Triple-negative breast cancer(TNBC)is marked by its high degree of malignancy and challenging treatment outcomes.While Western medicine predominantly relies on chemotherapy,issues such as drug resistance and toxic sid...Triple-negative breast cancer(TNBC)is marked by its high degree of malignancy and challenging treatment outcomes.While Western medicine predominantly relies on chemotherapy,issues such as drug resistance and toxic side effects remain prevalent.Drawing on the traditional Chinese medicine(TCM)principle of“treating the same disease with different methods,”Bian devises individualized therapeutic strategies tailored to the unique syndrome patterns of TNBC patients,adhering to the core tenets of“treatment based on syndrome differentiation”and“simultaneous regulation of the liver and spleen.”Through an analysis of clinical cases involving TNBC patients,this paper summarizes Bian’s clinical experience,which emphasizes foundational approaches such as strengthening the body’s resistance and soothing the liver to regulate qi,combined with personalized therapies including clearing heat and draining dampness,pacifying the liver and subduing yang,and resolving phlegm to unblock collaterals.The study highlights a diagnostic model of“multiple prescriptions for one disease,tailored to individual conditions,”providing valuable insights for the personalized TCM treatment of TNBC.展开更多
Conversation A(in the break room)Sara:Do I see a picture of a pie?Greg:Youdo.I'm looking at achart of people'sfavoritefall sweettreats.Sara:Yummy!Applepie ismyfavorite.Greg:It'salsothefavoriteof 30percento...Conversation A(in the break room)Sara:Do I see a picture of a pie?Greg:Youdo.I'm looking at achart of people'sfavoritefall sweettreats.Sara:Yummy!Applepie ismyfavorite.Greg:It'salsothefavoriteof 30percentofpeople.This chartsays that.Sara:Well,apple pie is great.展开更多
BACKGROUND Sustained viral load(VL)suppression is an important indicator of successful treatment among people living with human immunodeficiency virus(HIV).AIM To assess trends of different VL outcomes before and afte...BACKGROUND Sustained viral load(VL)suppression is an important indicator of successful treatment among people living with human immunodeficiency virus(HIV).AIM To assess trends of different VL outcomes before and after adoption of the Treat All policy among people living with HIV in Rwanda.METHODS Between 2014 and 2017,VL suppression[VL suppression(VLS)<200 copies/mL]was measured among people living with HIV from 28 healthcare facilities in Rwanda.Participant VL was measured at 6 months,18 months,and 30 months.The unit of analysis was visit-pair,with subjects across four visit-pair categories:(1)Sustained VL suppression(VL<200 copies/mL at two consecutive visits);(2)Persistent viremia(VL≥200 copies/mL at two consecutive visits);(3)Viral rebound(VL<200 copies/mL at prior visit only);and(4)Newly suppressed(VL<200 copies/mL at subsequent visit only).Poisson regression models with generalized estimating equations were used to estimate adjusted incidence risk ratio(aIRR)and 95%confidence intervals(CIs)for factors associated with sustained VLS.To handle missing data,multiple imputations was performed.RESULTS A total of 634 participants contributed 973 visit-pairs(295 single pairs and 339 double pairs).The median age was 37 years(interquartile range:32-43 years).The incidence rates of sustained VLS,persistent viremia,viral rebound,and new suppression were 85.2%,4.3%,4.6%,and 5.7%,respectively.Young individuals aged 18-24 years had higher incidence of viral rebound compared to those 25 years or older(14.8%vs 4.3%;P=0.011).Of the visit-pairs that had sustained VLS during the first two visits(49.8%;n=485),56.7%exhibited sustained VLS throughout follow-up.Compared to having no education,having at least primary education was associated with an increased likelihood of sustained VLS(aIRR=1.09;95%CI:1.01-1.17).Those who presented with advanced HIV disease at baseline had a 12%reduced likelihood of sustained VLS(aIRR=0.88;95%CI:0.79-0.99).Achieving sustained VLS did not differ before or after adoption of the Treat All policy.When the analysis was repeated on imputed datasets,similar results were found.CONCLUSION Although most people living with HIV have sustained VLS in Rwanda,individuals without formal education,those presenting with advanced HIV,and younger individuals were lagging on multiple outcomes.Interventions tailored to these individuals would improve treatment outcomes to achieve epidemic control.展开更多
BACKGROUND Research has been increasingly conducted on the connection between mesenchymal stem cell(MSC)-conditioned medium(MSC-CM)and aging.However,most studies have focused on adipose-derived MSC-CM(ADMSC-CM),result...BACKGROUND Research has been increasingly conducted on the connection between mesenchymal stem cell(MSC)-conditioned medium(MSC-CM)and aging.However,most studies have focused on adipose-derived MSC-CM(ADMSC-CM),resulting in a research bias.We hypothesized that umbilical cord-derived MSCs,being younger than adipose-derived MSCs,would be more suitable for overcoming aging-related processes.AIM To assess the efficacy and safety of umbilical cord-derived MSC-CM(UCMSCCM)for preventing and treating skin aging.METHODS In vitro and in vivo studies were conducted to compare UCMSC-CM with ADMSC-CM,the most studied active aging-preventive conditioned medium to date.Additionally,the most effective delivery method of UCMSC-CM for aged skin was identified.RESULTS UCMSC-CM had a higher content of effective factors,stimulated higher proliferation of fibroblasts,and strongly inhibited melanin production in B16F1 cells.In aged mice,UCMSC-CM application increased skin thickness,the number of Ki-67-positive cells,and the area of collagen deposition.UCMSC-CM was more effective than ADMSC-CM in preventing and treating skin aging.Additionally,a safety evaluation of UCMSC-CM performed in various animal models indicated that it was safe even when used directly on the skin.CONCLUSION UCMSC-CM is effective and safe for preventing and treating skin aging.展开更多
In our life,we can 4 avoid to make 1 mistakes.So some advice on how to correct them are2 very important and helpful to us.Advice is love from people who care about you.When you are in trouble,good advice can always te...In our life,we can 4 avoid to make 1 mistakes.So some advice on how to correct them are2 very important and helpful to us.Advice is love from people who care about you.When you are in trouble,good advice can always teach you how to solve it and do better.Advice is the warmest expectation that people who love you give to you.When yon can,t get on well with your friends,good advice can tell you how to understand him'.After listening to others'advice carefully,you will gain friendship and warmth.So,we should accept others'advice instead of refusing it.优点:本文分三段展开:第一段给出论点:建议重要且有用;第二段对论点进行论证:建议是在乎你的人给予你的关爱以及爱护你的人给予你最温暖的期待,认真倾听会得到友谊和温暖;第三段得出结论:接受建议而不拒绝建议。全文结构完整、详略得当、重点突出,是一篇值得借鉴的学生习作。展开更多
