A robust Reynolds-Averaged Navier-Stokes(RANS)based solver is established to predict the complex unsteady aerodynamic characteristics of the Active Flap Control(AFC)rotor.The complex motion with multiple degrees of fr...A robust Reynolds-Averaged Navier-Stokes(RANS)based solver is established to predict the complex unsteady aerodynamic characteristics of the Active Flap Control(AFC)rotor.The complex motion with multiple degrees of freedom of the Trailing Edge Flap(TEF)is analyzed by employing an inverse nested overset grid method.Simulation of non-rotational and rotational modes of blade motion are carried out to investigate the formation and development of TEF shedding vortex with high-frequency deflection of TEF.Moreover,the mechanism of TEF deflection interference with blade tip vortex and overall rotor aerodynamics is also explored.In nonrotational mode,two bundles of vortices form at the gap ends of TEF and the main blade and merge into a single TEF vortex.Dynamic deflection of the TEF significantly interferes with the blade tip vortex.The position of the blade tip vortex consistently changes,and its frequency is directly related to the frequency of TEF deflection.In rotational mode,the tip vortex forms a helical structure.The end vortices at the gap sides co-swirl and subsequently merge into the concentrated beam of tip vortices,causing fluctuations in the vorticity and axial position of the tip vortex under the rotor.This research concludes with the investigation on suppression of Blade Vortex Interaction(BVI),showing an increase in miss distance and reduction in the vorticity of tip vortex through TEF phase control at a particular control frequency.Through this mechanism,a designed TEF deflection law increases the miss distance by 34.7%and reduces vorticity by 11.9%at the target position,demonstrating the effectiveness of AFC in mitigating BVI.展开更多
Vortex-induced vibration of hydrofoils is concerned with structural safety and noise level in hydraulic machinery and marine engineering.The research on vibration characteristics under different operating conditions i...Vortex-induced vibration of hydrofoils is concerned with structural safety and noise level in hydraulic machinery and marine engineering.The research on vibration characteristics under different operating conditions is significant.In this study,numerical simulations are conducted to investigate the vortex-induced vibration responses of an elastically suspended hydrofoil with blunt trailing edge in pitch direction.The work studies the effects of four parameters,namely the structural natural frequency,mass ratio,initial attack angle,and Reynolds number on vibration characteristics,with special emphasis on frequency lock-in.Results indicate that as the structural natural frequency changes,the vibration amplitude may increase substantially within a certain frequency range,in which the vortex shedding frequency locks into the structural natural frequency,and frequency lock-in occurs.In addition,with increasing the mass ratio,the frequency range of lock-in becomes narrower,and both the upper and lower thresholds decrease.As the initial attack angle increases from 0◦to 6◦,the lock-in range gets reduced.Over the three Reynolds numbers(6×10^(5),9×10^(5),and 12×10^(5)),the lock-in range remains virtually unchanged.Moreover,for a certain structural natural frequency,modifying the mass ratio,initial attack angle,and Reynolds number could effectively suppress the vibration amplitude.展开更多
Biomimetics has recently emerged as an interesting approach to enhance renewable energy technologies.In this work,bioinspired Trailing Edge Serrations(TES)were evaluated on a typical Vertical Axis Wind Turbine(VAWT)ai...Biomimetics has recently emerged as an interesting approach to enhance renewable energy technologies.In this work,bioinspired Trailing Edge Serrations(TES)were evaluated on a typical Vertical Axis Wind Turbine(VAWT)airfoil,the DU06-W200.As noise reduction benefits of these mechanisms are already well-established,this study focuses on their impact on airfoil and VAWT performance.A saw-tooth geometry was chosen based on VAWT specifications and existing research,followed by a detailed assessment through wind tunnel tests using a newly developed aerodynamic balance.For a broad spectrum of attack angles and Reynolds numbers,lift,drag,and pitching moments were carefully measured.The results show that TES enhance the lift-to-drag ratio,especially in stalled conditions,and postpone stall at negative angles,expanding the effective performance range.A notable increase in pitching moment also is also observed,relevant for blade-strut joint design.Additionally,the impact on turbine performance was estimated using an analytical model,demonstrating excellent accuracy when compared against previous experimental results.TES offer a modest 2%improve-ment in peak performance,though they slightly narrow the optimal tip-speed ratio zone.Despite this,the potential noise reduction and performance gains make TES a valuable addition to VAWT designs,especially in urban settings.展开更多
