The Tang Dynasty was a great time for poetry.Since then,China has drawn global attention for its rich culture.Time flows,but Tang poetry still shines like bright stars in the sky.Today,let's get to know two of its...The Tang Dynasty was a great time for poetry.Since then,China has drawn global attention for its rich culture.Time flows,but Tang poetry still shines like bright stars in the sky.Today,let's get to know two of its most famous poets!展开更多
Visitors are flocking to China’s first immersive tourist area recreating everyday life as it appeared in the Tang Dynasty,to embrace the past and understand the importance of culture and tradition.
The unbreakable doll performance at Tang Dynasty Night City has become extremely popular,sparking a wave of enthusiasm online.In the performance,actors dressed in elegant Tang Dynasty attire appear as if they have ste...The unbreakable doll performance at Tang Dynasty Night City has become extremely popular,sparking a wave of enthusiasm online.In the performance,actors dressed in elegant Tang Dynasty attire appear as if they have stepped out of a historical painting,gracefully dancing on the unbreakable doll apparatus.Every gesture and expression exudes the unparalleled elegance of the Tang Dynasty.This paper primarily analyzes the mechanical principles behind the Tang Dynasty Night City’s Unbreakable Doll Performance,starting with structural design to examine its mechanical principles and summarize its dynamic mechanical control mechanisms.展开更多
Traditional Medicine Research published an article entitled Investigation on the mechanism of Qi-Hong-Tang-Zu ointment in thetreatmentofdiabetic wound by network pharmacology and experimental validation on 24 January ...Traditional Medicine Research published an article entitled Investigation on the mechanism of Qi-Hong-Tang-Zu ointment in thetreatmentofdiabetic wound by network pharmacology and experimental validation on 24 January 2025.The author confirmed this article’s proof on 23 January 2025 without any questions.But on 06 July 2025,the editorial team found,there was an error in Figure 8.Specifically,Figure 8E,Figure 8F and Figure 8G were mistakenly duplicated.The authors acknowledge that the original version of Figure 8 was incorrect and have provided the revised,correct version in this corrigendum.The authors would like to assert that there is no change in the body text of the article.展开更多
The origin of engraving and printing has a variety of points of view,especially the“early Tang Dynasty”has the most far-reaching impact.Based on media evolution theory,engraved printing as a new media technology is ...The origin of engraving and printing has a variety of points of view,especially the“early Tang Dynasty”has the most far-reaching impact.Based on media evolution theory,engraved printing as a new media technology is first used in secular culture,folk entertainment,and other fields,after a long period of development,the new medium was accepted by the ruling class,the mainstream society;the use of the media began to intervene in the real society.This reflects that the choice of new media by the society depends on the media itself and is intrinsically linked to the whole social communication environment.Therefore,from the point of view of media evolution,the view that engraving originated in the early Tang Dynasty is not in line with the logic of media evolution and is unreasonable.展开更多
From dishwashing shifts to pioneering pharmaceutical innovation,Tang Wei’s journey epitomises the tenacity driving FPA Group’s rise as a transnational health industry leader.In this exclusive interview,the founder a...From dishwashing shifts to pioneering pharmaceutical innovation,Tang Wei’s journey epitomises the tenacity driving FPA Group’s rise as a transnational health industry leader.In this exclusive interview,the founder and CEO shares how grassroots hustle,a vertical integration strategy,and a cross-cultural vision transformed a Sydney startup into a global player,straddling pharmaceutical raw materials,nutraceuticals brands,and the modernisation of traditional Chinese medicine(TCM).展开更多
