Editorial Policy Asian Journal of Traditional Medicines is an international journal devoted to the advancement of research on traditional medicines.The followed areas are covered:scientific and technological developme...Editorial Policy Asian Journal of Traditional Medicines is an international journal devoted to the advancement of research on traditional medicines.The followed areas are covered:scientific and technological developments and research achievements in the fields of traditional medicine resources,medicinal material processing,pharmacognosy,natural medicinal chemistry,quality control,pharmacology,pharmacy,and clinical efficacy.展开更多
Cancer pain is one of the most prevalent and debilitating symptoms in patients with advanced malignancies,arising from multifactorial mechanisms involving peripheral,central,and systemic pathways.Conventional analgesi...Cancer pain is one of the most prevalent and debilitating symptoms in patients with advanced malignancies,arising from multifactorial mechanisms involving peripheral,central,and systemic pathways.Conventional analgesics,including opioids and nonsteroidal anti-inflammatory drugs,are often limited by their insufficient efficacy,tolerance,and risk of dependence.Traditional Chinese Medicine(TCM),characterized by its multi-component,multi-target,and systemic regulatory properties,has shown promising potential in cancer pain management.This review provides a comprehensive overview of the clinical classification and underlying mechanisms of cancer pain(including nerve infiltration,dysregulation of inflammatory mediators and ion channels,central sensitization,neuro-immune crosstalk,metabolic reprogramming,and gut-brain axis impairment),as well as the analgesic effects of representative TCM agents in cancer pain management.For example,bioactive components such as tetrahydroberberine,levo-tetrahydropalmatine,and piperine exert analgesic effects,thereby improving the quality of life of patients by inhibiting inflammatory cascades,regulating neurotransmitter systems,and preserving neural integrity.Commonly used preclinical models,including bone cancer pain,pancreatic cancer pain,and chemotherapy-induced peripheral neuropathy models,are summarized for their utility in mechanistic studies and efficacy evaluations.This review also discusses the current limitations of clinical evidence,such as small sample sizes,short follow-up periods,and limited translation from animal models,alongside major challenges in standardization,mechanistic elucidation,and clinical trial design.Future directions should focus on precise pain phenotyping,integrated multi-target interventions,rigorous efficacy safety validation,and innovations in drug delivery to facilitate the standardization and global adoption of TCM in cancer pain management.展开更多
Chinese medicinal materials are the material basis for the inheritance and development of traditional Chinese medicine.Intellectual property protection for the entire industrial chain of traditional Chinese medicinal ...Chinese medicinal materials are the material basis for the inheritance and development of traditional Chinese medicine.Intellectual property protection for the entire industrial chain of traditional Chinese medicinal materials promotes the inheritance and innovation of traditional Chinese medicine,and contributes to rural revitalization and the building of an agricultural power.This article provides an overview of the traditional Chinese medicinal materials in Hubei Province.It conducts a detailed investigation into the intellectual property resources of the province s traditional Chinese medicinal materials from aspects such as traditional knowledge,genetic resources,new plant varieties,patents,geographical indications,and trademarks.It analyzes the eight main problems in the protection,inheritance,and innovative development of intellectual property rights,and puts forward corresponding suggestions,such as establishing an intellectual property rights rule system for specific fields of traditional Chinese medicinal materials,promoting the"Famous Brand Action in Rural Areas",and building a"Hubei s Sixteen Superior Herbs"cluster of traditional Chinese medicinal materials.展开更多
“The silk of Suzhou,Hangzhou,Jiaxing and Huzhou are unrivalled in the world;all under heaven draw their supply from it.”So observed the Ming Dynasty(1368-1644)agronomist Xu Guangqi in his Complete Treatise on Agricu...“The silk of Suzhou,Hangzhou,Jiaxing and Huzhou are unrivalled in the world;all under heaven draw their supply from it.”So observed the Ming Dynasty(1368-1644)agronomist Xu Guangqi in his Complete Treatise on Agriculture,capturing the undisputed dominance of east China in sericulture centuries ago.展开更多
On the stone-paved lanes of Songyang County that date back to ancient times,morning mist lingered as a faint fragrance of tea wafted from a century-old house.Inside,Yang Junjie,a tea maker born in the 1980s,worked def...On the stone-paved lanes of Songyang County that date back to ancient times,morning mist lingered as a faint fragrance of tea wafted from a century-old house.Inside,Yang Junjie,a tea maker born in the 1980s,worked deftly at the stove,his hands moving swiftly over the scorching iron wok as tender green tea leaves dance between his fingers.展开更多
Background:Cyperi Rhizoma,derived from Cyperus rotundus L.,is a widely used medicinal herb in traditional Chinese medicine(TCM),with Shandong Province recognized as its geo-authentic habitat.However,the quality of Cyp...Background:Cyperi Rhizoma,derived from Cyperus rotundus L.,is a widely used medicinal herb in traditional Chinese medicine(TCM),with Shandong Province recognized as its geo-authentic habitat.However,the quality of Cyperi Rhizoma varies significantly across different regions,potentially influencing its therapeutic efficacy.This study investigates the influence of geographic origin on the chemical composition and overall quality of Cyperi Rhizoma.Methods:A comprehensive approach,including traditional quality assessment,GC-MS(g as c hromatography-m ass s pectrometry),RP-HPLC(r everse p hase h igh-p erformance l iquid c hromatography),and FT-IR(f ourier t ransform i nfrared s pectroscopy)techniques,was employed to analyze Cyperi Rhizoma samples from Shandong Province.These methods examined the physical appearance,chemical profile,and content variations,particularly focusing onα-cyperone.Results:Traditional quality assessments revealed noticeable differences in the external characteristics of the samples.GC-MS analysis identified a variety of unique chemical constituents,while RP-HPLC and FT-IR showed significant variations inα-cyperone content,with higher levels found in Shandong samples.Conclusion:These results demonstrate that geographic origin is a critical determinant of Cyperi Rhizoma quality,with Shandong specimens exhibiting superiorα-cyperone levels and characteristic phytochemical profiles.This validates the geo-authenticity concept in TCM and provides actionable data for developing evidence-based quality standards,suggesting that provenance should be prioritized in medicinal material selection and pharmacopeial specifications.展开更多