In this study, polyethylene-terephthalate （PET） nonwovens are treated using an atmospheric plasma and the effects of the treatment time, treatment power and discharge distance on the ability of water-penetration int...In this study, polyethylene-terephthalate （PET） nonwovens are treated using an atmospheric plasma and the effects of the treatment time, treatment power and discharge distance on the ability of water-penetration into the nonwovens are investigated. The result indicates that the method can improve the wettability of PET nonwovens remarkably, but the aging decay of the sample＇s wettability is found to be notable as a function of the storage time after treatment due to the internal rotation of the single bond of surface macromolecules. As shown by SEM and XPS analysis, the etching and surface reaction are significant, and water-penetration weight is found to increase remarkably with the increasing power. This variation can be attributed to momentum transfer and enhanced higher-energy particle excitation.展开更多
A treat-to-target(T2T)approach applies the principles of early intervention and tight disease control to optimise long-term outcomes in Crohn's disease.The Selecting Therapeutic Targets in Inflammatory Bowel Disea...A treat-to-target(T2T)approach applies the principles of early intervention and tight disease control to optimise long-term outcomes in Crohn's disease.The Selecting Therapeutic Targets in Inflammatory Bowel Disease(STRIDE)-II guidelines specify short,intermediate,and long-term treatment goals,documenting specific treatment targets to be achieved at each of these timepoints.Scheduled appraisal of Crohn’s disease activity against pre-defined treatment targets at these timepoints remains central to determining whether current therapy should be continued or modified.Consensus treatment targets in Crohn’s disease comprise combination clinical and patient-reported outcome remission,in conjunction with biomarker normalisation and endoscopic healing.Although the STRIDE-II guidelines endorse the pursuit of endoscopic healing,clinicians must consider that this may not always be appropriate,acceptable,or achievable in all patients.This underscores the need to engage patients at the outset in an effort to personalise care and individualise treatment targets.The use of non-invasive biomarkers such as faecal calprotectin in conjunction with cross-sectional imaging techniques,particularly intestinal ultrasound,holds great promise;as do emerging treatment targets such as transmural healing.Two randomised clinical trials,namely,CALM and STARDUST,have evaluated the efficacy of a T2T approach in achieving endoscopic endpoints in patients with Crohn’s disease.Findings from these studies reflect that patient subgroups and Crohn’s disease characteristics likely to benefit most from a T2T approach,remain to be clarified.Moreover,outside of clinical trials,data pertaining to the real-world effectiveness of a T2T approach remains scare,highlighting the need for pragmatic real-world studies.Despite the obvious promise of a T2T approach,a lack of guidance to support its integration into real-world clinical practice has the potential to limit its uptake.This highlights the need to describe strategies,processes,and models of care capable of supporting the integration and execution of a T2T approach in real-world clinical practice.Hence,this review seeks to examine the current and emerging literature to provide clinicians with practical guidance on how to incorporate the principles of T2T into routine clinical practice for the management of Crohn’s disease.展开更多
Based on the theory of "regulating body" integrated with "regulating mind",following the principle of "treating the body and mind simultaneously,treating both symptoms and root causes",Pr...Based on the theory of "regulating body" integrated with "regulating mind",following the principle of "treating the body and mind simultaneously,treating both symptoms and root causes",Prof.Shao-jun WANG adopts flexibly the different techniques,including body acupuncture,wrist-ankle acupuncture,umbilical acupuncture,fire needling,moxibustion,and cupping,etc.for the treatment of psychosomatic skin diseases.According to the manifestations of skin diseases in different stages,she adopts different acupuncture and moxibustion techniques for the comprehensive treatment of psychosomatic skin diseases,including senile pruritus,alopecia areata,neurodermatitis,eczema,urticaria,and acne,on the basis of syndrome differentiation and different acupoint selections,and achieves good results.展开更多
The widespread emergence of antibiotic resistance among bacterial pathogens has become one of the most serious challenges in Ethiopia. This study determined the prevalence and drug resistance patterns of bacterial pat...The widespread emergence of antibiotic resistance among bacterial pathogens has become one of the most serious challenges in Ethiopia. This study determined the prevalence and drug resistance patterns of bacterial pathogens isolated from treated and untreated wastewater released from Ayder Referral Hospital in Northern Ethiopia. A cross sectional study design was conducted from September-December, 2015 in wastewater released from Ayder referral hospital. A total of 40 composite samples were aseptically collected, transported and processed for enumeration of indicator organisms, bacteriological identification and susceptibility testing following standard procedure. Data obtained were entered and analyzed using SPSS version 20. Mean heterotrophic plate count, total coliform count, fecal coliform count and E. coli count were found to be 1.6 × 106 CFU/mL, 2.2 × 106 CFU/100 mL, 2.0 × 105 CFU/100 mL and 1.1 × 104 CFU/100 mL from treated wastewater respectively. Among the total samples 134 bacterial isolates were detected and [84 (62.7%)] were from untreated wastewater and [50 (37.3%)] were from treated wastewater. The most frequently isolated bacteria from untreated wastewater samples was Klebsiella spp [14 (16.7%)] followed by S. aureus [13 (15.5%)] and P. aeruginosa [12 (14.3%)], similarly in treated wastewater samples Klebsiella spp [10 (20%)], P. aeruginosa [8 (16%)] and S. aureus [8 (16%)] were frequently detected. The overall multi-drug resistance (MDR) in this study was [79/134 (79.1%)]. MDR from untreated wastewater sample was [64/84 (76.2%)] while from treated wastewater sample was [42/50 (84%)] and shows significant difference with (COR: 1.64, 95% CI: 1.15 - 3.29, P: 0.001). It is concluded that treated hospital wastewater contains large numbers of antibiotic resistant bacteria. Therefore, there should be continuous monitoring and evaluation of the effluent quality of the ponds and chlorination of the final effluent should be developed.展开更多