By taking gardens in Tang Dynasty which play an important historical role in Chinese garden development history as case study,garden features in Tang Dynasty had been described from the aspects of cultural,ecological ...By taking gardens in Tang Dynasty which play an important historical role in Chinese garden development history as case study,garden features in Tang Dynasty had been described from the aspects of cultural,ecological and planning characteristics,so as to explore the development trace of Tang garden culture,based on which relevant problems in urban planning and construction of Xi'an were discussed;and some countermeasures and suggestions on cultural,ecological and planning construction in the preservation of this ancient city were put forward.展开更多
Public garden, as a type of Chinese classical garden, is an important historical heritage and cultural landscape of the current traditional city. However, under the background of modern urbanization, urban living envi...Public garden, as a type of Chinese classical garden, is an important historical heritage and cultural landscape of the current traditional city. However, under the background of modern urbanization, urban living environment is out of the traditional history and culture and facing such issue as cement jungle. In order to improve the living environment and make the city coordinate with the natural environment, the development of modern urban gardens needs inheritance and development of traditional garden practices. The planning and design methods with scientific guidance were studied in this paper through exploring the application of garden design style in Tang Dynasty in the design of modern city public gardens, so as to inherit the classical garden culture and create a city open space that meets the needs of contemporary citizens as well.展开更多
An HPLC-DAD-ELSD method was developed and validated for the simultaneous quantitation of seven active components（liquiritin, baicalin, wogonoside, baicalein, wogonin, ginsenosides Re and ginsenosides Rb1） in n-butan...An HPLC-DAD-ELSD method was developed and validated for the simultaneous quantitation of seven active components（liquiritin, baicalin, wogonoside, baicalein, wogonin, ginsenosides Re and ginsenosides Rb1） in n-butanol effective fraction of Xiao Chai Hu Tang. A Diamonsil C18（2） column（4.6 mm × 250 mm, 5 μm） was used as the stationary phase and the mobile phase was consisted of acetonitrile and aqueous phosphate acid（0.05%, v/v）. Gradient elution was carried out at the flow rate of 1 m L/min. The detection wavelength was set at 276 nm and an evaporative light scattering detector was also used. Good linearity for all the seven active components was observed. The established method is simple, fast, reliable, and suitable for the quality control of n-butanol effective fraction of Xiao Chai Hu Tang.展开更多
Tang poetry is a shining pearl in the history of Chinese literature.C-E translation of Tang poetry is regarded as a very complex and hard task because of its special style and form,concise diction and profound artisti...Tang poetry is a shining pearl in the history of Chinese literature.C-E translation of Tang poetry is regarded as a very complex and hard task because of its special style and form,concise diction and profound artistic conception.Eco-translatology provides a new perspective for the study on C-E translation of Tang poetry.Based on analysis of some practical examples,this paper discusses some C-E translation methods of tang poetry from the perspective of eco-translatology,namely,adaptive transformation from linguistic,cultural and communicative dimensions.展开更多
