Hyperthermia has been a modality to treat cancer for thousands of years. During this time, intensive efforts are concentrated on determining the dose of the proper treatment, but the dominantly in vitro induced cellul...Hyperthermia has been a modality to treat cancer for thousands of years. During this time, intensive efforts are concentrated on determining the dose of the proper treatment, but the dominantly in vitro induced cellular death does not provide enough confidence for the clinical dosing. The cell-death by heat-monotherapy applications in laboratory experiments is difficult to apply in the complementary therapies in clinical applications. The newly developed nanotechnologies offer completely new possibilities in this field as well. Modulated electro-hyperthermia (mEHT, trade-name Oncothermia) is a nanoheating technology that has selective effects on membrane rafts and on the transmembrane proteins. This effect is thermal. The thermal action is in nanoscopic range which makes the phenomenon special. Our objective is to show the dose concept on this emerging method.展开更多
A computer program MACA was developed for simulating high-dose ion implantation into amorphous solids. The topology of amorphous solids was modelled by adjusting the free flight path distribution between collisions, s...A computer program MACA was developed for simulating high-dose ion implantation into amorphous solids. The topology of amorphous solids was modelled by adjusting the free flight path distribution between collisions, so that the radial distribution function will characterize the short - range order and long - range disorder of amorphous targets. A simulation example is given.展开更多
The developments of medicine always follow innovations in science and technology.In the past decade,such innovations have made cancer-related targeted therapies possible.In general,the term "targeted therapy"...The developments of medicine always follow innovations in science and technology.In the past decade,such innovations have made cancer-related targeted therapies possible.In general,the term "targeted therapy" has been used in reference to cellular and molecular level oriented therapies.However,improvements in the delivery and planning of traditional radiation therapy have also provided cancer patients more options for "targeted" treatment,notably stereotactic radiosurgery(SRS) and stereotactic body radiotherapy(SBRT).In this review,the progress and controversies of SRS and SBRT are discussed to show the role of stereotactic radiation therapy in the ever evolving multidisciplinary care of cancer patients.展开更多
Neutron energy, fluence rate, angular distributions and dose equivalent rate distributions around the thick Be, Cu, An targets bombarded by 50 MeV/u 18O-ion were measured using a threshold detector activation method. ...Neutron energy, fluence rate, angular distributions and dose equivalent rate distributions around the thick Be, Cu, An targets bombarded by 50 MeV/u 18O-ion were measured using a threshold detector activation method. At the same time,the neutron yields of 18O-ion and the neutron emission rates in the forward direction were obtained approximately.展开更多
目的:研究脊柱转移癌患者射波刀(CK)治疗计划设计时,边界距离散射剂量模式对治疗计划的剂量学影响。方法:回顾性选取2022年1月至2024年3月间联勤保障部队第九四〇医院放射治疗科共计20例胸椎转移癌患者的定位影像资料,利用第四代射波刀...目的:研究脊柱转移癌患者射波刀(CK)治疗计划设计时,边界距离散射剂量模式对治疗计划的剂量学影响。方法:回顾性选取2022年1月至2024年3月间联勤保障部队第九四〇医院放射治疗科共计20例胸椎转移癌患者的定位影像资料,利用第四代射波刀治疗计划系统Multi Plan 4.0.3,分别针对计划靶区(PTV)和肿瘤靶区(GTV)进行CK治疗计划设计,按计划制作目标分为PTV组(20例)和GTV组(20例),PTV组采用危及器官脊髓限量运用常规计划方式,GTV组采用危及器官脊髓限量运用边界距离散射剂量模式,并最终归一处方剂量线至PTV。比较两组计划的靶区及正常组织剂量参数、剂量曲线分布等情况。结果:GTV组靶区覆盖率(91.57±8.73)%相较PTV组(83.23±16.05)%有明显优势,二者比较差异有统计学意义(t=3.44,P<0.05);靶区适形指数,GTV组和PTV组的适形指数(CI)分别为1.07±0.35和1.14±0.04,两组比较差异有统计学意义(t=14.69,P<0.05),GTV组适形度更好;单位距离剂量梯度指标指数(DDGI)分别为(89.43±46.12)和(152.07±109.81)mm,差异有统计学意义(t=4.89,P<0.05),GTV组正常组织剂量跌落梯度更具优势;GTV组和PTV组的靶区内剂量均匀性指数(HI)分别为1.55±0.84和1.42±0.20,差异亦有统计学意义(t=24.37,P<0.05),GTV组靶区内剂量梯度更高;在GTV靶区吸收剂量参数D_2、D_(mean)、D_(95)两组比较,差异均有统计学意义(t=14.96、4.71、3.03,P<0.05), GTV组GTV靶区内吸收剂量更高;两组PTV靶区吸收剂量参数D_2、D_(mean)、D_(95)比较,差异均有统计学意义(t=8.27、5.51、2.50,P<0.05), GTV组PTV靶区内吸收剂量高于PTV组。两组计划的脊髓受照剂量、机器跳数(MU)、总治疗时间(times)及总射线数(beams)比较,差异均无统计学意义(P>0.05)。结论:CK治疗计划设计时,以GTV为目标利用边界距离散射剂量模式设计的GTV组计划,在靶区覆盖率、CI、DDGI、HI及靶区吸收剂量各参数上均优于以PTV为目标设计的PTV组计划,是更优的CK治疗计划设计模式。展开更多
文摘Hyperthermia has been a modality to treat cancer for thousands of years. During this time, intensive efforts are concentrated on determining the dose of the proper treatment, but the dominantly in vitro induced cellular death does not provide enough confidence for the clinical dosing. The cell-death by heat-monotherapy applications in laboratory experiments is difficult to apply in the complementary therapies in clinical applications. The newly developed nanotechnologies offer completely new possibilities in this field as well. Modulated electro-hyperthermia (mEHT, trade-name Oncothermia) is a nanoheating technology that has selective effects on membrane rafts and on the transmembrane proteins. This effect is thermal. The thermal action is in nanoscopic range which makes the phenomenon special. Our objective is to show the dose concept on this emerging method.