Three concentrations （2.8%, 2.0%, 1.2%） of Ammoniacal Copper Quaternary （ACQ） was selected to treat Lodgepole pine wood for evaluating ACQ treatment on mechanical properties of blue-stained wood. The bending modul...Three concentrations （2.8%, 2.0%, 1.2%） of Ammoniacal Copper Quaternary （ACQ） was selected to treat Lodgepole pine wood for evaluating ACQ treatment on mechanical properties of blue-stained wood. The bending modules of elasticity （MOE）, modules of rupture （MOR）, toughness and shearing strength parallel to grain on tangential surface, are tested according to the criteria GB1927-1943-91. Non-treated sample were also tested according to the same procedure. The results showed that the three groups specimen impregnated by different concentrations of ACQ solution met the AWPA standard 2003 of America （UC4A 6.4g/cm^3）. There were significant difference of toughness between treated wood and non-treated wood （p=0.01）, but there were no statistically significant differences among three concentrations in terms of toughness, and toughness of treated wood was approximately 20% lower than non-treated. MOR, MOE as well as sheafing strength parallel to grain were found to be not significantly different between treated wood and non-treated one, and there were no statistically significant difference among three concentrations of ACQ too. Toughness, MOR, MOE and sheafing strength parallel to grain increased with decrease of concentration of ACQ, but they were hardly affected by ACQ preservatives.展开更多
Asthma is characterized by paroxysmaldyspnea,rales in the throat,difficulty in breathing,and inability to lie horizontally.It is commonly seenin children with a weak body constitution,and tendsto be intractable,thus b...Asthma is characterized by paroxysmaldyspnea,rales in the throat,difficulty in breathing,and inability to lie horizontally.It is commonly seenin children with a weak body constitution,and tendsto be intractable,thus being harmful to the展开更多
Nano-TiO2 photocatalytic oxidation was used to perform the advanced treatment of biologically treated chemical comprehensive wastewater. The effects of reaction time,nano-TiO2 dosage and initial p H of the wastewater ...Nano-TiO2 photocatalytic oxidation was used to perform the advanced treatment of biologically treated chemical comprehensive wastewater. The effects of reaction time,nano-TiO2 dosage and initial p H of the wastewater on the removal rate of COD were tested. The GC/MS and EEM techniques were used to qualitatively analyze organic compounds in the wastewater before and after treatment. The result showed that after the biologically treated chemical comprehensive wastewater was treated by nano-TiO2 photocatalytic oxidation under the conditions of reaction time 3 h,nano-TiO2 dosage 8 g/L,and pH 8. 0,the effluent COD was 61. 9 mg/L and its removal rate was 63. 8%. Additionally,the species of organic pollutants reduced from 12 to 6. Meanwhile,the content of humic-like and fulvic-like substances dropped dramatically.展开更多
Heat-treated wood has good dimensional stability,corrosion resistance and visual quality,but it is prone to mold,which limits its application.Based on the pH value of heat-treated wood,this study examines the factors ...Heat-treated wood has good dimensional stability,corrosion resistance and visual quality,but it is prone to mold,which limits its application.Based on the pH value of heat-treated wood,this study examines the factors affecting the pathogenesis causing heat-treated wood mold.Normally,the pH value of the heat-treated wood is between 4.38 and 5.10,which is suitable for the growth of mold.However,the pH of the heat-treated copper-containing material is between 6.63 and 7.12,which deviates the treated wood from the comfortable growth conditions for the mold,thereby reducing the occurrence of mold.展开更多
In the area of recycling of spent chromated copper arsenate (CCA)-treated wood, most studies to date have focused on methods of removing/extracting the residual preservative from the wood matrix. It is well recognized...In the area of recycling of spent chromated copper arsenate (CCA)-treated wood, most studies to date have focused on methods of removing/extracting the residual preservative from the wood matrix. It is well recognized that exposure of CCA-treated wood to an acid solution can reverse the CCA fixation process thereby converting the CCA elements into their water-soluble form. The economic viability of the process is enhanced because it can be integrated with other technologies and products (e.g., “green” spray foam insulation, etc.). The market for the “green” CCA is the same as for traditional CCA-the wood treating industry, principally utility poles and pilings. A market research study was conducted to determine the suitability of spent CCA-treated wood as a source for recycled, “green” CCA for manufacturing “green” spray-foam insulation. Specifically, we wanted to discern the attitudes and overall perspectives of buyers/sellers (i.e., utilities and wood treating companies) of CCA preservatives and treated wood products, disposal methods and costs for decommissioned CCA-treated wood, and understand perceptions of and willingness-to-pay for “green” CCA preservatives extracted from the technologies used in this research. Results show that 60% of wood preservative treating respondents and 60% of electric utility company respondents are somewhat or greatly interested in using out-of-service utility poles as feedstock for “green insulation” as part of a new potential business venture.展开更多
Hepatocellular carcinoma（HCC） is one of leading causes of death in the world. Although various treatments have been developed, the therapeutic side effects are far from desirable. Chinese medicines（CMs, including p...Hepatocellular carcinoma（HCC） is one of leading causes of death in the world. Although various treatments have been developed, the therapeutic side effects are far from desirable. Chinese medicines（CMs, including plants, animal parts and minerals） have drawn a great deal of attention in recent years for their potential in the treatment of HCC. Most studies have shown that CMs may be able to retard HCC progression with multiple actions, either alone or in combination with other conventional therapies to improve quality of life in HCC patients. Additionally, CMs are used for preventing HCC occurrence. The aim of this study is to review the potential prophylactic and curative effects of CMs on human HCC and the possible mechanisms that underlie these pharmacological actions. Publications were collected and reviewed from Pub Med and China National Knowledge Infrastructure from 2000 to 2014. Keywords for literature searches include ＂Chinese medicine＂, ＂Chinese herb＂, ＂traditional Chinese Medicine＂, ＂hepatocellular carcinoma＂ and ＂liver cancer＂. CMs in forms of pure compounds, isolated fractions, and composite formulas are included. Combination therapies are also considered. Both in vitro and in vivo efficacies of CMs are being discussed and the translational potential to bedside is to be discussed with clinical cases, which show the actions of CMs on HCC may include tumor growth inhibition, antimetastatic activities, anti-inflammation, anti-liver cancer stem cells, reversal on multi-drug resistance and induction/reduction of oxidative stress. Multiple types of molecules are found to contribute in the above actions. The review paper indicated that CMs might have potential to both prevent HCC occurrence and retard HCC progression with several molecular targets involved.展开更多
