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甘薯Tai6.33665基因生物信息学、亚细胞定位及表达分析
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作者 熊军 唐秀桦 韦民政 《热带作物学报》 北大核心 2025年第11期2549-2558,共10页
甘薯(Ipomoeabatatas)作为全球重要的粮食与功能作物,其紫肉品种因富含花青素而备受关注。花青素不仅赋予块根鲜明的色泽,更具有抗氧化、抗炎及预防慢性疾病的生理功能,因此在健康食品开发中具有重要价值。然而,花青素的生物合成受多层... 甘薯(Ipomoeabatatas)作为全球重要的粮食与功能作物,其紫肉品种因富含花青素而备受关注。花青素不仅赋予块根鲜明的色泽,更具有抗氧化、抗炎及预防慢性疾病的生理功能,因此在健康食品开发中具有重要价值。然而,花青素的生物合成受多层级调控网络影响,其中bHLH转录因子的功能尚未在甘薯中被充分解析。本研究聚焦甘薯基因Tai6.33665,旨在阐明其分子特性、亚细胞定位模式及其在花青素积累中的调控作用,为高花青素甘薯品种的分子育种提供理论依据。本研究以紫肉甘薯(PFSP)和白肉甘薯(WFSP)为材料,通过生物信息学分析Tai6.33665蛋白的结构与进化关系,利用qRT-PCR检测基因表达模式,构建Tai6.33665-GFP融合载体进行烟草瞬时转化,结合激光共聚焦显微镜明确亚细胞定位,分析基因表达与花青素含量的相关性及miRNA互作机制。结果表明:Tai6.33665编码的蛋白具有典型bHLH结构域,与花青素合成调控因子高度同源,其表达量与花青素积累呈显著负相关(P<0.05),且受ib-miR52靶向抑制;亚细胞定位显示该蛋白定位于内质网,推测其可能通过翻译后修饰或内质网通路间接调控代谢。本研究证实了Tai6.33665作为负调控因子抑制甘薯花青素生物合成,其功能实现依赖于亚细胞定位特异性及miRNA介导的转录后调控网络。这一发现不仅丰富了植物次生代谢调控的理论框架,更为分子育种提供了双轨策略:通过CRISPR/Cas9靶向敲除Tai6.33665或过表达ib-miR52,可突破花青素积累的遗传限制,培育高花青素含量甘薯新品种。未来工作将聚焦于解析该基因与MYB/WD40蛋白的互作机制,以及内质网定位对其转录活性的调控路径。 展开更多
关键词 甘薯 Tai6.33665 生物信息学 亚细胞定位 表达分析
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Targeted exercise interventions on stress,anxiety,depression,and sleep disorders in PhD students
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作者 Fei-Long Wu Qun Yang +2 位作者 Juan Jiang Jing Yu Yin-Chuan Jin 《World Journal of Psychiatry》 2025年第12期177-187,共11页
BACKGROUND Doctoral students often encounter mental health challenges,including stress,anxiety,depression,and sleep disorders.It is important to explore effective intervention methods to enhance their overall physical... BACKGROUND Doctoral students often encounter mental health challenges,including stress,anxiety,depression,and sleep disorders.It is important to explore effective intervention methods to enhance their overall physical and mental well-being.It is anticipated that targeted exercise will lead to a significant reduction in stress,anxiety,and depression levels as well as an improvement in sleep quality.AIM To assess the feasibility and potential benefits of both intervention models in enhancing the sleep quality of doctoral students while alleviating stress,anxiety,and depression.METHODS A retrospective analysis of health data from 64 doctoral students across three universities in Shenyang during the 2024-2025 academic year was conducted.The participants were divided into a targeted exercise group and a Tai Chi group.The study employed the Epworth Sleepiness Scale,Insomnia Severity Index,Pittsburgh Sleep Quality Index,Perceived Stress Scale-10,Generalized Anxiety Disorder Scale-7,and Patient Health Questionnaire-9 to evaluate the impact of the two interventions on reducing stress,anxiety,depression,and sleep disorders.RESULTS The primary results of the study indicated that targeted exercise interventions are significantly effective in alleviating symptoms of anxiety,stress,and depression,as well as in improving sleep quality.Compared to Tai Chi interventions,this approach demonstrates greater durability of effects.Although the efficacy of targeted interventions may gradually diminish over time,the overall research findings suggest that targeted exercise remains a more effective therapeutic approach than Tai Chi interventions.CONCLUSION The impact of targeted exercise on stress,anxiety,depression,and sleep disorders was greater than that of Tai Chi,confirming the potential benefits for psychological health intervention for doctoral students. 展开更多
