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Deformation patterns of steel targets against long rod penetration
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作者 Chengxin Du Peng Wang +4 位作者 Bingnan Xing Feng Zhou Wenzheng Lv Zhonghua Du Guangfa Gao 《Defence Technology(防务技术)》 2025年第8期272-287,共16页
An experimental and finite element simulation investigation are conducted to study the deformation patterns of steel targets during the penetration process of tungsten alloy long rods,as well as the influence of stren... An experimental and finite element simulation investigation are conducted to study the deformation patterns of steel targets during the penetration process of tungsten alloy long rods,as well as the influence of strength of the target on the deformation patterns.The experimental results revealed slight mass loss in the first layer of the steel target during the transient entrance phase,with an extremely negligible loss in target mass during the quasi-steady penetration phase.The results of macro-analysis,micro-analysis and simulation show that the eroded target material migrated towards the periphery of the crater,causing an increase in the target's thickness,remained within the target,instead of flowing out of the crater.Therefore,the process of long rods penetrating the metal target is considered as a process of backward extrusion.By combining the backward extrusion theory with energy conservation,a penetration depth model for long rods penetrating a metal target,taking into account both the diameter of the crater and the friction coefficient between the rod and the target,has been established.Although the model is not yet perfect,it innovatively applies the principles of solid mechanics to the study of long rod penetration.Additionally,it takes into account the friction coefficient between the rod and the target during the penetration process.Therefore,this model provides a new research direction for future studies on long rod penetration. 展开更多
关键词 Long-rod penetration Mass loss of target Deformation patterns of targets Penetration depth model Backward extrusion theory
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The characteristic target-pattern regional ore zonality of the Nanling region,China(Ⅱ) 被引量:2
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作者 Chongwen Yu 《Geoscience Frontiers》 SCIE CAS 2011年第3期323-347,共25页
By applying the 'theory of synchronization' from the science of complexity to studying the regional regularity of ore formation within the Nanling region of southern China, a characteristic targetpattern regional or... By applying the 'theory of synchronization' from the science of complexity to studying the regional regularity of ore formation within the Nanling region of southern China, a characteristic targetpattern regional ore zonality has been discovered. During the early and late Yanshanian epoch (corresponding respectively to the Jurassic and Cretaceous periods), two centers of ore formation emerged successively in the Nanling region; the former is mainly for rare metals (W, Sn, Mo, Bi, Nb) and one rare-earth element (La) and was generated in the Jurassic period; whereas the latter is mainly for base metals (Cu, Pb, Zn, Sb, Hg), noble metals (Au, Ag), and one radioactive element (U) and was generated in the Cretaceous period. Centers of ore formation were brought about by interface dynamics respectively at the Qitianling and Jiuyishan districts in southern Hunan Province. The characteristic giant nonlinear target-pattern regional ore zonality was generated by spatio-temporal