This paper presents the design and manufacturing of a new morphing wing system carried out at the Laboratory of Applied Research in Active Controls, Avionics and AeroServoElasticity(LARCASE) at the ETS in Montréa...This paper presents the design and manufacturing of a new morphing wing system carried out at the Laboratory of Applied Research in Active Controls, Avionics and AeroServoElasticity(LARCASE) at the ETS in Montréal. This first version of a morphing wing allows the deformation of its trailing edge, denote by Morphing Trailing Edge(MTE). In order to characterize the technical impact of this deformation, we compare its performance with that of a rigid aileron by testing in the LARCASE’s price-Pa?doussis subsonic wind tunnel. The first set of results shows that it is possible to replace an aileron by a MTE on a wing, as an improvement was observed for the MTE aerodynamic performances with respect to the aileron aerodynamic performances.The improvement consisted in the fact that the drag coefficient was smaller, and the lift-to-drag ratio was higher for the same lift coefficient.展开更多
Morphing wing has attracted many research attention and effort in aircraft technology development because of its advantage in lift to draft ratio and flight performance.Morphing wing technology combines the lift and c...Morphing wing has attracted many research attention and effort in aircraft technology development because of its advantage in lift to draft ratio and flight performance.Morphing wing technology combines the lift and control surfaces into a seamless wing and integrates the primary structure together with the internal control system.It makes use of the wing aeroelastic deformation induced by the control surface to gain direct force control through desirable redistribution of aerodynamic forces.However some unknown mechanical parameters of the control system and complexity of the integrated structure become a main challenge for dynamic modeling of morphing wing.To solve the problem,a method of test data based modal sensitivity analysis is presented to improve the morphing wing FE model by evaluating the unknown parameters and identifying the modeling boundary conditions.An innovative seamless morphing wing with the structure integrated with a flexible trailing edge control system is presented for the investigation.An experimental model of actuation system driven by a servo motor for the morphing wing is designed and established.By performing a vibration test and the proposed modal sensitivity analysis,the unknown torsional stiffness of the servo motor and the boundary condition of the actuation mechanism model is identified and evaluated.Comparing with the test data,the average error of the first four modal frequency of the improved FE model is reduced significantly to less than 4%.To further investigate the morphing wing modeling,a wing box and then a whole morphing wing model including the skin and integrated with the trailing edge actuation system are established and tested.By using the proposed method,the FE model is improved by relaxing the constraint between the skin and actuation mechanism.The results show that the average error of the first three modal frequency of the improved FE model is reduced to less than 6%.The research results demonstrate that the presented seamless morphing wing integrated with a flexible trailing edge control surface can improve aerodynamic characteristics.By using the test data based modal sensitivity analysis method,the unknown parameter and boundary condition of the actuation model can be determined to improve the FE model.The problem in dynamic modeling of high accuracy for a morphing wing can be solved in an effective manner.展开更多
Flagstaff Urban Trails System(FUTS) is a city-wide network of non-motorized, shared-use pathways that are used by bicyclists, walkers, hikers, runners, and other users for both recreation and transportation. FUTS tota...Flagstaff Urban Trails System(FUTS) is a city-wide network of non-motorized, shared-use pathways that are used by bicyclists, walkers, hikers, runners, and other users for both recreation and transportation. FUTS totals 79.2 km in Flagstaff, the Flagstaff government approved the fi rst plan in 1988, and FUTS Trail Priority Evaluation 2011 outlined the evaluation criteria, trail rankings and ranking results The new FUTS Master Plan shows about 130-km planned trails, and creates an ultimate trail system about 210 km. FUTS management organization and Transportation Tax Program is the key to keep the successful works of FUTS. Status quo of China National Trails System(CNTS) is reviewed as: scenic areas have relatively sound trail systems, but there is no any standard system; green corridors within the urban and rural system become popular, but there is no connection system. The development of China National Trails System can be promoted in 3 aspects: establishing national trails system, planning and design trails comprehensively, stressing daily operation and management.展开更多
Objective Individuals with pulmonary hypertension(PH)have reduced exercise capacity and quality of life.Exercise-based rehabilitation may have beneficial effects to improve the exercise capacity and quality of life in...Objective Individuals with pulmonary hypertension(PH)have reduced exercise capacity and quality of life.Exercise-based rehabilitation may have beneficial effects to improve the exercise capacity and quality of life in patients with PH.We aim to assess the efficacy and safety of exercised-based rehabilitation for people eith PH by performing a randomized controlled trails(RCTs)meta-analysis of exercised-based rehabilitation for people with PH by performing a randomized controlled trails meta-analysis.展开更多