Objective To develop a depression recognition model by integrating the spirit-expression diagnostic framework of traditional Chinese medicine(TCM)with machine learning algorithms.The proposed model seeks to establish ...Objective To develop a depression recognition model by integrating the spirit-expression diagnostic framework of traditional Chinese medicine(TCM)with machine learning algorithms.The proposed model seeks to establish a TCM-informed tool for early depression screening,thereby bridging traditional diagnostic principles with modern computational approaches.Methods The study included patients with depression who visited the Shanghai Pudong New Area Mental Health Center from October 1,2022 to October 1,2023,as well as students and teachers from Shanghai University of Traditional Chinese Medicine during the same period as the healthy control group.Videos of 3–10 s were captured using a Xiaomi Pad 5,and the TCM spirit and expressions were determined by TCM experts(at least 3 out of 5 experts agreed to determine the category of TCM spirit and expressions).Basic information,facial images,and interview information were collected through a portable TCM intelligent analysis and diagnosis device,and facial diagnosis features were extracted using the Open CV computer vision library technology.Statistical analysis methods such as parametric and non-parametric tests were used to analyze the baseline data,TCM spirit and expression features,and facial diagnosis feature parameters of the two groups,to compare the differences in TCM spirit and expression and facial features.Five machine learning algorithms,including extreme gradient boosting(XGBoost),decision tree(DT),Bernoulli naive Bayes(BernoulliNB),support vector machine(SVM),and k-nearest neighbor(KNN)classification,were used to construct a depression recognition model based on the fusion of TCM spirit and expression features.The performance of the model was evaluated using metrics such as accuracy,precision,and the area under the receiver operating characteristic(ROC)curve(AUC).The model results were explained using the Shapley Additive exPlanations(SHAP).Results A total of 93 depression patients and 87 healthy individuals were ultimately included in this study.There was no statistically significant difference in the baseline characteristics between the two groups(P>0.05).The differences in the characteristics of the spirit and expressions in TCM and facial features between the two groups were shown as follows.(i)Quantispirit facial analysis revealed that depression patients exhibited significantly reduced facial spirit and luminance compared with healthy controls(P<0.05),with characteristic features such as sad expressions,facial erythema,and changes in the lip color ranging from erythematous to cyanotic.(ii)Depressed patients exhibited significantly lower values in facial complexion L,lip L,and a values,and gloss index,but higher values in facial complexion a and b,lip b,low gloss index,and matte index(all P<0.05).(iii)The results of multiple models show that the XGBoost-based depression recognition model,integrating the TCM“spirit-expression”diagnostic framework,achieved an accuracy of 98.61%and significantly outperformed four benchmark algorithms—DT,BernoulliNB,SVM,and KNN(P<0.01).(iv)The SHAP visualization results show that in the recognition model constructed by the XGBoost algorithm,the complexion b value,categories of facial spirit,high gloss index,low gloss index,categories of facial expression and texture features have significant contribution to the model.Conclusion This study demonstrates that integrating TCM spirit-expression diagnostic features with machine learning enables the construction of a high-precision depression detection model,offering a novel paradigm for objective depression diagnosis.展开更多
Tumor growth depends on neoangiogenesis,and current anti-angiogenic therapies face limitations owing to side effects and drug resistance.Traditional Chinese medicines(TCM)have shown potential to inhibit tumor angiogen...Tumor growth depends on neoangiogenesis,and current anti-angiogenic therapies face limitations owing to side effects and drug resistance.Traditional Chinese medicines(TCM)have shown potential to inhibit tumor angiogenesis owing to their multi-component and multi-target properties.This review focuses on the mechanisms of action of TCM monomers(e.g.,curcumin,tanshinone IIA,and ginsenoside)through the modulation of key pathways,such as HIF-1α,VEGF/VEGFRs,and Notch signaling,and explores their modulatory effects on the tumor microenvironment(e.g.,tumor-associated macrophage polarization).Despite the low toxicity and multi-targeting advantages of TCM,their clinical translation is still limited by low bioavailability and standardization difficulties.In this review,we further analyze the role of modern approaches,such as nanocarriers(liposomes,polymer nanoparticles,metal-coordinated nanomaterials,and plant exosome-like vesicles),in overcoming these bottlenecks and propose a strategy of combining TCM with chemotherapy,radiotherapy,and immunotherapy to overcome drug resistance and enhance therapeutic efficacy.By integrating traditional wisdom with cutting-edge technologies,anti-angiogenesis research in TCM is expected to contribute to the development of safer and more effective individualised cancer treatment.展开更多
This paper divides the centuries-long communication of traditional Chinese medicine(TCM)in France into three progressive stages:the first stage(17th to 19th centuries),characterized by academic recognition and knowled...This paper divides the centuries-long communication of traditional Chinese medicine(TCM)in France into three progressive stages:the first stage(17th to 19th centuries),characterized by academic recognition and knowledge transmission;the second stage(mid-19th century to late 20th century),focusing on clinical verification and school-based innovation;and the third stage(late 20th century to the present),marked by cultural integration and pluralistic coexistence within systems.The introduction of TCM in France is a process of cross-cultural adaptation and coexistence driven by specific health needs in French society,such as chronic disease management and complementary therapies.The French medical community and sociocultural context have not only verified and interpreted TCM through an empirical scientific perspective,but also realized creative localization by developing indigenous schools such as electroacupuncture and auricular acupuncture.Eventually,through institutional measures including national certification,terminology standardization,and networked healthcare services,TCM has been deeply integrated into France’s medical system and social context,forming a stable ecosystem of cross-cultural adaptation and pluralistic coexistence.The French experience,which takes aligning with local health needs as the starting point,stimulating localized cultural innovation as the core,and promoting systematic integration into local systems as the support,presents a picture of traditional medicine serving modern society,the improvement of global health,as well as mutual learning and symbiosis among different civilizations.展开更多
With the advancement of the Belt and Road Initiative and increasing activity in high-altitude regions,the incidence of high-altitude-related diseases has steadily increased.Notably,the prevention and treatment of high...With the advancement of the Belt and Road Initiative and increasing activity in high-altitude regions,the incidence of high-altitude-related diseases has steadily increased.Notably,the prevention and treatment of high-altitude brain injuries remain particularly challenging,making them a key focus of current medical research.The low-pressure and low-oxygen environments at high altitudes significantly increase the risk of hypoxic brain injury.Consequently,understanding the mechanisms that drive these injuries and developing targeted treatments are crucial for maintaining the health of individuals who rapidly ascend to high altitudes.This review examines the mechanisms underlying high-altitude brain injury,outlines the development and evaluation of commonly used animal models for altitude stress,and explores potential therapeutic approaches to support effective prevention and treatment strategies for these conditions.展开更多