A study was carded out at the Loess Plateau in Dongzhi, China, to test the feasibility of using secondary treatment sewage effluent and to determine whether the water quality would then meet the recommended irrigation...A study was carded out at the Loess Plateau in Dongzhi, China, to test the feasibility of using secondary treatment sewage effluent and to determine whether the water quality would then meet the recommended irrigation norm. Seven crops, including celery, wheat, maize, millet, apples, rapeseed and yellow beans, were tested in the study. Physical and chemical properties of the soil, crop yield and quality and leachate at different soil depths were measured. In most cases, the quality of the crops that made use of treated sewage was not distinctively different from those that did not use treated sewage. However, yields for the former were much higher than they were for the latter. Leachates at different soil depths were analyzed and the results did not show alarming levels of constituents. For a period of approximately 14 months, the treated sewage irrigation had no significant effect on the loess soil and no cases of illness resulting from contact with the treated sewage were reported. With treated sewage irrigation, a slight increase in the organic content of the soil was observed.展开更多
The effciency of sodium hydroxide treated rubber (Hevea brasiliensis) leaves powder (NHBL) for removing copper ions from aqueous solutions has been investigated. The e?ects of physicochemical parameters on biosorption...The effciency of sodium hydroxide treated rubber (Hevea brasiliensis) leaves powder (NHBL) for removing copper ions from aqueous solutions has been investigated. The e?ects of physicochemical parameters on biosorption capacities such as stirring speed, pH, biosorbent dose, initial concentrations of copper, and ionic strength were studied. The biosorption capacities of NHBL increased with increase in pH, stirring speed and copper concentration but decreased with increase in biosorbent dose and ionic strength. The isotherm study indicated that NHBL fitted well with Langmuir model compared to Freundlich and Dubinin-Radushkevich models. The maximum biosorption capacity determined from Langmuir isotherm was 14.97 mg/g at 27°C. The kinetic study revealed that pseudo- second order model fitted well the kinetic data, while Boyd kinetic model indicated that film diffusion was the main rate determining step in biosorption process. Based on surface area analysis, NHBL has low surface area and categorized as macroporous. Fourier transform infrared (FT-IR) analyses revealed that hydroxyl, carboxyl, and amino are the main functional groups involved in the binding of copper ions. Complexation was one of the main mechanisms for the removal of copper ions as indicated by FT-IR spectra. Ion exchange was another possible mechanism since the ratio of adsorbed cations (Cu2+ and H+) to the released cations (Na+, Ca2+, and Mg2+) from NHBL was almost unity. Copper ions bound on NHBL were able to be desorbed at > 99% using 0.05 mol/L HCl, 0.01 mol/L HNO3, and 0.01 mol/L EDTA solutions.展开更多
This study was designed to compare the impact of post and core systems on resistance to fracture of endodontically treated anterior teeth with flared root canals and to assess their fracture pattern. Sixty central inc...This study was designed to compare the impact of post and core systems on resistance to fracture of endodontically treated anterior teeth with flared root canals and to assess their fracture pattern. Sixty central incisors were cut horizontally 2 mm coronal to the cementoenamel junction(CEJ). After root canal therapy, teeth were assigned into 6 groups(n = 10 each) based on a post system and used as follows: Group C, non-flared root received size #1 glass fiber posts(Control); Group AP, flared root restored with anatomical post; Group RC, flared root restored with size #1 fiber post and cemented with thick layer of resin cement; Group CR, flared root restored with size #1 and reinforced with composite resin; Group CM, cast post-core; Group CP, CAD/CAM polymer-infiltrated ceramic post and core.Following post cementation, core build-up and crown insertion, the specimens were thermo-cycled up to 10,000 cycles(5 C/55 C; 30 seconds dwell time, 6 seconds transition time) and then statically loaded at 1 mm/minute crosshead speed using a universal testing machine. One-way ANOVA and Tukey HSD post hoc test(α= 0.05) were used for data analysis. Group C recorded significantly higher resistance to fracture values [(826.9±39.1) N] followed by group CP [(793.8±55.6) N] while group RC yielded the lowest fracture resistance values [(586.7±51.4) N]. The resistance to fracture of wide root canals can be enhanced by using one-piece CAM/CAM post and core as an alternative to the use of either glass fiber post, relined with composite resin increasing the thickness of luting cement or the use of cast post and core system. However, this was an in vitro investigation and further in vivo studies are necessary.展开更多
The improvement of question soils with cement shows great technical, economic and environmental advantages. And interest in introducing electrical resistivity measurement to assess the quality of cement treated soils ...The improvement of question soils with cement shows great technical, economic and environmental advantages. And interest in introducing electrical resistivity measurement to assess the quality of cement treated soils has increased markedly recently due to its economical, non-destructive, and relatively non-invasive advantages. This work aims to quantify the effect of cement content （aw）, porosity （nt）, and curing time（T） on the electrical resistivity （p） and unconfined compression strength （UCS） of cement treated soil. A series of electrical resistivity tests and UCS tests of cement treated soil specimen after various curing periods were carried out. A modified Archie empirical law was proposed taking into account the effect of cement content and curing period on the electrical resistivity of cement treated soil. The results show that nt/（aw·T） and nt/（aw·T^1/2） ratio are appropriate parameters to assess electrical resistivity and UCS of cement treated soil, respectively. Finally, the relationship between UCS and electrical resistivity was also established.展开更多