Ancient poetry represents historical and cultural legacies accumulated by the Chinese nation for thousands of years and underpins the strong cultural confidence of the Chinese people.Tang poetry distinguishes itself f...Ancient poetry represents historical and cultural legacies accumulated by the Chinese nation for thousands of years and underpins the strong cultural confidence of the Chinese people.Tang poetry distinguishes itself from other literary works with its beautiful rhyme and symmetry.Previous studies of English translations of Tang poetry mostly focused on appreciation,analysis,and critics of different translation versions.Few researchers have delved into the specific translation methods for achieving the rhyming and symmetrical effects of Tang poetry in the target text.This paper examined Professor Xu Yuanchong’s English translation of 300 Tang Poems as the research object,and elaborated on how to retain the rhyming and symmetrical effects of Tang poems.This paper also summarized some practical methods that can be applied to translating Tang poems.Rhyming can be realized by the addition of end rhyme words and changes in word or line order.Symmetry can be achieved by the omission of a modifier or predicate,the addition of function words,changes in word order,or parallelism with the original sentence structure.展开更多
The imperial examination system not only has profound influence on prose development in Tang and Song Dynasty, but also has an important influence on the whole Tang and Song Dynasty and even the later literature and c...The imperial examination system not only has profound influence on prose development in Tang and Song Dynasty, but also has an important influence on the whole Tang and Song Dynasty and even the later literature and cultural development. In the feudal autocratic rule, any system implemented by the state will have an important influence on all aspects of the whole society~ especially it is related with the imperial examination system of education and talents. Once it becomes a ＂basic national policy＂ , the role in social development is incalculable. This paper takes the relationship between imperial examination system and Tang and Song prose development as the breakthrough point, analyzing the influence of thesis writing of imperial examination on the prose in Tang and Song Dynasty and ＂Eight great men in Tang and Song Dynasty＂ .展开更多
目的:探讨Tang缝合法在手指屈肌腱断裂治疗中的效果。方法:回顾性分析手指屈肌腱断裂患者96例临床资料,随机分为两组,Tang缝合法组48例(研究组)、Kessler缝合法组48例(对照组),分别采用Tang缝合法和Kessler缝合法修复手指屈肌腱,应用透...目的:探讨Tang缝合法在手指屈肌腱断裂治疗中的效果。方法:回顾性分析手指屈肌腱断裂患者96例临床资料,随机分为两组,Tang缝合法组48例(研究组)、Kessler缝合法组48例(对照组),分别采用Tang缝合法和Kessler缝合法修复手指屈肌腱,应用透明质酸钠填充治疗,24 h后开始手指功能锻炼,术后3周内采用Kleinert橡皮筋牵引疗法(动态支具保护),并定期随访,术后6个月手指功能采用主动活动度(Total active movement,TAM)法评定。结果:研究组TAM优良率为91.6%;对照组TAM优良率为54.1%,两组比较,差异有统计学意义(P<0.01)。结论:Tang缝合法在手指屈肌腱断裂治疗中获得满意的修复效果。展开更多
Danggui Buxue Tang(DBT) is a famous Chinese medicinal decoction. Mechanism of DBT action is wide ranging and unclear. Exploring new ways of treatment with DBT is useful. Sprague–Dawley(SD) rats were randomly divided ...Danggui Buxue Tang(DBT) is a famous Chinese medicinal decoction. Mechanism of DBT action is wide ranging and unclear. Exploring new ways of treatment with DBT is useful. Sprague–Dawley(SD) rats were randomly divided into 3 groups including control(NC, Saline), the DBT(at a dose of 8.10 g?kg–1), and blood deficiency(BD)(Cyclophosphamide(APH)-and Cyclophosphamide(CTX)-induced anaemia). A metabolomics approach using Liquid Chromatography-Quadrupole-Time-of-Flight/Mass Spectrometry(LC/Q-TOFMS) was developed to perform the plasma metabolic profiling analysis and differential metabolites were screened according to the multivariate statistical analysis comparing the NC and BD groups, and the hub metabolites were outliers with high scores of the centrality indices. Anaemia disease-related protein target and compound of DBT databases were constructed. The TCMSP, Chem Mapper and STITCH databases were used to predict the protein targets of DBT. Using the Cytoscape 3.2.1 to establish a phytochemical component–target protein interaction network and establish a component, protein and hub metabolite protein–protein interaction(PPI) network and merging the three PPI networks basing on BisoGenet. The gene enrichment analysis was used to analyse the relationship between proteins based on the relevant genetic similarity by ClueGO. The results shown DBT effectively treated anaemia in vivo. 11 metabolic pathways are involved in the therapeutic effect of DBT in vivo; S-adenosyl-L-methionine, glycine, L-cysteine, arachidonic acid(AA) and phosphatidylcholine(PC) were screened as hub metabolites in APH-and CTX-induced anaemia. A total of 288 targets were identified as major candidates for anaemia progression. The gene-set enrichment analysis revealed that the targets are involved in iron ion binding, haemopoiesis, reactive oxygen species production, inflammation and apoptosis. The results also showed that these targets were associated with iron ion binding, haemopoiesis, ROS production, apoptosis, inflammation and related signalling pathways. DBT can promote iron ion binding and haemopoiesis activities, restrain inflammation, production of reactive oxygen, block apoptosis, and contribute significantly to the DBT treat anaemia.展开更多