The seamless trailing edge morphing flap is investigated using a high-fidelity steady-state aerodynamic shape optimization to determine its optimum configuration for different flight conditions,including climb,cruise,...The seamless trailing edge morphing flap is investigated using a high-fidelity steady-state aerodynamic shape optimization to determine its optimum configuration for different flight conditions,including climb,cruise,and gliding descent.A comparative study is also conducted between a wing equipped with morphing flap and a wing with conventional hinged flap.The optimization is performed by specifying a certain objective function and the flight performance goal for each flight condition.Increasing the climb rate,extending the flight range and endurance in cruise,and decreasing the descend rate,are the flight performance goals covered in this study.Various optimum configurations were found for the morphing wing by determining the optimum morphing flap deflection for each flight condition,based on its objective function,each of which performed better than that of the baseline wing.It was shown that by using optimum configuration for the morphing wing in climb condition,the required power could be reduced by up to 3.8%and climb rate increases by 6.13%.The comparative study also revealed that the morphing wing enhances aerodynamic efficiency by up to 17.8%and extends the laminar flow.Finally,the optimum configuration for the gliding descent brought about a 43%reduction in the descent rate.展开更多
Background:Despite significant advancements in the development of anticancer therapies over the past few decades,the clinical management of colorectal cancer remains a challenging task.This study aims to investigate t...Background:Despite significant advancements in the development of anticancer therapies over the past few decades,the clinical management of colorectal cancer remains a challenging task.This study aims to investigate the inhibitory effects of cancer-targeting liposomes against colorectal cancer.Materials and Methods:Liposomes consisting of 3β-[N-(N′,N′-dimethylamino ethane)carbamoyl]-cholesterol(DC-CHOL),cholesterol(CHOL),and dioleoylphosphatidylethanolamine(DOPE)at a molar ratio of 1:1:0.5 were created and used as carriers to deliver an apoptosis-inducing plasmid encoding the tumor necrosis factor-related apoptosis-inducing ligand(pTRAIL)gene,along with the toll-like receptor(TLR7)agonist Rsiquimod(R848).The rationale behind this design is that pTRAIL can trigger cancer cell apoptosis by activating the DR4/5 receptor,while R848 can stimulate the immune microenvironment.Results:Experimental results demonstrated the synergistic effects of R848 and pTRAIL encapsulated by liposomes(RTL)in suppressing the proliferation of colorectal cancer cells.Moreover,further in vivo investigations revealed the strong anti-tumor efficacy of RTL in xenograft and orthotropic in situ models of colorectal cancer.Conclusions:These findings collectively highlight the therapeutic potential of R848/pTRAIL-loaded liposomes in the treatment of colorectal cancer.展开更多
Cultural ancient roads,known in Chinese as gudao,serve as heritage trails that carry historical exchanges across various regions in China.Due to their extensive preservation,wide geographical distribution,diverse them...Cultural ancient roads,known in Chinese as gudao,serve as heritage trails that carry historical exchanges across various regions in China.Due to their extensive preservation,wide geographical distribution,diverse thematic variations,and considerable tourist appeal,these paths have emerged as representative heritage trails,increasingly transforming into a novel tourism product experience that is highly favored by tourists and recognized by government authorities.However,research on ancient roads for tourism in China currently lacks a systematic theoretical framework,as well as relevant policies,regulations,and standards to guide their practical development.Therefore,there is a pressing need to draw upon international best practices and conduct foundational research to develop an experience element system that aligns with the perceptions,behaviors,and consumption characteristics of Chinese tourists,thereby advancing theoretical exploration in this field.This study focuses on the representative Ancient Shu Road as a case study and employs a mixed-method approach that integrates qualitative and quantitative research.It aims to construct a tourist-centric scale for the experience elements of ancient road tourism while analyzing the interactive relationship between these experience elements and tourist needs.This study addresses a significant gap in the development of indicator systems for domestic studies of ancient road tourism experiences.Ultimately,the study establishes a comprehensive scale that encompasses three core categories—trail resources and environment,facilities and services,and modes of tourism activities—along with eight primary dimensions:core resources,surrounding cultural environment,surrounding natural environment,tourism reception facilities and services,infrastructure and support services,information facilities and information services,and outdoor and recreational activities.This scale consists of thirty-two specific items,providing a robust reference for future research endeavors.Additionally,the study proposes specific development strategies related to key mechanisms,spatial configuration,and facility construction to enhance the overall development of ancient road tourism.展开更多
