目的观察芪参还五胶囊对冠心病患者心功能的改善及对外周血Th17/Treg平衡的影响。方法选择于医院治疗的110例冠心病患者,2021年1月—2022年6月为病例入组时间,分组方式为随机数字表法,西医组55例,给予西医基础治疗;芪参还五胶囊组55例,...目的观察芪参还五胶囊对冠心病患者心功能的改善及对外周血Th17/Treg平衡的影响。方法选择于医院治疗的110例冠心病患者,2021年1月—2022年6月为病例入组时间,分组方式为随机数字表法,西医组55例,给予西医基础治疗;芪参还五胶囊组55例,在西医基础治疗同时给予患者芪参还五胶囊治疗。治疗前、后检测两组患者Th17/Treg细胞比例、血红素加氧酶1(HO-1)、一氧化氮(NO)、白细胞介素-35(IL-35)、脂联素(APN)、白细胞介素-17A(IL-17A)、血管性血友病因子(vWF)、脂蛋白相关磷脂酶A2(Lp-PLA2)水平,检测患者冠状动脉微循环指标:冠状动脉血流储备(CFR)、血流量(Qmean)、平均循环抵抗指数(IMR),检测患者心肌耗氧量、左室射血分数(LVEF)、连续窦性R-R间期标准差(SDNN)、24 h QT离散度(QTd),给予患者动则喘息、胸闷气短、心胸隐痛、胸痛反复发作、倦怠懒言、面色㿠白评价,比较西医组及芪参还五胶囊组临床疗效。结果芪参还五胶囊组患者Th17/Treg、IL-17A含量较西医组明显降低(P<0.05),芪参还五胶囊组HO-1、IL-35含量较西医组升高(P<0.005);芪参还五胶囊组患者Lp-PLA2、vWF含量较西医组明显降低(P<0.05),芪参还五胶囊组患者NO、APN含量较西医组升高(P<0.05);芪参还五胶囊组CFR、Qmean较西医组明显升高(P<0.05),芪参还五胶囊组IMR较西医组明显降低(P<0.05);芪参还五胶囊组患者心肌耗氧量、QTd较西医组明显降低(P<0.05),芪参还五胶囊组LVEF、SDNN较西医组升高(P<0.05);芪参还五胶囊组患者心悸易汗、动则喘息、胸闷气短、心胸隐痛、胸痛反复发作、倦怠懒言、面色㿠白评分较西医组明显降低(P<0.05),芪参还五胶囊组总有效率为98.18%,西医组总有效率为83.64%,芪参还五胶囊组患者总有效率高于西医组(P<0.05)。结论芪参还五胶囊治疗冠心病患者,可调节机体Th17/Treg平衡,抑制机体炎症,减少血管内皮损伤,改善患者心功能、冠状动脉微循环及心电图指标,提升患者临床疗效。展开更多
Objective Sepsis patients exhibit diverse immune states,making it crucial to identify subtypes with distinct inflammatory profiles through Th1/Th2 cytokine data for personalized treatment and improved prognosis.Method...Objective Sepsis patients exhibit diverse immune states,making it crucial to identify subtypes with distinct inflammatory profiles through Th1/Th2 cytokine data for personalized treatment and improved prognosis.Methods We retrieved data from sepsis patients who underwent Th1/Th2 cytokine testing in Nanfang Hospital,Southern Medical University from June 1,2020,to February 1,2022.An unsupervised K-means clustering method classified participants based on Th1/Th2 cytokine levels,with the primary outcome being the 7-day mortality rate post-ICU admission.Cox proportional hazards and Restricted Mean Survival Time(RMST)analyses were utilized to explore survival outcomes.Results A total of 321 sepsis patients were included.IL-6(HR 1.69,95%CI:1.22,2.34)and IL-10(HR 1.81,95%CI:1.37,2.40)emerged as independent predictors of 7-day mortality.Unsupervised K-means clustering revealed 3 inflammatory/immune subgroups:Cluster 1(n=166,low inflammatory response),Cluster 2(n=99,moderate inflammatory response with immune suppression),and Cluster 3(n=56,strong inflammatory and immune suppression).Compared to Cluster 1,Clusters 2 and 3 had higher 7-day mortality risks(14.4%vs 23.2%,HR=4.30,95%CI:1.51-12.26;14.4%vs 35.7%,HR=7.32,95%CI:2.57-20.79).Conclusion Septic patients in a protective immune response state(Cluster 1)exhibit better short-term prognoses,suggesting the importance of understanding inflammatory/immune states for precise treatment and improved outcomes.展开更多
China’s 2025 Central Economic Work Conference,held in Beijing from December 10 to 11,2025,is one of the most consequential policy-setting meetings of the year.Chaired by Xi Jinping,general secretary of the Communist ...China’s 2025 Central Economic Work Conference,held in Beijing from December 10 to 11,2025,is one of the most consequential policy-setting meetings of the year.Chaired by Xi Jinping,general secretary of the Communist Party of China Central Committee and Chinese president,this year's meeting coincided with the final year of the 14th Five-Year Plan,serving as an assessment of accom-plishments while setting the policy direction for the first year of the 15th Five-Year Plan(2026-2030).展开更多
