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A Task-oriented Approach to the Pre-service Teacher Education in the Classroom of English Teaching Methodology (ETM) 被引量:1
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作者 Hongyan Wu 《Sino-US English Teaching》 2006年第7期18-21,47,共5页
This paper concerns itself with a task-oriented approach to the pre-service teacher education in the Classroom of English Teaching Methodology (ETM). We attempt to use an explicit theoretic framework to guide the pr... This paper concerns itself with a task-oriented approach to the pre-service teacher education in the Classroom of English Teaching Methodology (ETM). We attempt to use an explicit theoretic framework to guide the practice of ETM classroom in teacher education. The basic assumption is that we can use methodology which we use in teaching language, and apply those techniques and methods to train student teachers. By this approach the student teachers can adopt a research orientation to their own classrooms and their own teaching, an inquiry-based and discovery-oriented approach to learning is greatly emphasized, and they also can form the habit of generating theories and hypotheses and reflecting critically on teaching. 展开更多
关键词 pre-service teacher education English teaching methodology task-oriented approachtask-design
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Clinical Research on Effects of Acupoint Injection Combined with Task-Oriented Training on Post-Stroke Hemiplegic Gait Based on the Gait Watch Analysis System
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作者 Chao ZUO Haiju LI +3 位作者 Yiqin LI Guangbao NI Tingting XIAO Xueping ZHANG 《Medicinal Plant》 2025年第4期43-44,49,共3页
[Objectives]To investigate the clinical efficacy of acupoint injection of nerve growth factors combined with task-oriented training for patients with post-stroke hemiplegic gait,and quantitatively evaluate the outcome... [Objectives]To investigate the clinical efficacy of acupoint injection of nerve growth factors combined with task-oriented training for patients with post-stroke hemiplegic gait,and quantitatively evaluate the outcomes using the Gait Watch analysis system.[Methods]A total of 90 patients with post-stroke hemiplegia,who were hospitalized at the Rehabilitation Center of Taihe Hospital between January 2023 and December 2023,were selected for this study.The participants were randomly assigned to three groups:the task-oriented rehabilitation training group(control group I,n=30),the ordinary acupuncture combined with task-oriented training group(control group II,n=30),and the acupoint injection combined with task-oriented training group(observation group,n=30).Each group underwent treatment for 4 weeks.The Gait Watch analysis system was employed to assess the spatiotemporal gait parameters of the patients prior to treatment,as well as 2 weeks post treatment and 4 weeks post treatment.The efficacy of the treatment was subsequently analyzed.[Results]After 4 weeks of treatment,the spatiotemporal gait parameters,specifically step length,step speed,step frequency,percentage of the standing phase,and percentage of the swinging phase,exhibited significant improvement in the observation group compared to those before treatment(P<0.05).Furthermore,the degree of improvement in the observation group was superior to that observed in both control group I and control group II,with the differences reaching statistical significance(P<0.05).[Conclusions]Acupoint injection combined with task-oriented training has been shown to significantly enhance gait function in patients with post-stroke hemiplegia.The Gait Watch analysis system offers an accurate and objective quantitative assessment,making it a valuable tool for clinical application and promotion. 展开更多
关键词 Stroke HEMIPLEGIA Acupoint injection task-oriented training Gait analysis Gait Watch
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Evaluation of Task-Oriented Training Combined with Lower Limb Rehabilitation Robot on Improvement of Motor Function and Ankle Joint Function in Stroke Patients with Hemiplegia
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作者 Xingjun Shi 《Journal of Clinical and Nursing Research》 2025年第8期332-338,共7页
Objective:To evaluate the effect of task-oriented training combined with a lower limb rehabilitation robot on improving motor function and ankle joint function in stroke patients with hemiplegia.Methods:Sixty-three st... Objective:To evaluate the effect of task-oriented training combined with a lower limb rehabilitation robot on improving motor function and ankle joint function in stroke patients with hemiplegia.Methods:Sixty-three stroke patients with hemiplegia admitted to our hospital from January 2022 to June 2024 were randomly divided into observation group(32 cases)and control group(31 cases)using the envelope method.The control group received task-oriented training,while the observation group received additional lower limb rehabilitation robot training.The motor function(Fugl-Meyer Assessment of Lower Extremity,FMA-LE)and ankle joint function(Active Dorsiflexion Range of Motion,DF AROM)were compared between the two groups.Results:After treatment,the levels of FMA-LE and DF AROM in both groups increased significantly,and the improvement in each index in the observation group was better than that in the control group(P<0.05).Conclusion:The combination of task-oriented training and lower limb rehabilitation robot training can more effectively improve the overall motor function of the lower limbs and the active dorsiflexion ability of the ankle joint in stroke patients with hemiplegia. 展开更多