The global prevalence of metabolic-associated fatty liver disease(MAFLD)is on the rise,seriously threatening human health.Currently,no specific approved drugs are available for its treatment.This paper reviews the pat...The global prevalence of metabolic-associated fatty liver disease(MAFLD)is on the rise,seriously threatening human health.Currently,no specific approved drugs are available for its treatment.This paper reviews the pathogenesis of MAFLD,covering aspects like lipid accumulation and insulin resistance,oxidative stress,endoplasmic reticulum stress(ERS),lipotoxicity-induced hepatocyte damage,and fibrosis.It also elaborates on multiple treatment approaches for MAFLD,including metabolic regulation,improvement of the gut-liver axis interaction,modulation of immune and inflammatory pathways,enhancement of the adipose tissue-liver interaction,alleviation of fibrosis,prevention of hepatocyte injury,and traditional Chinese medicine(TCM)external therapies.Additionally,natural product research advancements,individual Chinese medicine components,and mixed herbal formulas for MAFLD treatment is provided.Many natural products and traditional Chinese medicines exhibit favorable effects in regulating lipid metabolism,anti-inflammation,and anti-oxidation,offering new directions and potential drug options for MAFLD treatment.This is expected to provide a reference for future clinical treatment and drug development.展开更多
Currently,the number of patients with myopia is increasing rapidly across the globe.Traditional Chinese medicine(TCM),with its long history and rich experience,has shown promise in effectively managing and treating th...Currently,the number of patients with myopia is increasing rapidly across the globe.Traditional Chinese medicine(TCM),with its long history and rich experience,has shown promise in effectively managing and treating this condition.Nevertheless,considering the vast amount of research that is currently being conducted,focusing on the utilization of TCM in the management of myopia,there is an urgent requirement for a thorough and comprehensive review.The review would serve to clarify the practical applications of TCM within this specific field,and it would also aim to elucidate the underlying mechanisms that are at play,providing a deeper understanding of how TCM principles can be effectively integrated into modern medical practices.Here,some modern medical pathogenesis of myopia and appropriate TCM techniques studies are summarized in the prevention and treatment of myopia.Further,we discussed the potential mechanisms and the future research directions of TCM against myopia.Identifying these mechanisms is crucial for understanding how TCM can be effectively utilized in this context.The combination of various TCM methods or the combination of traditional Chinese and Western medicine is of great significance for the prevention and control of myopia in the future.展开更多
Potentilla discolor Bunge, a traditional Chinese medicinal herb, has been extensively utilized for treating diverse ailments including diabetes, bacterial infections, viral diseases, and inflammatory disorders. Modern...Potentilla discolor Bunge, a traditional Chinese medicinal herb, has been extensively utilized for treating diverse ailments including diabetes, bacterial infections, viral diseases, and inflammatory disorders. Modern phytochemical investigations have identified over 200 bioactive compounds, predominantly flavonoids, tannins, triterpenoids, and phenolic acids. Pharmacological studies demonstrate that P. discolor exerts multi-target therapeutic effects through antioxidant, anti-inflammatory, antimicrobial, antiviral, antidiabetic, and anticancer activities. Its mechanisms involve modulation of key signaling pathways including PI3K/Akt, MAPK, NF-κB, and Nrf2/HO-1, alongside regulation of glucose-lipid metabolism and gut microbiota. This review systematically summarizes the phytochemistry, traditional applications, and contemporary pharmacological advances of P. discolor, emphasizing its multi-target characteristics and molecular mechanisms. Furthermore, current research limitations and future perspectives are discussed to provide scientific evidence for its clinical development and therapeutic applications.展开更多
When one steps inside Caoxian's Youai Cloud Warehouse,a livestreaming base dedicated to hanfu,it feels less like a clothing warehouse and more like a time capsule.Thousands of intricately embroidered garments line...When one steps inside Caoxian's Youai Cloud Warehouse,a livestreaming base dedicated to hanfu,it feels less like a clothing warehouse and more like a time capsule.Thousands of intricately embroidered garments line the racks-from elegant horseface skirts to modernized editions of traditional Chinese clothing.On one side,livestreamers dressed in hanfu smile at their smartphone cameras,twirling for their online audiences while the chime of incoming orders punctuates the air.Behind them,visitors run their hands over organza fabrics,marvelling at the fusion of ageold craftsmanship and contemporary taste.展开更多
Objective: To investigate the current status of inheritance and development of folk traditional Chinese medicine in Linfen City, analyze practitioner characteristics, inheritance modes, and social acceptance, and to p...Objective: To investigate the current status of inheritance and development of folk traditional Chinese medicine in Linfen City, analyze practitioner characteristics, inheritance modes, and social acceptance, and to provide references for standardized management and rational development of folk traditional Chinese medicine. Methods: A questionnaire-based survey was conducted from January to December 2025 among folk traditional Chinese medicine practitioners, medical staff, and urban and rural residents in Linfen City. The survey content included basic characteristics of practitioners, inheritance modes, practice status, and levels of recognition of folk traditional Chinese medicine among different population groups. An Excel database was established, and descriptive statistical analysis was performed using SPSS version 26.0. Results: A total of 349 participants were surveyed, including 99 folk traditional Chinese medicine practitioners, 100 medical staff members, and 150 urban and rural residents. Most practitioners were middle-aged or elderly, had more than 10 years of practice experience, primarily inherited their skills through apprenticeship or family transmission, and had a relatively low proportion of systematic theoretical training in traditional Chinese medicine. Residents showed a high level of acceptance of folk traditional Chinese medicine, whereas medical staff demonstrated a relatively cautious attitude. Conclusion: Folk traditional Chinese medicine in Linfen City has a certain social foundation and practical value;however, further improvements are needed in standardized inheritance, management mechanisms, and sustainable development.展开更多
