Malnutrition is described as a state of insufficient intake of energy,protein and other nutrients leading to changes in body composition(weight loss,reduced fat-free mass)as well as adverse functional and clinical out...Malnutrition is described as a state of insufficient intake of energy,protein and other nutrients leading to changes in body composition(weight loss,reduced fat-free mass)as well as adverse functional and clinical outcomes.[1]Depending on the assessments and definition used,the prevalence in older patients ranges between 12%in communitydwelling adults to 60%of patients in geriatric care facilities.[2–5]Older populations are at high risk of nutritional deficiencies because of risk factors such as multimorbidity,polypharmacy,cognitive and physical decline,poor appetite,depressive syndromes and socioeconomic changes.[4,6].展开更多
Introduction:Rotatory chair testing has been used to evaluate horizontal canal function.Frequently used tests include sinusoidal harmonic acceleration test(SHAT)and velocity step test(VST).Objectives:Assessment of age...Introduction:Rotatory chair testing has been used to evaluate horizontal canal function.Frequently used tests include sinusoidal harmonic acceleration test(SHAT)and velocity step test(VST).Objectives:Assessment of age effect on the SHAT and VST and assessment of test-retest reliability of the parameters of those two tests.Methods:A prospective study was performed on 100 subjects with no ear or vestibular complaints and normal vestibular evaluation.They were divided into two groups;Group A:below 50 years of age and Group B:50 years of age or above.SHAT was presented at frequencies 0.02,0.04,0.08,0.16,0.32,0.64 Hz with a peak velocity of 60°/s.VST was performed using a maximum velocity of 100°/s with acceleration and deceleration of 200°/s2.Thirty subjects were tested twice to assess reliability.Results:Study participants ranged in age from 20 to 67 years.Regarding group A,the mean age was30.92±7.31 and 55.36±4.61 for group B.No significant differences were found in SHAT parameters between the two groups.As well,there was no significant difference in VST per-rotatory time constant,however,post-rotatory time constant was significantly longer for Group B(P value<0.05).Intraclass correlation coefficient(ICC)values showed moderate to good reliability(ICC 0.5800.818)for SHAT parameters for the lower frequencies and indicated moderate reliability for VST time constant(ICC 0.5090.652).Conclusions:Age has no significant effect on the parameters of SHAT and VST.Test-retest reliability is generally good for both tests.展开更多
Vergence eye movements are the inward and outward rotation of the eyes responsible for binocular coordination.While studies have mapped and investigated the neural substrates of vergence,it is not well understood whet...Vergence eye movements are the inward and outward rotation of the eyes responsible for binocular coordination.While studies have mapped and investigated the neural substrates of vergence,it is not well understood whether vergence eye movements evoke the blood oxygen level-dependent signal reliably in separate experimental visits.The test-retest reliability of stimulus-induced vergence eye movement tasks during a functional magnetic resonance imaging(fMRI)experiment is important for future randomized clinical trials(RCTs).In this study,we established region of interest(ROI)masks for the vergence neural circuit.Twenty-seven binocularly normal young adults participated in two functional imaging sessions measured on different days on the same 3 T Siemens scanner.The fMRI experiments used a block design of sustained visual fixation and rest blocks interleaved between task blocks that stimulated eight or four vergence eye movements.The test-retest reliability of task-activation was assessed using the intraclass correlation coefficient(ICC),and that of spatial extent was assessed using the Dice coefficient.Functional activation during the vergence eye movement task of eight movements compared to rest was repeatable within the primary visual cortex(ICC=0.8),parietal eye fields(ICC=0.6),supplementary eye field(ICC=0.5),frontal eye fields(ICC=0.5),and oculomotor vermis(ICC=0.6).The results demonstrate significant test-retest reliability in the ROIs of the vergence neural substrates for functional activation magnitude and spatial extent using the stimulus protocol of a task block stimulating eight vergence eye movements compared to sustained fixation.These ROIs can be used in future longitudinal RCTs to study patient populations with vergence dysfunctions.展开更多
