Tubulin polymerization-promoting protein family member 3(TPPP3)is a neuronal-specific protein involved in cytoskeletal stability,axonal maintenance,and neuronal survival.Dysregulation of TPPP3 is implicated in neurode...Tubulin polymerization-promoting protein family member 3(TPPP3)is a neuronal-specific protein involved in cytoskeletal stability,axonal maintenance,and neuronal survival.Dysregulation of TPPP3 is implicated in neurodegenerative diseases such as Parkinson’s disease and diabetic retinopathy.Unlike TPPP1,which is oligodendrocyte-specific,TPPP3 was reported to primarily promote neuronal regeneration and serve as a therapeutic target for neurodegenerative diseases such as Parkinson’s disease and glaucoma.Beyond the nervous system,TPPP3 has been linked to oncogenesis and tissue regeneration,suggesting potential roles in tumor suppression and wound healing.This review summarizes neuronal functions of TPPP3,therapeutic opportunities,and future research directions.Understanding the molecular mechanisms underlying function of TPPP3 could provide valuable insights into its therapeutic applications in neuroprotection.展开更多
基金supported by NIH Core Grants P30-EY008098,the Eye and Ear Foundation of Pittsburgh,and unrestricted grants from Research to Prevent Blindness,New York,NY,USA(to KCC).
文摘Tubulin polymerization-promoting protein family member 3(TPPP3)is a neuronal-specific protein involved in cytoskeletal stability,axonal maintenance,and neuronal survival.Dysregulation of TPPP3 is implicated in neurodegenerative diseases such as Parkinson’s disease and diabetic retinopathy.Unlike TPPP1,which is oligodendrocyte-specific,TPPP3 was reported to primarily promote neuronal regeneration and serve as a therapeutic target for neurodegenerative diseases such as Parkinson’s disease and glaucoma.Beyond the nervous system,TPPP3 has been linked to oncogenesis and tissue regeneration,suggesting potential roles in tumor suppression and wound healing.This review summarizes neuronal functions of TPPP3,therapeutic opportunities,and future research directions.Understanding the molecular mechanisms underlying function of TPPP3 could provide valuable insights into its therapeutic applications in neuroprotection.