Chemotherapy-induced diarrhea(CID)is a major concern for cancer patients and is associated with significant morbidity and mortality.Currently,the clinical management of CID is limited.The utilization of antidiarrheal ...Chemotherapy-induced diarrhea(CID)is a major concern for cancer patients and is associated with significant morbidity and mortality.Currently,the clinical management of CID is limited.The utilization of antidiarrheal medications,such as loperamide and octreotide,is relatively limited because of their unsatisfactory efficacy and adverse effects.In recent years,traditional Chinese medicine(TCM)has attracted great interest because of its beneficial effect in treating CID,which has multitarget and low-toxicity therapeutic characteristics.TCM exhibits remarkable therapeutic potential in the prevention and treatment of CID.It can alleviate and treat CID by regulating chemical drug metabolism,improving the integrity of the intestinal barrier,stimulating proliferation while suppressing the apoptosis of intestinal epithelial cells,ameliorating oxidative stress and inflammation and regulating bile acids and aquaporins.However,large-scale,randomized,double-blind clinical trials of TCM for the treatment of CID are lacking,and most preclinical experiments have not been translated to clinical trials.Accordingly,this review highlights the clinical efficacy and molecular mechanisms of TCM against CID via PubMed,Web of Science and China National Knowledge Infrastructure and proposes that future research on TCM against CID should focus on strengthening the connection from bench to bed,which may help to comprehensively evaluate the therapeutic potential of TCM against CID.展开更多
Serbisütherapy(ST)is a distinctive external treatment modality within traditional Mongolian medicine(TMM),historically developed within a nomadic cultural framework.This study presents a comprehensive philologica...Serbisütherapy(ST)is a distinctive external treatment modality within traditional Mongolian medicine(TMM),historically developed within a nomadic cultural framework.This study presents a comprehensive philological and historical analysis of ST,tracing its evolution from early battlefield applications to contemporary clinical use.By critically examining classical Mongolian medical texts alongside modern case studies,we aim to systematize ST’s therapeutic methods,indications,and limitations,while exploring its mechanisms of action through both traditional theory and modern biomedical perspectives.ST has undergone significant transformation,shifting from whole-body cavity immersion in the 13th century to targeted,organ-specific applications in modern practice.Its four primary methods–Covering,Mounted,Organ Placement,and Suction–demonstrate efficacy in treating cold-natured diseases,musculoskeletal disorders,gynecological conditions,and certain emergencies.ST embodies the core principles of TMM,particularly the balance of the“Three Roots”and the correction of cold-induced pathologies through heat.Despite challenges related to standardization,cultural translation,and regulatory acceptance,ST holds translational potential for integrative medicine.Future research should prioritize mechanistic validation,clinical standardization,and the development of biocompatible thermal technologies to bridge traditional practice with modern healthcare systems.展开更多
OBJECTIVE:To develop an automated system for identifying and classifying constitution types in Traditional Chinese Medicine(TCM)by leveraging multi-model fusion algorithms.METHODS:A condensed version of a physical inf...OBJECTIVE:To develop an automated system for identifying and classifying constitution types in Traditional Chinese Medicine(TCM)by leveraging multi-model fusion algorithms.METHODS:A condensed version of a physical information collection form was designed to facilitate efficient data acquisition.The collected data were analyzed using a multi-model fusion approach,which integrated several machine learning techniques.These included support vector machines,Naive Bayes,decision trees,random forests,logistic regression,multilayer perceptrons,K-nearest neighbors,gradient boosting,adaptive ensemble learning,and recurrent neural networks.A soft voting strategy was used to combine the predictive outputs of each model,enabling the selection of the most effective model combination.RESULTS:The classification models demonstrated consistent and robust performance across most TCM constitution types when enhanced by the multi-model fusion strategy.In particular,high levels of accuracy,precision,recall,and F1-score were achieved for constitution types such as Yang deficiency,Qi deficiency,and Qi stagnation.However,the classification performance for the Yin deficiency constitution was relatively lower,indicating the need for further refinement and optimization in future research.CONCLUSION:This study introduces a novel,automated method for classifying TCM constitution types through the application of multi-model fusion algorithms.The approach simplifies the complex task of constitution identification while offering a practical and theoretical framework for the intelligent diagnosis of TCM body types.The findings have the potential to enhance personalized health management and support clinical decision-making in TCM diagnosis and treatment.展开更多
Objectives:To explore the use of a traditional Chinese medicine(TCM)pattern scale as an outcome measure to evaluate the management of patients with chronic low back pain(CLBP).Methods:A total of 204 participants were ...Objectives:To explore the use of a traditional Chinese medicine(TCM)pattern scale as an outcome measure to evaluate the management of patients with chronic low back pain(CLBP).Methods:A total of 204 participants were recruited and randomly allocated into three CLBP treatment groups:Tuina only,physiotherapy only,and a combined physiotherapy+Tuina group.All participants were assessed for treatment outcomes using the TCM pattern scale as a substudy to a randomized controlled trial in which the Visual Analog Scale(VAS)was the primary outcome measure.TCM pattern scores were recorded by non-TCM research assistants who were trained to administer a TCM pattern questionnaire developed by the authors in collaboration with TCM experts.Results:Most participants(83%)were classified as having kidney deficiency pattern as the primary TCM pattern at baseline.All three intervention groups showed a significant decrease in overall TCM pattern score at month 2(M2)and month 5(M5).However,when the nimodipine method was applied,none of the three treatment arms showed a statistically significant change in the effective rate,even though the parent study reported a significant decrease in VAS scores in all treatment arms.Conclusion:This study found improvements in both the dominant TCM pattern score and the overall TCM pattern score for each group.These findings suggest that TCM pattern diagnosis,including entities recognized in International Classification of Diseases,11th Revision(ICD)-11,may be used as a quantitative outcome measure to reflect response to TCM-based intervention.The TCM pattern scale reported here may potentially be applied in other chronic pain studies involving TCM patterns.Further studies are warranted to validate this scale in other clinical conditions.展开更多
This paper elaborates on the concept of Traditional Chinese Medicine(TCM)nursing appropriate techniques,selects techniques including moxibustion,auricular seed pressing,acupoint application,massage and Tuina,Chinese h...This paper elaborates on the concept of Traditional Chinese Medicine(TCM)nursing appropriate techniques,selects techniques including moxibustion,auricular seed pressing,acupoint application,massage and Tuina,Chinese herbal foot bath,five-tone therapy,and aromatherapy,and summarizes the application mechanisms,methods,and clinical effects of these techniques in patients with insomnia.It also analyzes the existing problems in their application and discusses future development and practice directions,aiming to provide references for establishing more standardized and scientific nursing plans for patients with insomnia.展开更多
文摘Editorial Policy Asian Journal of Traditional Medicines is an international journal devoted to the advancement of research on traditional medicines.The followed areas are covered:scientific and technological developments and research achievements in the fields of traditional medicine resources,medicinal material processing,pharmacognosy,natural medicinal chemistry,quality control,pharmacology,pharmacy,and clinical efficacy.