Hepatocellular carcinoma(HCC) is the most common primary liver malignancy. The treatment of HCC is complex and complicated by the severity of associated chronic liver disease, the stage of HCC, and the clinical condit...Hepatocellular carcinoma(HCC) is the most common primary liver malignancy. The treatment of HCC is complex and complicated by the severity of associated chronic liver disease, the stage of HCC, and the clinical condition of the patient. Liver resection(LR) is one of the most efficient treatments for patients with HCC, with an expected 5-year survival of 38%-61% depending on the stage of the disease. Improved liver function assessment, increased understanding of segmental liver anatomy from advanced imaging studies, and surgical technical progress are important factors that have led to reduced mortality in patients with HCC. The indication for LR may be expanded due to emerging evidences from laparoscopic hepatectomies and combined treatments with newly developed chemotherapies. Liver transplantation(LT) is considered as an ideal treatment for removal of existing tumors and the injured/preneoplastic underlying liver tissue with impaired liver function and the risk of multicentric carcinogenesis that results from chronically injured liver. However, LT is restricted to patients with minimal risk of tumor recurrence under immunosuppression. The expansion of criteria for LT in HCC patients is still under trial and discussion. Limited availability of grafts, as well as the risk and the cost of transplantation have led to considerable interest in expansion of the donor pool, living donor-related transplantation, and combined treatment involving LR and LT. This highlight presents evidence concerning recent studies evaluating LR and LT in HCC patients. In addition, alternative therapies for the treatment of early stage tumors and the management of patients on transplant waiting lists are discussed.展开更多
文摘Triple-negative breast cancer(TNBC)is marked by its high degree of malignancy and challenging treatment outcomes.While Western medicine predominantly relies on chemotherapy,issues such as drug resistance and toxic side effects remain prevalent.Drawing on the traditional Chinese medicine(TCM)principle of“treating the same disease with different methods,”Bian devises individualized therapeutic strategies tailored to the unique syndrome patterns of TNBC patients,adhering to the core tenets of“treatment based on syndrome differentiation”and“simultaneous regulation of the liver and spleen.”Through an analysis of clinical cases involving TNBC patients,this paper summarizes Bian’s clinical experience,which emphasizes foundational approaches such as strengthening the body’s resistance and soothing the liver to regulate qi,combined with personalized therapies including clearing heat and draining dampness,pacifying the liver and subduing yang,and resolving phlegm to unblock collaterals.The study highlights a diagnostic model of“multiple prescriptions for one disease,tailored to individual conditions,”providing valuable insights for the personalized TCM treatment of TNBC.
文摘Conversation A(in the break room)Sara:Do I see a picture of a pie?Greg:Youdo.I'm looking at achart of people'sfavoritefall sweettreats.Sara:Yummy!Applepie ismyfavorite.Greg:It'salsothefavoriteof 30percentofpeople.This chartsays that.Sara:Well,apple pie is great.
文摘BACKGROUND Sustained viral load(VL)suppression is an important indicator of successful treatment among people living with human immunodeficiency virus(HIV).AIM To assess trends of different VL outcomes before and after adoption of the Treat All policy among people living with HIV in Rwanda.METHODS Between 2014 and 2017,VL suppression[VL suppression(VLS)<200 copies/mL]was measured among people living with HIV from 28 healthcare facilities in Rwanda.Participant VL was measured at 6 months,18 months,and 30 months.The unit of analysis was visit-pair,with subjects across four visit-pair categories:(1)Sustained VL suppression(VL<200 copies/mL at two consecutive visits);(2)Persistent viremia(VL≥200 copies/mL at two consecutive visits);(3)Viral rebound(VL<200 copies/mL at prior visit only);and(4)Newly suppressed(VL<200 copies/mL at subsequent visit only).Poisson regression models with generalized estimating equations were used to estimate adjusted incidence risk ratio(aIRR)and 95%confidence intervals(CIs)for factors associated with sustained VLS.To handle missing data,multiple imputations was performed.RESULTS A total of 634 participants contributed 973 visit-pairs(295 single pairs and 339 double pairs).The median age was 37 years(interquartile range:32-43 years).The incidence rates of sustained VLS,persistent viremia,viral rebound,and new suppression were 85.2%,4.3%,4.6%,and 5.7%,respectively.Young individuals aged 18-24 years had higher incidence of viral rebound compared to those 25 years or older(14.8%vs 4.3%;P=0.011).Of the visit-pairs that had sustained VLS during the first two visits(49.8%;n=485),56.7%exhibited sustained VLS throughout follow-up.Compared to having no education,having at least primary education was associated with an increased likelihood of sustained VLS(aIRR=1.09;95%CI:1.01-1.17).Those who presented with advanced HIV disease at baseline had a 12%reduced likelihood of sustained VLS(aIRR=0.88;95%CI:0.79-0.99).Achieving sustained VLS did not differ before or after adoption of the Treat All policy.When the analysis was repeated on imputed datasets,similar results were found.CONCLUSION Although most people living with HIV have sustained VLS in Rwanda,individuals without formal education,those presenting with advanced HIV,and younger individuals were lagging on multiple outcomes.Interventions tailored to these individuals would improve treatment outcomes to achieve epidemic control.
文摘BACKGROUND Research has been increasingly conducted on the connection between mesenchymal stem cell(MSC)-conditioned medium(MSC-CM)and aging.However,most studies have focused on adipose-derived MSC-CM(ADMSC-CM),resulting in a research bias.We hypothesized that umbilical cord-derived MSCs,being younger than adipose-derived MSCs,would be more suitable for overcoming aging-related processes.AIM To assess the efficacy and safety of umbilical cord-derived MSC-CM(UCMSCCM)for preventing and treating skin aging.METHODS In vitro and in vivo studies were conducted to compare UCMSC-CM with ADMSC-CM,the most studied active aging-preventive conditioned medium to date.Additionally,the most effective delivery method of UCMSC-CM for aged skin was identified.RESULTS UCMSC-CM had a higher content of effective factors,stimulated higher proliferation of fibroblasts,and strongly inhibited melanin production in B16F1 cells.In aged mice,UCMSC-CM application increased skin thickness,the number of Ki-67-positive cells,and the area of collagen deposition.UCMSC-CM was more effective than ADMSC-CM in preventing and treating skin aging.Additionally,a safety evaluation of UCMSC-CM performed in various animal models indicated that it was safe even when used directly on the skin.CONCLUSION UCMSC-CM is effective and safe for preventing and treating skin aging.