synchronization process of the Nanling complex metallogenic system. It induced the collective dynamics and cooperative behavior of the system and displayed the configuration of the regional ore zonality. Then dynamical clustering transformed the configuration into rudimentary ordered coherent structures. Phase dynamics eventually defined the spatio-temporal structures of the target-pattern regional ore zonality and determined their localization and distribution. A new methodology for revealing regional ore zonality is developed, which will encourage further investigation of the formation of deep-seated ore resources and the onset of large-scale mineralization. 展开更多
关键词 Rare elements Ore zonality target pattern Synchronization Complexity Jurassic/Cretaceous NANLING China
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The characteristic target-pattern regional ore zonality of the Nanling region,China(Ⅰ) 被引量:2
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作者 Chongwen Yu 《Geoscience Frontiers》 SCIE CAS 2011年第2期147-148,I0001,I0002,149-156,共12页
By applying the 'theory of synchronization' from the science of complexity to studying the regional regularity of ore formation within the Nanling region of southern China, a characteristic targetpattern regional or... By applying the 'theory of synchronization' from the science of complexity to studying the regional regularity of ore formation within the Nanling region of southern China, a characteristic targetpattern regional ore zonality has been discovered. During the early and late Yanshanian epoch (corresponding respectively to the Jurassic and Cretaceous periods), two centers of ore formation emerged successively in the Nanling region; the former is mainly for rare metals (W, Sn, Mo, Bi, Nb) and one rare-earth element (La) and was generated in the Jurassic period; whereas the latter is mainly for base metals (Cu, Pb, Zn, Sb, Hg), noble metals (Au, Ag), and one radioactive element (U) and was generated in the Cretaceous period. Centers of ore formation were brought about by interface dynamics respectively at the Qitianling and Jiuyishan districts in southern Hunan province. The characteristic giant nonlinear target-pattern regional ore zonality was generated by spatio-temporal synchronization process of the Nanling complex metallogenic system. It induced the collective dynamics and cooperative behavior of the system and displayed the configuration of the regional ore zonality. Then dynamical clustering transformed the configuration into rudimentary ordered coherent structures. Phase dynamics eventually defined the spatio-temporal structures of the target-pattern regional ore zonality and determined their localization and distribution. A new methodology for revealing regional ore zonality is developed, which will encourage further investigation of the formation of deep-seated ore resources and the onset of laree-scale mineralization. 展开更多
关键词 Ore zonality target pattern SynchronizationComplexity NANLING China
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The characteristic target-pattern regional ore zonality of the Nanling region,China(Ⅲ) 被引量:1
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作者 Chongwen Yu 《Geoscience Frontiers》 SCIE CAS 2011年第4期551-569,共19页