关键词 STROKE HEMIPLEGIA task-oriented training Lower limb rehabilitation robot Motor function Ankle joint function
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Comparing trans-oral endoscopic thyroidectomy vestibular approach and trans-areolar approaches regarding postoperative infections and swallowing difficulty
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作者 Hyder Mirghani 《World Journal of Clinical Cases》 2026年第1期21-27,共7页
BACKGROUND Due to the increasing rate of thyroid nodules diagnosis,and the desire to avoid the unsightly cervical scar,remote thyroidectomies were invented and are increasingly performed.Transoral endoscopic thyroidec... BACKGROUND Due to the increasing rate of thyroid nodules diagnosis,and the desire to avoid the unsightly cervical scar,remote thyroidectomies were invented and are increasingly performed.Transoral endoscopic thyroidectomy vestibular approach and trans-areolar approaches(TAA)are the two most commonly used remote approaches.No previous meta-analysis has compared postoperative infections and swallowing difficulties among the two procedures.AIM To compared the same among patients undergoing lobectomy for unilateral thyroid carcinoma/benign thyroid nodule.METHODS We searched PubMed MEDLINE,Google Scholar,and Cochrane Library from the date of the first published article up to August 2025.The term used were transoral thyroidectomy vestibular approach,trans areolar thyroidectomy,scarless thyroidectomy,remote thyroidectomy,infections,postoperative,inflammation,dysphagia,and swallowing difficulties.We identified 130 studies,of them,30 full texts were screened and only six studies were included in the final meta-analysis.RESULTS Postoperative infections were not different between the two approaches,odd ratio=1.33,95%confidence interval:0.50-3.53,theχ2 was 1.92 and the P-value for overall effect of 0.57.Similarly,transient swallowing difficulty was not different between the two forms of surgery,with odd ratio=0.91,95%confidence interval:0.35-2.40;theχ2 was 1.32,and the P-value for overall effect of 0.85.CONCLUSION No significant statistical differences were evident between trans-oral endoscopic Mirghani H.Infections and swallowing difficulty in scarless thyroidectomy WJCC https://www.wjgnet.com 2 January 6,2026 Volume 14 Issue 1 thyroidectomy vestibular approach and trans-areolar approach regarding postoperative infection and transient swallowing difficulties.Further longer randomized trials are needed. 展开更多
关键词 Trans-oral endoscopic thyroidectomy vestibular approach Trans-areolar approaches Postoperative Infections swallowing difficulty
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The application of multi-combinatorial approach in sensitivity improvement of lipid photoacoustic imaging
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作者 Yi Tan Dongjian Wu +4 位作者 Xiatian Wang Chengbo Liu Mingjian Sun Xiaojing Gong Zhihua Xie 《Journal of Innovative Optical Health Sciences》 2026年第1期96-109,共14页
The photoacoustic imaging of lipid is intrinsically constrained by the feeble nature of endogenous lipid signals,posing a persistent sensitivity challenge that demands innovative solutions.Although adopting high-effic... The photoacoustic imaging of lipid is intrinsically constrained by the feeble nature of endogenous lipid signals,posing a persistent sensitivity challenge that demands innovative solutions.Although adopting high-efficiency excitation and detection elements may improve the imaging sensitivity to a certain extent,the application of the elements is inevitably subject to various limitations in practical applications,particularly during in vivo imaging and endoscopic imaging.In this study,we propose a multi-combinatorial approach to enhance the sensitivity of lipid photoacoustic imaging.The approach involves wavelet transform processing of one-dimensional A-line signals,gradient-based denoising of two-dimensional B-scan images,and finally,threedimensional spatial weighted averaging of the data processed by the previous two steps.This method not only significantly improves the signal-to-noise ratio(SNR)in distinguished feature regions of the image by around 10 dB,but also efficiently extracts weak signals with no distinct features in the original image.After processing with this method,the images acquired under single scanning were compared with those obtained under multiple scanning.The results showed highly consistent image features,with the structural similarity index increasing from 0.2 to 0.8,confirming the accuracy and reliability of the multi-combinatorial approach. 展开更多