关键词 Targeted exercise Tai Chi Pressure ANXIETY DEPRESSION Sleep disorders
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eDNA enhances detection efficiency but reveals lower waterbird diversity:A comparison with point counting method
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作者 Hongming Shuai Xiaoru Liu +3 位作者 Yigui Zhang Yuqi Sun Hao Li Zhongqiu Li 《Avian Research》 2025年第2期221-229,共9页
Environmental DNA(e DNA)methods have emerged as a promising tool for studying a broad spectrum of biological taxa.However,metabarcoding studies of avian biodiversity using e DNA have received little attention.In this ... Environmental DNA(e DNA)methods have emerged as a promising tool for studying a broad spectrum of biological taxa.However,metabarcoding studies of avian biodiversity using e DNA have received little attention.In this study,we compared waterbird biodiversity derived from e DNA metabarcoding with that obtained from traditional point counting surveys at 23 sites in Tai Lake of eastern China and evaluated the accuracy of e DNA metabarcoding for waterbird community studies.The point counting method recorded a higher total number of waterbird species(22)compared to the e DNA technique(16).While e DNA achieved a 74.5%detection rate for waterbird species and was able to identify a significantly greater number of species(12.48±1.97)at each sampling site than point counting method(6.13±2.69),particularly highlighting several rare and elusive species,it failed to detect some species commonly observed by the point counting method.The alpha diversity analysis revealed no significant differences in waterbird diversity between the e DNA method and the point counting method,except that the e DNA method exhibited lower Pielou evenness.Waterbird e DNA sequencing abundance correlated significantly with species occurrence,whereas Spearman's analysis indicated no significant difference between e DNA sequence abundance and species abundance from the point counting method.e DNA method detected no significant difference in waterbird composition between sampling sites,while the point counting method revealed significant differences.Consequently,e DNA is an effective complementary tool for assessing the diversity of wintering waterbirds in lakes,though it is unable to capture the full diversity of waterbird communities.It is crucial to develop sampling strategies that comprehensively monitor species composition and integrate e DNA with traditional survey methods for accurate evaluation of community structure. 展开更多
关键词 Environmental DNA Metabarcoding Point counting Species abundance Tai lake Waterbird diversity
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Effects of traditional Chinese exercise on diabetes with neuropathy:A systematic review and meta-analysis
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作者 Junru Mao Anni Zhao +1 位作者 Yiqing Cai Xin Liu 《Journal of Traditional Chinese Medical Sciences》 2025年第2期297-307,共11页
