Autism Spectrum Disorders(ASDs)are reported as a group of neurodevelopmental disorders.The structural changes of brain regions including the hippocampus were widely reported in autistic patients and mouse models with ...Autism Spectrum Disorders(ASDs)are reported as a group of neurodevelopmental disorders.The structural changes of brain regions including the hippocampus were widely reported in autistic patients and mouse models with dysfunction of ASD risk genes,but the underlying mechanisms are not fully understood.Here,we report that deletion of Trio,a high-susceptibility gene of ASDs,causes a postnatal dentate gyrus(DG)hypoplasia with a zigzagged suprapyramidal blade,and the Trio-defcient mice display autism-like behaviors.The impaired morphogenesis of DG is mainly caused by disturbing the postnatal distribution of postmitotic granule cells(GCs),which further results in a migration defcit of neural progenitors.Furthermore,we reveal that Trio plays diferent roles in various excitatory neural cells by spatial transcriptomic sequencing,especially the role of regulating the migration of postmitotic GCs.In summary,our fndings provide evidence of cellular mechanisms that Trio is involved in postnatal DG morphogenesis.展开更多
研发了一种应用于白车身焊装装备制造的火焰切割机开放式数控系统。基于工业控制计算机IPC和运动控制器Trio MC 206提出了开放式火焰切割机控制系统的结构方案,并进行了详细的软硬件设计。在Visual Studio 2008软件环境中利用C#语言开...研发了一种应用于白车身焊装装备制造的火焰切割机开放式数控系统。基于工业控制计算机IPC和运动控制器Trio MC 206提出了开放式火焰切割机控制系统的结构方案,并进行了详细的软硬件设计。在Visual Studio 2008软件环境中利用C#语言开发了数控系统的上位机管理软件,在TrioMotion Perfect2软件环境下开发了下位机底层控制程序。实践结果表明,该火焰切割机数控系统运行稳定可靠,能很好地满足汽车白车身焊装装备制造中的工作要求。展开更多
基金supported by grants from the Key Realm R&D Program of Guangdong Province(2019B030335001)the National Natural Science Foundation of China(82071541,81971283,82271576,and 82101570)the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2023-PT320-08).
文摘Autism Spectrum Disorders(ASDs)are reported as a group of neurodevelopmental disorders.The structural changes of brain regions including the hippocampus were widely reported in autistic patients and mouse models with dysfunction of ASD risk genes,but the underlying mechanisms are not fully understood.Here,we report that deletion of Trio,a high-susceptibility gene of ASDs,causes a postnatal dentate gyrus(DG)hypoplasia with a zigzagged suprapyramidal blade,and the Trio-defcient mice display autism-like behaviors.The impaired morphogenesis of DG is mainly caused by disturbing the postnatal distribution of postmitotic granule cells(GCs),which further results in a migration defcit of neural progenitors.Furthermore,we reveal that Trio plays diferent roles in various excitatory neural cells by spatial transcriptomic sequencing,especially the role of regulating the migration of postmitotic GCs.In summary,our fndings provide evidence of cellular mechanisms that Trio is involved in postnatal DG morphogenesis.
文摘研发了一种应用于白车身焊装装备制造的火焰切割机开放式数控系统。基于工业控制计算机IPC和运动控制器Trio MC 206提出了开放式火焰切割机控制系统的结构方案,并进行了详细的软硬件设计。在Visual Studio 2008软件环境中利用C#语言开发了数控系统的上位机管理软件,在TrioMotion Perfect2软件环境下开发了下位机底层控制程序。实践结果表明,该火焰切割机数控系统运行稳定可靠,能很好地满足汽车白车身焊装装备制造中的工作要求。