By applying the 'theory of synchronization' from the science of complexity to studying the regional regularity of ore formation within the Nanling region of South China,a characteristic target-pattern regional ore z... By applying the 'theory of synchronization' from the science of complexity to studying the regional regularity of ore formation within the Nanling region of South China,a characteristic target-pattern regional ore zonality has been discovered.During the early and late Yanshanian epoch (corresponding respectively to the Jurassic and Cretaceous periods),two centers of ore formation emerged successively in the Nanling region;the former is mainly for rare metals(W,Sn,Mo,Bi,Nb) and one rare-earth element(La) and was generated in the Jurassic period;whereas the latter is mainly for base metals (Cu,Pb,Zn,Sb,Hg),noble metals(Au,Ag),and one radioactive element(U) and was generated in the Cretaceous period.Centers of ore formation were brought about by interface dynamics respectively at the Qitianling and Jiuyishan districts in southern Hunan Province.The characteristic giant nonlinear target-pattern regional ore zonality was generated respectively from the two centers of ore formation by the spatio-temporal synchronization process of the Nanling complex metallogenic system.It induced the collective dynamics and cooperative behavior of the system and displayed the configuration of the regional ore zonality.Then dynamical clustering transformed the configuration into rudimentary ordered coherent structures.Phase dynamics eventually defined the spatio-temporal structures of the target-pattern regional ore zonality and determined their localization and distribution.The integral successive processes of synchronization-dynamical clustering-phase dynamics accomplished the regional ore zonality by way of "multiple field dynamics" of spatio-temporal superposition of multiple coupled pulsatory solitary wave trains of the zonal sequences of different ores.A new methodology for revealing regional ore zonality is developed,which will encourage further investigation of the formation of deep-seated ore resources and the onset of large-scale mineralization. 展开更多
关键词 Ore zonality target pattern Synchronization Complexity Jurassic/Cretaceous NANLING
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TARGET PATTERNS AND SPIRAL WAVES IN REACTION-DIFFUSION SYSTEMS WITH LIMIT CYCLE KINETICSAND WEAK DIFFUSION
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作者 赵晓强 《Acta Mathematicae Applicatae Sinica》 SCIE CSCD 1998年第4期347-354,356-357,共10页
In this paper, we study periodic waves in reaction-diffusion systems with limit cycle kinetics and weak diffusion. The results are based on the analysis of a nonlinear partial differential equation which is derived fr... In this paper, we study periodic waves in reaction-diffusion systems with limit cycle kinetics and weak diffusion. The results are based on the analysis of a nonlinear partial differential equation which is derived from singular perturbation techniques. We obtain the first order approximation expression of the dispersion curve for periodic wave trains and then show that in the generic case of limit cycle kinetics there is a one parameter family of target patterns and the rotating spiral waves of Archimedian type exist. Finally, we apply these results to the general λ-ω systems. 展开更多
关键词 target patterns spiral waves reaction-diffusion systems and singular perturbation
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Target morphology and cell memory:a model of regenerative pattern formation
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作者 Nikolai Bessonov Michael Levin +3 位作者 Nadya Morozova Natalia Reinberg Alen Tosenberger Vitaly Volpert 《Neural Regeneration Research》 SCIE CAS CSCD 2015年第12期1901-1905,共5页