Based on the further analysis of trail's concept,trail tourist attractions was proposed as a new concept,and the 5-dimension(trail resource,trail operation,trail technology,trail management and trail economic inde...Based on the further analysis of trail's concept,trail tourist attractions was proposed as a new concept,and the 5-dimension(trail resource,trail operation,trail technology,trail management and trail economic index) theoretical assessment framework for trail tourist attractions was established. Trail route selection,trail pavement and trail management grade were taken for example to explain the specifications for these secondary indexes. The future research should expand the index system to cover all secondary indexes of the 5 dimensions,put the concept of trail tourist attractions into tourism planning practices,and provide examples for the construction of trail tourist attractions across the country. Proposal of the concept of trail tourist attractions and its assessment standards is an attempt and innovation in the development of scenic areas,and will possibly result in the new development rules of scenic areas.展开更多
Hiking trails are a basic type of tourist infrastructure,which,on the one hand,make areas available for tourist traffic,and on the other hand,can contribute to the protection of the natural environment(if they are wel...Hiking trails are a basic type of tourist infrastructure,which,on the one hand,make areas available for tourist traffic,and on the other hand,can contribute to the protection of the natural environment(if they are well designed and maintained).Owing to the variety of performed functions,their designation is determined by several factors:natural,technical,economic,social.Networks of trails change constantly.The aim of this article is to determine exactly what factors influence transformations within the hiking trail networks and what is their significance.To this end,three study areas in the Sudetes were analysed:one on the Polish side of the Sudetes-the Table(Stołowe)Mountains,and two on the Czech side-the rock town near the village of Sloup vČechách and the central part of Zlatohorskávrchovina.An analysis of changes in the shape of the networks over time was carried out,as well as surveys of institutions that were responsible for or influenced these transformations.These areas are characterised by a significant level of changes in the trail network.Among the factors influencing these changes,the tourist attractiveness of the area,the resilience of the environment,the intensity of tourism traffic,the environmental transformations associated with it,the history of tourism development and land ownership changes should be considered the most important.At each stage of forming networks,the key factor should be tourists’needs,including the desire to escape the urbanised environment.For this reason,trails should avoid roads with artificial(hard)surfaces and heavy automobile traffic.展开更多
BACKGROUND Several studies have reported that the walking trail making test(WTMT)completion time is significantly higher in patients with developmental coordination disorders and mild cognitive impairments.We hypothes...BACKGROUND Several studies have reported that the walking trail making test(WTMT)completion time is significantly higher in patients with developmental coordination disorders and mild cognitive impairments.We hypothesized that WTMT performance would be altered in older adults with white matter hyperintensities(WMH).AIM To explore the performance in the WTMT in older people with WMH.METHODS In this single-center,observational study,25 elderly WMH patients admitted to our hospital from June 2019 to June 2020 served as the WMH group and 20 participants matched for age,gender,and educational level who were undergoing physical examination in our hospital during the same period served as the control group.The participants completed the WTMT-A and WTMT-B to obtain their gait parameters,including WTMT-A completion time,WTMT-B completion time,speed,step length,cadence,and stance phase percent.White matter lesions were scored according to the Fazekas scale.Multiple neuropsychological assessments were carried out to assess cognitive function.The relationships between WTMT performance and cognition and motion in elderly patients with WMH were analyzed by partial Pearson correlation analysis.RESULTS Patients with WMH performed significantly worse on the choice reaction test(CRT)(0.51±0.09 s vs 0.44±0.06 s,P=0.007),verbal fluency test(VFT,14.2±2.75 vs 16.65±3.54,P=0.012),and digit symbol substitution test(16.00±2.75 vs 18.40±3.27,P=0.010)than participants in the control group.The WMH group also required significantly more time to complete the WTMT-A(93.00±10.76 s vs 70.55±11.28 s,P<0.001)and WTMT-B(109.72±12.26 s vs 82.85±7.90 s,P<0.001).WTMT-A completion time was positively correlated with CRT time(r=0.460,P=0.001),while WTMT-B completion time was negatively correlated with VFT(r=-0.391,P=0.008).On the WTMT-A,only speed was found to statistically differ between the WMH and control groups(0.803±0.096 vs 0.975±0.050 m/s,P<0.001),whereas on the WTMT-B,the WMH group exhibited a significantly lower speed(0.778±0.111 vs 0.970±0.053 m/s,P<0.001)and cadence(82.600±4.140 vs 85.500±5.020 steps/m,P=0.039),as well as a higher stance phase percentage(65.061±1.813%vs 63.513±2.465%,P=0.019)relative to controls.CONCLUSION Older adults with WMH showed obviously poorer WTMT performance.WTMT could be a potential indicator for cognitive and motor deficits in patients with WMH.展开更多
