AIM： To investigate the glutathione-S-transferase M1 （GSTM1） polymorphisms in three Chinese minorities, Kazakh, Uygur, and Tajik; and the pathological significance of GSTM1 polymorphisms in esophageal carcinogenesi...AIM： To investigate the glutathione-S-transferase M1 （GSTM1） polymorphisms in three Chinese minorities, Kazakh, Uygur, and Tajik; and the pathological significance of GSTM1 polymorphisms in esophageal carcinogenesis in Kazakh.METHODS： A total of 1121 blood samples （442 males and 679 females） were obtained from healthy Kazakh （654）, Uygur （412） and Tajik （55）. Primary esophageal squamous cell cancer （ESCC） tissues from Kazakh were obtained from 116 patients who underwent surgery. GSTM1 polymorphisms were analyzed by a combined approach of PCR and electrophoresis techniques.RESULTS： GSTM1 null genotype was found in 62.63% Uygur, 50.91% Tajik and 47.40% Kazakh. A significantly higher frequency of GSTM1 null genotype in Uygur was observed compared with Kazakh （OR： 1.859, 95% CI： 1.445 -2.391, χ^2 = 23.71, P = 0.000）. In addition, GSTM1 null genotype was found in 23.53% of welldifferentiated ESCC in Kazakh, in 49.23% of poorly differentiated ESCC, with a significant difference （OR： 3.152, 95% CI： 1.403-7.080, χ^2 = 8.018, P = 0.007）.CONCLUSION： There is a marked difference in the frequency of common GSTM1 null genotype between Uygur and Kazakh. GSTM1 null genotype is associated with differentiation of ESCC in Kazakh.展开更多
The Tajik Basin holds one of Central Asia’s most complete geological archives of how the Proto-Paratethys Sea retreated and gave way to continental landscapes during the Cenozoic.Yet the spatial continuity of these P...The Tajik Basin holds one of Central Asia’s most complete geological archives of how the Proto-Paratethys Sea retreated and gave way to continental landscapes during the Cenozoic.Yet the spatial continuity of these Paleogene–Neogene formations remains only partly understood.In this study,we combined satellite-based spectral analysis with detailed fieldwork to better map and interpret the Ganjina–Khuroson area in southwestern Tajikistan.Using Advanced Spaceborne Thermal Emission and Reflection Radiometer(ASTER)data,we applied tailored band-ratio composites(R:2/5,G:3N,B:5/6 and R:2/1,G:3N,B:5/7)to distinguish marine carbonates from continental sandstones and clays.The Maximum Likelihood Classification achieved an overall accuracy of 90.72%and a Kappa value of 0.87,demonstrating high reliability.Field spectroscopy and geological verification confirmed excellent agreement with observed lithologies.The results reveal a clear shift from fossil-rich marine limestones to oxidized continental deposits,marking the final regression of the Proto-Paratethys Sea.This integrated approach shows how multispectral data,when validated in the field,can illuminate the history of marine withdrawal and sedimentary transformation across the Tajik Basin.展开更多
The tempo-spatial development of the Cenozoic Asian aridification across the Eocene-Oligocene and its controlling factors are important scientific topics in Earth Sciences, which are pertinent to regional and global t...The tempo-spatial development of the Cenozoic Asian aridification across the Eocene-Oligocene and its controlling factors are important scientific topics in Earth Sciences, which are pertinent to regional and global tectonic and climatic events. However, sedimentary rocks preserving the record of aridification during this time from central Asia(ACA) are rare. Here we present a preliminary analysis of sedimentary facies of the lower Paleogene in the northeastern Tajik Basin, which reveals that: the lower part of the studied section is dominated by shallow marine deposits of the Paratethys, the middle part is typical of alternations of eolian dune and fluvial deposits, the upper part is represented by eolian loess-sandy loess(L&SL) like facies, and the top exhibits alternations of fluvial-lacustrine and loess like facies. Based on a chronological framework derived from preliminary magnetostratigraphy, published U-Pb dating of a volcanic ash, and regional litho-stratigraphic correlations, we determine that eolian and L&SL facies accumulated in the northeastern Tajik Basin during the Late Eocene and through most of the Oligocene. These sedimentary units indicate that semi-arid to arid environments of ACA had developed at least since the late Eocene. This initial aridification is closely linked to the westward retreat of the Paratethys that was likely driven by a combination of tectonic activity and sea level changes.展开更多