基金supported by the National Natural Science Foundation of China(No.82360238,82071245)。
文摘Cancer pain is one of the most prevalent and debilitating symptoms in patients with advanced malignancies,arising from multifactorial mechanisms involving peripheral,central,and systemic pathways.Conventional analgesics,including opioids and nonsteroidal anti-inflammatory drugs,are often limited by their insufficient efficacy,tolerance,and risk of dependence.Traditional Chinese Medicine(TCM),characterized by its multi-component,multi-target,and systemic regulatory properties,has shown promising potential in cancer pain management.This review provides a comprehensive overview of the clinical classification and underlying mechanisms of cancer pain(including nerve infiltration,dysregulation of inflammatory mediators and ion channels,central sensitization,neuro-immune crosstalk,metabolic reprogramming,and gut-brain axis impairment),as well as the analgesic effects of representative TCM agents in cancer pain management.For example,bioactive components such as tetrahydroberberine,levo-tetrahydropalmatine,and piperine exert analgesic effects,thereby improving the quality of life of patients by inhibiting inflammatory cascades,regulating neurotransmitter systems,and preserving neural integrity.Commonly used preclinical models,including bone cancer pain,pancreatic cancer pain,and chemotherapy-induced peripheral neuropathy models,are summarized for their utility in mechanistic studies and efficacy evaluations.This review also discusses the current limitations of clinical evidence,such as small sample sizes,short follow-up periods,and limited translation from animal models,alongside major challenges in standardization,mechanistic elucidation,and clinical trial design.Future directions should focus on precise pain phenotyping,integrated multi-target interventions,rigorous efficacy safety validation,and innovations in drug delivery to facilitate the standardization and global adoption of TCM in cancer pain management.
基金Supported by the Project of National Social Science Fund of China(22CMZ015).
文摘Chinese medicinal materials are the material basis for the inheritance and development of traditional Chinese medicine.Intellectual property protection for the entire industrial chain of traditional Chinese medicinal materials promotes the inheritance and innovation of traditional Chinese medicine,and contributes to rural revitalization and the building of an agricultural power.This article provides an overview of the traditional Chinese medicinal materials in Hubei Province.It conducts a detailed investigation into the intellectual property resources of the province s traditional Chinese medicinal materials from aspects such as traditional knowledge,genetic resources,new plant varieties,patents,geographical indications,and trademarks.It analyzes the eight main problems in the protection,inheritance,and innovative development of intellectual property rights,and puts forward corresponding suggestions,such as establishing an intellectual property rights rule system for specific fields of traditional Chinese medicinal materials,promoting the"Famous Brand Action in Rural Areas",and building a"Hubei s Sixteen Superior Herbs"cluster of traditional Chinese medicinal materials.
文摘“The silk of Suzhou,Hangzhou,Jiaxing and Huzhou are unrivalled in the world;all under heaven draw their supply from it.”So observed the Ming Dynasty(1368-1644)agronomist Xu Guangqi in his Complete Treatise on Agriculture,capturing the undisputed dominance of east China in sericulture centuries ago.
文摘On the stone-paved lanes of Songyang County that date back to ancient times,morning mist lingered as a faint fragrance of tea wafted from a century-old house.Inside,Yang Junjie,a tea maker born in the 1980s,worked deftly at the stove,his hands moving swiftly over the scorching iron wok as tender green tea leaves dance between his fingers.
基金supported by the National Natural Science Foundation of China(No.82204610)Qihang Talent Program(L2022046)+1 种基金the Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences(CI2021A04013)Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ15-YQ-041 and L2021029).
文摘Background:Cyperi Rhizoma,derived from Cyperus rotundus L.,is a widely used medicinal herb in traditional Chinese medicine(TCM),with Shandong Province recognized as its geo-authentic habitat.However,the quality of Cyperi Rhizoma varies significantly across different regions,potentially influencing its therapeutic efficacy.This study investigates the influence of geographic origin on the chemical composition and overall quality of Cyperi Rhizoma.Methods:A comprehensive approach,including traditional quality assessment,GC-MS(g as c hromatography-m ass s pectrometry),RP-HPLC(r everse p hase h igh-p erformance l iquid c hromatography),and FT-IR(f ourier t ransform i nfrared s pectroscopy)techniques,was employed to analyze Cyperi Rhizoma samples from Shandong Province.These methods examined the physical appearance,chemical profile,and content variations,particularly focusing onα-cyperone.Results:Traditional quality assessments revealed noticeable differences in the external characteristics of the samples.GC-MS analysis identified a variety of unique chemical constituents,while RP-HPLC and FT-IR showed significant variations inα-cyperone content,with higher levels found in Shandong samples.Conclusion:These results demonstrate that geographic origin is a critical determinant of Cyperi Rhizoma quality,with Shandong specimens exhibiting superiorα-cyperone levels and characteristic phytochemical profiles.This validates the geo-authenticity concept in TCM and provides actionable data for developing evidence-based quality standards,suggesting that provenance should be prioritized in medicinal material selection and pharmacopeial specifications.
