目的:建立一种分离苯磺酸氨氯地平外消旋体的方法。方法:先合成手性金属-有机骨架材料[Zn_2(D-Cam)_2(4,4′-bpy)]_n(简称为Zn-MOF)并对其进行X射线粉末衍射表征,由其与GF254硅胶混合制备薄层色谱固定相后用于分离苯磺酸氨氯地平外消旋...目的:建立一种分离苯磺酸氨氯地平外消旋体的方法。方法:先合成手性金属-有机骨架材料[Zn_2(D-Cam)_2(4,4′-bpy)]_n(简称为Zn-MOF)并对其进行X射线粉末衍射表征,由其与GF254硅胶混合制备薄层色谱固定相后用于分离苯磺酸氨氯地平外消旋体;以两个对映体的比移值和分离度为指标优选分离条件(展开剂组成及比例、手性Zn-MOF的用量等)并进行方法的重现性试验。结果:成功合成了手性Zn-MOF材料并经表征证实;优选的分离条件为取0.10 g手性Zn-MOF混合1.5 g GF254硅胶制备薄层色谱板、展开剂为乙腈-仲丁醇(30∶70,V/V)。在此条件下,苯磺酸氨氯地平外消旋体实现了有效分离,所得斑点大小均一,比移值>0.27,分离度约为2(RSD=3.8%,n=3)。结论:由手性Zn-MOF制备的薄层色谱固定相对苯磺酸氨氯地平外消旋体具有较好的手性识别能力,且其分离方法操作简单,结果直观、准确、重现性好。展开更多
DL-2-methyl-1-butanol was resoluted by porcine pancreatic lipase(PPL)with tributyrin served as substrate and organic phase.Tributyrin,2-methylbutyl butyrate and dibutyrin in the sample from the reaction process were s...DL-2-methyl-1-butanol was resoluted by porcine pancreatic lipase(PPL)with tributyrin served as substrate and organic phase.Tributyrin,2-methylbutyl butyrate and dibutyrin in the sample from the reaction process were separated by TLC.Their respective spots were obtained by using developing solution of hexane:ether:ethyl-acetate:methanol(10:2:1:1 in vol.)and placing spreaded gel panel in iodine steam.The spots were analyzed by a TLC analyzing software designed by Visual C++programming language,with satisfactory accuracy.It shows that monitoring the reaction by TLC is realizable.展开更多
A project of the expedition to the north pole of Mars, which is carried out in two stages, has been developed. In the first stage, a space refueller and a mobile solar battery are delivered to the icy surface of the n...A project of the expedition to the north pole of Mars, which is carried out in two stages, has been developed. In the first stage, a space refueller and a mobile solar battery are delivered to the icy surface of the north pole of Mars. The delivery is carried out with the help of electric rocket ER-7, driven by the electric rocket engine “MARS”, and the source of electricity is a solar battery from gallium arsenide. In the second stage, the space train is formed from two interconnected ER-7 rockets and an orbital takeoff-landing capsule TLC-2, in which three astronauts land on the surface and carry out a complex of physical, biological and geological researches on Mars surface. The space refueller has been developed, which melts the water ice on the surface of Mars and with the help of an electrolyser and a liquefier produces fuel and oxidizer for the operation of the chemical rocket engine of the takeoff-landing capsule. To move astronauts from the north pole to the equator, a spacecraft—?marsoplane, which consists of the electric rocket ER-7 and the takeoff-landing capsule TLC-1 is developed. The duration of the expedition is 110 days at a cost of 2 billion dollars.展开更多
文摘目的:建立一种分离苯磺酸氨氯地平外消旋体的方法。方法:先合成手性金属-有机骨架材料[Zn_2(D-Cam)_2(4,4′-bpy)]_n(简称为Zn-MOF)并对其进行X射线粉末衍射表征,由其与GF254硅胶混合制备薄层色谱固定相后用于分离苯磺酸氨氯地平外消旋体;以两个对映体的比移值和分离度为指标优选分离条件(展开剂组成及比例、手性Zn-MOF的用量等)并进行方法的重现性试验。结果:成功合成了手性Zn-MOF材料并经表征证实;优选的分离条件为取0.10 g手性Zn-MOF混合1.5 g GF254硅胶制备薄层色谱板、展开剂为乙腈-仲丁醇(30∶70,V/V)。在此条件下,苯磺酸氨氯地平外消旋体实现了有效分离,所得斑点大小均一,比移值>0.27,分离度约为2(RSD=3.8%,n=3)。结论:由手性Zn-MOF制备的薄层色谱固定相对苯磺酸氨氯地平外消旋体具有较好的手性识别能力,且其分离方法操作简单,结果直观、准确、重现性好。
文摘DL-2-methyl-1-butanol was resoluted by porcine pancreatic lipase(PPL)with tributyrin served as substrate and organic phase.Tributyrin,2-methylbutyl butyrate and dibutyrin in the sample from the reaction process were separated by TLC.Their respective spots were obtained by using developing solution of hexane:ether:ethyl-acetate:methanol(10:2:1:1 in vol.)and placing spreaded gel panel in iodine steam.The spots were analyzed by a TLC analyzing software designed by Visual C++programming language,with satisfactory accuracy.It shows that monitoring the reaction by TLC is realizable.
文摘A project of the expedition to the north pole of Mars, which is carried out in two stages, has been developed. In the first stage, a space refueller and a mobile solar battery are delivered to the icy surface of the north pole of Mars. The delivery is carried out with the help of electric rocket ER-7, driven by the electric rocket engine “MARS”, and the source of electricity is a solar battery from gallium arsenide. In the second stage, the space train is formed from two interconnected ER-7 rockets and an orbital takeoff-landing capsule TLC-2, in which three astronauts land on the surface and carry out a complex of physical, biological and geological researches on Mars surface. The space refueller has been developed, which melts the water ice on the surface of Mars and with the help of an electrolyser and a liquefier produces fuel and oxidizer for the operation of the chemical rocket engine of the takeoff-landing capsule. To move astronauts from the north pole to the equator, a spacecraft—?marsoplane, which consists of the electric rocket ER-7 and the takeoff-landing capsule TLC-1 is developed. The duration of the expedition is 110 days at a cost of 2 billion dollars.