Ghrelin, a brain-gut peptide that induces anxiety and other abnormal emotions, contributes to the effects of insomnia on emotional behavior. In contrast, the traditional Chinese Medi- cine remedy Wen Dan Tang reduces ...Ghrelin, a brain-gut peptide that induces anxiety and other abnormal emotions, contributes to the effects of insomnia on emotional behavior. In contrast, the traditional Chinese Medi- cine remedy Wen Dan Tang reduces insomnia-related anxiety, which may perhaps correspond to changes in the brain-gut axis. This suggests a possible relationship between Wen Dan Tan^s pharmacological mechanism and the brain-gut axis. Based on this hypothesis, a sleep-deprived rat model was induced and Wen Dan Tang was administered using oral gavage during model es- tablishment. Wen Dan Tang significantly reduced insomnia-related anxiety and prevented Ghrelin level decreases following sleep deprivation, especially in the hypothalamus. Increased expression of Ghrelin receptor mRNA in the hypothalamus was also observed, suggesting that reduced anxi- ety may be a result of Wen Dan Tan＇s regulation of Ghrelin-Ghrelin receptors.展开更多
AIM To investigate the effects of Lizhong Tang,a traditional Chinese medicine formula,on gastrointestinal motility in mice.METHODS The in vivo effects of Lizhong Tang on GI motility were investigated by measuring the ...AIM To investigate the effects of Lizhong Tang,a traditional Chinese medicine formula,on gastrointestinal motility in mice.METHODS The in vivo effects of Lizhong Tang on GI motility were investigated by measuring the intestinal transit rates(ITRs) and gastric emptying(GE) values in normal mice and in mice with experimentally induced GI motility dysfunction(GMD).RESULTS In normal ICR mice,the ITR and GE values were significantly and dose-dependently increased by Lizhong Tang(ITR values: 54.4% ± 1.9% vs 65.2% ± 1.8%,P < 0.01 with 0.1 g/kg Lizhong Tang and 54.4% ± 1.9% vs 83.8% ± 1.9%,P < 0.01 with 1 g/kg Lizhong Tang; GE values: 60.7% ± 1.9% vs 66.8% ± 2.1%,P < 0.05 with 0.1 g/kg Lizhong Tang and 60.7% ± 1.9% vs 72.5% ± 1.7%,P < 0.01 with 1 g/kg Lizhong Tang). The ITRs of the GMD mice were significantly reduced compared with those of the normal mice,which were significantly and dose-dependently reversed by Lizhong Tang. Additionally,in loperamide- and cisplatin-induced models of GE delay,Lizhong Tang administration reversed the GE deficits.CONCLUSION These results suggest that Lizhong Tang may be a novel candidate for development as a prokinetic treatment for the GI tract.展开更多
文摘The Tang Dynasty was a great time for poetry.Since then,China has drawn global attention for its rich culture.Time flows,but Tang poetry still shines like bright stars in the sky.Today,let's get to know two of its most famous poets!
文摘Visitors are flocking to China’s first immersive tourist area recreating everyday life as it appeared in the Tang Dynasty,to embrace the past and understand the importance of culture and tradition.
文摘The unbreakable doll performance at Tang Dynasty Night City has become extremely popular,sparking a wave of enthusiasm online.In the performance,actors dressed in elegant Tang Dynasty attire appear as if they have stepped out of a historical painting,gracefully dancing on the unbreakable doll apparatus.Every gesture and expression exudes the unparalleled elegance of the Tang Dynasty.This paper primarily analyzes the mechanical principles behind the Tang Dynasty Night City’s Unbreakable Doll Performance,starting with structural design to examine its mechanical principles and summarize its dynamic mechanical control mechanisms.