关键词 Multi-combinatorial approach extraction of weak signals imaging sensitivity photoacoustic lipid imaging
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SSA*-PDWA:A Hierarchical Path Planning Framework with Enhanced A*Algorithm and Dynamic Window Approach for Mobile Robots
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作者 Lishu Qin Yu Gao Xinyuan Lu 《Computers, Materials & Continua》 2026年第4期2069-2094,共26页
With the rapid development of intelligent navigation technology,efficient and safe path planning for mobile robots has become a core requirement.To address the challenges of complex dynamic environments,this paper pro... With the rapid development of intelligent navigation technology,efficient and safe path planning for mobile robots has become a core requirement.To address the challenges of complex dynamic environments,this paper proposes an intelligent path planning framework based on grid map modeling.First,an improved Safe and Smooth A*(SSA*)algorithm is employed for global path planning.By incorporating obstacle expansion and cornerpoint optimization,the proposed SSA*enhances the safety and smoothness of the planned path.Then,a Partitioned Dynamic Window Approach(PDWA)is integrated for local planning,which is triggered when dynamic or sudden static obstacles appear,enabling real-time obstacle avoidance and path adjustment.A unified objective function is constructed,considering path length,safety,and smoothness comprehensively.Multiple simulation experiments are conducted on typical port grid maps.The results demonstrate that the improved SSA*significantly reduces the number of expanded nodes and computation time in static environmentswhile generating smoother and safer paths.Meanwhile,the PDWA exhibits strong real-time performance and robustness in dynamic scenarios,achieving shorter paths and lower planning times compared to other graph search algorithms.The proposedmethodmaintains stable performance across maps of different scales and various port scenarios,verifying its practicality and potential for wider application. 展开更多
关键词 Dynamic window approach improved A*algorithm dynamic path planning trajectory optimization
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Collaborative Approaches to Poverty Reduction:Experts and o"cials from China and abroad exchange views on cooperation and sustainable development at seminar
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作者 LU JIAJUN 《ChinAfrica》 2026年第2期34-35,共2页
The 17 Sustainable Development Goals(SDGs)for 2030,adopted by all United Nations member states in 2015,are facing a range of challenges.Factors such as climate change,regional conflicts and economic recession are havi... The 17 Sustainable Development Goals(SDGs)for 2030,adopted by all United Nations member states in 2015,are facing a range of challenges.Factors such as climate change,regional conflicts and economic recession are having a significant impact,particularly on global poverty governance.As a platform for dialogue,exchange and technical cooperation,the 2025 International Seminar on Global Poverty Reduction Partnerships was held in Beijing on 10 December 2025. 展开更多
关键词 climate changeregional conflicts collaborative approaches China global poverty reduction OFFICIALS sustainable development goals sdgs economic recession experts
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Fast identification of -emitting radionuclides based on sequential Bayesian approach
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作者 Xuan Zhang Jian-Wei Huang +5 位作者 Lin-Jian Wan Jia-Cheng Liu Xiao-Le Zhang De-Hong Li Fei Tuo Zhi-Jun Yang 《Nuclear Science and Techniques》 2026年第2期1-15,共15页
The rapid identification of γ-emitting radionuclides with low activity levels in public areas is crucial for nuclear safety.However,classical methods rely on full-energy peaks in the integral spectrum,requiring suffi... The rapid identification of γ-emitting radionuclides with low activity levels in public areas is crucial for nuclear safety.However,classical methods rely on full-energy peaks in the integral spectrum,requiring sufficient count accumulation for evaluation,thereby limiting response time.The sequential Bayesian approach,which utilizes prior information and considers both photon energies and interarrival times,can significantly enhance the performance of radionuclides identification.This study proposes a theoretical optimization method for the traditional sequential Bayesian approach.Each photon is processed sequentially,and the corresponding posterior probability is updated in real time using a noninformative prior from the Bayesian theory.By comparing the posterior probabilities of the background and radionuclides based on the energy variance and time interval,the type of γ-rays can be identified(background characteristic γ-rays,Compton plateaus γ-rays,or radionuclide-specific characteristic γ-rays).By integrating the information from these multiple characteristic γ-rays,the presence and type of radionuclides were determined based on the final decision function and a set threshold.Based on theoretical research,verification experiments were conducted using a LaBr_(3)(Ce)detector in both low-and natural background radiation environments with typical radionuclides(^(137)Cs,^(60)Co,and ^(133)Ba).The results show that this approach can identify ^(137)Cs in 7.9 s and 8.5 s(source dose rate contribution:approximately 6.5×10^(−3)μGy/h),^(60)Co in 8.1 s and 9.8 s(approximately 4.8×10^(−2)μGy/h),and ^(133)Ba in 4.05 s and 5.99 s(approximately 3.4×10^(−2)μGy/h)under low and natural background radiation,respectively,with a miss rate below 0.01%.This demonstrates the effectiveness of the proposed approach for fast radionuclides identification,even at low activity levels and highlights its potential for enhancing public safety in diverse radiation environments. 展开更多
