Background： Recent studies suggest that dietary transfatty acids （TFAs） at relative high levels （i） increase the risk of coronary heart disease, （ii） inhibit the metabolism of linoleic acid and consequently inc...Background： Recent studies suggest that dietary transfatty acids （TFAs） at relative high levels （i） increase the risk of coronary heart disease, （ii） inhibit the metabolism of linoleic acid and consequently increase requirement for essential fatty acids （EFAs）. The aim of this prospective study was to estimate TFAs the placental transfer of TFAs to the foetus cord blood and cord tissues in France. Material： TFAs consumption was measured in 59 mother-foetus couples. TFAs transferring across the placenta were estimated by comparative measurement （Capillary Gaz Chromatography） of TFAs in mother＇s blood lipids （n = 59）, cord blood lipids and cord tissue plasma lipids （n = 25） cord red blood tissue （n = 25） and umbilical vessels （n = 15）. Results-Discussion： TFA deposition in cord blood is 0.58% slightly lower than mother level. TFAs incorporation in total lips of cord show selectivity of transfer with lower 18：1 t in cord blood and preferential transfer of diene 18：2 tc in cord blood. There is competition between the 18：2 tc in cholesterol esters （CE） with the linolenic acid and a negative correlation in PLT of arterial tissues with the 18：2 tc and C20：4 n-6 or arachidonic acid （AA）, then there is the same competition in PE of venous tissue. But there is no effect on growth in our population of term newborn. Conclusions： Our results confirm the placental TFAs transfer, a better incorporation in the fetus CE; we demonstrated a selective transfer for the 18：2 9 trans 12 cis （18：2 tc） and a negative correlation （r = -0.76） with the linoleic acid and AA （r = 0.98）. This competition, and the presence of these TFAs in cord tissues, even at a low TFAs consumption, remind us to be a potential risk for the fetus concerning EFA metabolism and growth.展开更多
目的研究黄蜀葵花总黄酮(Total F lavone of Abelmos-chusM an ihot(L)M ed ic,TFA)药理性预适应对家兔心肌缺血再灌注损伤的保护作用及机制。方法采用持续静脉推注TFA模拟预适应的实验方法,观察家兔冠状动脉左旋支经结扎、再灌后,其心...目的研究黄蜀葵花总黄酮(Total F lavone of Abelmos-chusM an ihot(L)M ed ic,TFA)药理性预适应对家兔心肌缺血再灌注损伤的保护作用及机制。方法采用持续静脉推注TFA模拟预适应的实验方法,观察家兔冠状动脉左旋支经结扎、再灌后,其心肌组织病理损伤情况、血浆中MDA含量和SOD、GSH-PX活力的变化以及心肌组织中细胞间粘附分子ICAM-1的表达情况。结果TFA不同程度减轻缺血再灌注损伤家兔心肌病理损伤的严重程度;明显降低血浆中MDA的含量,同时增强SOD及GSH-PX的活力;下调缺血心肌组织中ICAM-1 mRNA的表达。结论TFA药理性预适应可通过抑制心肌脂质过氧化、抑制心肌炎症反应,对缺血再灌注损伤的心肌具有保护作用。展开更多
文摘Background： Recent studies suggest that dietary transfatty acids （TFAs） at relative high levels （i） increase the risk of coronary heart disease, （ii） inhibit the metabolism of linoleic acid and consequently increase requirement for essential fatty acids （EFAs）. The aim of this prospective study was to estimate TFAs the placental transfer of TFAs to the foetus cord blood and cord tissues in France. Material： TFAs consumption was measured in 59 mother-foetus couples. TFAs transferring across the placenta were estimated by comparative measurement （Capillary Gaz Chromatography） of TFAs in mother＇s blood lipids （n = 59）, cord blood lipids and cord tissue plasma lipids （n = 25） cord red blood tissue （n = 25） and umbilical vessels （n = 15）. Results-Discussion： TFA deposition in cord blood is 0.58% slightly lower than mother level. TFAs incorporation in total lips of cord show selectivity of transfer with lower 18：1 t in cord blood and preferential transfer of diene 18：2 tc in cord blood. There is competition between the 18：2 tc in cholesterol esters （CE） with the linolenic acid and a negative correlation in PLT of arterial tissues with the 18：2 tc and C20：4 n-6 or arachidonic acid （AA）, then there is the same competition in PE of venous tissue. But there is no effect on growth in our population of term newborn. Conclusions： Our results confirm the placental TFAs transfer, a better incorporation in the fetus CE; we demonstrated a selective transfer for the 18：2 9 trans 12 cis （18：2 tc） and a negative correlation （r = -0.76） with the linoleic acid and AA （r = 0.98）. This competition, and the presence of these TFAs in cord tissues, even at a low TFAs consumption, remind us to be a potential risk for the fetus concerning EFA metabolism and growth.
文摘目的研究黄蜀葵花总黄酮(Total F lavone of Abelmos-chusM an ihot(L)M ed ic,TFA)药理性预适应对家兔心肌缺血再灌注损伤的保护作用及机制。方法采用持续静脉推注TFA模拟预适应的实验方法,观察家兔冠状动脉左旋支经结扎、再灌后,其心肌组织病理损伤情况、血浆中MDA含量和SOD、GSH-PX活力的变化以及心肌组织中细胞间粘附分子ICAM-1的表达情况。结果TFA不同程度减轻缺血再灌注损伤家兔心肌病理损伤的严重程度;明显降低血浆中MDA的含量,同时增强SOD及GSH-PX的活力;下调缺血心肌组织中ICAM-1 mRNA的表达。结论TFA药理性预适应可通过抑制心肌脂质过氧化、抑制心肌炎症反应,对缺血再灌注损伤的心肌具有保护作用。
