CRISPR-Cas system has been widely adapted as a platform for genome editing in various eukaryotic organisms, including zebrafish（Cong et al., 2013; Hwang et al., 2013）. One of the important applications of CRISPR-Cas...CRISPR-Cas system has been widely adapted as a platform for genome editing in various eukaryotic organisms, including zebrafish（Cong et al., 2013; Hwang et al., 2013）. One of the important applications of CRISPR-Cas9 system is to produce double-strand DNA breaks（DSBs） at targeted sites with guide RNA（gRNA）.展开更多
多靶点药物能同时调节多靶点、调节疾病网络的多个环节,在获得较高疗效的同时可降低单靶点引起的毒副作用,是治疗复杂性疾病的理想药物,因此已成为药物研发的主要方向。而天然产物凭借其结构的多样性,较高的多靶点活性和较小的毒副作用...多靶点药物能同时调节多靶点、调节疾病网络的多个环节,在获得较高疗效的同时可降低单靶点引起的毒副作用,是治疗复杂性疾病的理想药物,因此已成为药物研发的主要方向。而天然产物凭借其结构的多样性,较高的多靶点活性和较小的毒副作用等优势,是多靶点药物开发的重要来源。计算机辅助药物设计(computer-aided drug design,CADD)是常用的多靶点药物研发方法,其主要包括虚拟筛选和药效团设计。该文对其进行了系统梳理,探讨了各方法用于天然产物多靶点药物研发的前景与优势。展开更多
基金supported by the funding from the Science and Technology Program of Shenzhen (JCYJ20150924110425180 and JCYJ20151030170755264)
文摘CRISPR-Cas system has been widely adapted as a platform for genome editing in various eukaryotic organisms, including zebrafish（Cong et al., 2013; Hwang et al., 2013）. One of the important applications of CRISPR-Cas9 system is to produce double-strand DNA breaks（DSBs） at targeted sites with guide RNA（gRNA）.
文摘多靶点药物能同时调节多靶点、调节疾病网络的多个环节,在获得较高疗效的同时可降低单靶点引起的毒副作用,是治疗复杂性疾病的理想药物,因此已成为药物研发的主要方向。而天然产物凭借其结构的多样性,较高的多靶点活性和较小的毒副作用等优势,是多靶点药物开发的重要来源。计算机辅助药物设计(computer-aided drug design,CADD)是常用的多靶点药物研发方法,其主要包括虚拟筛选和药效团设计。该文对其进行了系统梳理,探讨了各方法用于天然产物多靶点药物研发的前景与优势。