关键词 Sequential Bayesian approach Fast radionuclides identification LaBr_(3)(Ce)detector Low background radiation laboratory
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A Task-oriented Modular and Agent-based Collaborative Design Mechanism for Distributed Product Development 被引量:4
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作者 LIU Jinfei CHEN Ming +1 位作者 WANG Lei WU Qidi 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2014年第3期641-654,共14页
The rapid expansion of enterprises makes product collaborative design (PCD) a critical issue under the distributed heterogeneous environment, but as the collaborative task of large-scale network becomes more complic... The rapid expansion of enterprises makes product collaborative design (PCD) a critical issue under the distributed heterogeneous environment, but as the collaborative task of large-scale network becomes more complicated, neither unified task decomposition and allocation methodology nor Agent-based network management platform can satisfy the increasing demands. In this paper, to meet requirements of PCD for distributed product development, a collaborative design mechanism based on the thought of modularity and the Agent technology is presented. First, the top-down 4-tier process model based on task-oriented modular and Agent is constructed for PCD after analyzing the mapping relationships between requirements and functions in the collaborative design. Second, on basis of sub-task decomposition for PCD based on a mixed method, the mathematic model of task-oriented modular based on multi-objective optimization is established to maximize the module cohesion degree and minimize the module coupling degree, while considering the module executable degree as a restriction. The mathematic model is optimized and simulated by the modified PSO, and the decomposed modules are obtained. Finally, the Agent structure model for collaborative design is put forward, and the optimism matching Agents are selected by using similarity algorithm to implement different task-modules by the integrated reasoning and decision-making mechanism with the behavioral model of collaborative design Agents. With the results of experimental studies for automobile collaborative design, the feasibility and efficiency of this methodology of task-oriented modular and Agent-based collaborative design in the distributed heterogeneous environment are verified. On this basis, an integrative automobile collaborative R&D platform is developed. This research provides an effective platform for automobile manufacturing enterprises to achieve PCD, and helps to promote product numeralization collaborative R&D and management development. 展开更多
关键词 collaborative design task-oriented modular MULTI-AGENT collaboration mechanism collaborative platform
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Impact of task-oriented training based on acupuncture rehabilitation on upper extremity function and quality of life of patients with early stroke 被引量:1
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作者 Hong-Guang Liu Jing-Jing Liu +5 位作者 Yan-Ping Wang Hong-Ying Wang Ao Sun Yue Zhou Ming-Ming Cai Ming-Ming Qi 《World Journal of Clinical Cases》 SCIE 2024年第19期3776-3784,共9页
BACKGROUND Eighty percent of stroke patients develop upper limb dysfunction,especially hand dysfunction,which has a very slow recovery,resulting in economic burden to families and society.AIM To investigate the impact... BACKGROUND Eighty percent of stroke patients develop upper limb dysfunction,especially hand dysfunction,which has a very slow recovery,resulting in economic burden to families and society.AIM To investigate the impact of task-oriented training based on acupuncture therapy on upper extremity function in patients with early stroke.METHODS Patients with early stroke hemiplegia who visited our hospital between January 2021 and October 2022 were divided into a control group and an observation group,each with 50 cases.The control group underwent head acupuncture plus routine upper limb rehabilitation training(acupuncture therapy).In addition to acupuncture and rehabilitation,the observation group underwent upper limb task-oriented training(30 min).Each group underwent treatment 5 d/wk for 4 wk.Upper extremity function was assessed in both groups using the Fugl-Meyer Assessment-Upper Extremity(FMA-UE),Wolf Motor Function Rating Scale(WMFT),modified Barthel Index(MBI),and Canadian Occupational Performance Measure(COPM).Quality of life was evaluated using the Short-Form 36-Item Health Survey(SF-36).Clinical efficacy of the interventions was also evaluated.RESULTS Before intervention,no significant differences were observed in the FMA-UE,MBI,and WMFT scores between the two groups(P>0.05).After intervention,the FMA-UE,WMFT,MBI,COPM-Functional Mobility and Satisfaction,and SF-36 scores increased in both groups(P<0.05),with even higher scores in the observation group(P<0.05).The observation group also obtained a higher total effective rate than the control group(P<0.05).CONCLUSION Task-oriented training based on acupuncture rehabilitation significantly enhanced upper extremity mobility,quality of life,and clinical efficacy in patients with early stroke. 展开更多