Despite the growing body of work on molecular components required for regenerative repair,we still lack a deep understanding of the ability of some animal species to regenerate their appropriate complex anatomical str... Despite the growing body of work on molecular components required for regenerative repair,we still lack a deep understanding of the ability of some animal species to regenerate their appropriate complex anatomical structure following damage.A key question is how regenerating systems know when to stop growth and remodeling-what mechanisms implement recognition of correct morphology that signals a stop condition?In this work,we review two conceptual models of pattern regeneration that implement a kind of pattern memory.In the first one,all cells communicate with each other and keep the value of the total signal received from the other cells.If a part of the pattern is amputated,the signal distribution changes.The difference fromthe original signal distribution stimulates cell proliferation and leads to pattern regeneration,in effect implementing an error minimization process that uses signaling memory to achieve pattern correction.In the second model,we consider a more complex pattern organization with different cell types.Each tissue contains a central(coordinator)cell that controls the tissue and communicates with the other central cells.Each of them keeps memory about the signals received from other central cells.The values of these signals depend on the mutual cell location,and the memory allows regeneration of the structure when it is modified.The purpose of these models is to suggest possible mechanisms of pattern regeneration operating on the basis of cell memory which are compatible with diverse molecular implementation mechanisms within specific organisms. 展开更多
关键词 target morphology pattern regeneration cell memory MORPHOGENESIS cell signaling mathematical modeling agent-based model
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Air Target Fuzzy Pattern Recognition Threat-Judgment Model
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作者 Tong Youtang & Wang JianmingDalian University of Technology, Dalian 110624, P. R. China Dalian Naval Academy, Dalian 116018, P. R. China 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2003年第1期41-46,共6页
Threat-judgment is a complicated fuzzy inference problem. Up to now no relevant unified theory and measur-ing standard have been developed. It is very difficult to establish a threat-judgment model with high reliabili... Threat-judgment is a complicated fuzzy inference problem. Up to now no relevant unified theory and measur-ing standard have been developed. It is very difficult to establish a threat-judgment model with high reliability in the airdefense system for the naval warships. Air target threat level judgment is an important component in naval warship com-bat command decision-making systems. According to the threat level judgment of air targets during the air defense of sin-gle naval warship, a fuzzy pattern recognition model for judging the threat from air targets is established. Then an algo-rithm for identifying the parameters in the model is presented. The model has an adaptive feature and can dynamicallyupdate its parameters according to the state change of the attacking targets and the environment. The method presentedhere can be used for the air defense system threat judgment in the naval warships. 展开更多
关键词 Air targets Threat judgment Fuzzy pattern recognition Fuzzy sets
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Analysis on Spiral Search Pattern for Moving Target