Objective:To evaluate the efficacy and safety of traditional Chinese exercises(TCE)in patients with diabetic peripheral neuropathy(DPN)and to recommend best practices for using TCE to improve neurological function,gly... Objective:To evaluate the efficacy and safety of traditional Chinese exercises(TCE)in patients with diabetic peripheral neuropathy(DPN)and to recommend best practices for using TCE to improve neurological function,glycemic control,and psychological well-being.Methods:Nine databases were searched from the inception to October 2024.Effect relationships were assessed using meta-analysis with Stata 17,and the methodological quality and certainty of the evidence were evaluated using standard tools.Results:Twelve studies comprising three study designs(nine randomized controlled,one quasi-exper-imental controlled,and two single-arm clinical trials),were identified.Compared with usual care,TCE improved various indicators and enhanced the nerve conduction velocities of the peroneal motor(mean difference[MD]=3.86 m/s,95%confidence interval[CI]:0.38 to 7.34,P=0.03),sural sensory(MD=4.15 m/s,95%CI:0.68 to 7.63,P=0.02),median motor(MD=3.84 m/s,95%CI:2.14 to 5.54,P<.001),and median sensory nerves(MD=6.14 m/s,95%CI:4.54 to 7.74,P<.001).TCE practices also reduced glycosylated hemoglobin level(MD=-0.59%,95%CI:-0.91 to-0.27,P<.001)and fasting blood glucose(standardized mean difference[SMD]=-1.08,95%CI:-1.79 to-0.37,P<.001).The overall quality of evidence was very low.Conclusion:The results indicate that TCE therapy improves certain outcomes in patients with DPN.Although the optimal type,intensity,frequency,and duration of TCE interventions are uncertain,these preliminary findings suggest that TCE should be further studied as a potentially affordable and effective treatment for DPN. 展开更多
关键词 Tai Chi QIGONG Diabetes neuropathy Diabetic complication Systematic review META-ANALYSIS
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Characterization of atmospheric humic-like substances(HULIS)at a high elevation in North China:Abundance,molecular composition and optical properties
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作者 Chaofan Gong Xinghui Liu +4 位作者 Xiaoling Nie Xinmiao Xu Xinfeng Wang Likun Xue Yan Wang 《Journal of Environmental Sciences》 2025年第9期673-685,共13页
The optical absorption of large molecular compounds HULIS(humic-like substances)can significantly impact the aerosol light absorption and radiative forcing,influencing cloud condensation nuclei formation and thus the ... The optical absorption of large molecular compounds HULIS(humic-like substances)can significantly impact the aerosol light absorption and radiative forcing,influencing cloud condensation nuclei formation and thus the climate and atmospheric environment.This study collected aerosol(PM_(2.5))samples from the summit of Mount Tai in North China to investigate the concentration,molecular composition,and optical properties of HULIS.The average concentration of HULIS in the PM_(2.5) in this study was 1.26±0.54μg/m^(3),comprising for 56%of the water-soluble organic carbon(WSOC),with levels lower than urban areas but higher than other mountainous regions.Mass spectrometry revealed that CHO and CHON components,with high aromaticity and phenolic groups,are major contributors to absorption and fluorescence.These results indicate that HULIS is mainly composed of lignin and proteins/amino sugars,derived from combustion and secondary formation,and possesses a high light absorption capacity(withMAE365(mass absorption efficiency)and AAE(A˚ngstrom exponent)indices of 0.62m^(2)/g and 4.99,respectively).Parallel factor analysis identified three fluorescence components of HULIS,with proportions of 60.8%for less oxygen humic-like substances,21.0%for high oxygen humic-like substances,and 18.2%for protein-like substances.Our study highlights the significance of the light-absorbing capacity and secondary formation of HULIS at Mount Tai,laying the groundwork for investigation into the climate effects,formation mechanisms,and sources of HULIS generation. 展开更多