The highly anticipated Fourth Plenary Session of the 20th Central Committee of the Communist Party of China(CPC)was held in Beijing from 20 to 23 October.During the meeting,participants reviewed and approved the Recom...The highly anticipated Fourth Plenary Session of the 20th Central Committee of the Communist Party of China(CPC)was held in Beijing from 20 to 23 October.During the meeting,participants reviewed and approved the Recommendations of the CPC Central Committee for Formulating the 15th Five-Year Plan for Economic and Social Development.The communiquéacknowledged the substantial progress made during the 14th Five-Year Plan period,while outlining the principal objectives for economic and social development in the 15th Five-Year Plan.It also laid out a detailed framework of tasks and strategic priorities designed to drive the country’s modernisation.展开更多
Andrographolide sulfonate(AS)is a sulfonated derivative of andrographolide extracted from Andrographis paniculata(Burm.f.)Nees,and has been approved for several decades in China.The present study aimed to investigate ...Andrographolide sulfonate(AS)is a sulfonated derivative of andrographolide extracted from Andrographis paniculata(Burm.f.)Nees,and has been approved for several decades in China.The present study aimed to investigate the novel therapeutic application and possible mechanisms of AS in the treatment of rheumatoid arthritis.Results indicated that administration of AS by injection or gavage significantly reduced the paw swelling,improved body weights,and attenuated pathological changes in joints of rats with adjuvant-induced arthritis.Additionally,the levels of tumor necrosis factor-alpha(TNF-α),interleukin-6(IL-6),and IL-1β in the serum and ankle joints were reduced.Bioinformatics analysis,along with the spleen index and measurements of IL-17 and IL-10 levels,suggested a potential relationship between AS and Th17 cells under arthritic conditions.In vitro,AS was shown to block Th17 cell differentiation,as evidenced by the reduced percentages of CD4^(+)IL-17A^(+)T cells and decreased expression levels of RORγt,IL-17A,IL-17F,IL-21,and IL-22,without affecting the cell viability and apoptosis.This effect was attributed to the limited glycolysis,as indicated by metabolomics analysis,reduced glucose uptake,and p H measurements.Further investigation revealed that AS might bind to hexokinase2(HK2)to down-regulate the protein levels of HK2 but not glyceraldehyde-3-phosphate dehydrogenase(GAPDH)or pyruvate kinase M2(PKM2),and overexpression of HK2 reversed the inhibition of AS on Th17 cell differentiation.Furthermore,AS impaired the activation of phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)signals in vivo and in vitro,which was abolished by the addition of lactate.In conclusion,AS significantly improved adjuvant-induced arthritis(AIA)in rats by inhibiting glycolysis-mediated activation of PI3K/AKT to restrain Th17 cell differentiation.展开更多