Functional hubs with disproportionately extensive connectivities play a crucial role in global information integration in human brain networks.However,most resting-state functional magnetic resonance imaging(R-fMRI)st...Functional hubs with disproportionately extensive connectivities play a crucial role in global information integration in human brain networks.However,most resting-state functional magnetic resonance imaging(R-fMRI)studies have identified functional hubs by examining spontaneous fluctuations of the blood oxygen level-dependent signal within a typical low-frequency band(e.g.,0.01–0.08 Hz or 0.01–0.1 Hz).Little is known about how the spatial distributions of functional hubs depend on frequency bands of interest.Here,we used repeatedly measured R-fMRI data from 53 healthy young adults and a degree centrality analysis to identify voxelwise frequency-resolved functional hubs and further examined their test-retest reliability across two sessions.We showed that a wide-range frequency band(0.01–0.24 Hz)accessible with a typical sampling rate(fsample=0.5 Hz)could be classified into three frequency bands with distinct patterns,namely,low-frequency(LF,0.01–0.06 Hz),middle-frequency(MF,0.06–0.16 Hz),and high-frequency(HF,0.16–0.24 Hz)bands.The functional hubs were mainly located in the medial and lateral frontal and parietal cortices in the LF band,and in the medial prefrontal cortex,superior temporal gyrus,parahippocampal gyrus,amygdala,and several cerebellar regions in the MF and HF bands.These hub regions exhibited fair to good test-retest reliability,regardless of the frequency band.The presence of the three frequency bands was well replicated using an independent R-fMRI dataset from 45 healthy young adults.Our findings demonstrate reliable frequency-resolved functional connectivity hubs in three categories,thus providing insights into the frequency-specific connectome organization in healthy and disordered brains.展开更多
This pilot study examined the psychometric properties and clinical utility of a brief neuropsychological instrument (Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). The test-retest reliabil...This pilot study examined the psychometric properties and clinical utility of a brief neuropsychological instrument (Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). The test-retest reliability, practice effects and convergent validity of RBANS were examined in participants without objective cognitive impairment. The tests were administered at two time points at approximately a two weeks’ interval, with 30 cognitively intact participants with a mean age of 63.3 ± 5.8 years. Adequate test-retest reliabilities were found for RBANS subtests, index and total scale scores with significant gain scores in immediate memory and visuospatial function. The RBANS showed good convergent validity and the RBANS supplemented with executive and language measures (Colour Trails Test and 30-item modified Boston Naming Test, respectively) demonstrated excellent convergent validity with a formal neuropsychological battery. This pilot study has provided the preliminary evidence of reliability and convergent validity of the RBANS. Additionally, it also provides insight on the practice effects so that clinicians may assess significant changes in RBANS subtests and domain indexes for clinical practice.展开更多
Background: Test-retest strength reliability of the Electronic Push/Pull Dynamometer (EPPD) in the measurement of the extensor and flexor muscles on a new constructed chair. The objective of the study was to assess re...Background: Test-retest strength reliability of the Electronic Push/Pull Dynamometer (EPPD) in the measurement of the extensor and flexor muscles on a new constructed chair. The objective of the study was to assess reliability of Electronic Push/Pull Dynamometer in the measurement of the knee flexion and extension at 90° and 60° on a new constructed chair. The aims of the author: To assess reliability of Electronic Push/Pull Dynamometer in the measurement of the knee flexion and extension at 90° and 60° on a new constructed chair. Design: A test-retest reliability study. Subjects: One hundred healthy students male and female (mean age, 21y). Methods: Maximum isometric strength of the quadriceps and hamstring muscle groups was measured using the EPPD were recorded at 60° and 90° for 3 trials on 2 occasions. Reliability was assessed with the Intraclass correlation coefficient (ICC), mean and standard deviation (SD) of measurements, and smallest real differences were calculated for the maximum and for the mean and work of the 3 repetitions. Results: Mean strength ranged from 50.44 kg for knee flexion to 55.76 kg for knee extension 50.44 kg to 61.98 kg at 90° hip flexion. Test-retest reliability Intraclass correlation coefficients (ICCs) ranged from 0.85 to 0.99. ICCs for test-retest reliability ranged from 0.780 to 0.998. Conclusions: The results of the reliability study indicate that the EPPD in reliable dynamometer to use in determining lower limb muscle force production. It can be used to measure disease progression and to evaluate changes in knee extension and flexion strength at the individual patient level.展开更多