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作者 鄂群 马远良 +2 位作者 周舟 王明晨 王连柱 《Defence Technology(防务技术)》 SCIE EI CAS 2008年第1期44-47,共4页
The distribution function of the target moving in constant velocity and linear course and its meeting condition to the searcher are analyzed.Another proof method for spiral search pattern is presented and the mathemat... The distribution function of the target moving in constant velocity and linear course and its meeting condition to the searcher are analyzed.Another proof method for spiral search pattern is presented and the mathematic model of the target possible position is established when performing the linear search.Base on them,the wrong idea about the spiral search pattern can be 展开更多
关键词 操作研究 搜索理论 搜索模式 移动目标 聚集条件
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A Moving IR Point Target Detection Algorithm Based on Reverse Phase Feature of Neighborhood in Difference Between Neighbor Frame Images 被引量:3
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作者 朱风云 秦世引 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2006年第3期225-232,共8页
An algorithm for detecting moving IR point target in complex background is proposed, which is based on the Reverse Phase Feature of Neighborhood (RPFN) of target in difference between neighbor frame images that two ... An algorithm for detecting moving IR point target in complex background is proposed, which is based on the Reverse Phase Feature of Neighborhood (RPFN) of target in difference between neighbor frame images that two positions of the target in the difference image are near and the gray values of them are close to in absolute value but with inverse sign. Firstly, pairs of points with RPFN are detected in the difference image between neighbor frame images, with which a virtual vector graph is made, and then the moving point target can be detected by the vectors' sequence cumulated in vector graphs. In addition, a theorem for the convergence of detection of target contrail by this algorithm is given and proved so as to afford a solid guarantee for practical applications of the algorithm proposed in this paper. Finally, some simulation results with 1000 frames from 10 typical images in complex background show that moving point targets with SNR not lower than 1.5 can be detected effectively. 展开更多
关键词 pattern recognition target detection point target difference image RPFN
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Application of Improved Grey Target Technology in Weapon Evaluation 被引量:1
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作者 解志坚 薄玉成 王志林 《Defence Technology(防务技术)》 SCIE EI CAS 2005年第2期146-150,共5页
A new method of effectiveness evaluation of weapon systems is set up by improving the formula of approaching degree. According to the grey target theory of grey system theory, the patterns of the weapon systems to be ... A new method of effectiveness evaluation of weapon systems is set up by improving the formula of approaching degree. According to the grey target theory of grey system theory, the patterns of the weapon systems to be evaluated are formed with the main tactical and technical performance indices of these weapon systems, thereby the standard pattern of these patterns is determined. By solving the approaching degree of patterns to their standard one and making a comparison among them, the evaluation results can be obtained. 展开更多
关键词 GREY target theory APPROACHING DEGREE contributing DEGREE standard pattern comparison
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A Modified Four Path Method for Calculating Coupling Field of Super-Low Altitude Aircraft Target