文摘Traditional Medicine Research published an article entitled Investigation on the mechanism of Qi-Hong-Tang-Zu ointment in thetreatmentofdiabetic wound by network pharmacology and experimental validation on 24 January 2025.The author confirmed this article’s proof on 23 January 2025 without any questions.But on 06 July 2025,the editorial team found,there was an error in Figure 8.Specifically,Figure 8E,Figure 8F and Figure 8G were mistakenly duplicated.The authors acknowledge that the original version of Figure 8 was incorrect and have provided the revised,correct version in this corrigendum.The authors would like to assert that there is no change in the body text of the article.
基金the National Social Science Foundation of China’s Art Program“Study on the Transformation of Tang and Song Calligraphy through the Perspective of Media Change and Engraved Plate Printing”(Project No.2020BF00876).
文摘The origin of engraving and printing has a variety of points of view,especially the“early Tang Dynasty”has the most far-reaching impact.Based on media evolution theory,engraved printing as a new media technology is first used in secular culture,folk entertainment,and other fields,after a long period of development,the new medium was accepted by the ruling class,the mainstream society;the use of the media began to intervene in the real society.This reflects that the choice of new media by the society depends on the media itself and is intrinsically linked to the whole social communication environment.Therefore,from the point of view of media evolution,the view that engraving originated in the early Tang Dynasty is not in line with the logic of media evolution and is unreasonable.
文摘From dishwashing shifts to pioneering pharmaceutical innovation,Tang Wei’s journey epitomises the tenacity driving FPA Group’s rise as a transnational health industry leader.In this exclusive interview,the founder and CEO shares how grassroots hustle,a vertical integration strategy,and a cross-cultural vision transformed a Sydney startup into a global player,straddling pharmaceutical raw materials,nutraceuticals brands,and the modernisation of traditional Chinese medicine(TCM).
文摘By taking gardens in Tang Dynasty which play an important historical role in Chinese garden development history as case study,garden features in Tang Dynasty had been described from the aspects of cultural,ecological and planning characteristics,so as to explore the development trace of Tang garden culture,based on which relevant problems in urban planning and construction of Xi'an were discussed;and some countermeasures and suggestions on cultural,ecological and planning construction in the preservation of this ancient city were put forward.
文摘Public garden, as a type of Chinese classical garden, is an important historical heritage and cultural landscape of the current traditional city. However, under the background of modern urbanization, urban living environment is out of the traditional history and culture and facing such issue as cement jungle. In order to improve the living environment and make the city coordinate with the natural environment, the development of modern urban gardens needs inheritance and development of traditional garden practices. The planning and design methods with scientific guidance were studied in this paper through exploring the application of garden design style in Tang Dynasty in the design of modern city public gardens, so as to inherit the classical garden culture and create a city open space that meets the needs of contemporary citizens as well.
基金Foundation for Young Scholars of Shanxi Province,China(Grant No.2011021007-2)
文摘An HPLC-DAD-ELSD method was developed and validated for the simultaneous quantitation of seven active components（liquiritin, baicalin, wogonoside, baicalein, wogonin, ginsenosides Re and ginsenosides Rb1） in n-butanol effective fraction of Xiao Chai Hu Tang. A Diamonsil C18（2） column（4.6 mm × 250 mm, 5 μm） was used as the stationary phase and the mobile phase was consisted of acetonitrile and aqueous phosphate acid（0.05%, v/v）. Gradient elution was carried out at the flow rate of 1 m L/min. The detection wavelength was set at 276 nm and an evaporative light scattering detector was also used. Good linearity for all the seven active components was observed. The established method is simple, fast, reliable, and suitable for the quality control of n-butanol effective fraction of Xiao Chai Hu Tang.