基金Supported by a grant from the Xinjiang Science and TechnologyBureau, No. XJKJT200511113 and a grant for 100 YoungExcellent Returned Overseas Chinese Scholars Program, ChineseAcademy of Sciences
文摘AIM： To investigate the glutathione-S-transferase M1 （GSTM1） polymorphisms in three Chinese minorities, Kazakh, Uygur, and Tajik; and the pathological significance of GSTM1 polymorphisms in esophageal carcinogenesis in Kazakh.METHODS： A total of 1121 blood samples （442 males and 679 females） were obtained from healthy Kazakh （654）, Uygur （412） and Tajik （55）. Primary esophageal squamous cell cancer （ESCC） tissues from Kazakh were obtained from 116 patients who underwent surgery. GSTM1 polymorphisms were analyzed by a combined approach of PCR and electrophoresis techniques.RESULTS： GSTM1 null genotype was found in 62.63% Uygur, 50.91% Tajik and 47.40% Kazakh. A significantly higher frequency of GSTM1 null genotype in Uygur was observed compared with Kazakh （OR： 1.859, 95% CI： 1.445 -2.391, χ^2 = 23.71, P = 0.000）. In addition, GSTM1 null genotype was found in 23.53% of welldifferentiated ESCC in Kazakh, in 49.23% of poorly differentiated ESCC, with a significant difference （OR： 3.152, 95% CI： 1.403-7.080, χ^2 = 8.018, P = 0.007）.CONCLUSION： There is a marked difference in the frequency of common GSTM1 null genotype between Uygur and Kazakh. GSTM1 null genotype is associated with differentiation of ESCC in Kazakh.
文摘The Tajik Basin holds one of Central Asia’s most complete geological archives of how the Proto-Paratethys Sea retreated and gave way to continental landscapes during the Cenozoic.Yet the spatial continuity of these Paleogene–Neogene formations remains only partly understood.In this study,we combined satellite-based spectral analysis with detailed fieldwork to better map and interpret the Ganjina–Khuroson area in southwestern Tajikistan.Using Advanced Spaceborne Thermal Emission and Reflection Radiometer(ASTER)data,we applied tailored band-ratio composites(R:2/5,G:3N,B:5/6 and R:2/1,G:3N,B:5/7)to distinguish marine carbonates from continental sandstones and clays.The Maximum Likelihood Classification achieved an overall accuracy of 90.72%and a Kappa value of 0.87,demonstrating high reliability.Field spectroscopy and geological verification confirmed excellent agreement with observed lithologies.The results reveal a clear shift from fossil-rich marine limestones to oxidized continental deposits,marking the final regression of the Proto-Paratethys Sea.This integrated approach shows how multispectral data,when validated in the field,can illuminate the history of marine withdrawal and sedimentary transformation across the Tajik Basin.
基金supported by the National Natural Science Foundation of China(Grant Nos.41302144&41130102)the Programme of Introducing Talents of Discipline to Universities(111 Project)(Grant No.B06026)the Open Foundation of MOE Key Laboratory of Western China’s Environmental System,Lanzhou University(Grant No.LZUJBKY-2013-BT01)
文摘The tempo-spatial development of the Cenozoic Asian aridification across the Eocene-Oligocene and its controlling factors are important scientific topics in Earth Sciences, which are pertinent to regional and global tectonic and climatic events. However, sedimentary rocks preserving the record of aridification during this time from central Asia(ACA) are rare. Here we present a preliminary analysis of sedimentary facies of the lower Paleogene in the northeastern Tajik Basin, which reveals that: the lower part of the studied section is dominated by shallow marine deposits of the Paratethys, the middle part is typical of alternations of eolian dune and fluvial deposits, the upper part is represented by eolian loess-sandy loess(L&SL) like facies, and the top exhibits alternations of fluvial-lacustrine and loess like facies. Based on a chronological framework derived from preliminary magnetostratigraphy, published U-Pb dating of a volcanic ash, and regional litho-stratigraphic correlations, we determine that eolian and L&SL facies accumulated in the northeastern Tajik Basin during the Late Eocene and through most of the Oligocene. These sedimentary units indicate that semi-arid to arid environments of ACA had developed at least since the late Eocene. This initial aridification is closely linked to the westward retreat of the Paratethys that was likely driven by a combination of tectonic activity and sea level changes.