Aug.21,2025,witnessed the festive celebration of Xizang Autonomous Region's 60th founding anniversary.On the Potala Palace Square,Lhasa,around 20,000 people from all ethnic groups and all walks of life across Xiza...Aug.21,2025,witnessed the festive celebration of Xizang Autonomous Region's 60th founding anniversary.On the Potala Palace Square,Lhasa,around 20,000 people from all ethnic groups and all walks of life across Xizang joined in the grand gathering to express their sin cere love and best wishes for the great motherland China and loved Xizang.展开更多
文摘目的观察芪参还五胶囊对冠心病患者心功能的改善及对外周血Th17/Treg平衡的影响。方法选择于医院治疗的110例冠心病患者,2021年1月—2022年6月为病例入组时间,分组方式为随机数字表法,西医组55例,给予西医基础治疗;芪参还五胶囊组55例,在西医基础治疗同时给予患者芪参还五胶囊治疗。治疗前、后检测两组患者Th17/Treg细胞比例、血红素加氧酶1(HO-1)、一氧化氮(NO)、白细胞介素-35(IL-35)、脂联素(APN)、白细胞介素-17A(IL-17A)、血管性血友病因子(vWF)、脂蛋白相关磷脂酶A2(Lp-PLA2)水平,检测患者冠状动脉微循环指标:冠状动脉血流储备(CFR)、血流量(Qmean)、平均循环抵抗指数(IMR),检测患者心肌耗氧量、左室射血分数(LVEF)、连续窦性R-R间期标准差(SDNN)、24 h QT离散度(QTd),给予患者动则喘息、胸闷气短、心胸隐痛、胸痛反复发作、倦怠懒言、面色㿠白评价,比较西医组及芪参还五胶囊组临床疗效。结果芪参还五胶囊组患者Th17/Treg、IL-17A含量较西医组明显降低(P<0.05),芪参还五胶囊组HO-1、IL-35含量较西医组升高(P<0.005);芪参还五胶囊组患者Lp-PLA2、vWF含量较西医组明显降低(P<0.05),芪参还五胶囊组患者NO、APN含量较西医组升高(P<0.05);芪参还五胶囊组CFR、Qmean较西医组明显升高(P<0.05),芪参还五胶囊组IMR较西医组明显降低(P<0.05);芪参还五胶囊组患者心肌耗氧量、QTd较西医组明显降低(P<0.05),芪参还五胶囊组LVEF、SDNN较西医组升高(P<0.05);芪参还五胶囊组患者心悸易汗、动则喘息、胸闷气短、心胸隐痛、胸痛反复发作、倦怠懒言、面色㿠白评分较西医组明显降低(P<0.05),芪参还五胶囊组总有效率为98.18%,西医组总有效率为83.64%,芪参还五胶囊组患者总有效率高于西医组(P<0.05)。结论芪参还五胶囊治疗冠心病患者,可调节机体Th17/Treg平衡,抑制机体炎症,减少血管内皮损伤,改善患者心功能、冠状动脉微循环及心电图指标,提升患者临床疗效。
文摘Objective Sepsis patients exhibit diverse immune states,making it crucial to identify subtypes with distinct inflammatory profiles through Th1/Th2 cytokine data for personalized treatment and improved prognosis.Methods We retrieved data from sepsis patients who underwent Th1/Th2 cytokine testing in Nanfang Hospital,Southern Medical University from June 1,2020,to February 1,2022.An unsupervised K-means clustering method classified participants based on Th1/Th2 cytokine levels,with the primary outcome being the 7-day mortality rate post-ICU admission.Cox proportional hazards and Restricted Mean Survival Time(RMST)analyses were utilized to explore survival outcomes.Results A total of 321 sepsis patients were included.IL-6(HR 1.69,95%CI:1.22,2.34)and IL-10(HR 1.81,95%CI:1.37,2.40)emerged as independent predictors of 7-day mortality.Unsupervised K-means clustering revealed 3 inflammatory/immune subgroups:Cluster 1(n=166,low inflammatory response),Cluster 2(n=99,moderate inflammatory response with immune suppression),and Cluster 3(n=56,strong inflammatory and immune suppression).Compared to Cluster 1,Clusters 2 and 3 had higher 7-day mortality risks(14.4%vs 23.2%,HR=4.30,95%CI:1.51-12.26;14.4%vs 35.7%,HR=7.32,95%CI:2.57-20.79).Conclusion Septic patients in a protective immune response state(Cluster 1)exhibit better short-term prognoses,suggesting the importance of understanding inflammatory/immune states for precise treatment and improved outcomes.
