A comprehensive examination of detrital sandstone modes from the Sylhet Trough reveals a diverse range of sub-lithic to sub-feldspathic quartz arenites.Soil samples were gathered from Dupi Gaon(Jaintiapur)in Banglades...A comprehensive examination of detrital sandstone modes from the Sylhet Trough reveals a diverse range of sub-lithic to sub-feldspathic quartz arenites.Soil samples were gathered from Dupi Gaon(Jaintiapur)in Bangladesh,followed by a thorough analysis using field examination,X-ray diffraction(XRD),X-ray fluorescence(XRF),petrography,and heavy mineral concentration analyses.Field observations revealed the soil sample varying from white to yellowish to variegated,with thicknesses ranging from 15 cm to about 4 m,and exhibiting moderate softness.XRF analysis revealed significant SiO_(2),Al_(2)O_(3),and Fe_(2)O_(3)levels in the samples,with zirconium(Zr)and copper(Cu)showing consistently high concentrations.XRD analysis identified quartz as predominant,along with muscovite,biotite,and accessory minerals like rutile and magnetite.Petrographic analysis highlighted quartz as dominant,with fractures suggesting tectonic influences,while heavy mineral separation techniques identified zircon,garnet,goethite,rutile,and magnetite.These findings provide insights into sediment provenance,depositional processes,and environ-mental conditions during the formation of the Dupi Tila Formation.The comprehensive geochemical data of the entire rock indicates that most of the sediments originated from felsic igneous sources,and also suggests a moderate to high level of weathering in the source region.Overall,the analyses suggested an in situ origin of the Dupi Tila Formation,with parent materials being predominantly detrital rather than authigenic,supported by the presence of detrital quartz and an assessment of the depositional environment,providing insights into the geological conditions of the era and potential modes of sediment transportation.展开更多
The objective response rate of conventional transarterial chemoembolization(TACE)for locoregional control of hepatocellular carcinoma(HCC)is approximately 50%.We previously developed bicarbonate-integrated TACE,termed...The objective response rate of conventional transarterial chemoembolization(TACE)for locoregional control of hepatocellular carcinoma(HCC)is approximately 50%.We previously developed bicarbonate-integrated TACE,termed TILA-TACE,which demonstrated 100%effectiveness for locoregional control of unresectable HCC.This study aimed to validate its efficacy,selectivity,and safety in real-world clinical practice(ChiCTR-ONC-17013416).A total of 413 patients were enrolled,including 40(9.7%)with early-stage HCC,29(7.0%)with intermediate-stage HCC,and 344(83.3%)with advanced-stage HCC.Primary tumors and macrovascular invasion/extrahepatic metastases were treated with TILA-TACE and radiation therapy,respectively.The side effects of TILA-TACE were recorded.The objective response rate of HCC tumors to TILA-TACE was 99.01%,including a complete response in 72.77%of patients.The objective response rate of tumor thrombus to radiation therapy was 96.88%.During a median follow-up of 38 months,there were 1 and 4 deaths among early-and intermediate-stage patients,respectively.The median survival of advanced-stage patients was 27 months.We found that intrahepatic metastases accounted for 70.4%(107/152)of cancer-related deaths after effective control of primary tumors and vascular invasion.The main adverse events associated with TILA-TACE were transient liver enzyme or bilirubin abnormalities(86.44%and 56.66%,respectively),which was consistent with the known sideeffect profile of TACE.In conclusion,TILA-TACE is a novel and highly effective treatment for the local control of HCC with a tolerable safety profile.When combined with radiation therapy for macrovascular invasion,it offers significant survival benefits for patients with advanced HCC.展开更多
文摘A comprehensive examination of detrital sandstone modes from the Sylhet Trough reveals a diverse range of sub-lithic to sub-feldspathic quartz arenites.Soil samples were gathered from Dupi Gaon(Jaintiapur)in Bangladesh,followed by a thorough analysis using field examination,X-ray diffraction(XRD),X-ray fluorescence(XRF),petrography,and heavy mineral concentration analyses.Field observations revealed the soil sample varying from white to yellowish to variegated,with thicknesses ranging from 15 cm to about 4 m,and exhibiting moderate softness.XRF analysis revealed significant SiO_(2),Al_(2)O_(3),and Fe_(2)O_(3)levels in the samples,with zirconium(Zr)and copper(Cu)showing consistently high concentrations.XRD analysis identified quartz as predominant,along with muscovite,biotite,and accessory minerals like rutile and magnetite.Petrographic analysis highlighted quartz as dominant,with fractures suggesting tectonic influences,while heavy mineral separation techniques identified zircon,garnet,goethite,rutile,and magnetite.These findings provide insights into sediment provenance,depositional processes,and environ-mental conditions during the formation of the Dupi Tila Formation.The comprehensive geochemical data of the entire rock indicates that most of the sediments originated from felsic igneous sources,and also suggests a moderate to high level of weathering in the source region.Overall,the analyses suggested an in situ origin of the Dupi Tila Formation,with parent materials being predominantly detrital rather than authigenic,supported by the presence of detrital quartz and an assessment of the depositional environment,providing insights into the geological conditions of the era and potential modes of sediment transportation.
基金supported by a key project(2018C03009)funded by the Zhejiang Provincial Department of Sciences and Technologies to X.H.and M.C.
文摘The objective response rate of conventional transarterial chemoembolization(TACE)for locoregional control of hepatocellular carcinoma(HCC)is approximately 50%.We previously developed bicarbonate-integrated TACE,termed TILA-TACE,which demonstrated 100%effectiveness for locoregional control of unresectable HCC.This study aimed to validate its efficacy,selectivity,and safety in real-world clinical practice(ChiCTR-ONC-17013416).A total of 413 patients were enrolled,including 40(9.7%)with early-stage HCC,29(7.0%)with intermediate-stage HCC,and 344(83.3%)with advanced-stage HCC.Primary tumors and macrovascular invasion/extrahepatic metastases were treated with TILA-TACE and radiation therapy,respectively.The side effects of TILA-TACE were recorded.The objective response rate of HCC tumors to TILA-TACE was 99.01%,including a complete response in 72.77%of patients.The objective response rate of tumor thrombus to radiation therapy was 96.88%.During a median follow-up of 38 months,there were 1 and 4 deaths among early-and intermediate-stage patients,respectively.The median survival of advanced-stage patients was 27 months.We found that intrahepatic metastases accounted for 70.4%(107/152)of cancer-related deaths after effective control of primary tumors and vascular invasion.The main adverse events associated with TILA-TACE were transient liver enzyme or bilirubin abnormalities(86.44%and 56.66%,respectively),which was consistent with the known sideeffect profile of TACE.In conclusion,TILA-TACE is a novel and highly effective treatment for the local control of HCC with a tolerable safety profile.When combined with radiation therapy for macrovascular invasion,it offers significant survival benefits for patients with advanced HCC.
