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Endostar对肿瘤血管内皮细胞生长及功能的抑制作用 被引量:3
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作者 蒋力 何勇 蒋耀光 《第三军医大学学报》 CAS CSCD 北大核心 2009年第21期2069-2072,共4页
目的探讨Endostar对肿瘤血管内皮细胞生长和功能的抑制作用及其相关的抗血管形成机制。方法采用A549细胞上清诱导人脐静脉内皮细胞(human umbilical vein endothelial cells,HUVEC)成为肿瘤血管内皮细胞(tumor-derived endothelial cell... 目的探讨Endostar对肿瘤血管内皮细胞生长和功能的抑制作用及其相关的抗血管形成机制。方法采用A549细胞上清诱导人脐静脉内皮细胞(human umbilical vein endothelial cells,HUVEC)成为肿瘤血管内皮细胞(tumor-derived endothelial cells,Td-EC),通过MTT法、细胞迁徙试验、流式细胞术、TUNEL法等检测Endostar对Td-EC细胞生物学特性的影响。结果Endostar在体外对于Td-EC有显著的生长抑制作用,并具有时间和浓度依赖性,但对于HUVEC的生长抑制作用并不显著;一定浓度的Endostar能显著降低Td-EC细胞迁徙活性,促使细胞凋亡数目增加、细胞形态学发生改变,并能显著增加Td-ECS期细胞比例(P<0.01),而同样条件下,Endostar影响细胞迁徙活性及促进细胞凋亡的作用对于HUVEC并不显著(P>0.05)。结论Endostar可以特异性地抑制肿瘤血管内皮细胞的生长及功能。 展开更多
关键词 ENDOSTAR td-ec 细胞迁徙
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天山乌鲁木齐河流域山区水化学特征分析 被引量:14
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作者 冯芳 冯起 +2 位作者 李忠勤 刘蔚 金爽 《自然资源学报》 CSSCI CSCD 北大核心 2014年第1期143-155,共13页
2006、2007年在乌鲁木齐河流域山区,沿河源冰川区到中游山区的6个水文站点(1号冰川、空冰斗、总控、巴拉提沟、跃进桥和后峡)定期持续采集径流样品,对流域山区河流水化学组成、演化过程及影响因素进行了分析。结果表明,所有径流样品的... 2006、2007年在乌鲁木齐河流域山区,沿河源冰川区到中游山区的6个水文站点(1号冰川、空冰斗、总控、巴拉提沟、跃进桥和后峡)定期持续采集径流样品,对流域山区河流水化学组成、演化过程及影响因素进行了分析。结果表明,所有径流样品的离子组成均为Ca2+-HCO-3-SO2-4型,呈弱碱性。河源区冰川径流中TDS和EC均值总控>1号冰川>空冰斗,其中1号冰川径流峰值最大。与河源区相比,上中游3个水文站径流离子含量、TDS和EC明显增高。通过Piper图显示,上中游径流水化学类型与河源区相似,表明整个流域山区径流水化学形成过程存在相似原理。结合Gibbs图和离子比值进行分析,得出碳酸盐、黄铁矿和长石类矿物风化是水化学组成的控制因素。上中游径流中Mg2+和SO2-4离子浓度比例有所增长,表明流域演化过程中含S矿物的氧化作用对径流离子组成的贡献率逐渐增加。 展开更多
关键词 水化学特征 离子浓度 TDS和EC 岩石风化 乌鲁木齐河
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天山乌鲁木齐河源区径流水化学特征及影响因素分析 被引量:10
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作者 冯芳 李忠勤 +2 位作者 张明军 金爽 王飞腾 《资源科学》 CSSCI CSCD 北大核心 2011年第12期2238-2247,共10页
在乌鲁木齐河源区采集两年的大气降水和1号冰川、空冰斗、总控3个水文点逐日定时径流样品,对主要离子、pH、电导率EC和总溶解固体TDS进行了分析。结果表明,大气降水离子类型为Ca2+-Na+-HCO3--SO42-,接近中性;径流离子类型为Ca2+-HCO3--S... 在乌鲁木齐河源区采集两年的大气降水和1号冰川、空冰斗、总控3个水文点逐日定时径流样品,对主要离子、pH、电导率EC和总溶解固体TDS进行了分析。结果表明,大气降水离子类型为Ca2+-Na+-HCO3--SO42-,接近中性;径流离子类型为Ca2+-HCO3--SO42-,呈弱碱性。径流中EC和TDS均值总控>1号冰川>空冰斗,其中1号冰川径流的峰值远高于其它两个水文点。受不同下垫面的影响,1号冰川水文点TDS变化受日径流量影响显著,而空冰斗水文点基本不受影响。径流中离子组成主要受岩石风化作用影响,离子比值和Piper图分析说明控制径流离子的主要过程是碳酸盐、黄铁矿和长石类矿物风化。海盐校正分析得出,大气降水对1号冰川、空冰斗、总控径流离子贡献率分别为4.91%,9.10%和5.42%。通过阳离子通量计算,2006年、2007年1号冰川径流的化学风化侵蚀率分别为18.1t/(km2·a)和12.3t/(km2·a)。 展开更多
关键词 离子浓度 EC和TDS 岩石风化 离子通量 乌鲁木齐河源
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天山哈密榆树沟流域春洪期水化学特征及其控制因素研究 被引量:11
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作者 王晓艳 李忠勤 +2 位作者 周平 若孜罕.塔依尔 高鹏 《干旱区地理》 CSCD 北大核心 2014年第5期922-930,共9页
2013年4月26日-5月2日,逐日采集哈密榆树沟流域下游榆树沟水文站点的河水样。综合运用描述性统计、相关性分析、Gibbs图、阴阳离子三角图示法,对主要的化学离子、pH值、电导率EC、总可溶性固体TDS进行了分析。结果表明:榆树沟流域春洪... 2013年4月26日-5月2日,逐日采集哈密榆树沟流域下游榆树沟水文站点的河水样。综合运用描述性统计、相关性分析、Gibbs图、阴阳离子三角图示法,对主要的化学离子、pH值、电导率EC、总可溶性固体TDS进行了分析。结果表明:榆树沟流域春洪期径流水体呈弱碱性;HCO3-、Ca2+是阴、阳离子中最主要的离子,Ca2+质量浓度占阳离子总数的74.31%,HCO3-质量浓度占阴离子总数的82.07%;水化学类型为HCO3--Ca2+;径流中主要离子组成、TDS、EC、pH值受即时径流量的调节作用不大,岩石的风化作用是水化学主要离子来源的主要控制因素,其中主要来源于石灰岩等碳酸盐岩的风化。 展开更多
关键词 EC和TDS 离子浓度 岩石风化 榆树沟流域
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An Inexpensive and Simple Experimental Approach for the Estimation of Solute Import into Groundwater and Subsequent Export Using Inflow/Outflow Data
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作者 Velu Rasiah 《Journal of Water Resource and Protection》 2017年第8期908-930,共23页