关键词 Humic-like substances(HULIS) PM_(2.5) ABUNDANCE Optical property FT-ICR MS Mount Tai
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Enhancing health,harmony and cultural traditions:Contextualizing the development of Tai Chi associations in
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作者 Yi-Zhen Cai Eileen O’Connor 《History and Philosophy of Medicine》 2025年第2期1-9,共9页
Background:This study examined the development of Tai Chi in Ottawa,Canada,focusing on:(1)traditions and modernization of Tai Chi in China's mainland;(2)the evolution of Ottawa’s Chinese community;and(3)the role ... Background:This study examined the development of Tai Chi in Ottawa,Canada,focusing on:(1)traditions and modernization of Tai Chi in China's mainland;(2)the evolution of Ottawa’s Chinese community;and(3)the role of Ottawa Tai Chi Chuan Association(OTCA)and Taoist Tai Chi Society(TTCS)-in promoting Tai Chi and traditional health practices rooted in Traditional Chinese Medicine(TCM)in Ottawa.Methods:Archive research was used to investigate origins,organizational structures,and programs of the associations.Documents were obtained from the personal collections,websites,and Ottawa Archives.Secondary literature on Tai Chi’s history in China and Chinese immigration to Ottawa provided contextual insights.Results:In the twentieth century,Tai Chi in China's mainland underwent significant transformations,aligning with nation-building,social reform,public health promotion,and cultural influence.Since the 1970s,the demographic composition of Canada’s Chinese community has become diversified.Some community members played a critical role in transmitting Tai Chi to Canada by establishing OTCA and TTCS.Through a variety of Tai Chi programs,workshops,and community engagement,OTCA and TTCS promoted Tai Chi as a holistic health practice rooted in TCM and traditional cultural principles in different approaches.OTCA primarily served the Chinese community,focusing on diverse forms,techniques,and theories.In contrast,Ottawa’s TTCS,as a satellite association,emphasized Taoist-inspired Tai Chi and cultivation passed down by the founder,Moy Linshin,to accommodate members from diverse cultural backgrounds.OTCA and TTCS created inclusive mind-body communities for individuals to engage in Tai Chi as a culturally meaningful practice and a means of fostering social connection and holistic wellness.Conclusion:OTCA and TTCS significantly revitalized while adapted Tai Chi and TCM practices to Western contexts,integrating its historical roots with western health ideas to establish it as a widely recognized mind-body discipline and alternative therapy. 展开更多
关键词 Tai Chi HEALTH CANADA
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Living Smarter How intelligent technology is transforming everyday life in China