文摘In our life,we can 4 avoid to make 1 mistakes.So some advice on how to correct them are2 very important and helpful to us.Advice is love from people who care about you.When you are in trouble,good advice can always teach you how to solve it and do better.Advice is the warmest expectation that people who love you give to you.When yon can,t get on well with your friends,good advice can tell you how to understand him'.After listening to others'advice carefully,you will gain friendship and warmth.So,we should accept others'advice instead of refusing it.优点:本文分三段展开:第一段给出论点:建议重要且有用;第二段对论点进行论证:建议是在乎你的人给予你的关爱以及爱护你的人给予你最温暖的期待,认真倾听会得到友谊和温暖;第三段得出结论:接受建议而不拒绝建议。全文结构完整、详略得当、重点突出,是一篇值得借鉴的学生习作。
文摘In this study, polyethylene-terephthalate （PET） nonwovens are treated using an atmospheric plasma and the effects of the treatment time, treatment power and discharge distance on the ability of water-penetration into the nonwovens are investigated. The result indicates that the method can improve the wettability of PET nonwovens remarkably, but the aging decay of the sample＇s wettability is found to be notable as a function of the storage time after treatment due to the internal rotation of the single bond of surface macromolecules. As shown by SEM and XPS analysis, the etching and surface reaction are significant, and water-penetration weight is found to increase remarkably with the increasing power. This variation can be attributed to momentum transfer and enhanced higher-energy particle excitation.
文摘A treat-to-target(T2T)approach applies the principles of early intervention and tight disease control to optimise long-term outcomes in Crohn's disease.The Selecting Therapeutic Targets in Inflammatory Bowel Disease(STRIDE)-II guidelines specify short,intermediate,and long-term treatment goals,documenting specific treatment targets to be achieved at each of these timepoints.Scheduled appraisal of Crohn’s disease activity against pre-defined treatment targets at these timepoints remains central to determining whether current therapy should be continued or modified.Consensus treatment targets in Crohn’s disease comprise combination clinical and patient-reported outcome remission,in conjunction with biomarker normalisation and endoscopic healing.Although the STRIDE-II guidelines endorse the pursuit of endoscopic healing,clinicians must consider that this may not always be appropriate,acceptable,or achievable in all patients.This underscores the need to engage patients at the outset in an effort to personalise care and individualise treatment targets.The use of non-invasive biomarkers such as faecal calprotectin in conjunction with cross-sectional imaging techniques,particularly intestinal ultrasound,holds great promise;as do emerging treatment targets such as transmural healing.Two randomised clinical trials,namely,CALM and STARDUST,have evaluated the efficacy of a T2T approach in achieving endoscopic endpoints in patients with Crohn’s disease.Findings from these studies reflect that patient subgroups and Crohn’s disease characteristics likely to benefit most from a T2T approach,remain to be clarified.Moreover,outside of clinical trials,data pertaining to the real-world effectiveness of a T2T approach remains scare,highlighting the need for pragmatic real-world studies.Despite the obvious promise of a T2T approach,a lack of guidance to support its integration into real-world clinical practice has the potential to limit its uptake.This highlights the need to describe strategies,processes,and models of care capable of supporting the integration and execution of a T2T approach in real-world clinical practice.Hence,this review seeks to examine the current and emerging literature to provide clinicians with practical guidance on how to incorporate the principles of T2T into routine clinical practice for the management of Crohn’s disease.
基金Supported by the National Natural Science Foundation of China:81373724the Joint Innovation Foundation of China Academy of Chinese Medical Sciences:ZZ11-050。
文摘Based on the theory of "regulating body" integrated with "regulating mind",following the principle of "treating the body and mind simultaneously,treating both symptoms and root causes",Prof.Shao-jun WANG adopts flexibly the different techniques,including body acupuncture,wrist-ankle acupuncture,umbilical acupuncture,fire needling,moxibustion,and cupping,etc.for the treatment of psychosomatic skin diseases.According to the manifestations of skin diseases in different stages,she adopts different acupuncture and moxibustion techniques for the comprehensive treatment of psychosomatic skin diseases,including senile pruritus,alopecia areata,neurodermatitis,eczema,urticaria,and acne,on the basis of syndrome differentiation and different acupoint selections,and achieves good results.
文摘The widespread emergence of antibiotic resistance among bacterial pathogens has become one of the most serious challenges in Ethiopia. This study determined the prevalence and drug resistance patterns of bacterial pathogens isolated from treated and untreated wastewater released from Ayder Referral Hospital in Northern Ethiopia. A cross sectional study design was conducted from September-December, 2015 in wastewater released from Ayder referral hospital. A total of 40 composite samples were aseptically collected, transported and processed for enumeration of indicator organisms, bacteriological identification and susceptibility testing following standard procedure. Data obtained were entered and analyzed using SPSS version 20. Mean heterotrophic plate count, total coliform count, fecal coliform count and E. coli count were found to be 1.6 × 106 CFU/mL, 2.2 × 106 CFU/100 mL, 2.0 × 105 CFU/100 mL and 1.1 × 104 CFU/100 mL from treated wastewater respectively. Among the total samples 134 bacterial isolates were detected and [84 (62.7%)] were from untreated wastewater and [50 (37.3%)] were from treated wastewater. The most frequently isolated bacteria from untreated wastewater samples was Klebsiella spp [14 (16.7%)] followed by S. aureus [13 (15.5%)] and P. aeruginosa [12 (14.3%)], similarly in treated wastewater samples Klebsiella spp [10 (20%)], P. aeruginosa [8 (16%)] and S. aureus [8 (16%)] were frequently detected. The overall multi-drug resistance (MDR) in this study was [79/134 (79.1%)]. MDR from untreated wastewater sample was [64/84 (76.2%)] while from treated wastewater sample was [42/50 (84%)] and shows significant difference with (COR: 1.64, 95% CI: 1.15 - 3.29, P: 0.001). It is concluded that treated hospital wastewater contains large numbers of antibiotic resistant bacteria. Therefore, there should be continuous monitoring and evaluation of the effluent quality of the ponds and chlorination of the final effluent should be developed.