文摘China’s 2025 Central Economic Work Conference,held in Beijing from December 10 to 11,2025,is one of the most consequential policy-setting meetings of the year.Chaired by Xi Jinping,general secretary of the Communist Party of China Central Committee and Chinese president,this year's meeting coincided with the final year of the 14th Five-Year Plan,serving as an assessment of accom-plishments while setting the policy direction for the first year of the 15th Five-Year Plan(2026-2030).
文摘The highly anticipated Fourth Plenary Session of the 20th Central Committee of the Communist Party of China(CPC)was held in Beijing from 20 to 23 October.During the meeting,participants reviewed and approved the Recommendations of the CPC Central Committee for Formulating the 15th Five-Year Plan for Economic and Social Development.The communiquéacknowledged the substantial progress made during the 14th Five-Year Plan period,while outlining the principal objectives for economic and social development in the 15th Five-Year Plan.It also laid out a detailed framework of tasks and strategic priorities designed to drive the country’s modernisation.
基金supported by the project of Central Funds Guiding the Local Science and Technology Development(No.20212ZDD02010)。
文摘Andrographolide sulfonate(AS)is a sulfonated derivative of andrographolide extracted from Andrographis paniculata(Burm.f.)Nees,and has been approved for several decades in China.The present study aimed to investigate the novel therapeutic application and possible mechanisms of AS in the treatment of rheumatoid arthritis.Results indicated that administration of AS by injection or gavage significantly reduced the paw swelling,improved body weights,and attenuated pathological changes in joints of rats with adjuvant-induced arthritis.Additionally,the levels of tumor necrosis factor-alpha(TNF-α),interleukin-6(IL-6),and IL-1β in the serum and ankle joints were reduced.Bioinformatics analysis,along with the spleen index and measurements of IL-17 and IL-10 levels,suggested a potential relationship between AS and Th17 cells under arthritic conditions.In vitro,AS was shown to block Th17 cell differentiation,as evidenced by the reduced percentages of CD4^(+)IL-17A^(+)T cells and decreased expression levels of RORγt,IL-17A,IL-17F,IL-21,and IL-22,without affecting the cell viability and apoptosis.This effect was attributed to the limited glycolysis,as indicated by metabolomics analysis,reduced glucose uptake,and p H measurements.Further investigation revealed that AS might bind to hexokinase2(HK2)to down-regulate the protein levels of HK2 but not glyceraldehyde-3-phosphate dehydrogenase(GAPDH)or pyruvate kinase M2(PKM2),and overexpression of HK2 reversed the inhibition of AS on Th17 cell differentiation.Furthermore,AS impaired the activation of phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)signals in vivo and in vitro,which was abolished by the addition of lactate.In conclusion,AS significantly improved adjuvant-induced arthritis(AIA)in rats by inhibiting glycolysis-mediated activation of PI3K/AKT to restrain Th17 cell differentiation.
文摘Aug.21,2025,witnessed the festive celebration of Xizang Autonomous Region's 60th founding anniversary.On the Potala Palace Square,Lhasa,around 20,000 people from all ethnic groups and all walks of life across Xizang joined in the grand gathering to express their sin cere love and best wishes for the great motherland China and loved Xizang.