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作者 Huang Jiangqin 《China Report ASEAN》 2025年第11期52-55,共4页
“Wow,this robot is so cool!”In the Hangzhou Shenhao Technology Co.,Ltd.showroom,a humanoid robot gracefully performed Tai Chi,grabbing the attention of a visiting delegation from ASEAN.In September,the group of scho... “Wow,this robot is so cool!”In the Hangzhou Shenhao Technology Co.,Ltd.showroom,a humanoid robot gracefully performed Tai Chi,grabbing the attention of a visiting delegation from ASEAN.In September,the group of scholars from regional think tanks and journalists toured Hangzhou,Jinhua,and Huzhou in east China’s Zhejiang Province.Along the way,they enjoyed an up-close look at how digital and intelligent technologies are subtly changing everyday life. 展开更多
关键词 Zhejiang province digital technology tai chigrabbing humanoid robot digital intelligent technologies China everyday life intelligent technology
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Evaluation and Improvement Strategies of Accessible Tourism Experience in Mount Tai Scenic Area
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作者 LIU Xiaomei WANG Hui +1 位作者 LYU Chen MA Yibing 《Journal of Landscape Research》 2025年第4期59-61,67,共4页
Mount Tai Scenic Area has achieved certain results in the construction of accessible tourism facilities,realizing the exploration of digital and intelligent transformation in traditional mountain scenic areas.In this ... Mount Tai Scenic Area has achieved certain results in the construction of accessible tourism facilities,realizing the exploration of digital and intelligent transformation in traditional mountain scenic areas.In this study,using questionnaire surveys and in-depth interviews,the development of accessible tourism in Mount Tai Scenic Area was investigated and analyzed.Some countermeasures were put forward,including strengthening information guidance services,enhancing awareness and skills in accessibility services,improving feedback mechanisms for continuous refinement,and strengthening collaborations in the fields of the disabled and accessibility development,aiming to further promote humanistic care and enhance service satisfaction at the scenic area. 展开更多
关键词 ACCESSIBILITY Questionnaire survey In-depth interview Digital and intelligent transformation Mount Tai Scenic Area
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Improvement of Tourism Service Quality in Tai’an Tianyi Lake Scenic Area
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作者 ZHANG Ying WANG Hui +1 位作者 LIU Xiaomei SONG Zhenxing 《Journal of Landscape Research》 2025年第2期54-57,共4页
In order to better enhance the tourism service quality and tourist satisfaction of scenic spots,this study applies the theory of tourism service quality to Tai’an Tianyi Lake scenic area,exploring the current situati... In order to better enhance the tourism service quality and tourist satisfaction of scenic spots,this study applies the theory of tourism service quality to Tai’an Tianyi Lake scenic area,exploring the current situation and existing problems of its tourism service quality through field investigation and questionnaire surveys,and proposing specific promotion strategies,with the aim to improve tourist satisfaction and enhance the competitiveness and attraction of the scenic area. 展开更多
关键词 Tai’an Tianyi Lake scenic area Tourism service quality PROMOTION INVESTIGATION SATISFACTION
