Tubulin polymerization-promoting protein family member 3(TPPP3)is a neuronal-specific protein involved in cytoskeletal stability,axonal maintenance,and neuronal survival.Dysregulation of TPPP3 is implicated in neurode...Tubulin polymerization-promoting protein family member 3(TPPP3)is a neuronal-specific protein involved in cytoskeletal stability,axonal maintenance,and neuronal survival.Dysregulation of TPPP3 is implicated in neurodegenerative diseases such as Parkinson’s disease and diabetic retinopathy.Unlike TPPP1,which is oligodendrocyte-specific,TPPP3 was reported to primarily promote neuronal regeneration and serve as a therapeutic target for neurodegenerative diseases such as Parkinson’s disease and glaucoma.Beyond the nervous system,TPPP3 has been linked to oncogenesis and tissue regeneration,suggesting potential roles in tumor suppression and wound healing.This review summarizes neuronal functions of TPPP3,therapeutic opportunities,and future research directions.Understanding the molecular mechanisms underlying function of TPPP3 could provide valuable insights into its therapeutic applications in neuroprotection.展开更多
为了合成高热电性能的 n型 Si C基材料 ,尝试用过渡塑性相工艺对 Si C基复合材料进行了 Ti掺杂的实验。当以纳米级 Si C为原料 ,并选择合适的保温时间及温度 ,室温时功率因子 f P 可达 1.5× 10 -5W.m.K-2 ,40 0℃时上升至1.5×...为了合成高热电性能的 n型 Si C基材料 ,尝试用过渡塑性相工艺对 Si C基复合材料进行了 Ti掺杂的实验。当以纳米级 Si C为原料 ,并选择合适的保温时间及温度 ,室温时功率因子 f P 可达 1.5× 10 -5W.m.K-2 ,40 0℃时上升至1.5× 10 -4W.m.K-2 ,与聚碳硅烷浸渍法合成的样品相比 ,f P 提高约 10 0倍。X射线衍射谱及扫描电镜结果显示 ,纳米Si C原料与微米原料相比 ,更易于烧结 ,Ti掺杂入 Si C的浓度更高 ,因而 Seeback系数有显著提高。展开更多
基金supported by NIH Core Grants P30-EY008098,the Eye and Ear Foundation of Pittsburgh,and unrestricted grants from Research to Prevent Blindness,New York,NY,USA(to KCC).
文摘Tubulin polymerization-promoting protein family member 3(TPPP3)is a neuronal-specific protein involved in cytoskeletal stability,axonal maintenance,and neuronal survival.Dysregulation of TPPP3 is implicated in neurodegenerative diseases such as Parkinson’s disease and diabetic retinopathy.Unlike TPPP1,which is oligodendrocyte-specific,TPPP3 was reported to primarily promote neuronal regeneration and serve as a therapeutic target for neurodegenerative diseases such as Parkinson’s disease and glaucoma.Beyond the nervous system,TPPP3 has been linked to oncogenesis and tissue regeneration,suggesting potential roles in tumor suppression and wound healing.This review summarizes neuronal functions of TPPP3,therapeutic opportunities,and future research directions.Understanding the molecular mechanisms underlying function of TPPP3 could provide valuable insights into its therapeutic applications in neuroprotection.