基金General Program of National Natural Science Foundation of China(82474390)Construction Project of Pudong New Area Famous TCM Studios(National Pilot Zone for TCM Development,Shanghai)(PDZY-2025-0716)Shanghai Municipal Science and Technology Program Project Shanghai Key Laboratory of Health Identification and Assessment(21DZ2271000).
文摘Objective To develop a depression recognition model by integrating the spirit-expression diagnostic framework of traditional Chinese medicine(TCM)with machine learning algorithms.The proposed model seeks to establish a TCM-informed tool for early depression screening,thereby bridging traditional diagnostic principles with modern computational approaches.Methods The study included patients with depression who visited the Shanghai Pudong New Area Mental Health Center from October 1,2022 to October 1,2023,as well as students and teachers from Shanghai University of Traditional Chinese Medicine during the same period as the healthy control group.Videos of 3–10 s were captured using a Xiaomi Pad 5,and the TCM spirit and expressions were determined by TCM experts(at least 3 out of 5 experts agreed to determine the category of TCM spirit and expressions).Basic information,facial images,and interview information were collected through a portable TCM intelligent analysis and diagnosis device,and facial diagnosis features were extracted using the Open CV computer vision library technology.Statistical analysis methods such as parametric and non-parametric tests were used to analyze the baseline data,TCM spirit and expression features,and facial diagnosis feature parameters of the two groups,to compare the differences in TCM spirit and expression and facial features.Five machine learning algorithms,including extreme gradient boosting(XGBoost),decision tree(DT),Bernoulli naive Bayes(BernoulliNB),support vector machine(SVM),and k-nearest neighbor(KNN)classification,were used to construct a depression recognition model based on the fusion of TCM spirit and expression features.The performance of the model was evaluated using metrics such as accuracy,precision,and the area under the receiver operating characteristic(ROC)curve(AUC).The model results were explained using the Shapley Additive exPlanations(SHAP).Results A total of 93 depression patients and 87 healthy individuals were ultimately included in this study.There was no statistically significant difference in the baseline characteristics between the two groups(P>0.05).The differences in the characteristics of the spirit and expressions in TCM and facial features between the two groups were shown as follows.(i)Quantispirit facial analysis revealed that depression patients exhibited significantly reduced facial spirit and luminance compared with healthy controls(P<0.05),with characteristic features such as sad expressions,facial erythema,and changes in the lip color ranging from erythematous to cyanotic.(ii)Depressed patients exhibited significantly lower values in facial complexion L,lip L,and a values,and gloss index,but higher values in facial complexion a and b,lip b,low gloss index,and matte index(all P<0.05).(iii)The results of multiple models show that the XGBoost-based depression recognition model,integrating the TCM“spirit-expression”diagnostic framework,achieved an accuracy of 98.61%and significantly outperformed four benchmark algorithms—DT,BernoulliNB,SVM,and KNN(P<0.01).(iv)The SHAP visualization results show that in the recognition model constructed by the XGBoost algorithm,the complexion b value,categories of facial spirit,high gloss index,low gloss index,categories of facial expression and texture features have significant contribution to the model.Conclusion This study demonstrates that integrating TCM spirit-expression diagnostic features with machine learning enables the construction of a high-precision depression detection model,offering a novel paradigm for objective depression diagnosis.
基金supported by the Xinglin Scholars Nursery Program Talent Fund of Chengdu University of Traditional Chinese Medicine(MPRC2023005).
文摘Tumor growth depends on neoangiogenesis,and current anti-angiogenic therapies face limitations owing to side effects and drug resistance.Traditional Chinese medicines(TCM)have shown potential to inhibit tumor angiogenesis owing to their multi-component and multi-target properties.This review focuses on the mechanisms of action of TCM monomers(e.g.,curcumin,tanshinone IIA,and ginsenoside)through the modulation of key pathways,such as HIF-1α,VEGF/VEGFRs,and Notch signaling,and explores their modulatory effects on the tumor microenvironment(e.g.,tumor-associated macrophage polarization).Despite the low toxicity and multi-targeting advantages of TCM,their clinical translation is still limited by low bioavailability and standardization difficulties.In this review,we further analyze the role of modern approaches,such as nanocarriers(liposomes,polymer nanoparticles,metal-coordinated nanomaterials,and plant exosome-like vesicles),in overcoming these bottlenecks and propose a strategy of combining TCM with chemotherapy,radiotherapy,and immunotherapy to overcome drug resistance and enhance therapeutic efficacy.By integrating traditional wisdom with cutting-edge technologies,anti-angiogenesis research in TCM is expected to contribute to the development of safer and more effective individualised cancer treatment.
文摘This paper divides the centuries-long communication of traditional Chinese medicine(TCM)in France into three progressive stages:the first stage(17th to 19th centuries),characterized by academic recognition and knowledge transmission;the second stage(mid-19th century to late 20th century),focusing on clinical verification and school-based innovation;and the third stage(late 20th century to the present),marked by cultural integration and pluralistic coexistence within systems.The introduction of TCM in France is a process of cross-cultural adaptation and coexistence driven by specific health needs in French society,such as chronic disease management and complementary therapies.The French medical community and sociocultural context have not only verified and interpreted TCM through an empirical scientific perspective,but also realized creative localization by developing indigenous schools such as electroacupuncture and auricular acupuncture.Eventually,through institutional measures including national certification,terminology standardization,and networked healthcare services,TCM has been deeply integrated into France’s medical system and social context,forming a stable ecosystem of cross-cultural adaptation and pluralistic coexistence.The French experience,which takes aligning with local health needs as the starting point,stimulating localized cultural innovation as the core,and promoting systematic integration into local systems as the support,presents a picture of traditional medicine serving modern society,the improvement of global health,as well as mutual learning and symbiosis among different civilizations.
基金financially supported by Beijing Natural Science Foundation(L232085,L222126).
文摘With the advancement of the Belt and Road Initiative and increasing activity in high-altitude regions,the incidence of high-altitude-related diseases has steadily increased.Notably,the prevention and treatment of high-altitude brain injuries remain particularly challenging,making them a key focus of current medical research.The low-pressure and low-oxygen environments at high altitudes significantly increase the risk of hypoxic brain injury.Consequently,understanding the mechanisms that drive these injuries and developing targeted treatments are crucial for maintaining the health of individuals who rapidly ascend to high altitudes.This review examines the mechanisms underlying high-altitude brain injury,outlines the development and evaluation of commonly used animal models for altitude stress,and explores potential therapeutic approaches to support effective prevention and treatment strategies for these conditions.