Xiamen,a coastal city famous for its impressive seascape,draws numerous tourists each year.One of the prime locations to appreciate the city’s beauty is the Mountains-to-Sea Trail,an approximately 23-kilometer-long p...Xiamen,a coastal city famous for its impressive seascape,draws numerous tourists each year.One of the prime locations to appreciate the city’s beauty is the Mountains-to-Sea Trail,an approximately 23-kilometer-long pedestrian corridor that offers a unique experience for visitors.展开更多
基金supported by the National Natural Science Foundation of China(No.11972190)。
文摘A robust Reynolds-Averaged Navier-Stokes(RANS)based solver is established to predict the complex unsteady aerodynamic characteristics of the Active Flap Control(AFC)rotor.The complex motion with multiple degrees of freedom of the Trailing Edge Flap(TEF)is analyzed by employing an inverse nested overset grid method.Simulation of non-rotational and rotational modes of blade motion are carried out to investigate the formation and development of TEF shedding vortex with high-frequency deflection of TEF.Moreover,the mechanism of TEF deflection interference with blade tip vortex and overall rotor aerodynamics is also explored.In nonrotational mode,two bundles of vortices form at the gap ends of TEF and the main blade and merge into a single TEF vortex.Dynamic deflection of the TEF significantly interferes with the blade tip vortex.The position of the blade tip vortex consistently changes,and its frequency is directly related to the frequency of TEF deflection.In rotational mode,the tip vortex forms a helical structure.The end vortices at the gap sides co-swirl and subsequently merge into the concentrated beam of tip vortices,causing fluctuations in the vorticity and axial position of the tip vortex under the rotor.This research concludes with the investigation on suppression of Blade Vortex Interaction(BVI),showing an increase in miss distance and reduction in the vorticity of tip vortex through TEF phase control at a particular control frequency.Through this mechanism,a designed TEF deflection law increases the miss distance by 34.7%and reduces vorticity by 11.9%at the target position,demonstrating the effectiveness of AFC in mitigating BVI.
基金the National Natural Science Foundation of China(Nos.52171316 and 51479116)。
文摘Vortex-induced vibration of hydrofoils is concerned with structural safety and noise level in hydraulic machinery and marine engineering.The research on vibration characteristics under different operating conditions is significant.In this study,numerical simulations are conducted to investigate the vortex-induced vibration responses of an elastically suspended hydrofoil with blunt trailing edge in pitch direction.The work studies the effects of four parameters,namely the structural natural frequency,mass ratio,initial attack angle,and Reynolds number on vibration characteristics,with special emphasis on frequency lock-in.Results indicate that as the structural natural frequency changes,the vibration amplitude may increase substantially within a certain frequency range,in which the vortex shedding frequency locks into the structural natural frequency,and frequency lock-in occurs.In addition,with increasing the mass ratio,the frequency range of lock-in becomes narrower,and both the upper and lower thresholds decrease.As the initial attack angle increases from 0◦to 6◦,the lock-in range gets reduced.Over the three Reynolds numbers(6×10^(5),9×10^(5),and 12×10^(5)),the lock-in range remains virtually unchanged.Moreover,for a certain structural natural frequency,modifying the mass ratio,initial attack angle,and Reynolds number could effectively suppress the vibration amplitude.
基金The authors wish to thank the financial support of the Spanish Ministry of Science,Innovation and Universities in reference to the Project:Efficiency improvement and noise reduction of a vertical axis wind turbine for urban environments(MERTURB)-Ref.MCINN-22-TED2021-131307B-100.
文摘Biomimetics has recently emerged as an interesting approach to enhance renewable energy technologies.In this work,bioinspired Trailing Edge Serrations(TES)were evaluated on a typical Vertical Axis Wind Turbine(VAWT)airfoil,the DU06-W200.As noise reduction benefits of these mechanisms are already well-established,this study focuses on their impact on airfoil and VAWT performance.A saw-tooth geometry was chosen based on VAWT specifications and existing research,followed by a detailed assessment through wind tunnel tests using a newly developed aerodynamic balance.For a broad spectrum of attack angles and Reynolds numbers,lift,drag,and pitching moments were carefully measured.The results show that TES enhance the lift-to-drag ratio,especially in stalled conditions,and postpone stall at negative angles,expanding the effective performance range.A notable increase in pitching moment also is also observed,relevant for blade-strut joint design.Additionally,the impact on turbine performance was estimated using an analytical model,demonstrating excellent accuracy when compared against previous experimental results.TES offer a modest 2%improve-ment in peak performance,though they slightly narrow the optimal tip-speed ratio zone.Despite this,the potential noise reduction and performance gains make TES a valuable addition to VAWT designs,especially in urban settings.