关键词 STROKE Acupuncture rehabilitation task-oriented training Upper extremity training
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Intervention Effect of Lower Limb Rehabilitation Robot with Task-Oriented Training on Stroke Patients and Its Influence on KFAROM Score 被引量:2
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作者 Maiding He Li Huang +9 位作者 Dekun Tang Mei Qin Ping Zhan Xichan Wang Xia Gao Jianzhu Wang Na Yin Hui Xu Yonghua Yang Kaihua Tang 《Journal of Biosciences and Medicines》 2024年第9期62-72,共11页
Objective: To explore the effect of lower limb rehabilitation robot combined with task-oriented training on stroke patients and its influence on KFAROM score. Methods: 100 stroke patients with hemiplegia admitted to o... Objective: To explore the effect of lower limb rehabilitation robot combined with task-oriented training on stroke patients and its influence on KFAROM score. Methods: 100 stroke patients with hemiplegia admitted to our hospital from January 2023 to December 2023 were randomly divided into two groups, the control group (50 cases) was given task-oriented training assisted by nurses, and the observation group (50 cases) was given lower limb rehabilitation robot with task-oriented training. Lower limb balance, lower limb muscle strength, motor function, ankle function, knee flexion range of motion and walking ability were observed. Results: After treatment, the scores of BBS, quadriceps femoris and hamstrings in the observation group were significantly higher than those in the control group (P Conclusion: In the clinical treatment of stroke patients, the combination of task-oriented training and lower limb rehabilitation robot can effectively improve the lower limb muscle strength, facilitate the recovery of balance function, and have a significant effect on the recovery of motor function, which can improve the walking ability of stroke patients and the range of motion of knee flexion, and achieve more ideal therapeutic effectiveness. 展开更多
关键词 Lower Limb Rehabilitation Robot task-oriented Training STROKE KFAROM
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Task-Oriented Semantic Communication with Foundation Models
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作者 Chen Mingkai Liu Minghao +2 位作者 Zhang Zhe Xu Zhiping Wang Lei 《China Communications》 SCIE CSCD 2024年第7期65-77,共13页
In the future development direction of the sixth generation(6G)mobile communication,several communication models are proposed to face the growing challenges of the task.The rapid development of artificial intelligence... In the future development direction of the sixth generation(6G)mobile communication,several communication models are proposed to face the growing challenges of the task.The rapid development of artificial intelligence(AI)foundation models provides significant support for efficient and intelligent communication interactions.In this paper,we propose an innovative semantic communication paradigm called task-oriented semantic communication system with foundation models.First,we segment the image by using task prompts based on the segment anything model(SAM)and contrastive language-image pretraining(CLIP).Meanwhile,we adopt Bezier curve to enhance the mask to improve the segmentation accuracy.Second,we have differentiated semantic compression and transmission approaches for segmented content.Third,we fuse different semantic information based on the conditional diffusion model to generate high-quality images that satisfy the users'specific task requirements.Finally,the experimental results show that the proposed system compresses the semantic information effectively and improves the robustness of semantic communication. 展开更多
关键词 diffusion model foundation model joint source-channel coding task-oriented semantic communication
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Novel cardiac biomarkers and multiple-marker approach in the early detection,prognosis,and risk stratification of cardiac diseases 被引量:1
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作者 Syed Faqeer Hussain Bokhari Muhammad Umais +8 位作者 Syed Muhammad Faizan Sattar Umair Mehboob Asma Iqbal Maaz Amir Danyal Bakht Khawar Ali Abdul Haseeb Hasan Muhammad Arsham Javed Wahidullah Dost 《World Journal of Cardiology》 2025年第7期11-52,共42页
