Objective Osteosarcoma is a prevalent primary malignant bone tumor in children and adolescents,accounting for approximately 5%of childhood malignancies.Because of its rarity and biological complexity,treatment breakth...Objective Osteosarcoma is a prevalent primary malignant bone tumor in children and adolescents,accounting for approximately 5%of childhood malignancies.Because of its rarity and biological complexity,treatment breakthroughs for osteosarcoma have been limited.To advance research in this field,we aimed to construct the first comprehensive osteosarcoma knowledge graph(OSKG)using the PubMed database.Methods A systematic search of PubMed(2003-2023)using the keyword"osteosarcoma"yielded 25,415 abstracts.Leveraging BioBERT,pretrained on biomedical corpora and fine-tuned with osteosarcoma-specific manual annotations,we identified 16 entity types and 17 biological relationships.The extracted elements were synthesized to create the OSKG,resulting in a deep learning-based knowledge base to explore osteosarcoma pathogenesis and molecular mechanisms.We then developed a specialized question-answering system(knowledge graph question answering(KGQA))powered by ChatGLM3.This system employs advanced natural language processing and incorporates the OSKG to ensure optimal response quality and accuracy.Results The pretrained BioBERT averaged>92%accuracy in entity and relationship training.Evaluation using 100 pairs of gold-standard quizzes showed that the final quiz system outperformed other large language models in accuracy and robustness.Conclusion The system is designed to provide accurate disease-related queries and answers,effectively facilitating knowledge acquisition and reasoning in medical research and clinical practice.This project offers a robust tool for osteosarcoma research and promotes the deep integration of knowledge graphs and artificial intelligence technologies in the medical field.展开更多
基金supported by grants fromthe National Key Research and Development Program of China(Program No.2021YFC2400600/2021YFC2400605)the Post-graduate Science Popularization Capability Promotion Program for 2022 sponsored by China Association for Science and Technology(Grant No.KXYJS2022098).
文摘Objective Osteosarcoma is a prevalent primary malignant bone tumor in children and adolescents,accounting for approximately 5%of childhood malignancies.Because of its rarity and biological complexity,treatment breakthroughs for osteosarcoma have been limited.To advance research in this field,we aimed to construct the first comprehensive osteosarcoma knowledge graph(OSKG)using the PubMed database.Methods A systematic search of PubMed(2003-2023)using the keyword"osteosarcoma"yielded 25,415 abstracts.Leveraging BioBERT,pretrained on biomedical corpora and fine-tuned with osteosarcoma-specific manual annotations,we identified 16 entity types and 17 biological relationships.The extracted elements were synthesized to create the OSKG,resulting in a deep learning-based knowledge base to explore osteosarcoma pathogenesis and molecular mechanisms.We then developed a specialized question-answering system(knowledge graph question answering(KGQA))powered by ChatGLM3.This system employs advanced natural language processing and incorporates the OSKG to ensure optimal response quality and accuracy.Results The pretrained BioBERT averaged>92%accuracy in entity and relationship training.Evaluation using 100 pairs of gold-standard quizzes showed that the final quiz system outperformed other large language models in accuracy and robustness.Conclusion The system is designed to provide accurate disease-related queries and answers,effectively facilitating knowledge acquisition and reasoning in medical research and clinical practice.This project offers a robust tool for osteosarcoma research and promotes the deep integration of knowledge graphs and artificial intelligence technologies in the medical field.