基金Chinese Academy of Forestry cooperated with Canada Innovation Investment.
文摘Three concentrations （2.8%, 2.0%, 1.2%） of Ammoniacal Copper Quaternary （ACQ） was selected to treat Lodgepole pine wood for evaluating ACQ treatment on mechanical properties of blue-stained wood. The bending modules of elasticity （MOE）, modules of rupture （MOR）, toughness and shearing strength parallel to grain on tangential surface, are tested according to the criteria GB1927-1943-91. Non-treated sample were also tested according to the same procedure. The results showed that the three groups specimen impregnated by different concentrations of ACQ solution met the AWPA standard 2003 of America （UC4A 6.4g/cm^3）. There were significant difference of toughness between treated wood and non-treated wood （p=0.01）, but there were no statistically significant differences among three concentrations in terms of toughness, and toughness of treated wood was approximately 20% lower than non-treated. MOR, MOE as well as sheafing strength parallel to grain were found to be not significantly different between treated wood and non-treated one, and there were no statistically significant difference among three concentrations of ACQ too. Toughness, MOR, MOE and sheafing strength parallel to grain increased with decrease of concentration of ACQ, but they were hardly affected by ACQ preservatives.
文摘Asthma is characterized by paroxysmaldyspnea,rales in the throat,difficulty in breathing,and inability to lie horizontally.It is commonly seenin children with a weak body constitution,and tendsto be intractable,thus being harmful to the
文摘Nano-TiO2 photocatalytic oxidation was used to perform the advanced treatment of biologically treated chemical comprehensive wastewater. The effects of reaction time,nano-TiO2 dosage and initial p H of the wastewater on the removal rate of COD were tested. The GC/MS and EEM techniques were used to qualitatively analyze organic compounds in the wastewater before and after treatment. The result showed that after the biologically treated chemical comprehensive wastewater was treated by nano-TiO2 photocatalytic oxidation under the conditions of reaction time 3 h,nano-TiO2 dosage 8 g/L,and pH 8. 0,the effluent COD was 61. 9 mg/L and its removal rate was 63. 8%. Additionally,the species of organic pollutants reduced from 12 to 6. Meanwhile,the content of humic-like and fulvic-like substances dropped dramatically.
基金Provincial Science and Technology Research Project of Guangdong(2014A040401043)
文摘Heat-treated wood has good dimensional stability,corrosion resistance and visual quality,but it is prone to mold,which limits its application.Based on the pH value of heat-treated wood,this study examines the factors affecting the pathogenesis causing heat-treated wood mold.Normally,the pH value of the heat-treated wood is between 4.38 and 5.10,which is suitable for the growth of mold.However,the pH of the heat-treated copper-containing material is between 6.63 and 7.12,which deviates the treated wood from the comfortable growth conditions for the mold,thereby reducing the occurrence of mold.
文摘In the area of recycling of spent chromated copper arsenate (CCA)-treated wood, most studies to date have focused on methods of removing/extracting the residual preservative from the wood matrix. It is well recognized that exposure of CCA-treated wood to an acid solution can reverse the CCA fixation process thereby converting the CCA elements into their water-soluble form. The economic viability of the process is enhanced because it can be integrated with other technologies and products (e.g., “green” spray foam insulation, etc.). The market for the “green” CCA is the same as for traditional CCA-the wood treating industry, principally utility poles and pilings. A market research study was conducted to determine the suitability of spent CCA-treated wood as a source for recycled, “green” CCA for manufacturing “green” spray-foam insulation. Specifically, we wanted to discern the attitudes and overall perspectives of buyers/sellers (i.e., utilities and wood treating companies) of CCA preservatives and treated wood products, disposal methods and costs for decommissioned CCA-treated wood, and understand perceptions of and willingness-to-pay for “green” CCA preservatives extracted from the technologies used in this research. Results show that 60% of wood preservative treating respondents and 60% of electric utility company respondents are somewhat or greatly interested in using out-of-service utility poles as feedstock for “green insulation” as part of a new potential business venture.
基金supported in part by grants from the research council of the University of Hong Kongthe Research Grant Committee (RGC) of Hong Kong SAR of China+1 种基金the Open Project of Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine (Grant No. WDCM001)Wong’s donation for modern oncology of Chinese medicine (Project Code: 20006276)
文摘Hepatocellular carcinoma（HCC） is one of leading causes of death in the world. Although various treatments have been developed, the therapeutic side effects are far from desirable. Chinese medicines（CMs, including plants, animal parts and minerals） have drawn a great deal of attention in recent years for their potential in the treatment of HCC. Most studies have shown that CMs may be able to retard HCC progression with multiple actions, either alone or in combination with other conventional therapies to improve quality of life in HCC patients. Additionally, CMs are used for preventing HCC occurrence. The aim of this study is to review the potential prophylactic and curative effects of CMs on human HCC and the possible mechanisms that underlie these pharmacological actions. Publications were collected and reviewed from Pub Med and China National Knowledge Infrastructure from 2000 to 2014. Keywords for literature searches include ＂Chinese medicine＂, ＂Chinese herb＂, ＂traditional Chinese Medicine＂, ＂hepatocellular carcinoma＂ and ＂liver cancer＂. CMs in forms of pure compounds, isolated fractions, and composite formulas are included. Combination therapies are also considered. Both in vitro and in vivo efficacies of CMs are being discussed and the translational potential to bedside is to be discussed with clinical cases, which show the actions of CMs on HCC may include tumor growth inhibition, antimetastatic activities, anti-inflammation, anti-liver cancer stem cells, reversal on multi-drug resistance and induction/reduction of oxidative stress. Multiple types of molecules are found to contribute in the above actions. The review paper indicated that CMs might have potential to both prevent HCC occurrence and retard HCC progression with several molecular targets involved.
基金Project supported by the NSFC Innovation Team Project(No. 40421101)the Hundred Talent Scholar Foundation, Chinese Academy of Sciences(2004)the Tackling-Key Scientific and Technical Program Foudation of Gansu Province (No. JS002-A52-020).
