Objective Evidence from prospective studies on the consumption of tea and risk of gout is conflicting and limited.We aimed to investigate the potential causal effects of tea intake on gout using Mendelian randomizatio...Objective Evidence from prospective studies on the consumption of tea and risk of gout is conflicting and limited.We aimed to investigate the potential causal effects of tea intake on gout using Mendelian randomization(MR).Methods Genome-wide association studies in UK Biobank included 349376 individuals and successfully discovered single-nucleotide polymorphisms linked to consumption of one cup of tea per day.Summary statistics from the Chronic Kidney Disease Genetics consortium included 13179 cases and 750634 controls for gout.Two-sample MR analyses were used to evaluate the relationship between tea consumption and gout risk.The inverse-variance weighted(IVW)method was used for primary analysis,and sensitivity analyses were also conducted to validate the potential causal effect.Results In this study,the genetically predicted increase in tea consumption per cup was associated with a lower risk of gout in the IVW method(OR:0.90;95%CI:0.82–0.98).Similar results were found in weighted median methods(OR:0.88;95%CI:0.78–1.00),while no significant associations were found in MR-Egger(OR:0.89;95%CI:0.71–1.11),weighted mode(OR:0.80;95%CI:0.65–0.99),and simple mode(OR:1.01;95%CI:0.75–1.36).In addition,no evidence of pleiotropy was detected by MR-Egger regression(P=0.95)or MR-PRESSO analysis(P=0.07).Conclusion This study provides evidence for the daily consumption of an extra cup of tea to reduce the risk of gout.展开更多
To investigate whether alcohol and tea con-sumption has an etiological association with nasophar-yngeal carcinoma(NPC)in a high-incident population,a large scale case-control study was conducted.The study included 284...To investigate whether alcohol and tea con-sumption has an etiological association with nasophar-yngeal carcinoma(NPC)in a high-incident population,a large scale case-control study was conducted.The study included 2846 individuals in Guangdong Province,China,with 1387 newly diagnosed cases of NPC and 1459 frequency-matched controls.Exposure histories of alcohol and tea consumption were obtained via personal inter-views.Information regarding socio-demographic charac-teristics(age,sex,education,dialect and household type),family history of NPC,Epstein-Barr virus(EBV)infection,dietary habits and other potential confounding factors was also studied.An analysis was performed using uncondi-tional logistic regression to calculate odds ratios(OR)and 95%confidence intervals(CI).The risk of NPC was found to be associated with habitual alcohol consumption and tea consumption.Tea consumption has been associated with a decreased occurrence of NPC(OR=0.62),while con-sumption of alcohol was associated with a complex effect.Specifically,moderate consumption of alcohol was associated with decreased risk of NPC,while overuse,especially strong distillate spirits,appeared to be a risk factor.展开更多
Background and Objectives:The precise impact of tea consumption on the risk of depression remains unclear.This study aimed to explore the relationship between the consumption patterns of tea and the likelihood of de p...Background and Objectives:The precise impact of tea consumption on the risk of depression remains unclear.This study aimed to explore the relationship between the consumption patterns of tea and the likelihood of de pression onset,utilizing a two-sample Mendelian randomization(MR)methodology.Methods and S tudy Design:We utilized available genome-wide association study(GWAS)datasets on tea intake and depressive disorders.To investigate the causal relationship between tea consumption and depression,we employed a set of two-sample Mendelian Randomization(MR)methods.These included the inverse-variance weighted(IVW)analysis,weighted median approach,and MR-Egger regression.Additionally,we utilized MR-PRESSO and the MR-Egger intercept test for the detection of pleiotropic effects.To ensure the robustness and consistency of our findings,a sensitivity analysis was carried out,applying the'leave-one-out'strategy.The Bayesian weighted Mendelian ran domization(BWMR)was employed to conduct additional testing on the obtained results.Results:The study's outcomes revealed a causal association between increased tea intake and an increased risk of depression(Inverse-Variance Weighted Analysis:Odds Ratio[OR]=1.029,95%Confidence Interval[CI]:1.003-1.055,p=0.027).This was observed despite variations in instrumental variables and the nonexistence of horizontal pleiotropy.Fur ther more,the robustness of our Mendelian Randomization investigation was affirmed through the implementation of the'leave-one-out'method in our sensitivity analysis.The findings from BWMR were in line with those ob tained from IVW(BWMR:OR=1.030,95%CI:1.003-1.057,p=0.029).Conclusions:The results from this study indicate a substantial and positive causal link between the regularity of tea drinking and the risk of depres sion onset.展开更多
基金supported by grants from the Natural Science Foundation of China(No.82102199)the General Program of Shanghai Municipal Commission of Health and Family Planning(No.202040479).