In agricultural catchments where groundwater (GW) base flow discharge contributes substantially towards stream flow, the information linking GW inflow/outflow with contaminant import/export is scarce. However, this in... In agricultural catchments where groundwater (GW) base flow discharge contributes substantially towards stream flow, the information linking GW inflow/outflow with contaminant import/export is scarce. However, this information is essential to address aquatic ecosystem health hazard/risk associated with nitrate export and subsequent loading in sensitive surface water bodies (SWB). The objectives of this study were to assess the temporal dynamics of (i) rain water inflow/outflow behaviour in three agricultural catchments in the humid tropics of far-northeast Queensland of Australia, (ii) solute import via inflow and subsequent export in outflow, and (iii) the association between GW inflow/outflow and solute import/export. Approximately 71% of the average seasonal rainfall percolated (inflow) into the porous basaltic regolith of the Johnstone River Catchment (JRC) compared with 44% into the alluvial regolith in the Mulgrave River Catchment (MRC) and 29% into the metamorphic regolith in the Tully River Catchment (TRC), respectively. The outflows from the basaltic, alluvial, and metamorphic regoliths were 56%, 36%, and 55% of the inflows, respectively. The cumulative nitrate import per season was 25 k/ha in the JRC compared with 11 kg/ha in MRC and 34 kg/ha in TRC. The corresponding exports were 24 kg/ha, 8 kg/ha 26 kg/ha in JRC, MRC, and TRC, respectively. The total dissolved solute (TDS) exports were 82%, 77%, 75%, of the corresponding imports in JRC, MRC, and TRC, respectively. Simple correlations indicated that nitrate export was positively correlated with the outflow in each one of the regolith and similar trends were observed between inflow and import. The import/export mass balance for nitrate shows that 73% to 96% of the imports were exported during the same rainy season, suggesting the potential for nitrate associated ecosystem health hazard/risk in sensitive SWB receiving the outflows. 展开更多
关键词 GROUNDWATER Inflow/Outflow SOLUTE Import/Export Nitrate Total Dissolved SOLUTES (TDS/EC)
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Analysis of Groundwater for Potability from Tiruchirappalli City Using Backpropagation ANN Model and GIS
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作者 Natarajan Venkat Kumar Samson Mathew Ganapathiram Swaminathan 《Journal of Environmental Protection》 2010年第2期136-142,共7页
Monitoring groundwater quality by cost-effective techniques is important as the aquifers are vulnerable to contamination due to point sources and non point sources. This paper presents Artificial neural Network (ANN) ... Monitoring groundwater quality by cost-effective techniques is important as the aquifers are vulnerable to contamination due to point sources and non point sources. This paper presents Artificial neural Network (ANN) Models that might be used to predict water parameters from a few known parameters. The sample data from 112 hand pumps and hand operated tube well water samples used for drinking purposes by the local population was used. The ANN model features a back propagation algorithm and neuron members were determined for optimization of the model architecture by trial and error method. The model simulations show that the optimum network of 4-50-50-6 has mean error of –0.023% on complete data was utilized. This demonstrated that the developed model has high accuracy for predicting. Thus it has been established that the two hidden layers neural network has more efficiency than asymptotic regression in the present. This model can be used for analysis and prediction of subsurface water quality prediction. 展开更多
关键词 GROUNDWATER Quality ANN EC TDS SULPHATES pH Tiruchirappalli
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