Peripheral immunity forms the foundation of tumor immunity,while tumor immunity represents a more refined adaptation of peripheral immune responses.The tumor microenvironment(TME),a localized niche surrounding tumor c...Peripheral immunity forms the foundation of tumor immunity,while tumor immunity represents a more refined adaptation of peripheral immune responses.The tumor microenvironment(TME),a localized niche surrounding tumor cells,is inherently immunosuppressive(1,2).Effective tumor therapy necessitates the dismantling of this microenvironment,aiming to eradicate tumors from the host system.展开更多
目的:探讨经肛直肠全系膜切除术(transanal total mesorectal excision,taTME)治疗低位及超低位直肠癌的临床效果和安全性。方法:回顾性分析行taTME治疗的7例低位及超低位直肠癌患者的临床资料,评价治疗的可行性、安全性和疗效。结果:7...目的:探讨经肛直肠全系膜切除术(transanal total mesorectal excision,taTME)治疗低位及超低位直肠癌的临床效果和安全性。方法:回顾性分析行taTME治疗的7例低位及超低位直肠癌患者的临床资料,评价治疗的可行性、安全性和疗效。结果:7例患者均顺利完成腹腔镜辅助taTME,无中转开腹,3例用管型吻合器行结-直肠端端吻合,经腹经肛门同时手术6例,序贯进行1例,手术时间平均(205.7±104.8)min,术中出血量平均(35.7±31.1)mL;保肛率100%(7/7);3例患者行预防性回肠造口,均于术后3个月行回肠还纳。拔除骶前引流管时间(5.4±3.0)d,术后(9.6±2.4)d出院;吻合口漏2例,无死亡、吻合口狭窄、肠梗阻、切口感染等并发症发生。淋巴结检出数平均为(10.4±2.8)枚,阳性淋巴结(0.7±1.7)枚。结论:taTME技术治疗低位及超低位直肠癌安全可靠。展开更多
文摘Peripheral immunity forms the foundation of tumor immunity,while tumor immunity represents a more refined adaptation of peripheral immune responses.The tumor microenvironment(TME),a localized niche surrounding tumor cells,is inherently immunosuppressive(1,2).Effective tumor therapy necessitates the dismantling of this microenvironment,aiming to eradicate tumors from the host system.
文摘目的:探讨经肛直肠全系膜切除术(transanal total mesorectal excision,taTME)治疗低位及超低位直肠癌的临床效果和安全性。方法:回顾性分析行taTME治疗的7例低位及超低位直肠癌患者的临床资料,评价治疗的可行性、安全性和疗效。结果:7例患者均顺利完成腹腔镜辅助taTME,无中转开腹,3例用管型吻合器行结-直肠端端吻合,经腹经肛门同时手术6例,序贯进行1例,手术时间平均(205.7±104.8)min,术中出血量平均(35.7±31.1)mL;保肛率100%(7/7);3例患者行预防性回肠造口,均于术后3个月行回肠还纳。拔除骶前引流管时间(5.4±3.0)d,术后(9.6±2.4)d出院;吻合口漏2例,无死亡、吻合口狭窄、肠梗阻、切口感染等并发症发生。淋巴结检出数平均为(10.4±2.8)枚,阳性淋巴结(0.7±1.7)枚。结论:taTME技术治疗低位及超低位直肠癌安全可靠。
