Hydrogen peroxide(H2 O2), as important products of oxygen metabolism, plays an important role in many biological processes, such as immune responses and cellular signal transduction. However, abnormal production of H2...Hydrogen peroxide(H2 O2), as important products of oxygen metabolism, plays an important role in many biological processes, such as immune responses and cellular signal transduction. However, abnormal production of H2 O2 can damage cellular biomolecules, which was closely associated with many diseases.Thus, it is urgent to monitor the level change of H2 O2 in living cells, particularly at subcellular levels.Toward this end, a wide variety of H2 O2 fluorescent probes have been designed, developed and applied for imaging of H2 O2 in subcellular levels. In this review, we highlight the representative cases of H2 O2 fluorescent probes with mitochondria, nuclei and lysosomes-targetable ability. The review contains organelle target strategies, structures, fluorescence behavior and biological applications of these probes.展开更多
This study investigates the optimal projectile/target combination for the production of new neutron-deficient isotopes of superheavy nuclei(SHN). To this end, the dependence of the evaporation residue cross-section(ER...This study investigates the optimal projectile/target combination for the production of new neutron-deficient isotopes of superheavy nuclei(SHN). To this end, the dependence of the evaporation residue cross-section(ERCS) used to synthesize SHN on the mass asymmetry and the isospin of colliding nuclei are analyzed within the dinuclear system(DNS) concept. The predicted ERCSs for the production of new neutron-deficient isotopes of SHN were found to be quite large with the ^(36) S projectile, and the cross-section of SHN decreases slowly with the charge of compound nuclei owing to the increase in their survival probability,. Wsur is not canceled by the decreasing probability, PCN, that the system will evolve from a touching configuration to the compound nucleus in competition with the quasifission process.展开更多
天体环境中丰中子核素熔合反应率对研究中子星表面超级暴现象的点火机制有重要意义。由于次级束流强过低,无法使用传统固体靶实验技术测量垒下熔合反应截面。活性靶技术的发展为垒下丰中子核素熔合反应截面的测量提供了可行的途径。基于...天体环境中丰中子核素熔合反应率对研究中子星表面超级暴现象的点火机制有重要意义。由于次级束流强过低,无法使用传统固体靶实验技术测量垒下熔合反应截面。活性靶技术的发展为垒下丰中子核素熔合反应截面的测量提供了可行的途径。基于Geant4模拟详细地分析了多重采样电离室(MUSIC)与时间投影室(TPC)两种活性靶探测器中熔合反应与弹性散射的运动学性质,给出了4种熔合反应鉴别判据,并且计算了由这些判据误判引起的熔合截面系统误差。在Ecm=13.6 Me V时,MUSIC与TPC的弹性散射误判截面分别为0.5 mb和2.9×10^(-3)mb,都远小于此时熔合截面(877 mb)。在垒下,MSUIC的熔合截面系统误差已经超出实验测量要求,而TPC能够进行实验测量的能量可以降低至Ecm=4.7 Me V。展开更多
基金the National Natural Science Foundation of China (Nos. 21705102, 21775096)the Shanxi Province Science Foundation for Youths (No. 201701D221061)+1 种基金Shanxi Province Foundation for Returnees (No. 2017-026)Scientific Instrument Center of Shanxi University (No. 201512)
文摘Hydrogen peroxide(H2 O2), as important products of oxygen metabolism, plays an important role in many biological processes, such as immune responses and cellular signal transduction. However, abnormal production of H2 O2 can damage cellular biomolecules, which was closely associated with many diseases.Thus, it is urgent to monitor the level change of H2 O2 in living cells, particularly at subcellular levels.Toward this end, a wide variety of H2 O2 fluorescent probes have been designed, developed and applied for imaging of H2 O2 in subcellular levels. In this review, we highlight the representative cases of H2 O2 fluorescent probes with mitochondria, nuclei and lysosomes-targetable ability. The review contains organelle target strategies, structures, fluorescence behavior and biological applications of these probes.
基金Supported by the National Natural Science Foundation of China(11705055)Hunan Provincial Natural Science Foundation of China(2018JJ3324)Excellent Youth Fund of Hunan Provincial Education Department(17B154)
文摘This study investigates the optimal projectile/target combination for the production of new neutron-deficient isotopes of superheavy nuclei(SHN). To this end, the dependence of the evaporation residue cross-section(ERCS) used to synthesize SHN on the mass asymmetry and the isospin of colliding nuclei are analyzed within the dinuclear system(DNS) concept. The predicted ERCSs for the production of new neutron-deficient isotopes of SHN were found to be quite large with the ^(36) S projectile, and the cross-section of SHN decreases slowly with the charge of compound nuclei owing to the increase in their survival probability,. Wsur is not canceled by the decreasing probability, PCN, that the system will evolve from a touching configuration to the compound nucleus in competition with the quasifission process.
文摘天体环境中丰中子核素熔合反应率对研究中子星表面超级暴现象的点火机制有重要意义。由于次级束流强过低,无法使用传统固体靶实验技术测量垒下熔合反应截面。活性靶技术的发展为垒下丰中子核素熔合反应截面的测量提供了可行的途径。基于Geant4模拟详细地分析了多重采样电离室(MUSIC)与时间投影室(TPC)两种活性靶探测器中熔合反应与弹性散射的运动学性质,给出了4种熔合反应鉴别判据,并且计算了由这些判据误判引起的熔合截面系统误差。在Ecm=13.6 Me V时,MUSIC与TPC的弹性散射误判截面分别为0.5 mb和2.9×10^(-3)mb,都远小于此时熔合截面(877 mb)。在垒下,MSUIC的熔合截面系统误差已经超出实验测量要求,而TPC能够进行实验测量的能量可以降低至Ecm=4.7 Me V。