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作者 Gaoxiang Zou Chuangming Tong +2 位作者 Binglin Yu Hualong Sun Tao Song 《Journal of Computer and Communications》 2018年第12期64-73,共10页
A novel modified four path method (FPM) is presented for calculating coupling field of super-low altitude aircraft target. Based on the hybrid method PO + MEC (Physical Optics and Method of Equivalent Currents), the a... A novel modified four path method (FPM) is presented for calculating coupling field of super-low altitude aircraft target. Based on the hybrid method PO + MEC (Physical Optics and Method of Equivalent Currents), the antenna radiation pattern is introduced to consider the multipath interference from side lobe of seeker. The modified FPM is used to calculate the coupling field from super-low altitude aircraft target above different terrestrial environments. The curves of scattering coefficient are analyzed. The influences of height of target, root mean square (RMS), and incident angle on coupling field characteristics are discussed. The simulation results can be used for reference in detection for super-low altitude target and optimization for radar system. 展开更多
关键词 MODIFIED FOUR Path Method Antenna Radiation pattern Super-Low ALTITUDE AIRCRAFT target Coupling Field BREWSTER Angle
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基于BiLSTM-SA的空间非合作目标行为模式识别方法
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作者 方嘉卉 唐进 +1 位作者 黎克波 梁彦刚 《飞行力学》 北大核心 2025年第2期50-56,共7页
为了准确识别空间非合作目标的行为模式,针对空间目标运动状态的动态、时序变化特征,提出了基于双向长短期记忆(BiLSTM)-自注意力(SA)的空间非合作目标行为模式识别网络模型,以目标四类时序特征作为输入,以对应的目标行为模式标签作为输... 为了准确识别空间非合作目标的行为模式,针对空间目标运动状态的动态、时序变化特征,提出了基于双向长短期记忆(BiLSTM)-自注意力(SA)的空间非合作目标行为模式识别网络模型,以目标四类时序特征作为输入,以对应的目标行为模式标签作为输出,利用BiLSTM网络训练学习,并通过引入自注意力机制,识别出目标最有可能的行为模式。通过对比分析表明,所用模型有效提升了空间非合作目标行为模式识别的准确率。 展开更多
关键词 空间非合作目标 行为模式识别 双向长短期记忆 自注意力机制
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基于“态靶辨证”探析补肾开玄通络法治疗糖尿病肾病
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作者 徐淼 刘泽豪 +4 位作者 刘铜华 高明 秦灵灵 王海焱 吕翠岩 《湖南中医药大学学报》 2025年第11期2142-2148,共7页
糖尿病肾病(DKD)是糖尿病常见并发症之一,仝小林院士创新性地提出“态靶辨证”理论体系,通过“宏观态-微观靶”相结合的中西医诊疗模式,可有效改善患者水肿、乏力、泡沫尿等临床症状,为DKD临床治疗提供了新的思路与方向。本团队在“肾... 糖尿病肾病(DKD)是糖尿病常见并发症之一,仝小林院士创新性地提出“态靶辨证”理论体系,通过“宏观态-微观靶”相结合的中西医诊疗模式,可有效改善患者水肿、乏力、泡沫尿等临床症状,为DKD临床治疗提供了新的思路与方向。本团队在“肾络玄府”理论的基础上,结合临床实践,提出DKD病程中存在“虚、瘀、浊”三态演变规律,并针对病靶、症靶、标靶,提出运用补肾开玄通络法治疗DKD,强调病证结合、态靶同调,实现分层精准干预。临床实践表明,“态靶辨证”通过中医整体调节与西医靶向治疗的有机融合,在改善DKD临床症状、延缓肾功能进展方面展现出独特优势。 展开更多
关键词 态靶辨证 糖尿病肾病 补肾开玄通络法 靶方 靶药
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中医证候疗效评价研究现况及策略述评
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作者 兰晓雪 陈红 +1 位作者 孙亚男 于长禾 《中国中医药信息杂志》 2025年第12期183-186,共4页
证候疗效评价是验证中医药临床疗效的核心环节,但其概念界定、测量工具及方法学体系尚未形成共识。本文评述证候疗效评价的研究现状:在概念层面,需厘清广义(突出辨证论治疗效的所有结局指标)与狭义(限于证候相关指标)的范畴差异;在内容... 证候疗效评价是验证中医药临床疗效的核心环节,但其概念界定、测量工具及方法学体系尚未形成共识。本文评述证候疗效评价的研究现状:在概念层面,需厘清广义(突出辨证论治疗效的所有结局指标)与狭义(限于证候相关指标)的范畴差异;在内容与方法层面,需整合宏观-微观指标体系,规范病证结合与病证分离评价模式,应针对动态性、个体化及整体观特点;在测量层面,量表研制、四诊客观化及数理模型构建仍面临疾病因素干扰、指标匹配度不足等挑战。今后研究可关注以下方向:以“医患共建”强化以人为本的评价过程;确立“以证统病”为主体框架,推动证候指标定量化与精准化(如态靶辨证);融合多元数据源,构建循证导向的综合评价体系。通过规范定义、工具创新与方法整合,可推动证候疗效评价研究标准化与精准化发展。 展开更多
关键词 证候疗效评价 病证结合 动态性 医患共建 态靶辨证
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全球豆荚状铬铁矿资源特征与我国找矿潜力分析
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作者 袁建国 张万益 +7 位作者 庞振山 李广旭 陈刚 郭灵俊 翟庆国 滕学建 万阈 史淳元 《地学前缘》 北大核心 2025年第6期473-496,共24页
铬铁矿是一种重要的战略性关键金属矿产,具有层状和豆荚状两种成因类型。研究表明,全球豆荚状铬铁矿主要分布在特提斯、古亚洲洋、环太平洋成矿域和冈瓦纳成矿域中,尤其是特提斯、古亚洲洋两大成矿域占主导地位。在该两大成矿域,境外已... 铬铁矿是一种重要的战略性关键金属矿产,具有层状和豆荚状两种成因类型。研究表明,全球豆荚状铬铁矿主要分布在特提斯、古亚洲洋、环太平洋成矿域和冈瓦纳成矿域中,尤其是特提斯、古亚洲洋两大成矿域占主导地位。在该两大成矿域,境外已发现多处大型超大型豆荚状铬铁矿矿床,而在相同构造带的我国范围内,发现的铬铁矿矿床小而散。比较分析认为,我国铬铁矿资源潜力尚未充分挖掘,应增强我国铬铁矿找矿信心,聚焦在新疆萨尔托海、西藏雅鲁藏布江和班公湖—怒江、内蒙古二连—贺根山、甘肃大道尔吉等地区,改进找矿思路,优化找矿技术方法,加快钻探验证工作,尽快改变我国铬铁矿长期接近百分百依靠进口的局面。 展开更多