Cardiovascular diseases(CVDs)remain the leading cause of morbidity and mortality worldwide,necessitating innovative diagnostic and prognostic strategies.Traditional biomarkers like C-reactive protein,uric acid,troponi... Cardiovascular diseases(CVDs)remain the leading cause of morbidity and mortality worldwide,necessitating innovative diagnostic and prognostic strategies.Traditional biomarkers like C-reactive protein,uric acid,troponin,and natriuretic peptides play crucial roles in CVD management,yet they are often limited by sensitivity and specificity constraints.This narrative review critically examines the emerging landscape of cardiac biomarkers and advocates for a multiple-marker approach to enhance early detection,prognosis,and risk stratification of CVD.In recent years,several novel biomarkers have shown promise in revolutionizing CVD diagnostics.Gamma-glutamyltransferase,microRNAs,endothelial microparticles,placental growth factor,trimethylamine N-oxide,retinol-binding protein 4,copeptin,heart-type fatty acid-binding protein,galectin-3,growth differentiation factor-15,soluble suppression of tumorigenicity 2,fibroblast growth factor 23,and adrenomedullin have emerged as significant indicators of CV health.These biomarkers provide insights into various pathophysiological processes,such as oxidative stress,endothelial dysfunction,inflammation,metabolic disturbances,and myocardial injury.The integration of these novel biomarkers with traditional ones offers a more comprehensive understanding of CVD mechanisms.This multiple-marker approach can improve diagnostic accuracy,allowing for better risk stratification and more personalized treatment strategies.This review underscores the need for continued research to validate the clinical utility of these biomarkers and their potential incorporation into routine clinical practice.By leveraging the strengths of both traditional and novel biomarkers,precise therapeutic plans can be developed,thereby improving the management and prognosis of patients with CVDs.The ongoing exploration and validation of these biomarkers are crucial for advancing CV care and addressing the limitations of current diagnostic tools. 展开更多
关键词 Cardiac biomarkers Multiple-marker approach Cardiovascular disease diagnosis Risk stratification Prognostic indicators
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Adaptive Neural Finite-Time Deployment of Heterogeneous Multi-agent Systems via a Cross-Species Bionic PDE-ODE Approach 被引量:1
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作者 Jingtao MAN Zhigang ZENG 《Artificial Intelligence Science and Engineering》 2025年第1期52-63,共12页
For large-scale heterogeneous multi-agent systems(MASs)with characteristics of dense-sparse mixed distribution,this paper investigates the practical finite-time deployment problem by establishing a novel crossspecies ... For large-scale heterogeneous multi-agent systems(MASs)with characteristics of dense-sparse mixed distribution,this paper investigates the practical finite-time deployment problem by establishing a novel crossspecies bionic analytical framework based on the partial differential equation-ordinary differential equation(PDE-ODE)approach.Specifically,by designing a specialized network communication protocol and employing the spatial continuum method for densely distributed agents,this paper models the tracking errors of densely distributed agents as a PDE equivalent to a human disease transmission model,and that of sparsely distributed agents as several ODEs equivalent to the predator population models.The coupling relationship between the PDE and ODE models is established through boundary conditions of the PDE,thereby forming a PDE-ODE-based tracking error model for the considered MASs.Furthermore,by integrating adaptive neural control scheme with the aforementioned biological models,a“Flexible Neural Network”endowed with adaptive and self-stabilized capabilities is constructed,which acts upon the considered MASs,enabling their practical finite-time deployment.Finally,effectiveness of the developed approach is illustrated through a numerical example. 展开更多
关键词 large-scale heterogeneous MASs cross-species bionic framework practical finite-time deployment PDEODE approach adaptive neural control
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Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease
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作者 Ling-Xiao Yi Hui Ren Woon +3 位作者 Genevieve Saw Li Zeng Eng King Tan Zhi Dong Zhou 《Neural Regeneration Research》 SCIE CAS 2025年第11期3193-3206,共14页
The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative disease.Although the detailed patho... The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative disease.Although the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and therapy.The induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease therapies.The current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem cells.The benefits of induced pluripotent stem cell-based research are highlighted.Various dopaminergic neuron differentiation protocols from induced pluripotent stem cells are compared.The emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are evaluated.Finally,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease. 展开更多
