血液系统恶性肿瘤,而弥漫性大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)是临床上最为常见的NHL。据研究报道,DLBCL在西方国家占成人NHL的30%~40%,而在我国所占比例高达60%。
文摘CD4 T helper(Th) cell differentiation into distinct T cell subsets is critical to the normal function of the immune system. Until recently,the paradigm held that na?ve T cells differentiated into distinct subsets under the guidance of environmental cues(e.g.,cytokines) and that once polarized,these cells were committed to a particular functional state. However,the existence of transdifferentiated T cell populations,which express signature transcription factors and cytokines associated with more than one Th subset,challenges the immutability of T helper subsets and suggests that plasticity is a feature of multifaceted immune responses. How this process impacts immune dysregulation in diseases such as inflammatory bowel diseases(IBD) and the machinery that underlies this process is far from fully understood. Interleukin(IL)-17 secreting helper T(Th17) cells have been heavily implicated in tissue-specific immune pathology including murine models of IBD,human Crohn's disease and ulcerative colitis. Plasticity within this subset is suggested by the existence of IL-17 secreting cells,which,can also secrete interferon-γ,the signature cytokine for Th1 cells or,can co-express the anti-inflammatory transcription factor forkhead box p3,a signature transcription factor of regulatory T cells. In this review we mainly discuss evidence for Th17 plasticity,mechanisms,which govern it,and highlight the potential to therapeutically target this process in human IBD.
基金High-Speed Compound Unmanned Rotorcraft(HCUR)research laboratory with the support of Agency for Defense Development(ADD).
文摘This study creates and combines the general maneuver libraries for fixed-wing aircraft to implement tactical maneuvers.First,the generalized maneuver libraries are established by analyzing the characteristics of tactical maneuvers required in battlefields.The 7th order polynomial is applied to both the creation of the maneuver libraries and the generation of the trajectories or flight paths for modal inputs.To track the desired trajectory,we design the Attitude Command Attitude Hold(ACAH)system and the Rate Command Rate Hold(RCRH)system using Model Following Controller(MFC).Moreover,the Line-of-Sight(LOS)guidance law is designed.In particular,the CONDUIT~?is employed to optimize the gains so that the control systems meet the aircraft Handling Qualities(HQ)criteria.Finally,flight simulations are performed for the longitudinal loop,immelmann-turn,and climb-slalom-descent maneuvers to verify that tactical aggressive maneuvers are realizable via the combination of maneuver libraries.This study can contribute to the development of flight techniques for aircraft tactical maneuvers and to the revision of air force operational manuals.
文摘The 7th National Symposium on Coastal Engineering was held in Zhuhai, China, fromNovember 13th to 16th, 1993, co-sponsored by —Chinese Ocean Engineering Society —Harbour Engineering Committee, Chinese Society of Civil Engineering —Harbour and Waterway Committee, Chinese Society of Hydraulic Engineering —Coast and Estuary Committee, Chinese Ocean and Limnology Society —Guangdong Ocean and Limnology Society —Guandong Society of Oceanograph
文摘The 7th International Conference on Asian and Pacific Coasts （APAC2013） will be held in Bali, Indonesia in September 2013. The aim of the conference is to promote scientific advancement, technological progress, information exchange, and cooperation among engineers and researchers in coastal, port, and ocean engineering and other related fields
文摘Background: We retrospectively identified prognostic factors in patients with Stage III colon cancer and considered the effectiveness of postoperative adjuvant chemotherapy based on these prognostic factors. Methods: Two hundred and thirty four patients with lymph node metastases who underwent curative surgery for colon cancer between 1999 and 2005 were enrolled in the present study. Firstly, clinicopathological factors and survival data, were analyzed to determine prognostic factors related to cancer-specific survival. Secondly, we examined the effectiveness of postoperative adjuvant chemotherapy based upon these prognostic factors. Results: The multivariate analysis revealed that differentiation (P = 0.03, Hazard ratio = 2.50), lymphatic invasion (P = 0.02, Hazard ratio = 3.23) and the TNM classification, 7th?edition (P = 0.04, Hazard ratio = 1.94) were found to be significant independent prognostic factors. Among the patients classified as TNM IIIA, the recurrence-free survival rates were extremely good. Among the patients classified as IIIB and IIIC, there was no significant difference between the patients with and without postoperative adjuvant chemotherapy. Conclusion: The present study suggests that the patients with Stage IIIA colon cancer may not require postoperative adjuvant chemotherapy. The addition of oxaliplatin to 5-FU should be considered for the patients with Stage IIIB and IIIC colon cancer, for whom the prognoses are far from satisfactory.