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Influence of Catering Resource Distribution in Typical Forest Parks on Tourists’Visiting Willingness
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作者 YUE Junsheng BIAN Shumei +2 位作者 YU Yongchang CHEN Lei LIU Min 《Journal of Landscape Research》 2025年第2期73-78,82,共7页
Catering in scenic areas is an important part of tourist experiences,yet the existing research on catering resources mainly focuses on tourist satisfaction and resource development,with limited analysis on the impact ... Catering in scenic areas is an important part of tourist experiences,yet the existing research on catering resources mainly focuses on tourist satisfaction and resource development,with limited analysis on the impact of catering resources distribution on tourists’visiting willingness.Thus,based on case analysis,surveys and data analysis,this study selected Mount Tai Scenic Area as the research object to conduct an in-depth investigation on the impact of the distribution of catering resources on tourists’visiting willingness,which identified many challenges faced by the distribution of catering resources in the scenic area and their underlying causes,finding that while there were rich varieties and concentrated catering options in high-traffic areas with strong tourists’visiting willingness,significant gaps remained in locations with weak tourists’visiting willingness.Furthermore,the overall catering offerings in Mount Tai Scenic Area demonstrated a notable deficiency in food products that authentically integrate with Mount Tai’s distinctive cultural heritage.To address such issues,improvement strategies were proposed for the development of catering resources in Mount Tai Scenic Area,including spatial development and integration,exploration of cultural connotations,and enhancement of tourism value,which provided insights for refining management of catering resources in forest park scenic spot,optimizing catering services,and enhancing the tourism experience of tourists. 展开更多
关键词 Mount Tai Scenic Area Forest park catering Distribution of catering resources Visiting willingness
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奶牛同期发情处理技术的实践应用与关键管控策略
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作者 周长城 《中国乳业》 2025年第8期21-26,共6页
奶牛同期发情(Ovsynch)处理技术是现代牧场提升繁殖效率与经济效益的核心手段。该技术通过激素调控与精准管理,将奶牛发情周期集中在产后50~80天的“黄金受孕期”,有效缩短空怀天数、提高受胎率,并降低漏配风险。本文系统阐述了Ovsynch... 奶牛同期发情(Ovsynch)处理技术是现代牧场提升繁殖效率与经济效益的核心手段。该技术通过激素调控与精准管理,将奶牛发情周期集中在产后50~80天的“黄金受孕期”,有效缩短空怀天数、提高受胎率,并降低漏配风险。本文系统阐述了Ovsynch处理技术在牧场中的分层实施方案,包括产后未配种牛、空怀牛、青年牛及成母牛等不同群体的处理策略,并分析了牛只混群、牛颈夹利用率、药物注射有效性及发情揭发等关键影响因素。同时,提出以“定时配种(TAI)占比”为核心的数据监督体系,推动牧场实现从经验管理向数据驱动的转型,为提升牧场繁殖管理水平提供实践依据。 展开更多
关键词 奶牛 同期发情(Ovsynch) 繁殖效率 定时配种(TAI) 空怀期 受胎率 激素调控 牧场管理 数据监督
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太平保险股份有限公司保险单
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《上海保险》 2025年第3期F0003-F0003,共1页
太平保险股份有限公司(The Tai Ping Insurance Co.,Ltd.)1929年11月20日创立于上海,由金城银行独资筹设,资本总额100万元,实收50万元。总公司在上海金城银行大楼(今江西中路212号)。初名太平水火保险公司,周作民任董事长兼总经理,丁雪... 太平保险股份有限公司(The Tai Ping Insurance Co.,Ltd.)1929年11月20日创立于上海,由金城银行独资筹设,资本总额100万元,实收50万元。总公司在上海金城银行大楼(今江西中路212号)。初名太平水火保险公司,周作民任董事长兼总经理,丁雪农任协理兼止海分公司经理,经营水火保险业务。1933年改组为太平保险公司,黄奕住任董事长,周作民任总经理。公司除办理各种财产损失保险外. 展开更多
关键词 The Tai Ping Insurance Co.Ltd 太平保险股份有限公司