文摘Objective Evidence from prospective studies on the consumption of tea and risk of gout is conflicting and limited.We aimed to investigate the potential causal effects of tea intake on gout using Mendelian randomization(MR).Methods Genome-wide association studies in UK Biobank included 349376 individuals and successfully discovered single-nucleotide polymorphisms linked to consumption of one cup of tea per day.Summary statistics from the Chronic Kidney Disease Genetics consortium included 13179 cases and 750634 controls for gout.Two-sample MR analyses were used to evaluate the relationship between tea consumption and gout risk.The inverse-variance weighted(IVW)method was used for primary analysis,and sensitivity analyses were also conducted to validate the potential causal effect.Results In this study,the genetically predicted increase in tea consumption per cup was associated with a lower risk of gout in the IVW method(OR:0.90;95%CI:0.82–0.98).Similar results were found in weighted median methods(OR:0.88;95%CI:0.78–1.00),while no significant associations were found in MR-Egger(OR:0.89;95%CI:0.71–1.11),weighted mode(OR:0.80;95%CI:0.65–0.99),and simple mode(OR:1.01;95%CI:0.75–1.36).In addition,no evidence of pleiotropy was detected by MR-Egger regression(P=0.95)or MR-PRESSO analysis(P=0.07).Conclusion This study provides evidence for the daily consumption of an extra cup of tea to reduce the risk of gout.
基金supported by the National Natural Science Foundation of China(Grant Nos.30671798 and 30471487)the National Science and Technology Support Program of China(No.2006BAI02A11)the National Major Basic Research Program of China(863 Program)(No.2006AA02A404).
文摘To investigate whether alcohol and tea con-sumption has an etiological association with nasophar-yngeal carcinoma(NPC)in a high-incident population,a large scale case-control study was conducted.The study included 2846 individuals in Guangdong Province,China,with 1387 newly diagnosed cases of NPC and 1459 frequency-matched controls.Exposure histories of alcohol and tea consumption were obtained via personal inter-views.Information regarding socio-demographic charac-teristics(age,sex,education,dialect and household type),family history of NPC,Epstein-Barr virus(EBV)infection,dietary habits and other potential confounding factors was also studied.An analysis was performed using uncondi-tional logistic regression to calculate odds ratios(OR)and 95%confidence intervals(CI).The risk of NPC was found to be associated with habitual alcohol consumption and tea consumption.Tea consumption has been associated with a decreased occurrence of NPC(OR=0.62),while con-sumption of alcohol was associated with a complex effect.Specifically,moderate consumption of alcohol was associated with decreased risk of NPC,while overuse,especially strong distillate spirits,appeared to be a risk factor.
基金supported by Guangxi University of Chinese Medicine"Qihuang Project"high-level talent team(202410)Academic Team Building Project of the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine(146[2018])+2 种基金Guangxi Key Discipline Construction Project of Tradi tional Chinese Medicine(GZXK-Z-20-13)Guangxi Clinical Research Center for Encephalopathy of Traditional Chinese Medicine,No.Guike AD20238028High-level Innovation Team and Outstanding Scholars Program of Universities in Guangxi(Guangxi Education Talents(2020)No.6).
文摘Background and Objectives:The precise impact of tea consumption on the risk of depression remains unclear.This study aimed to explore the relationship between the consumption patterns of tea and the likelihood of de pression onset,utilizing a two-sample Mendelian randomization(MR)methodology.Methods and S tudy Design:We utilized available genome-wide association study(GWAS)datasets on tea intake and depressive disorders.To investigate the causal relationship between tea consumption and depression,we employed a set of two-sample Mendelian Randomization(MR)methods.These included the inverse-variance weighted(IVW)analysis,weighted median approach,and MR-Egger regression.Additionally,we utilized MR-PRESSO and the MR-Egger intercept test for the detection of pleiotropic effects.To ensure the robustness and consistency of our findings,a sensitivity analysis was carried out,applying the'leave-one-out'strategy.The Bayesian weighted Mendelian ran domization(BWMR)was employed to conduct additional testing on the obtained results.Results:The study's outcomes revealed a causal association between increased tea intake and an increased risk of depression(Inverse-Variance Weighted Analysis:Odds Ratio[OR]=1.029,95%Confidence Interval[CI]:1.003-1.055,p=0.027).This was observed despite variations in instrumental variables and the nonexistence of horizontal pleiotropy.Fur ther more,the robustness of our Mendelian Randomization investigation was affirmed through the implementation of the'leave-one-out'method in our sensitivity analysis.The findings from BWMR were in line with those ob tained from IVW(BWMR:OR=1.030,95%CI:1.003-1.057,p=0.029).Conclusions:The results from this study indicate a substantial and positive causal link between the regularity of tea drinking and the risk of depres sion onset.