This study explored how the human cortical folding pattern composed of convex gyri and concave sulci afected single-subject morphological brain networks,which are becoming an important method for studying the human br...This study explored how the human cortical folding pattern composed of convex gyri and concave sulci afected single-subject morphological brain networks,which are becoming an important method for studying the human brain connectome.We found that gyri-gyri networks exhibited higher morphological similarity,lower small-world parameters,and lower long-term test-retest reliability than sulci-sulci networks for cortical thickness-and gyrifcation index-based networks,while opposite patterns were observed for fractal dimension-based networks.Further behavioral association analysis revealed that gyri-gyri networks and connections between gyral and sulcal regions signifcantly explained inter-individual variance in Cognition and Motor domains for fractal dimension-and sulcal depth-based networks.Finally,the clinical application showed that only sulci-sulci networks exhibited morphological similarity reductions in major depressive disorder for cortical thickness-,fractal dimension-,and gyrifcation index-based networks.Taken together,these fndings provide novel insights into the constraint of the cortical folding pattern to the network organization of the human brain.展开更多
目的评价22张等价的单音节测听表在正常人群中的复测信度,以利于采用该言语测听材料时得出合理可靠的结论。方法招募北京22名18～30岁耳科正常人,在10 dB HLSpeech强度下,以拉丁方实验设计方案,依次进行22张单音节表的识别率测试。间隔6...目的评价22张等价的单音节测听表在正常人群中的复测信度,以利于采用该言语测听材料时得出合理可靠的结论。方法招募北京22名18～30岁耳科正常人,在10 dB HLSpeech强度下,以拉丁方实验设计方案,依次进行22张单音节表的识别率测试。间隔6～35天,在完全相同的条件下重新进行第二轮次的识别率测试。结果两轮测试的识别率分别为74.0%±12.2%和72.4%±10.3%,经配对t检验显示P=0.000152。逐表汇总两轮测试得分的差值,统计该差值在22名受试者中的标准差为9.3%,转化成95%置信度下的临界差值(crit-ical difference)为18.3%。两轮测试得分的相关系数为0.684。结论正常人使用该套单音节测听表进行有关言语工程的评价研究时,同一受试者前后两次识别率之差只有高于18.3%时,方可认为处置有效。展开更多
基金The study had been approved by the ethics committee of the University of Potsdam(No.39/2018).
文摘Malnutrition is described as a state of insufficient intake of energy,protein and other nutrients leading to changes in body composition(weight loss,reduced fat-free mass)as well as adverse functional and clinical outcomes.[1]Depending on the assessments and definition used,the prevalence in older patients ranges between 12%in communitydwelling adults to 60%of patients in geriatric care facilities.[2–5]Older populations are at high risk of nutritional deficiencies because of risk factors such as multimorbidity,polypharmacy,cognitive and physical decline,poor appetite,depressive syndromes and socioeconomic changes.[4,6].
文摘Introduction:Rotatory chair testing has been used to evaluate horizontal canal function.Frequently used tests include sinusoidal harmonic acceleration test(SHAT)and velocity step test(VST).Objectives:Assessment of age effect on the SHAT and VST and assessment of test-retest reliability of the parameters of those two tests.Methods:A prospective study was performed on 100 subjects with no ear or vestibular complaints and normal vestibular evaluation.They were divided into two groups;Group A:below 50 years of age and Group B:50 years of age or above.SHAT was presented at frequencies 0.02,0.04,0.08,0.16,0.32,0.64 Hz with a peak velocity of 60°/s.VST was performed using a maximum velocity of 100°/s with acceleration and deceleration of 200°/s2.Thirty subjects were tested twice to assess reliability.Results:Study participants ranged in age from 20 to 67 years.Regarding group A,the mean age was30.92±7.31 and 55.36±4.61 for group B.No significant differences were found in SHAT parameters between the two groups.As well,there was no significant difference in VST per-rotatory time constant,however,post-rotatory time constant was significantly longer for Group B(P value<0.05).Intraclass correlation coefficient(ICC)values showed moderate to good reliability(ICC 0.5800.818)for SHAT parameters for the lower frequencies and indicated moderate reliability for VST time constant(ICC 0.5090.652).Conclusions:Age has no significant effect on the parameters of SHAT and VST.Test-retest reliability is generally good for both tests.
