The Temtebasement in North Cameroon is crosscut by dyke swarms with N 20°–40°trending,including dykes 15–30 m wide,up to 3 km-long.Representative rocks exhibit intersertal to sub-ophitic textures.Electron ...The Temtebasement in North Cameroon is crosscut by dyke swarms with N 20°–40°trending,including dykes 15–30 m wide,up to 3 km-long.Representative rocks exhibit intersertal to sub-ophitic textures.Electron microprobe analyses identified diopside,augite,pargasite,biotite,Ti-magnetite,plagioclase,and sanidine.Whole-rock ICP-MS and ICP-AES chemical analyses showed compositions of basaltic andesite,basaltic trachyandesite and trachyandesite in composition.Igneous differentiation was likely governed by fractional crystallization associated with limited fluid metasomatism.Some lavas could have been moderately contaminated by crustal materials during feeding of local cracks through turbulent magma flows.Discrimination geochemical diagrams and immobile trace and REE element ratios show that the mantle source of Temtedolerites was a deep phlogopitebearing EMII mantle component and has undergone moderate to high partial melting rate.Correlations of fieldwork and analytical data with previous results evidence the Temtedolerite dyke swarms as fingerprints of crustal extension accompanying regional uplift in an active continental margin when early rifting led to the formation of the Poli marginal basin.展开更多
Total saponins of Panax notoginseng （PNS） have been shown to ameliorate renal interstitial fibrosis. Ginsenoside Rg 1, a panaxatriol saponin, is one of the major active molecules from PNS. The present study was unde...Total saponins of Panax notoginseng （PNS） have been shown to ameliorate renal interstitial fibrosis. Ginsenoside Rg 1, a panaxatriol saponin, is one of the major active molecules from PNS. The present study was undertaken to investigate the effect of ginsenoside Rgl on renal fibrosis in rats with unilateral ureteral obstruction （UUO）. The rats were randomly divided into 3 groups： sham-operation （n=15）, UUO （n=15） and UUO with ginsenoside Rgl treatment （n=15, 50 mg per kg body weight, intraperitoneally （i.p.） injected）. The rats were sacrificed on Days 7 and 14 after the surgery. Histological examination demonstrated that ginsenoside Rgl significantly inhibited interstitial fibrosis including tubular injury as well as collagen deposition, u-smooth muscle actin （α-SMA） and E-cadherin are two markers of tubular epithelial-myofibroblast transition （TEMT）. Interestingly, ginsenoside Rgl notably decreased α-SMA expression and simultaneously enhanced E-cadherin expression. The messenger RNA （mRNA） of transforming growth factor-β1 （TGF-β1）, a key mediator to regulate TEMT, in the obstructed kidney increased dramatically, but was found to decrease significantly after administration of ginsenoside Rg 1. Further study showed that ginsenoside Rgl considerably decreased the levels of both active TGF-β1 and phosphorylated Smad2 （pSmad2）. Moreover, ginsenoside Rgl substantially suppressed the expression of thrombospondin-1 （TSP-1）, a cytokine which can promote the transcription of TGF-β1 mRNA and the activation of latent TGF-β1. These results suggest that ginsenoside Rgl inhibits renal interstitial fibrosis in rats with UUO. The mechanism might be partly related to the blocking of TEMT via suppressing the expression of TSP-1.展开更多
基金"Agence Universitaire de la Francophonie (AUF)" through the BAGL (Bureau Afrique Centrale et des Grands Lacs) for financial support of Le Projet de soutien aux équipes de recherche 2012/2013 (No 51110SU201) for supplement analyses"Laboratoire GEOPS" of the University Paris-Saclay is thanked for financial support of thin sections and electron microprobe analyses。
文摘The Temtebasement in North Cameroon is crosscut by dyke swarms with N 20°–40°trending,including dykes 15–30 m wide,up to 3 km-long.Representative rocks exhibit intersertal to sub-ophitic textures.Electron microprobe analyses identified diopside,augite,pargasite,biotite,Ti-magnetite,plagioclase,and sanidine.Whole-rock ICP-MS and ICP-AES chemical analyses showed compositions of basaltic andesite,basaltic trachyandesite and trachyandesite in composition.Igneous differentiation was likely governed by fractional crystallization associated with limited fluid metasomatism.Some lavas could have been moderately contaminated by crustal materials during feeding of local cracks through turbulent magma flows.Discrimination geochemical diagrams and immobile trace and REE element ratios show that the mantle source of Temtedolerites was a deep phlogopitebearing EMII mantle component and has undergone moderate to high partial melting rate.Correlations of fieldwork and analytical data with previous results evidence the Temtedolerite dyke swarms as fingerprints of crustal extension accompanying regional uplift in an active continental margin when early rifting led to the formation of the Poli marginal basin.
基金Project (No. 30170437) supported by the National Natural Science Foundation of China
文摘Total saponins of Panax notoginseng （PNS） have been shown to ameliorate renal interstitial fibrosis. Ginsenoside Rg 1, a panaxatriol saponin, is one of the major active molecules from PNS. The present study was undertaken to investigate the effect of ginsenoside Rgl on renal fibrosis in rats with unilateral ureteral obstruction （UUO）. The rats were randomly divided into 3 groups： sham-operation （n=15）, UUO （n=15） and UUO with ginsenoside Rgl treatment （n=15, 50 mg per kg body weight, intraperitoneally （i.p.） injected）. The rats were sacrificed on Days 7 and 14 after the surgery. Histological examination demonstrated that ginsenoside Rgl significantly inhibited interstitial fibrosis including tubular injury as well as collagen deposition, u-smooth muscle actin （α-SMA） and E-cadherin are two markers of tubular epithelial-myofibroblast transition （TEMT）. Interestingly, ginsenoside Rgl notably decreased α-SMA expression and simultaneously enhanced E-cadherin expression. The messenger RNA （mRNA） of transforming growth factor-β1 （TGF-β1）, a key mediator to regulate TEMT, in the obstructed kidney increased dramatically, but was found to decrease significantly after administration of ginsenoside Rg 1. Further study showed that ginsenoside Rgl considerably decreased the levels of both active TGF-β1 and phosphorylated Smad2 （pSmad2）. Moreover, ginsenoside Rgl substantially suppressed the expression of thrombospondin-1 （TSP-1）, a cytokine which can promote the transcription of TGF-β1 mRNA and the activation of latent TGF-β1. These results suggest that ginsenoside Rgl inhibits renal interstitial fibrosis in rats with UUO. The mechanism might be partly related to the blocking of TEMT via suppressing the expression of TSP-1.