关键词 dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches
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Ensemble Deep Learning Approaches in Health Care:A Review 被引量:1
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作者 Aziz Alotaibi 《Computers, Materials & Continua》 2025年第3期3741-3771,共31页
Deep learning algorithms have been rapidly incorporated into many different applications due to the increase in computational power and the availability of massive amounts of data.Recently,both deep learning and ensem... Deep learning algorithms have been rapidly incorporated into many different applications due to the increase in computational power and the availability of massive amounts of data.Recently,both deep learning and ensemble learning have been used to recognize underlying structures and patterns from high-level features to make predictions/decisions.With the growth in popularity of deep learning and ensemble learning algorithms,they have received significant attention from both scientists and the industrial community due to their superior ability to learn features from big data.Ensemble deep learning has exhibited significant performance in enhancing learning generalization through the use of multiple deep learning algorithms.Although ensemble deep learning has large quantities of training parameters,which results in time and space overheads,it performs much better than traditional ensemble learning.Ensemble deep learning has been successfully used in several areas,such as bioinformatics,finance,and health care.In this paper,we review and investigate recent ensemble deep learning algorithms and techniques in health care domains,medical imaging,health care data analytics,genomics,diagnosis,disease prevention,and drug discovery.We cover several widely used deep learning algorithms along with their architectures,including deep neural networks(DNNs),convolutional neural networks(CNNs),recurrent neural networks(RNNs),and generative adversarial networks(GANs).Common healthcare tasks,such as medical imaging,electronic health records,and genomics,are also demonstrated.Furthermore,in this review,the challenges inherent in reducing the burden on the healthcare system are discussed and explored.Finally,future directions and opportunities for enhancing healthcare model performance are discussed. 展开更多
关键词 Deep learning ensemble learning deep ensemble learning deep learning approaches for health care health care
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Enhancing perianal disease management with integrated physical and psychological approaches
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作者 Uchenna E Okpete Haewon Byeon 《World Journal of Clinical Cases》 SCIE 2025年第2期59-63,共5页
This article provides a comprehensive analysis of the study by Hou et al,focusing on the complex interplay between psychological and physical factors in the postoperative recovery(POR)of patients with perianal disease... This article provides a comprehensive analysis of the study by Hou et al,focusing on the complex interplay between psychological and physical factors in the postoperative recovery(POR)of patients with perianal diseases.The study sheds light on how illness perception,anxiety,and depression significantly influence recovery outcomes.Hou et al developed a predictive model that demonstrated high accuracy in identifying patients at risk of poor recovery.The article explores the critical role of pre-operative psychological assessment,highlighting the need for mental health support and personalized recovery plans in enhancing POR quality.A multidisciplinary approach,integrating mental health professionals with surgeons,anesthesiologists,and other specialists,is emphasized to ensure comprehensive care for patients.The study’s findings serve as a call to integrate psychological care into surgical practice to optimize outcomes for patients with perianal diseases. 展开更多
关键词 Perianal disease Post-operative recovery ANXIETY DEPRESSION Pain management Emotional well-being Multidisciplinary approach
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Effect of microwave irradiation on thermal damage behavior of granite:Uniaxial compression test and finite-discrete approach 被引量:1
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作者 Bowen Sun Shengqi Yang +4 位作者 Shigui Du Wenling Tian Shibin Tang Heng Li Zhennan Zhu 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第2期827-844,共18页