基金supported by the National Eye Institute of the National Institutes of Health,Department of Health and Human Services,Bethesda,MD,USA(NEI ROIEY023261 to TLA)。
文摘Vergence eye movements are the inward and outward rotation of the eyes responsible for binocular coordination.While studies have mapped and investigated the neural substrates of vergence,it is not well understood whether vergence eye movements evoke the blood oxygen level-dependent signal reliably in separate experimental visits.The test-retest reliability of stimulus-induced vergence eye movement tasks during a functional magnetic resonance imaging(fMRI)experiment is important for future randomized clinical trials(RCTs).In this study,we established region of interest(ROI)masks for the vergence neural circuit.Twenty-seven binocularly normal young adults participated in two functional imaging sessions measured on different days on the same 3 T Siemens scanner.The fMRI experiments used a block design of sustained visual fixation and rest blocks interleaved between task blocks that stimulated eight or four vergence eye movements.The test-retest reliability of task-activation was assessed using the intraclass correlation coefficient(ICC),and that of spatial extent was assessed using the Dice coefficient.Functional activation during the vergence eye movement task of eight movements compared to rest was repeatable within the primary visual cortex(ICC=0.8),parietal eye fields(ICC=0.6),supplementary eye field(ICC=0.5),frontal eye fields(ICC=0.5),and oculomotor vermis(ICC=0.6).The results demonstrate significant test-retest reliability in the ROIs of the vergence neural substrates for functional activation magnitude and spatial extent using the stimulus protocol of a task block stimulating eight vergence eye movements compared to sustained fixation.These ROIs can be used in future longitudinal RCTs to study patient populations with vergence dysfunctions.
基金The study was supported by the National Key R&D Program of China(2018YFA0701402)the National Natural Science Foundation of China(82021004,81971690,81620108016,and 11835003)the Fundamental Research Funds for the Central Universities of China(2019NTST24).
文摘Functional hubs with disproportionately extensive connectivities play a crucial role in global information integration in human brain networks.However,most resting-state functional magnetic resonance imaging(R-fMRI)studies have identified functional hubs by examining spontaneous fluctuations of the blood oxygen level-dependent signal within a typical low-frequency band(e.g.,0.01–0.08 Hz or 0.01–0.1 Hz).Little is known about how the spatial distributions of functional hubs depend on frequency bands of interest.Here,we used repeatedly measured R-fMRI data from 53 healthy young adults and a degree centrality analysis to identify voxelwise frequency-resolved functional hubs and further examined their test-retest reliability across two sessions.We showed that a wide-range frequency band(0.01–0.24 Hz)accessible with a typical sampling rate(fsample=0.5 Hz)could be classified into three frequency bands with distinct patterns,namely,low-frequency(LF,0.01–0.06 Hz),middle-frequency(MF,0.06–0.16 Hz),and high-frequency(HF,0.16–0.24 Hz)bands.The functional hubs were mainly located in the medial and lateral frontal and parietal cortices in the LF band,and in the medial prefrontal cortex,superior temporal gyrus,parahippocampal gyrus,amygdala,and several cerebellar regions in the MF and HF bands.These hub regions exhibited fair to good test-retest reliability,regardless of the frequency band.The presence of the three frequency bands was well replicated using an independent R-fMRI dataset from 45 healthy young adults.Our findings demonstrate reliable frequency-resolved functional connectivity hubs in three categories,thus providing insights into the frequency-specific connectome organization in healthy and disordered brains.