基金supported by the National Natural Science Foundation of China(82574477)the Jiangsu Provincial Traditional Chinese Medicine Science and Technology Development Plan(QN202426)+5 种基金Jiangsu Province“333 High-level Talents Training Project”((2024)3-0189)Youth Talent Support Project of the Jiangsu Association for Science and Technology(TJ-2023-053)Shanxi Provincial Department-Municipal Key Laboratory Cultivation Base for Quality Enhancement and Utilization of Shangdang Chinese Medicinal Materials(KF202401)Fundamental Research Program of Shanxi Province(202403021221211)the research project supported by the Shanxi Scholarship Council of China(No.2023-158)Open Project of Key Laboratory of Tibetan Medicine Basic Research,Ministry of Education.
文摘The global prevalence of metabolic-associated fatty liver disease(MAFLD)is on the rise,seriously threatening human health.Currently,no specific approved drugs are available for its treatment.This paper reviews the pathogenesis of MAFLD,covering aspects like lipid accumulation and insulin resistance,oxidative stress,endoplasmic reticulum stress(ERS),lipotoxicity-induced hepatocyte damage,and fibrosis.It also elaborates on multiple treatment approaches for MAFLD,including metabolic regulation,improvement of the gut-liver axis interaction,modulation of immune and inflammatory pathways,enhancement of the adipose tissue-liver interaction,alleviation of fibrosis,prevention of hepatocyte injury,and traditional Chinese medicine(TCM)external therapies.Additionally,natural product research advancements,individual Chinese medicine components,and mixed herbal formulas for MAFLD treatment is provided.Many natural products and traditional Chinese medicines exhibit favorable effects in regulating lipid metabolism,anti-inflammation,and anti-oxidation,offering new directions and potential drug options for MAFLD treatment.This is expected to provide a reference for future clinical treatment and drug development.
基金supported by Healthy China initiative of Traditional Chinese Medicine(No.889042).
文摘Currently,the number of patients with myopia is increasing rapidly across the globe.Traditional Chinese medicine(TCM),with its long history and rich experience,has shown promise in effectively managing and treating this condition.Nevertheless,considering the vast amount of research that is currently being conducted,focusing on the utilization of TCM in the management of myopia,there is an urgent requirement for a thorough and comprehensive review.The review would serve to clarify the practical applications of TCM within this specific field,and it would also aim to elucidate the underlying mechanisms that are at play,providing a deeper understanding of how TCM principles can be effectively integrated into modern medical practices.Here,some modern medical pathogenesis of myopia and appropriate TCM techniques studies are summarized in the prevention and treatment of myopia.Further,we discussed the potential mechanisms and the future research directions of TCM against myopia.Identifying these mechanisms is crucial for understanding how TCM can be effectively utilized in this context.The combination of various TCM methods or the combination of traditional Chinese and Western medicine is of great significance for the prevention and control of myopia in the future.
文摘Potentilla discolor Bunge, a traditional Chinese medicinal herb, has been extensively utilized for treating diverse ailments including diabetes, bacterial infections, viral diseases, and inflammatory disorders. Modern phytochemical investigations have identified over 200 bioactive compounds, predominantly flavonoids, tannins, triterpenoids, and phenolic acids. Pharmacological studies demonstrate that P. discolor exerts multi-target therapeutic effects through antioxidant, anti-inflammatory, antimicrobial, antiviral, antidiabetic, and anticancer activities. Its mechanisms involve modulation of key signaling pathways including PI3K/Akt, MAPK, NF-κB, and Nrf2/HO-1, alongside regulation of glucose-lipid metabolism and gut microbiota. This review systematically summarizes the phytochemistry, traditional applications, and contemporary pharmacological advances of P. discolor, emphasizing its multi-target characteristics and molecular mechanisms. Furthermore, current research limitations and future perspectives are discussed to provide scientific evidence for its clinical development and therapeutic applications.
文摘When one steps inside Caoxian's Youai Cloud Warehouse,a livestreaming base dedicated to hanfu,it feels less like a clothing warehouse and more like a time capsule.Thousands of intricately embroidered garments line the racks-from elegant horseface skirts to modernized editions of traditional Chinese clothing.On one side,livestreamers dressed in hanfu smile at their smartphone cameras,twirling for their online audiences while the chime of incoming orders punctuates the air.Behind them,visitors run their hands over organza fabrics,marvelling at the fusion of ageold craftsmanship and contemporary taste.
文摘Objective: To investigate the current status of inheritance and development of folk traditional Chinese medicine in Linfen City, analyze practitioner characteristics, inheritance modes, and social acceptance, and to provide references for standardized management and rational development of folk traditional Chinese medicine. Methods: A questionnaire-based survey was conducted from January to December 2025 among folk traditional Chinese medicine practitioners, medical staff, and urban and rural residents in Linfen City. The survey content included basic characteristics of practitioners, inheritance modes, practice status, and levels of recognition of folk traditional Chinese medicine among different population groups. An Excel database was established, and descriptive statistical analysis was performed using SPSS version 26.0. Results: A total of 349 participants were surveyed, including 99 folk traditional Chinese medicine practitioners, 100 medical staff members, and 150 urban and rural residents. Most practitioners were middle-aged or elderly, had more than 10 years of practice experience, primarily inherited their skills through apprenticeship or family transmission, and had a relatively low proportion of systematic theoretical training in traditional Chinese medicine. Residents showed a high level of acceptance of folk traditional Chinese medicine, whereas medical staff demonstrated a relatively cautious attitude. Conclusion: Folk traditional Chinese medicine in Linfen City has a certain social foundation and practical value;however, further improvements are needed in standardized inheritance, management mechanisms, and sustainable development.
基金supported by the Innovative Team Project of Ordinary Universities in Guangdong Province(No.2022KCXTD016).