Microwave-assisted rock-breaking technology,as a novel hybrid approach,is anticipated to facilitate the efficient excavation of complex rock formations.It is therefore crucial to understand the damage and failure mech... Microwave-assisted rock-breaking technology,as a novel hybrid approach,is anticipated to facilitate the efficient excavation of complex rock formations.It is therefore crucial to understand the damage and failure mechanisms of rocks that have been subjected to irradiation.In this study,uniaxial compression experiments were conducted on granite specimens after 1.4 kW microwave irradiation for varying durations.Furthermore,a numerical method was proposed to solve electromagnetic-thermal-mechanical coupling problems by integrating finite and discrete elements.The results demonstrated a differential temperature distribution(high temperature in the middle and low-temperature areas at the ends)in the granite specimens under microwave irradiation,which resulted in a notable reduction in their physical and mechanical properties.As the duration of irradiation increased,the rate of heating and the extent of strength reduction both diminished,while the morphology and distribution of cracks at ultimate failure became increasingly complex.The numerical method effectively addresses the simulation challenges associated with the electromagnetic selective heating of granite containing multiple polar minerals under microwave irradiation.This approach accounted for the non-uniform thermal expansion of the minerals and provided a comprehensive model of damage progression under compression. 展开更多
关键词 Microwave-assisted rock breaking GRANITE Electromagnetic-thermal-mechanical(ETM)coupling Finite-discrete approach Three-dimensional(3D)grain-based model(GBM)
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Application of Health Action Process Approach Theory in Patients with Type D Personality Psoriasis
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作者 Qian Sun Jing Wang +3 位作者 Yachun Yao Xue Hu Yi Liu Jingjing Liu 《Journal of Biosciences and Medicines》 2025年第2期67-77,共11页
Objective: To explore the effect of Health Action Process Approach (HAPA) theory in patients with type D personality psoriasis. Methods: A total of 66 patients with type D personality psoriasis admitted to the dermato... Objective: To explore the effect of Health Action Process Approach (HAPA) theory in patients with type D personality psoriasis. Methods: A total of 66 patients with type D personality psoriasis admitted to the dermatology department of a top-three hospital in Jingzhou City from November 2022 to July 2023 were selected and divided into control group and test group with 33 cases in each group by random number table method. The control group received routine health education, and the experimental group received health education based on the HAPA theory. Chronic disease self-efficacy scale, hospital anxiety and depression scale and skin disease quality of life scale were used to evaluate the effect of intervention. Results: After 3 months of intervention, the scores of self-efficacy in experimental group were higher than those in control group (P P Conclusion: Health education based on the theory of HAPA can enhance the self-efficacy of patients with type D personality psoriasis, relieve negative emotions and improve their quality of life. 展开更多
关键词 Health Action Process approach Theory Type D Personality PSORIASIS SELF-EFFICACY Negative Emotions Quality of Life
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Exploring Adolescents’Social Anxiety,Physical Activity,and Core Self-Evaluation:A Latent Profile and Mediation Approach
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作者 Huazhe Wan Wenying Huang +1 位作者 Wen Zhang Chang Hu 《International Journal of Mental Health Promotion》 2025年第10期1611-1626,共16页
Background:Social anxiety is prevalent among adolescents and severely impacts their mental health and social functioning.This study aims to explore the underlying mechanisms and subgroup differences in adolescent soci... Background:Social anxiety is prevalent among adolescents and severely impacts their mental health and social functioning.This study aims to explore the underlying mechanisms and subgroup differences in adolescent social anxiety to provide a theoretical basis for targeted interventions.Methods:3025 Chinese adolescents(Meanage=13.91±1.60 years;47%male)completed self-report measures of physical activity,core self-evaluation,and social anxiety.Variable-centered analyses employed PROCESS Model 4 with 5000 bootstrap samples;covariates were gender,grade,and place of residence.Person-centered analyses used latent profile analysis in Mplus 8.3 to identify subgroups based on social anxiety item profiles.Results:Variable-centered analyses showed that physical activity had a significant negative association with social anxiety(β=−0.224,p<0.001)and a significant positive association with core self-evaluation(β=0.471,p<0.001);core self-evaluation partially mediated this relationship,accounting for 30%of the total effect.Person-centered analyses revealed an optimal two-profile solution:a low social anxiety profile(89.6%)and a high social anxiety profile(10.4%).The high social anxiety profile reported significantly lower physical activity and lower core self-evaluation than the low social anxiety profile.Conclusions:This study integrates variable-centered and person-centered evidence,identifies physical activity and core self-evaluation as key modifiable factors in reducing social anxiety,providing a theoretical basis for targeted and differentiated interventions. 展开更多
关键词 ocial anxiety physical activity core self-evaluation latent profile analysis variable-centered approach person-centered approach
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