文摘Tang poetry is a shining pearl in the history of Chinese literature.C-E translation of Tang poetry is regarded as a very complex and hard task because of its special style and form,concise diction and profound artistic conception.Eco-translatology provides a new perspective for the study on C-E translation of Tang poetry.Based on analysis of some practical examples,this paper discusses some C-E translation methods of tang poetry from the perspective of eco-translatology,namely,adaptive transformation from linguistic,cultural and communicative dimensions.
基金Project name:Empirical Studies on Translator’s Translation Process,a general project of the Department of Education (Project No.16SB0054)
文摘Ancient poetry represents historical and cultural legacies accumulated by the Chinese nation for thousands of years and underpins the strong cultural confidence of the Chinese people.Tang poetry distinguishes itself from other literary works with its beautiful rhyme and symmetry.Previous studies of English translations of Tang poetry mostly focused on appreciation,analysis,and critics of different translation versions.Few researchers have delved into the specific translation methods for achieving the rhyming and symmetrical effects of Tang poetry in the target text.This paper examined Professor Xu Yuanchong’s English translation of 300 Tang Poems as the research object,and elaborated on how to retain the rhyming and symmetrical effects of Tang poems.This paper also summarized some practical methods that can be applied to translating Tang poems.Rhyming can be realized by the addition of end rhyme words and changes in word or line order.Symmetry can be achieved by the omission of a modifier or predicate,the addition of function words,changes in word order,or parallelism with the original sentence structure.
文摘The imperial examination system not only has profound influence on prose development in Tang and Song Dynasty, but also has an important influence on the whole Tang and Song Dynasty and even the later literature and cultural development. In the feudal autocratic rule, any system implemented by the state will have an important influence on all aspects of the whole society~ especially it is related with the imperial examination system of education and talents. Once it becomes a ＂basic national policy＂ , the role in social development is incalculable. This paper takes the relationship between imperial examination system and Tang and Song prose development as the breakthrough point, analyzing the influence of thesis writing of imperial examination on the prose in Tang and Song Dynasty and ＂Eight great men in Tang and Song Dynasty＂ .
文摘目的:探讨Tang缝合法在手指屈肌腱断裂治疗中的效果。方法:回顾性分析手指屈肌腱断裂患者96例临床资料,随机分为两组,Tang缝合法组48例(研究组)、Kessler缝合法组48例(对照组),分别采用Tang缝合法和Kessler缝合法修复手指屈肌腱,应用透明质酸钠填充治疗,24 h后开始手指功能锻炼,术后3周内采用Kleinert橡皮筋牵引疗法(动态支具保护),并定期随访,术后6个月手指功能采用主动活动度(Total active movement,TAM)法评定。结果:研究组TAM优良率为91.6%;对照组TAM优良率为54.1%,两组比较,差异有统计学意义(P<0.01)。结论:Tang缝合法在手指屈肌腱断裂治疗中获得满意的修复效果。
基金supported by the National Natural Science Foundation of China(Nos.31560709 and 31472234)the College of Veterinary Medicine of Gansu Agricultural University(No.JYCX-KX005)
文摘Danggui Buxue Tang(DBT) is a famous Chinese medicinal decoction. Mechanism of DBT action is wide ranging and unclear. Exploring new ways of treatment with DBT is useful. Sprague–Dawley(SD) rats were randomly divided into 3 groups including control(NC, Saline), the DBT(at a dose of 8.10 g?kg–1), and blood deficiency(BD)(Cyclophosphamide(APH)-and Cyclophosphamide(CTX)-induced anaemia). A metabolomics approach using Liquid Chromatography-Quadrupole-Time-of-Flight/Mass Spectrometry(LC/Q-TOFMS) was developed to perform the plasma metabolic profiling analysis and differential metabolites were screened according to the multivariate statistical analysis comparing the NC and BD groups, and the hub metabolites were outliers with high scores of the centrality