基金NSERC for the Canada Research Chair in Aircraft Modeling and Simulation New Technologies Funding
文摘This paper presents the design and manufacturing of a new morphing wing system carried out at the Laboratory of Applied Research in Active Controls, Avionics and AeroServoElasticity(LARCASE) at the ETS in Montréal. This first version of a morphing wing allows the deformation of its trailing edge, denote by Morphing Trailing Edge(MTE). In order to characterize the technical impact of this deformation, we compare its performance with that of a rigid aileron by testing in the LARCASE’s price-Pa?doussis subsonic wind tunnel. The first set of results shows that it is possible to replace an aileron by a MTE on a wing, as an improvement was observed for the MTE aerodynamic performances with respect to the aileron aerodynamic performances.The improvement consisted in the fact that the drag coefficient was smaller, and the lift-to-drag ratio was higher for the same lift coefficient.
基金supported by National Natural Science Foundation of China (Grant No. 11102019)
文摘Morphing wing has attracted many research attention and effort in aircraft technology development because of its advantage in lift to draft ratio and flight performance.Morphing wing technology combines the lift and control surfaces into a seamless wing and integrates the primary structure together with the internal control system.It makes use of the wing aeroelastic deformation induced by the control surface to gain direct force control through desirable redistribution of aerodynamic forces.However some unknown mechanical parameters of the control system and complexity of the integrated structure become a main challenge for dynamic modeling of morphing wing.To solve the problem,a method of test data based modal sensitivity analysis is presented to improve the morphing wing FE model by evaluating the unknown parameters and identifying the modeling boundary conditions.An innovative seamless morphing wing with the structure integrated with a flexible trailing edge control system is presented for the investigation.An experimental model of actuation system driven by a servo motor for the morphing wing is designed and established.By performing a vibration test and the proposed modal sensitivity analysis,the unknown torsional stiffness of the servo motor and the boundary condition of the actuation mechanism model is identified and evaluated.Comparing with the test data,the average error of the first four modal frequency of the improved FE model is reduced significantly to less than 4%.To further investigate the morphing wing modeling,a wing box and then a whole morphing wing model including the skin and integrated with the trailing edge actuation system are established and tested.By using the proposed method,the FE model is improved by relaxing the constraint between the skin and actuation mechanism.The results show that the average error of the first three modal frequency of the improved FE model is reduced to less than 6%.The research results demonstrate that the presented seamless morphing wing integrated with a flexible trailing edge control surface can improve aerodynamic characteristics.By using the test data based modal sensitivity analysis method,the unknown parameter and boundary condition of the actuation model can be determined to improve the FE model.The problem in dynamic modeling of high accuracy for a morphing wing can be solved in an effective manner.
基金Supported by the Human and Social Science Foundation of China Education Ministry(11YJC850004)National Philosophy and Social Science Project(13BJY145)Art Science Planning Project of Jiangxi Province(YG2013004)
文摘Flagstaff Urban Trails System(FUTS) is a city-wide network of non-motorized, shared-use pathways that are used by bicyclists, walkers, hikers, runners, and other users for both recreation and transportation. FUTS totals 79.2 km in Flagstaff, the Flagstaff government approved the fi rst plan in 1988, and FUTS Trail Priority Evaluation 2011 outlined the evaluation criteria, trail rankings and ranking results The new FUTS Master Plan shows about 130-km planned trails, and creates an ultimate trail system about 210 km. FUTS management organization and Transportation Tax Program is the key to keep the successful works of FUTS. Status quo of China National Trails System(CNTS) is reviewed as: scenic areas have relatively sound trail systems, but there is no any standard system; green corridors within the urban and rural system become popular, but there is no connection system. The development of China National Trails System can be promoted in 3 aspects: establishing national trails system, planning and design trails comprehensively, stressing daily operation and management.
文摘Objective Individuals with pulmonary hypertension(PH)have reduced exercise capacity and quality of life.Exercise-based rehabilitation may have beneficial effects to improve the exercise capacity and quality of life in patients with PH.We aim to assess the efficacy and safety of exercised-based rehabilitation for people eith PH by performing a randomized controlled trails(RCTs)meta-analysis of exercised-based rehabilitation for people with PH by performing a randomized controlled trails meta-analysis.