文摘A study was carded out at the Loess Plateau in Dongzhi, China, to test the feasibility of using secondary treatment sewage effluent and to determine whether the water quality would then meet the recommended irrigation norm. Seven crops, including celery, wheat, maize, millet, apples, rapeseed and yellow beans, were tested in the study. Physical and chemical properties of the soil, crop yield and quality and leachate at different soil depths were measured. In most cases, the quality of the crops that made use of treated sewage was not distinctively different from those that did not use treated sewage. However, yields for the former were much higher than they were for the latter. Leachates at different soil depths were analyzed and the results did not show alarming levels of constituents. For a period of approximately 14 months, the treated sewage irrigation had no significant effect on the loess soil and no cases of illness resulting from contact with the treated sewage were reported. With treated sewage irrigation, a slight increase in the organic content of the soil was observed.
基金Universiti Sains Malaysia for the financial support under Short Term Research Grant(Grant No.304/PKIMIA/638056)
文摘The effciency of sodium hydroxide treated rubber (Hevea brasiliensis) leaves powder (NHBL) for removing copper ions from aqueous solutions has been investigated. The e?ects of physicochemical parameters on biosorption capacities such as stirring speed, pH, biosorbent dose, initial concentrations of copper, and ionic strength were studied. The biosorption capacities of NHBL increased with increase in pH, stirring speed and copper concentration but decreased with increase in biosorbent dose and ionic strength. The isotherm study indicated that NHBL fitted well with Langmuir model compared to Freundlich and Dubinin-Radushkevich models. The maximum biosorption capacity determined from Langmuir isotherm was 14.97 mg/g at 27°C. The kinetic study revealed that pseudo- second order model fitted well the kinetic data, while Boyd kinetic model indicated that film diffusion was the main rate determining step in biosorption process. Based on surface area analysis, NHBL has low surface area and categorized as macroporous. Fourier transform infrared (FT-IR) analyses revealed that hydroxyl, carboxyl, and amino are the main functional groups involved in the binding of copper ions. Complexation was one of the main mechanisms for the removal of copper ions as indicated by FT-IR spectra. Ion exchange was another possible mechanism since the ratio of adsorbed cations (Cu2+ and H+) to the released cations (Na+, Ca2+, and Mg2+) from NHBL was almost unity. Copper ions bound on NHBL were able to be desorbed at > 99% using 0.05 mol/L HCl, 0.01 mol/L HNO3, and 0.01 mol/L EDTA solutions.
文摘This study was designed to compare the impact of post and core systems on resistance to fracture of endodontically treated anterior teeth with flared root canals and to assess their fracture pattern. Sixty central incisors were cut horizontally 2 mm coronal to the cementoenamel junction(CEJ). After root canal therapy, teeth were assigned into 6 groups(n = 10 each) based on a post system and used as follows: Group C, non-flared root received size #1 glass fiber posts(Control); Group AP, flared root restored with anatomical post; Group RC, flared root restored with size #1 fiber post and cemented with thick layer of resin cement; Group CR, flared root restored with size #1 and reinforced with composite resin; Group CM, cast post-core; Group CP, CAD/CAM polymer-infiltrated ceramic post and core.Following post cementation, core build-up and crown insertion, the specimens were thermo-cycled up to 10,000 cycles(5 C/55 C; 30 seconds dwell time, 6 seconds transition time) and then statically loaded at 1 mm/minute crosshead speed using a universal testing machine. One-way ANOVA and Tukey HSD post hoc test(α= 0.05) were used for data analysis. Group C recorded significantly higher resistance to fracture values [(826.9±39.1) N] followed by group CP [(793.8±55.6) N] while group RC yielded the lowest fracture resistance values [(586.7±51.4) N]. The resistance to fracture of wide root canals can be enhanced by using one-piece CAM/CAM post and core as an alternative to the use of either glass fiber post, relined with composite resin increasing the thickness of luting cement or the use of cast post and core system. However, this was an in vitro investigation and further in vivo studies are necessary.
基金Project(BK2011618) supported by the Natural Science Foundation of Jiangsu Province, ChinaProject(51108288) supported by the National Natural Science Foundation of China
文摘The improvement of question soils with cement shows great technical, economic and environmental advantages. And interest in introducing electrical resistivity measurement to assess the quality of cement treated soils has increased markedly recently due to its economical, non-destructive, and relatively non-invasive advantages. This work aims to quantify the effect of cement content （aw）, porosity （nt）, and curing time（T） on the electrical resistivity （p） and unconfined compression strength （UCS） of cement treated soil. A series of electrical resistivity tests and UCS tests of cement treated soil specimen after various curing periods were carried out. A modified Archie empirical law was proposed taking into account the effect of cement content and curing period on the electrical resistivity of cement treated soil. The results show that nt/（aw·T） and nt/（aw·T^1/2） ratio are appropriate parameters to assess electrical resistivity and UCS of cement treated soil, respectively. Finally, the relationship between UCS and electrical resistivity was also established.
文摘Hepatocellular carcinoma(HCC) is the most common primary liver malignancy. The treatment of HCC is complex and complicated by the severity of associated chronic liver disease, the stage of HCC, and the clinical condition of the patient. Liver resection(LR) is one of the most efficient treatments for patients with HCC, with an expected 5-year survival of 38%-61% depending on the stage of the disease. Improved liver function assessment, increased understanding of segmental liver anatomy from advanced imaging studies, and surgical technical progress are important factors that have led to reduced mortality in patients with HCC. The indication for LR may be expanded due to emerging evidences from laparoscopic hepatectomies and combined treatments with newly developed chemotherapies. Liver transplantation(LT) is considered as an ideal treatment for removal of existing tumors and the injured/preneoplastic underlying liver tissue with impaired liver function and the risk of multicentric carcinogenesis that results from chronically injured liver. However, LT is restricted to patients with minimal risk of tumor recurrence under immunosuppression. The expansion of criteria for LT in HCC patients is still under trial and discussion. Limited availability of grafts, as well as the risk and the cost of transplantation have led to considerable interest in expansion of the donor pool, living donor-related transplantation, and combined treatment involving LR and LT. This highlight presents evidence concerning recent studies evaluating LR and LT in HCC patients. In addition, alternative therapies for the treatment of early stage tumors and the management of patients on transplant waiting lists are discussed.