文摘A computer program MACA was developed for simulating high-dose ion implantation into amorphous solids. The topology of amorphous solids was modelled by adjusting the free flight path distribution between collisions, so that the radial distribution function will characterize the short - range order and long - range disorder of amorphous targets. A simulation example is given.
文摘The developments of medicine always follow innovations in science and technology.In the past decade,such innovations have made cancer-related targeted therapies possible.In general,the term "targeted therapy" has been used in reference to cellular and molecular level oriented therapies.However,improvements in the delivery and planning of traditional radiation therapy have also provided cancer patients more options for "targeted" treatment,notably stereotactic radiosurgery(SRS) and stereotactic body radiotherapy(SBRT).In this review,the progress and controversies of SRS and SBRT are discussed to show the role of stereotactic radiation therapy in the ever evolving multidisciplinary care of cancer patients.
文摘Neutron energy, fluence rate, angular distributions and dose equivalent rate distributions around the thick Be, Cu, An targets bombarded by 50 MeV/u 18O-ion were measured using a threshold detector activation method. At the same time,the neutron yields of 18O-ion and the neutron emission rates in the forward direction were obtained approximately.
文摘目的:研究脊柱转移癌患者射波刀(CK)治疗计划设计时,边界距离散射剂量模式对治疗计划的剂量学影响。方法:回顾性选取2022年1月至2024年3月间联勤保障部队第九四〇医院放射治疗科共计20例胸椎转移癌患者的定位影像资料,利用第四代射波刀治疗计划系统Multi Plan 4.0.3,分别针对计划靶区(PTV)和肿瘤靶区(GTV)进行CK治疗计划设计,按计划制作目标分为PTV组(20例)和GTV组(20例),PTV组采用危及器官脊髓限量运用常规计划方式,GTV组采用危及器官脊髓限量运用边界距离散射剂量模式,并最终归一处方剂量线至PTV。比较两组计划的靶区及正常组织剂量参数、剂量曲线分布等情况。结果:GTV组靶区覆盖率(91.57±8.73)%相较PTV组(83.23±16.05)%有明显优势,二者比较差异有统计学意义(t=3.44,P<0.05);靶区适形指数,GTV组和PTV组的适形指数(CI)分别为1.07±0.35和1.14±0.04,两组比较差异有统计学意义(t=14.69,P<0.05),GTV组适形度更好;单位距离剂量梯度指标指数(DDGI)分别为(89.43±46.12)和(152.07±109.81)mm,差异有统计学意义(t=4.89,P<0.05),GTV组正常组织剂量跌落梯度更具优势;GTV组和PTV组的靶区内剂量均匀性指数(HI)分别为1.55±0.84和1.42±0.20,差异亦有统计学意义(t=24.37,P<0.05),GTV组靶区内剂量梯度更高;在GTV靶区吸收剂量参数D_2、D_(mean)、D_(95)两组比较,差异均有统计学意义(t=14.96、4.71、3.03,P<0.05), GTV组GTV靶区内吸收剂量更高;两组PTV靶区吸收剂量参数D_2、D_(mean)、D_(95)比较,差异均有统计学意义(t=8.27、5.51、2.50,P<0.05), GTV组PTV靶区内吸收剂量高于PTV组。两组计划的脊髓受照剂量、机器跳数(MU)、总治疗时间(times)及总射线数(beams)比较,差异均无统计学意义(P>0.05)。结论:CK治疗计划设计时,以GTV为目标利用边界距离散射剂量模式设计的GTV组计划,在靶区覆盖率、CI、DDGI、HI及靶区吸收剂量各参数上均优于以PTV为目标设计的PTV组计划,是更优的CK治疗计划设计模式。