基金the Hydra Technologies team in Mexicothe CREATEUTILI Program for their financial support。
文摘The seamless trailing edge morphing flap is investigated using a high-fidelity steady-state aerodynamic shape optimization to determine its optimum configuration for different flight conditions,including climb,cruise,and gliding descent.A comparative study is also conducted between a wing equipped with morphing flap and a wing with conventional hinged flap.The optimization is performed by specifying a certain objective function and the flight performance goal for each flight condition.Increasing the climb rate,extending the flight range and endurance in cruise,and decreasing the descend rate,are the flight performance goals covered in this study.Various optimum configurations were found for the morphing wing by determining the optimum morphing flap deflection for each flight condition,based on its objective function,each of which performed better than that of the baseline wing.It was shown that by using optimum configuration for the morphing wing in climb condition,the required power could be reduced by up to 3.8%and climb rate increases by 6.13%.The comparative study also revealed that the morphing wing enhances aerodynamic efficiency by up to 17.8%and extends the laminar flow.Finally,the optimum configuration for the gliding descent brought about a 43%reduction in the descent rate.
基金approved by the Institutional Animal Care and Use Committee(IACUC)of the First Affiliated Hospital of Fujian Medical University(No.2023048).
文摘Background:Despite significant advancements in the development of anticancer therapies over the past few decades,the clinical management of colorectal cancer remains a challenging task.This study aims to investigate the inhibitory effects of cancer-targeting liposomes against colorectal cancer.Materials and Methods:Liposomes consisting of 3β-[N-(N′,N′-dimethylamino ethane)carbamoyl]-cholesterol(DC-CHOL),cholesterol(CHOL),and dioleoylphosphatidylethanolamine(DOPE)at a molar ratio of 1:1:0.5 were created and used as carriers to deliver an apoptosis-inducing plasmid encoding the tumor necrosis factor-related apoptosis-inducing ligand(pTRAIL)gene,along with the toll-like receptor(TLR7)agonist Rsiquimod(R848).The rationale behind this design is that pTRAIL can trigger cancer cell apoptosis by activating the DR4/5 receptor,while R848 can stimulate the immune microenvironment.Results:Experimental results demonstrated the synergistic effects of R848 and pTRAIL encapsulated by liposomes(RTL)in suppressing the proliferation of colorectal cancer cells.Moreover,further in vivo investigations revealed the strong anti-tumor efficacy of RTL in xenograft and orthotropic in situ models of colorectal cancer.Conclusions:These findings collectively highlight the therapeutic potential of R848/pTRAIL-loaded liposomes in the treatment of colorectal cancer.
文摘Cultural ancient roads,known in Chinese as gudao,serve as heritage trails that carry historical exchanges across various regions in China.Due to their extensive preservation,wide geographical distribution,diverse thematic variations,and considerable tourist appeal,these paths have emerged as representative heritage trails,increasingly transforming into a novel tourism product experience that is highly favored by tourists and recognized by government authorities.However,research on ancient roads for tourism in China currently lacks a systematic theoretical framework,as well as relevant policies,regulations,and standards to guide their practical development.Therefore,there is a pressing need to draw upon international best practices and conduct foundational research to develop an experience element system that aligns with the perceptions,behaviors,and consumption characteristics of Chinese tourists,thereby advancing theoretical exploration in this field.This study focuses on the representative Ancient Shu Road as a case study and employs a mixed-method approach that integrates qualitative and quantitative research.It aims to construct a tourist-centric scale for the experience elements of ancient road tourism while analyzing the interactive relationship between these experience elements and tourist needs.This study addresses a significant gap in the development of indicator systems for domestic studies of ancient road tourism experiences.Ultimately,the study establishes a comprehensive scale that encompasses three core categories—trail resources and environment,facilities and services,and modes of tourism activities—along with eight primary dimensions:core resources,surrounding cultural environment,surrounding natural environment,tourism reception facilities and services,infrastructure and support services,information facilities and information services,and outdoor and recreational activities.This scale consists of thirty-two specific items,providing a robust reference for future research endeavors.Additionally,the study proposes specific development strategies related to key mechanisms,spatial configuration,and facility construction to enhance the overall development of ancient road tourism.