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Insights on Song Dynasty Medical Exams from Tai Yi Ju Zhu Ke Cheng Wen Ge(《太医局诸科程文格》Examination Answers and Standards of the Imperial Medical Bureau)
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作者 HU Lingbai ZHANG Xuedan 《Chinese Medicine and Culture》 2025年第1期68-77,共10页
The medical education of the Song dynasty constitutes a pivotal aspect within the broader framework of ancient Chinese medical education. The advent of the imperial examination system coincided with the emergence of a... The medical education of the Song dynasty constitutes a pivotal aspect within the broader framework of ancient Chinese medical education. The advent of the imperial examination system coincided with the emergence of a medical examination system, which served as the cornerstone for the subsequent evolution of medical education. According to historical records, the Song government established dedicated medical departments, along with comprehensive systems encompassing medical professors, students, and examinations. By examining extant medical historical documents, such as Tai Yi Ju Zhu Ke Cheng Wen Ge(《太医局诸科程文格》 Examination Answers and Standards of the Imperial Medical Bureau), researchers and readers can obtain a comprehensive understanding of the medical system that prevailed in the Song dynasty. While the intricate details of medical education during this era are not explicitly documented in historical records, modern researchers have the opportunity to uncover the entire view of medical education, particularly the medical examination system, through rigorous analysis of these extant historical medical documents. Such studies offer valuable insights into the developmental trajectory of the ancient Chinese medical examination system and provide crucial references for contemporary medical education. By conducting in-depth literature research and analysis of Tai Yi Ju Zhu Ke Cheng Wen Ge, this study endeavors to reconstruct the authentic scenario of medical examinations in the Song dynasty, as presented in the document, for the benefit of modern readers and researchers. 展开更多
关键词 Song dynasty Medical education History of medicine EXAMINATION Medical classics Tai Yi Ju Zhu Ke Cheng Wen Ge(《太医局诸科程文格》Examination Answers and Standards of the Imperial Medical Bureau)
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具有周期系数线性微分方程的性质
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作者 陈茂海 《工科数学》 2001年第1期94-96,共3页
本文先介绍可化为周期系数的微分方程 。
关键词 定常系统 周期系统 线性微分方程 特征指数 tay lor公式 特征方程
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国际原子时及NTSC守时工作进展 被引量:18
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作者 董绍武 王燕平 +3 位作者 武文俊 屈俐俐 袁海波 赵书红 《时间频率学报》 CSCD 2018年第2期73-79,共7页
介绍了国际原子时(TAI)、协调世界时(UTC)以及我国标准时间UTC(NTSC)的产生和发展。简要介绍了国际标准时间的定义、国际时间比对技术的发展、TAI和UTC计算方法、工作规范的发展和未来可能的形态。介绍了我国原子时工作的历史和发展,以... 介绍了国际原子时(TAI)、协调世界时(UTC)以及我国标准时间UTC(NTSC)的产生和发展。简要介绍了国际标准时间的定义、国际时间比对技术的发展、TAI和UTC计算方法、工作规范的发展和未来可能的形态。介绍了我国原子时工作的历史和发展,以及时间基准保持性能、国际比对及溯源和时间信号服务方面的最新进展。 展开更多
关键词 TAI和UTC UTC(CSAO) UTC(NTSC) 国际比对 北斗时
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TAI评量标准研究和信效度分析 被引量:12
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作者 范晓玲 彭纯子 彭丽 《中国临床心理学杂志》 CSCD 2004年第1期58-59,共2页
