通过优化汽轮机叶片的安装顺序,来减少安装后的残余不平衡量。对此提出一种阈值式迭代局部搜索(threshold iterative local search,TILS)算法,该算法在迭代局部搜索(iterative local search,ILS)算法基础上,采用阈值限定扰动与随机扰动...通过优化汽轮机叶片的安装顺序,来减少安装后的残余不平衡量。对此提出一种阈值式迭代局部搜索(threshold iterative local search,TILS)算法,该算法在迭代局部搜索(iterative local search,ILS)算法基础上,采用阈值限定扰动与随机扰动相结合的方法来跳出局部最优解,减少了平均到达局部最优解所需的迭代步数。实验证明,该方法可以在短时间内找到一个近似最优叶片排序组合,相对于ILS算法,搜索效率提高了20%以上。计算得到的合成质径积的近似最优解,相对于现有分组排序法、遗传算法、云自适应遗传算法(CAGA)等方法,分别减小到其最优解的0.33%~31%,且计算时间也大幅度减小。展开更多
Neoadjuvant immunochemotherapy has shown promising results,with major pathologic response(MPR,≤10%residual viable tumors[RVT])as the primary outcome.However,%RVT showed limited predictive power in stratifying outcome...Neoadjuvant immunochemotherapy has shown promising results,with major pathologic response(MPR,≤10%residual viable tumors[RVT])as the primary outcome.However,%RVT showed limited predictive power in stratifying outcomes within the MPR and non-MPR groups.To identify a better prognostic marker,this study analyzed 200 non-small-cell lung cancer(NSCLC)samples after neoadjuvant PD-1 blockade combined with chemotherapy across three medical centers.Among these patients,99 had necrotic regions in their residual lesions.We found that tumor-infiltrating lymphocytes in necrotic areas(nTILs)lose their cellular structure,but retained T-cell-specific antigens,making them detectable by immunohistochemistry.Regardless of PD-L1 status or lymph node metastasis,patients with high CD8+nTIL density had significantly improved event-free survival(EFS)(hazard ratio[HR]:0.08;95%CI:[0.01-0.62];p=0.0019).Furthermore,CD8+nTIL density improved prognostic predictions for patients within the MPR(p=0.017)and non-MPR groups(p=0.076).Radiological responses did not correlate with MPR,CD8+nTIL density or EFS.41.5%MPR cases were misclassified by radiological assessments.When compared with radiographic response and pathological response,CD8+nTIL density outperformed these traditional parameters in approximating EFS.These findings demonstrate that the CD8+nTIL density is a robust predictor of EFS in NSCLC patients treated with neoadjuvant immunochemotherapy and has great potential in guiding treatment decisions.展开更多
文摘通过优化汽轮机叶片的安装顺序,来减少安装后的残余不平衡量。对此提出一种阈值式迭代局部搜索(threshold iterative local search,TILS)算法,该算法在迭代局部搜索(iterative local search,ILS)算法基础上,采用阈值限定扰动与随机扰动相结合的方法来跳出局部最优解,减少了平均到达局部最优解所需的迭代步数。实验证明,该方法可以在短时间内找到一个近似最优叶片排序组合,相对于ILS算法,搜索效率提高了20%以上。计算得到的合成质径积的近似最优解,相对于现有分组排序法、遗传算法、云自适应遗传算法(CAGA)等方法,分别减小到其最优解的0.33%~31%,且计算时间也大幅度减小。
基金H.L.is supported by the Institute of Zoology,Chinese Academy of Sciences,by grant funding from the National Natural Science Foundation of China(the National Science Fund for Excellent Young Scholars,E2111711 and General Program,E4110911)the Ministry of Science and Technology of the People’s Republic of China(National Key Basic Research Program,E310R811)+4 种基金the Chinese Academy of Sciences(Young Investigator Program in Basic Research,E2296111the Strategic Priority Research Program,XDC0200000the Incubation Fund Project from the Institute for Stem Cell and Regeneration,2023FH101,2023FH102,2023FH103)Y.H.is supported by grant funding from the Beijing Municipal Public Welfare Development and Reform Pilot Project for Medical Research Institutes(JYY2023-15)the Capability Enhancement Program(nlys2025-14).
文摘Neoadjuvant immunochemotherapy has shown promising results,with major pathologic response(MPR,≤10%residual viable tumors[RVT])as the primary outcome.However,%RVT showed limited predictive power in stratifying outcomes within the MPR and non-MPR groups.To identify a better prognostic marker,this study analyzed 200 non-small-cell lung cancer(NSCLC)samples after neoadjuvant PD-1 blockade combined with chemotherapy across three medical centers.Among these patients,99 had necrotic regions in their residual lesions.We found that tumor-infiltrating lymphocytes in necrotic areas(nTILs)lose their cellular structure,but retained T-cell-specific antigens,making them detectable by immunohistochemistry.Regardless of PD-L1 status or lymph node metastasis,patients with high CD8+nTIL density had significantly improved event-free survival(EFS)(hazard ratio[HR]:0.08;95%CI:[0.01-0.62];p=0.0019).Furthermore,CD8+nTIL density improved prognostic predictions for patients within the MPR(p=0.017)and non-MPR groups(p=0.076).Radiological responses did not correlate with MPR,CD8+nTIL density or EFS.41.5%MPR cases were misclassified by radiological assessments.When compared with radiographic response and pathological response,CD8+nTIL density outperformed these traditional parameters in approximating EFS.These findings demonstrate that the CD8+nTIL density is a robust predictor of EFS in NSCLC patients treated with neoadjuvant immunochemotherapy and has great potential in guiding treatment decisions.