indices. Anaemia disease-related protein target and compound of DBT databases were constructed. The TCMSP, Chem Mapper and STITCH databases were used to predict the protein targets of DBT. Using the Cytoscape 3.2.1 to establish a phytochemical component–target protein interaction network and establish a component, protein and hub metabolite protein–protein interaction(PPI) network and merging the three PPI networks basing on BisoGenet. The gene enrichment analysis was used to analyse the relationship between proteins based on the relevant genetic similarity by ClueGO. The results shown DBT effectively treated anaemia in vivo. 11 metabolic pathways are involved in the therapeutic effect of DBT in vivo; S-adenosyl-L-methionine, glycine, L-cysteine, arachidonic acid(AA) and phosphatidylcholine(PC) were screened as hub metabolites in APH-and CTX-induced anaemia. A total of 288 targets were identified as major candidates for anaemia progression. The gene-set enrichment analysis revealed that the targets are involved in iron ion binding, haemopoiesis, reactive oxygen species production, inflammation and apoptosis. The results also showed that these targets were associated with iron ion binding, haemopoiesis, ROS production, apoptosis, inflammation and related signalling pathways. DBT can promote iron ion binding and haemopoiesis activities, restrain inflammation, production of reactive oxygen, block apoptosis, and contribute significantly to the DBT treat anaemia.
基金supported by the National Natural Science Youth Foundation in China,No.81001501the Natural Science Foundation of Beijing in China,No.7112071Beijing University of Chinese Medicine Key Project–Nautical Chinese Medicine in China,No.522/100604054
文摘Ghrelin, a brain-gut peptide that induces anxiety and other abnormal emotions, contributes to the effects of insomnia on emotional behavior. In contrast, the traditional Chinese Medi- cine remedy Wen Dan Tang reduces insomnia-related anxiety, which may perhaps correspond to changes in the brain-gut axis. This suggests a possible relationship between Wen Dan Tan^s pharmacological mechanism and the brain-gut axis. Based on this hypothesis, a sleep-deprived rat model was induced and Wen Dan Tang was administered using oral gavage during model es- tablishment. Wen Dan Tang significantly reduced insomnia-related anxiety and prevented Ghrelin level decreases following sleep deprivation, especially in the hypothalamus. Increased expression of Ghrelin receptor mRNA in the hypothalamus was also observed, suggesting that reduced anxi- ety may be a result of Wen Dan Tan＇s regulation of Ghrelin-Ghrelin receptors.
基金Supported by National Research Foundation of Korea Grant funded by the Korea Government,No.2014R1A5A2009936
文摘AIM To investigate the effects of Lizhong Tang,a traditional Chinese medicine formula,on gastrointestinal motility in mice.METHODS The in vivo effects of Lizhong Tang on GI motility were investigated by measuring the intestinal transit rates(ITRs) and gastric emptying(GE) values in normal mice and in mice with experimentally induced GI motility dysfunction(GMD).RESULTS In normal ICR mice,the ITR and GE values were significantly and dose-dependently increased by Lizhong Tang(ITR values: 54.4% ± 1.9% vs 65.2% ± 1.8%,P < 0.01 with 0.1 g/kg Lizhong Tang and 54.4% ± 1.9% vs 83.8% ± 1.9%,P < 0.01 with 1 g/kg Lizhong Tang; GE values: 60.7% ± 1.9% vs 66.8% ± 2.1%,P < 0.05 with 0.1 g/kg Lizhong Tang and 60.7% ± 1.9% vs 72.5% ± 1.7%,P < 0.01 with 1 g/kg Lizhong Tang). The ITRs of the GMD mice were significantly reduced compared with those of the normal mice,which were significantly and dose-dependently reversed by Lizhong Tang. Additionally,in loperamide- and cisplatin-induced models of GE delay,Lizhong Tang administration reversed the GE deficits.CONCLUSION These results suggest that Lizhong Tang may be a novel candidate for development as a prokinetic treatment for the GI tract.