文摘This pilot study examined the psychometric properties and clinical utility of a brief neuropsychological instrument (Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). The test-retest reliability, practice effects and convergent validity of RBANS were examined in participants without objective cognitive impairment. The tests were administered at two time points at approximately a two weeks’ interval, with 30 cognitively intact participants with a mean age of 63.3 ± 5.8 years. Adequate test-retest reliabilities were found for RBANS subtests, index and total scale scores with significant gain scores in immediate memory and visuospatial function. The RBANS showed good convergent validity and the RBANS supplemented with executive and language measures (Colour Trails Test and 30-item modified Boston Naming Test, respectively) demonstrated excellent convergent validity with a formal neuropsychological battery. This pilot study has provided the preliminary evidence of reliability and convergent validity of the RBANS. Additionally, it also provides insight on the practice effects so that clinicians may assess significant changes in RBANS subtests and domain indexes for clinical practice.
文摘Background: Test-retest strength reliability of the Electronic Push/Pull Dynamometer (EPPD) in the measurement of the extensor and flexor muscles on a new constructed chair. The objective of the study was to assess reliability of Electronic Push/Pull Dynamometer in the measurement of the knee flexion and extension at 90° and 60° on a new constructed chair. The aims of the author: To assess reliability of Electronic Push/Pull Dynamometer in the measurement of the knee flexion and extension at 90° and 60° on a new constructed chair. Design: A test-retest reliability study. Subjects: One hundred healthy students male and female (mean age, 21y). Methods: Maximum isometric strength of the quadriceps and hamstring muscle groups was measured using the EPPD were recorded at 60° and 90° for 3 trials on 2 occasions. Reliability was assessed with the Intraclass correlation coefficient (ICC), mean and standard deviation (SD) of measurements, and smallest real differences were calculated for the maximum and for the mean and work of the 3 repetitions. Results: Mean strength ranged from 50.44 kg for knee flexion to 55.76 kg for knee extension 50.44 kg to 61.98 kg at 90° hip flexion. Test-retest reliability Intraclass correlation coefficients (ICCs) ranged from 0.85 to 0.99. ICCs for test-retest reliability ranged from 0.780 to 0.998. Conclusions: The results of the reliability study indicate that the EPPD in reliable dynamometer to use in determining lower limb muscle force production. It can be used to measure disease progression and to evaluate changes in knee extension and flexion strength at the individual patient level.
基金supported by the STI 2030-Major Projects(2021ZD0200500)the National Social Science Foundation of China(20&ZD296)Key Realm R&D Program of Guangdong Province(2019B030335001).
文摘This study explored how the human cortical folding pattern composed of convex gyri and concave sulci afected single-subject morphological brain networks,which are becoming an important method for studying the human brain connectome.We found that gyri-gyri networks exhibited higher morphological similarity,lower small-world parameters,and lower long-term test-retest reliability than sulci-sulci networks for cortical thickness-and gyrifcation index-based networks,while opposite patterns were observed for fractal dimension-based networks.Further behavioral association analysis revealed that gyri-gyri networks and connections between gyral and sulcal regions signifcantly explained inter-individual variance in Cognition and Motor domains for fractal dimension-and sulcal depth-based networks.Finally,the clinical application showed that only sulci-sulci networks exhibited morphological similarity reductions in major depressive disorder for cortical thickness-,fractal dimension-,and gyrifcation index-based networks.Taken together,these fndings provide novel insights into the constraint of the cortical folding pattern to the network organization of the human brain.
文摘目的评价22张等价的单音节测听表在正常人群中的复测信度,以利于采用该言语测听材料时得出合理可靠的结论。方法招募北京22名18～30岁耳科正常人,在10 dB HLSpeech强度下,以拉丁方实验设计方案,依次进行22张单音节表的识别率测试。间隔6～35天,在完全相同的条件下重新进行第二轮次的识别率测试。结果两轮测试的识别率分别为74.0%±12.2%和72.4%±10.3%,经配对t检验显示P=0.000152。逐表汇总两轮测试得分的差值,统计该差值在22名受试者中的标准差为9.3%,转化成95%置信度下的临界差值(crit-ical difference)为18.3%。两轮测试得分的相关系数为0.684。结论正常人使用该套单音节测听表进行有关言语工程的评价研究时,同一受试者前后两次识别率之差只有高于18.3%时,方可认为处置有效。