目的 :制定TAI评量标准、焦虑水平分布及本次研究的信效度。方法 :以 95 0名高中生的TAI常模制订评量标准 ,另对 2 17名同类学生进行TAI、STAI测评和访谈。结果 :测验焦虑分正常、轻度、中度和重度四级 ,属焦虑者 5 %左右。TAI与STAI的... 目的 :制定TAI评量标准、焦虑水平分布及本次研究的信效度。方法 :以 95 0名高中生的TAI常模制订评量标准 ,另对 2 17名同类学生进行TAI、STAI测评和访谈。结果 :测验焦虑分正常、轻度、中度和重度四级 ,属焦虑者 5 %左右。TAI与STAI的同时效度为 0 .4 0~ 0 .5 6 ,与学生访谈结果的相关为 0 .5 82 ,TAI重测信度为 0 .76 4~0 .873,均在 0 .0 1水平达到相关显著。结论 :高中生测验焦虑水平较低 ,本次研究结果是有效的。 展开更多
关键词 TAI 评量标准 信效度 焦虑 学生
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无法手术切除的胰腺癌数字减影血管造影(DSA)的动脉造影分析及其对经动脉灌注化疗(TAI)的指导价值 被引量:6
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作者 施惠斌 陈颐 +4 位作者 程洁敏 龚高全 李国平 李长煜 王小林 《复旦学报(医学版)》 CAS CSCD 北大核心 2014年第3期352-356,共5页
目的观察无法手术切除的胰腺癌数字减影血管造影(digital subtract angiography,DSA)的表现特点,探讨DSA动脉造影对经动脉灌注化疗(transarterial infusion,TAD的指导价值。方法回顾性分析在中山医院介入治疗科接受TAI治疗的无法手术切... 目的观察无法手术切除的胰腺癌数字减影血管造影(digital subtract angiography,DSA)的表现特点,探讨DSA动脉造影对经动脉灌注化疗(transarterial infusion,TAD的指导价值。方法回顾性分析在中山医院介入治疗科接受TAI治疗的无法手术切除的胰腺癌患者146例。所有病例先行腹腔动脉和肠系膜上动脉造影,必要时选择进入肝总动脉、胃十二指肠动脉或脾动脉造影。观察胰腺癌的直接供血动脉及其起源、胰周主要动脉受侵犯情况。结果 61例胰头癌中,所有病例胰十二指肠前上、后上动脉均参与供血(100%),53例胰十二指肠前下、后下动脉参与供血(86.9%),14例胰背动脉参与供血(23.0%)。85例胰体尾癌中,9例未见明显血供,余76例中胰背动脉参与供血31例(36.5%),胰大动脉参与供血41例(48.2%),胰尾动脉参与供血35例(41.2%)。胰周大动脉中,16例腹腔动脉受侵犯(11.0%),其中2例动脉侵犯分级Ⅳ级;35例胃十二指肠动脉受侵犯(24.0%);10例肠系膜上动脉受侵犯(6.8%);8例肝总动脉受侵犯(5.5%);65例脾动脉受侵犯(44.5%),其中7例动脉受侵分级Ⅳ级。结论 DSA动脉造影对元法手术切除的胰腺癌TAI术中给药靶动脉的确有重要指导价值。 展开更多
关键词 胰腺癌 数字减影血管造影(DSA) 动脉灌注化疗(TAI)
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高中生考试焦虑程度、原因及表现的调查 被引量:10
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作者 刘莹 董云英 周仁来 《东南大学学报(哲学社会科学版)》 CSSCI 2008年第S1期271-274,共4页
本研究采用《TAI考试焦虑量表》与《考试焦虑原因和表现自我检查问卷》,对南京市第十三中学的高一、高二和高三年级学生的考试焦虑现状进行调查,以探讨高中生考试焦虑的程度、主要原因及表现形式。结果发现,考试焦虑程度存在年级主效应(... 本研究采用《TAI考试焦虑量表》与《考试焦虑原因和表现自我检查问卷》,对南京市第十三中学的高一、高二和高三年级学生的考试焦虑现状进行调查,以探讨高中生考试焦虑的程度、主要原因及表现形式。结果发现,考试焦虑程度存在年级主效应(F=4.199,P=.017);同时存在考试焦虑原因主效应(F=17.258,P=.000)以及焦虑原因与年级的交互效应(F=3.513,P=.002);此外,考试焦虑表现主效应极其显著(F=174.609,P=0.000),该结果表明,高一年级的考试焦虑程度显著高于其他两个年级;考试焦虑原因对不同年级学生的影响不同;思维阻抑是高中生考试焦虑的一个主要表现。 展开更多
关键词 考试焦虑 TAI量表 高中生 焦虑程度 焦虑原因 焦虑表现
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经皮穿肝胆道引流(PTBD)结合经动脉灌注化疗(TAI)治疗胰头癌伴梗阻性黄疸 被引量:5
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作者 李长煜 王小林 +5 位作者 龚高全 程洁敏 李国平 刘凌晓 施惠斌 陈颐 《复旦学报(医学版)》 CAS CSCD 北大核心 2014年第2期222-226,共5页
目的 评价经皮穿肝胆道引流(percutaneous transhepatic biliary drainage,PTBD)结合经动脉灌注化疗(transarterial infusion,TAI)治疗中晚期胰头癌伴梗阻性黄疸的临床价值。方法 回顾性收集伴有梗阻性黄疸的胰头癌患者 28例,所... 目的 评价经皮穿肝胆道引流(percutaneous transhepatic biliary drainage,PTBD)结合经动脉灌注化疗(transarterial infusion,TAI)治疗中晚期胰头癌伴梗阻性黄疸的临床价值。方法 回顾性收集伴有梗阻性黄疸的胰头癌患者 28例,所有患者均先行PTBD解除胆道梗阻症状,待有效引流后行经动脉灌注化疗。分析患者的临床受益反应(clinical benefit response,CBR)、支架通畅时间、生存期和并发症。结果 28例患者共行PTBD 28次,胆红素由术前(168.9±64.1) μmol/L降到术后最低(37.2±6.2) μmol/L,其中15例放置胆道支架,支架平均通畅时间为10.6个月,共接受经动脉灌注化疗 81次,所有病例均未出现Ⅲ-Ⅳ不良反应,总临床受益反应为64.3%,平均生存期7.07个月。结论 PTBD结合经动脉灌注化疗是治疗中晚期胰头癌伴梗阻性黄疸患者安全可行的办法。 展开更多
关键词 胰腺癌 梗阻性黄疸 经皮穿肝胆道引流(PTBD) 经动脉灌注化疗(TAI)
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以血管内皮生长因子及其受体为靶点的肿瘤血管生成抑制剂的研究进展 被引量:7
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作者 翟鑫 王玉亚 宫平 《中国药物化学杂志》 CAS CSCD 2006年第1期60-64,共5页
肿瘤的生长和转移依赖于新生血管的形成,血管内皮生长因子(VEGF)在肿瘤新生血管形成中起关键作用。以VEGF及其受体为靶点,通过抑制肿瘤血管生长,从而遏制肿瘤的生长和转移的研究已经取得了一定的成果,在此对肿瘤血管生成抑制剂(TAI)的... 肿瘤的生长和转移依赖于新生血管的形成,血管内皮生长因子(VEGF)在肿瘤新生血管形成中起关键作用。以VEGF及其受体为靶点,通过抑制肿瘤血管生长,从而遏制肿瘤的生长和转移的研究已经取得了一定的成果,在此对肿瘤血管生成抑制剂(TAI)的研究进展进行综述。 展开更多
关键词 药物化学 血管生成 综述 血管内皮生长因子 血管内皮生长因子受体 TAI
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