关键词 铬铁矿 战略性矿产 成矿规律 找矿方向 资源潜力
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基于“态靶辨证”思维论治肝硬化
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作者 刘源 姜煜资 +2 位作者 孙培琳 沈婷婷 聂红明 《中西医结合肝病杂志》 2025年第5期588-592,共5页
仝小林院士提出的“态靶因果”辨证思维充分考虑了中医调态和西医打靶的优势,态靶结合应对各种复杂疾病,尤其对慢性动态进展性疾病将具有明显优势。根据肝硬化的病因、分期以及“肝炎-肝纤维化-肝硬化”的进展不同阶段,病因治疗是根本,... 仝小林院士提出的“态靶因果”辨证思维充分考虑了中医调态和西医打靶的优势,态靶结合应对各种复杂疾病,尤其对慢性动态进展性疾病将具有明显优势。根据肝硬化的病因、分期以及“肝炎-肝纤维化-肝硬化”的进展不同阶段,病因治疗是根本,进展过程中进行中医“态”的分析,并注重把握疾病进展预后的“果”,提前阻断扭转,在肝硬化的不同阶段,审视该阶段目前中西医最佳的治疗策略,分别在不同环节上进行最佳的中西医结合。基于“态靶辨证”思维,结合临床实践和文献报道,将肝硬化的病机发展演变规律概括为四期四态,即肝硬化早期-六郁态、中期-虚瘀态、晚期-水滞态、终末期-寒浊态。据此宏观调态,再结合现代中药药理学研究及中医临床验之有效的靶药进行微观打靶,形成肝硬化中西医协同的态靶同调体系,以执简驭繁,规范诊疗,提高临床疗效。 展开更多
关键词 态靶辨证 肝硬化 诊治
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态靶辨证视角下药食同源理论在干眼症防治中的应用探讨
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作者 徐思琦 彭清华 彭俊 《药食同源杂志》 2025年第3期31-36,共6页
基于中医态靶辨证体系,探讨药食同源理论在干眼症防治中的应用研究。通过分析干眼症“阴虚态”对应泪液分泌不足、“燥热态”对应眼表炎症等“态-靶”对应关系,建立以“调态-定靶-食养”为核心的药食同源干预模式。构建“三态三靶”辨... 基于中医态靶辨证体系,探讨药食同源理论在干眼症防治中的应用研究。通过分析干眼症“阴虚态”对应泪液分泌不足、“燥热态”对应眼表炎症等“态-靶”对应关系,建立以“调态-定靶-食养”为核心的药食同源干预模式。构建“三态三靶”辨证分型系统,确立“证候-病理指标”的映射关系,阐明枸杞子、菊花等药食两用物质通过滋补肝肾、清热抗炎、调和气机等多重作用机制调节干眼症的发生,为其膳食防治提供理论基础。 展开更多
关键词 药食同源 态靶辨证 干眼症 食疗 理论探讨
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慢性乙型病毒性肝病态靶辨治体系构建
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作者 卢晨霞 周亚娜 +4 位作者 肖明中 周晓玲 孙学华 李晓东 仝小林(指导) 《中西医结合肝病杂志》 2025年第11期1321-1325,共5页
本文以态靶辨治理论为指导,结合中国慢性乙型肝炎(CHB)疾病谱规律和现代药理学研究成果,总结CHB相关肝炎、肝硬化、肝癌可分为“湿毒”“瘀毒”“癌毒”三态,以“高病毒载量、转氨酶异常、肝纤维化、肿瘤指标升高”为典型标靶,以“胁痛... 本文以态靶辨治理论为指导,结合中国慢性乙型肝炎(CHB)疾病谱规律和现代药理学研究成果,总结CHB相关肝炎、肝硬化、肝癌可分为“湿毒”“瘀毒”“癌毒”三态,以“高病毒载量、转氨酶异常、肝纤维化、肿瘤指标升高”为典型标靶,以“胁痛/肝区不适、消化道出血、腹水”为典型症靶予以相应靶药及推荐剂量,治疗上以“全程治毒、治络,中后期兼顾治虚”为基本原则,把握疾病态势发展。该体系依据分期、分态、识靶的态靶辨治思路,逐层剖析CHB相关肝炎、肝硬化、肝癌在各阶段的核心病理要素和施治重点,一定程度解决了病毒性肝病孤立辨病、辨证与遣方的问题。 展开更多
关键词 态靶辨治 乙型肝炎 慢性肝病 湿毒
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基于数据挖掘与网络药理学探究乔成林教授治疗慢性肾小球肾炎的用药规律及作用机制
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作者 叶冰玉 刘金连 +4 位作者 赵聪 牛泽基 董盛 吴喜利 乔成林 《陕西中医药大学学报》 2025年第6期59-67,共9页
目的运用数据挖掘技术及网络药理学揭示乔成林教授治疗慢性肾小球肾炎的组方思路、配伍规律及用药特点;同时构建数据库统计其使用的核心中药并运用网络药理学分析慢性肾小球肾炎的作用机制。方法选取西安交通大学第二附属医院2023年1月... 目的运用数据挖掘技术及网络药理学揭示乔成林教授治疗慢性肾小球肾炎的组方思路、配伍规律及用药特点;同时构建数据库统计其使用的核心中药并运用网络药理学分析慢性肾小球肾炎的作用机制。方法选取西安交通大学第二附属医院2023年1月1日—2024年1月31日在乔成林教授门诊就诊的患者病历资料,根据预设的条件筛选出有效病历101份,建立数据库并规范术语,借助中医传承计算平台(TCMICS)V.5,采用药物频次统计、中药属性分析、关联规则、药物功效分布及中药聚类处方分析,结合临床诊治经验,总结乔成林对慢性肾小球肾炎病机的认识,并完善数据挖掘结果,筛选核心中药;在TCMSP、OMIM数据库检索核心中药的成分及靶点,上传药物-疾病交集靶点至STRING在线平台,构建共同靶点蛋白质互作网络。结果获得101首处方,涉及121味中药,28味中药使用频次≥20次,常用药物组合为:黄芪-附子、茯苓-金樱子、黄芪-茯苓、黄芪-车前子、白术-茯苓、茯苓-薏苡仁等。核心组合使用频次分析提取出4首新处方,组合1:莲子、黄芪、僵蚕、青风藤、蝉蜕;组合2:桂枝、茯苓、黄芪、附子、车前子、山茱萸;组合3:生地黄、侧柏叶、旱莲草、大蓟、白茅根、槐花;组合4:黄芪、大黄、黄连、车前子、竹茹、陈皮。结论乔成林教授对慢性肾小球肾炎的治疗以健脾补肾为本,温阳利水、泄浊利湿治其标为原则。核心药物可能是通过调控炎症、肾脏纤维化、凋亡等信号通路,作用于IL6、TNF、AKT1、MMP9、TP53、CASP3、TGFβ1、EGFR等靶点发挥治疗作用。 展开更多
关键词 慢性肾小球肾炎 网络药理学 作用靶点 用药规律 数据挖掘
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人类命运共同体理念的国际传播:挑战、机遇与方略 被引量:4
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作者 冯海涛 贾付强 《贵州师范大学学报(社会科学版)》 2025年第3期20-28,共9页
有效开展人类命运共同体理念的国际传播,需清晰认知其面临的挑战与机遇。人工智能技术下的“失语”困境、“西强东弱”的国际舆论格局、发展中国家对中国的矛盾性认知等,对之构成了严峻挑战。国际传播进入“智媒时代”、国际舆论格局发... 有效开展人类命运共同体理念的国际传播,需清晰认知其面临的挑战与机遇。人工智能技术下的“失语”困境、“西强东弱”的国际舆论格局、发展中国家对中国的矛盾性认知等,对之构成了严峻挑战。国际传播进入“智媒时代”、国际舆论格局发生百年未有之变,以及中国国际传播能力建设取得的显著成效,则为之提供了难得的契机。对此,应运用人工智能技术推进传统媒体与新媒体的“融合传播”,对不同类型的受众实施“分众传播”,搭建“一体三翼”的多元主体传播矩阵,提升人类命运共同体理念国际传播的效能。 展开更多
关键词 人类命运共同体 智媒时代 国际舆论格局 分众传播 媒体融合
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