文摘Chemotherapy-induced diarrhea(CID)is a major concern for cancer patients and is associated with significant morbidity and mortality.Currently,the clinical management of CID is limited.The utilization of antidiarrheal medications,such as loperamide and octreotide,is relatively limited because of their unsatisfactory efficacy and adverse effects.In recent years,traditional Chinese medicine(TCM)has attracted great interest because of its beneficial effect in treating CID,which has multitarget and low-toxicity therapeutic characteristics.TCM exhibits remarkable therapeutic potential in the prevention and treatment of CID.It can alleviate and treat CID by regulating chemical drug metabolism,improving the integrity of the intestinal barrier,stimulating proliferation while suppressing the apoptosis of intestinal epithelial cells,ameliorating oxidative stress and inflammation and regulating bile acids and aquaporins.However,large-scale,randomized,double-blind clinical trials of TCM for the treatment of CID are lacking,and most preclinical experiments have not been translated to clinical trials.Accordingly,this review highlights the clinical efficacy and molecular mechanisms of TCM against CID via PubMed,Web of Science and China National Knowledge Infrastructure and proposes that future research on TCM against CID should focus on strengthening the connection from bench to bed,which may help to comprehensively evaluate the therapeutic potential of TCM against CID.
基金supported by The China Ethnic Medicine Association Research Grant(No.2023MY055-81)Science and Technology Program of the Joint Fund of Scientific Research for the Public Hospitals of Inner Mongolia Academy of Medical Sciences(2023GLLHD177,2023GLLH0174)Inner Mongolia Autonomous Region Regional Medical Center for Specialized Care(2025).
文摘Serbisütherapy(ST)is a distinctive external treatment modality within traditional Mongolian medicine(TMM),historically developed within a nomadic cultural framework.This study presents a comprehensive philological and historical analysis of ST,tracing its evolution from early battlefield applications to contemporary clinical use.By critically examining classical Mongolian medical texts alongside modern case studies,we aim to systematize ST’s therapeutic methods,indications,and limitations,while exploring its mechanisms of action through both traditional theory and modern biomedical perspectives.ST has undergone significant transformation,shifting from whole-body cavity immersion in the 13th century to targeted,organ-specific applications in modern practice.Its four primary methods–Covering,Mounted,Organ Placement,and Suction–demonstrate efficacy in treating cold-natured diseases,musculoskeletal disorders,gynecological conditions,and certain emergencies.ST embodies the core principles of TMM,particularly the balance of the“Three Roots”and the correction of cold-induced pathologies through heat.Despite challenges related to standardization,cultural translation,and regulatory acceptance,ST holds translational potential for integrative medicine.Future research should prioritize mechanistic validation,clinical standardization,and the development of biocompatible thermal technologies to bridge traditional practice with modern healthcare systems.
基金Supported by Traditional Chinese Medicine Standardization Project of National Administration of Traditional Chinese Medicine:Research on the Physical Characteristics and Pre-disease Health Management of the Elderly in Hubei Province(No.GZY-FJS-2022-046)。
文摘OBJECTIVE:To develop an automated system for identifying and classifying constitution types in Traditional Chinese Medicine(TCM)by leveraging multi-model fusion algorithms.METHODS:A condensed version of a physical information collection form was designed to facilitate efficient data acquisition.The collected data were analyzed using a multi-model fusion approach,which integrated several machine learning techniques.These included support vector machines,Naive Bayes,decision trees,random forests,logistic regression,multilayer perceptrons,K-nearest neighbors,gradient boosting,adaptive ensemble learning,and recurrent neural networks.A soft voting strategy was used to combine the predictive outputs of each model,enabling the selection of the most effective model combination.RESULTS:The classification models demonstrated consistent and robust performance across most TCM constitution types when enhanced by the multi-model fusion strategy.In particular,high levels of accuracy,precision,recall,and F1-score were achieved for constitution types such as Yang deficiency,Qi deficiency,and Qi stagnation.However,the classification performance for the Yin deficiency constitution was relatively lower,indicating the need for further refinement and optimization in future research.CONCLUSION:This study introduces a novel,automated method for classifying TCM constitution types through the application of multi-model fusion algorithms.The approach simplifies the complex task of constitution identification while offering a practical and theoretical framework for the intelligent diagnosis of TCM body types.The findings have the potential to enhance personalized health management and support clinical decision-making in TCM diagnosis and treatment.
基金financially supported by the HEAD foundation(IO number GRTHF0000101).
文摘Objectives:To explore the use of a traditional Chinese medicine(TCM)pattern scale as an outcome measure to evaluate the management of patients with chronic low back pain(CLBP).Methods:A total of 204 participants were recruited and randomly allocated into three CLBP treatment groups:Tuina only,physiotherapy only,and a combined physiotherapy+Tuina group.All participants were assessed for treatment outcomes using the TCM pattern scale as a substudy to a randomized controlled trial in which the Visual Analog Scale(VAS)was the primary outcome measure.TCM pattern scores were recorded by non-TCM research assistants who were trained to administer a TCM pattern questionnaire developed by the authors in collaboration with TCM experts.Results:Most participants(83%)were classified as having kidney deficiency pattern as the primary TCM pattern at baseline.All three intervention groups showed a significant decrease in overall TCM pattern score at month 2(M2)and month 5(M5).However,when the nimodipine method was applied,none of the three treatment arms showed a statistically significant change in the effective rate,even though the parent study reported a significant decrease in VAS scores in all treatment arms.Conclusion:This study found improvements in both the dominant TCM pattern score and the overall TCM pattern score for each group.These findings suggest that TCM pattern diagnosis,including entities recognized in International Classification of Diseases,11th Revision(ICD)-11,may be used as a quantitative outcome measure to reflect response to TCM-based intervention.The TCM pattern scale reported here may potentially be applied in other chronic pain studies involving TCM patterns.Further studies are warranted to validate this scale in other clinical conditions.
文摘This paper elaborates on the concept of Traditional Chinese Medicine(TCM)nursing appropriate techniques,selects techniques including moxibustion,auricular seed pressing,acupoint application,massage and Tuina,Chinese herbal foot bath,five-tone therapy,and aromatherapy,and summarizes the application mechanisms,methods,and clinical effects of these techniques in patients with insomnia.It also analyzes the existing problems in their application and discusses future development and practice directions,aiming to provide references for establishing more standardized and scientific nursing plans for patients with insomnia.