基金Sponsored by "Twelfth Five-year Plan" Program of Guangdong Provincial Philosophy and Social Sciences(GD15XLS07)
文摘Based on the further analysis of trail's concept,trail tourist attractions was proposed as a new concept,and the 5-dimension(trail resource,trail operation,trail technology,trail management and trail economic index) theoretical assessment framework for trail tourist attractions was established. Trail route selection,trail pavement and trail management grade were taken for example to explain the specifications for these secondary indexes. The future research should expand the index system to cover all secondary indexes of the 5 dimensions,put the concept of trail tourist attractions into tourism planning practices,and provide examples for the construction of trail tourist attractions across the country. Proposal of the concept of trail tourist attractions and its assessment standards is an attempt and innovation in the development of scenic areas,and will possibly result in the new development rules of scenic areas.
文摘Hiking trails are a basic type of tourist infrastructure,which,on the one hand,make areas available for tourist traffic,and on the other hand,can contribute to the protection of the natural environment(if they are well designed and maintained).Owing to the variety of performed functions,their designation is determined by several factors:natural,technical,economic,social.Networks of trails change constantly.The aim of this article is to determine exactly what factors influence transformations within the hiking trail networks and what is their significance.To this end,three study areas in the Sudetes were analysed:one on the Polish side of the Sudetes-the Table(Stołowe)Mountains,and two on the Czech side-the rock town near the village of Sloup vČechách and the central part of Zlatohorskávrchovina.An analysis of changes in the shape of the networks over time was carried out,as well as surveys of institutions that were responsible for or influenced these transformations.These areas are characterised by a significant level of changes in the trail network.Among the factors influencing these changes,the tourist attractiveness of the area,the resilience of the environment,the intensity of tourism traffic,the environmental transformations associated with it,the history of tourism development and land ownership changes should be considered the most important.At each stage of forming networks,the key factor should be tourists’needs,including the desire to escape the urbanised environment.For this reason,trails should avoid roads with artificial(hard)surfaces and heavy automobile traffic.
基金Supported by The Wu Jieping Medical Foundation,No.320.6750.18456.
文摘BACKGROUND Several studies have reported that the walking trail making test(WTMT)completion time is significantly higher in patients with developmental coordination disorders and mild cognitive impairments.We hypothesized that WTMT performance would be altered in older adults with white matter hyperintensities(WMH).AIM To explore the performance in the WTMT in older people with WMH.METHODS In this single-center,observational study,25 elderly WMH patients admitted to our hospital from June 2019 to June 2020 served as the WMH group and 20 participants matched for age,gender,and educational level who were undergoing physical examination in our hospital during the same period served as the control group.The participants completed the WTMT-A and WTMT-B to obtain their gait parameters,including WTMT-A completion time,WTMT-B completion time,speed,step length,cadence,and stance phase percent.White matter lesions were scored according to the Fazekas scale.Multiple neuropsychological assessments were carried out to assess cognitive function.The relationships between WTMT performance and cognition and motion in elderly patients with WMH were analyzed by partial Pearson correlation analysis.RESULTS Patients with WMH performed significantly worse on the choice reaction test(CRT)(0.51±0.09 s vs 0.44±0.06 s,P=0.007),verbal fluency test(VFT,14.2±2.75 vs 16.65±3.54,P=0.012),and digit symbol substitution test(16.00±2.75 vs 18.40±3.27,P=0.010)than participants in the control group.The WMH group also required significantly more time to complete the WTMT-A(93.00±10.76 s vs 70.55±11.28 s,P<0.001)and WTMT-B(109.72±12.26 s vs 82.85±7.90 s,P<0.001).WTMT-A completion time was positively correlated with CRT time(r=0.460,P=0.001),while WTMT-B completion time was negatively correlated with VFT(r=-0.391,P=0.008).On the WTMT-A,only speed was found to statistically differ between the WMH and control groups(0.803±0.096 vs 0.975±0.050 m/s,P<0.001),whereas on the WTMT-B,the WMH group exhibited a significantly lower speed(0.778±0.111 vs 0.970±0.053 m/s,P<0.001)and cadence(82.600±4.140 vs 85.500±5.020 steps/m,P=0.039),as well as a higher stance phase percentage(65.061±1.813%vs 63.513±2.465%,P=0.019)relative to controls.CONCLUSION Older adults with WMH showed obviously poorer WTMT performance.WTMT could be a potential indicator for cognitive and motor deficits in patients with WMH.
文摘Xiamen,a coastal city famous for its impressive seascape,draws numerous tourists each year.One of the prime locations to appreciate the city’s beauty is the Mountains-to-Sea Trail,an approximately 23-kilometer-long pedestrian corridor that offers a unique experience for visitors.
