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基于Ang-Tie2/VEGF信号轴探讨益景汤对糖尿病微血管异常的干预机制
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作者 任秉仪 刘光辉 +2 位作者 柯小清 潘铭东 郑永征 《亚太传统医药》 2025年第9期24-28,共5页
目的:基于血管生成素(Ang)-内膜内皮酪氨酸激酶(Tie2)信号通路/血管内皮生长因子(VEGF)信号轴探讨益景汤对糖尿病微血管异常的干预机制。方法:采用12周龄雄性SPF级大鼠40只(Wistar大鼠10只,GK自发糖尿病大鼠30只),Wistar大鼠为正常组,30... 目的:基于血管生成素(Ang)-内膜内皮酪氨酸激酶(Tie2)信号通路/血管内皮生长因子(VEGF)信号轴探讨益景汤对糖尿病微血管异常的干预机制。方法:采用12周龄雄性SPF级大鼠40只(Wistar大鼠10只,GK自发糖尿病大鼠30只),Wistar大鼠为正常组,30只GK大鼠随机分为模型组、西药组(羟苯磺酸钙组)和中药组(益景汤组),每组10只。正常组和模型组予以PBS缓冲液灌胃;西药组予以羟苯磺酸钙片156 mg/(kg·d),采用PBS缓冲液稀释灌胃;益景汤组予以益景汤水煎液,按方剂饮片合剂量10.71 g/(kg·d)灌胃,qd。以上处理持续12周。治疗结束后处死全部大鼠,摘除眼球,取视网膜组织,RT-PCR检测Ang1、Ang2、Tie1、Tie2、VEGF、CⅣ、Occludin因子的mRNA表达;Western Blot检测Ang2、Tie2、VEGF、CⅣ、Occludin因子相关的蛋白表达。结果:模型组Ang1、Tie2、Occludin mRNA表达量较正常组明显下降,而Ang2、Tie1、VEGF及CⅣ的mRNA表达量均较正常组明显上升,差异均具有统计学意义(P<0.05);西药组和中药组Ang1、Tie2、Occludin mRNA表达量较模型组明显升高,而Ang2、Tie1、VEGF及CⅣmRNA表达量均较模型组下降,差异均具有统计学意义(P<0.05)。模型组Ang2、VEGF、CⅣ蛋白表达较正常组升高,Tie2、Occludin蛋白表达较正常组降低,差异均具有统计学意义(P<0.05);西药组和中药组Ang2、VEGF、CⅣ蛋白表达较模型组明显降低,Tie2、Occludin蛋白表达均较模型组升高,差异均具有统计学意义(P<0.05)。结论:益景汤可通过抑制Ang2、VEGF、CⅣ的异常表达,激活Tie2及Occludin蛋白的高表达,减轻糖尿病早期微血管损害,修复iBRB功能。 展开更多
关键词 益景汤 糖尿病微血管异常 Ang tie VEGF CⅣ OCCLUDIN
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Spain-China:Strengthening Strategic Ties in a Changing Global Landscape
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作者 MARCELO MUÑOZ 《China Today》 2025年第10期24-27,共4页
Marking 20 years as comprehensive strategic partners,Spain and China should now deepen their ties through sustained dialogue,mutual respect,and pragmatic cooperation.
关键词 pragmatic cooperation comprehensive strategic partners dialogue strategic ties deepen their ties mutual respect global landscape
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SHAPING STABILITY THROUGH PARTNERSHIP China and ASEAN are navigating global uncertainties by deepening strategic ties
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作者 Ahmad Syaifuddin Zuhri 《China Report ASEAN》 2025年第8期53-55,共3页
The evolution of China-ASEAN relations ranks among the most significant geopolitical and economic dynamics of the 21st Century.Comprising 10 Southeast Asian nations,ASEAN has held the position of China’s largest trad... The evolution of China-ASEAN relations ranks among the most significant geopolitical and economic dynamics of the 21st Century.Comprising 10 Southeast Asian nations,ASEAN has held the position of China’s largest trading partner since 2020.This partnership is underpinned by sustained economic growth,political stability,security cooperation,and vibrant socio-cultural exchanges.Over the past two decades,the China-ASEAN relationship has emerged as a main axis in Asia’s geopolitical and economic landscape.By 2025,this partnership has entered a more intricate and strategic phase marked by deeper economic collaboration,expanded multilateral diplomacy,and mounting challenges stemming from global developments such as tari"wars and South China Sea tensions. 展开更多
关键词 southeast asian China ASEAN relations economic growth political stability geopolitical economic dynamics global uncertainties strategic ties security cooperation
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面向工程教育的TIE提示语框架的设计与应用研究 被引量:2
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作者 钟柏昌 裴永漫 《电化教育研究》 北大核心 2025年第4期40-48,共9页
工程教育在提高学生的创新能力方面发挥着重要作用,而生成式人工智能(GAI)的教育应用对学生创新能力的培养提出了新的挑战。因此,将GAI引入工程教育需要进行审慎的设计。为此,研究在现有通用GAI提示语框架的基础上,融入发明问题解决理论... 工程教育在提高学生的创新能力方面发挥着重要作用,而生成式人工智能(GAI)的教育应用对学生创新能力的培养提出了新的挑战。因此,将GAI引入工程教育需要进行审慎的设计。为此,研究在现有通用GAI提示语框架的基础上,融入发明问题解决理论(TRIZ理论)和逆向工程方法,构建了面向工程教育的TIE提示语框架。为验证其在工程教育中的有效性,课题组采用实验研究方法,随机选择了两个初中班级进行比较实验。结果表明,与不使用GAI的班级相比,TIE提示语框架的使用能够显著提升学生的创新能力、工程知识水平和工程设计能力,具有较为重要的应用潜力与教育价值。 展开更多
关键词 生成式人工智能 工程教育 tie提示语框架 TRIZ理论 逆向工程方法
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大直径泥水盾构地表沉降Tie约束模型数值模拟研究 被引量:2
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作者 赫明胜 《建筑机械化》 2025年第4期132-136,共5页
针对泥水盾构开挖越江隧道时经过粉细砂地层易产生较大地表沉降的问题,结合武汉市轨道交通12号线越江隧道工程,建立三维有限元模型进行数值模拟,并引入衬砌与土体刚性连接的Tie约束模型模拟盾构工程实际情况,计算分步开挖下的地表横向... 针对泥水盾构开挖越江隧道时经过粉细砂地层易产生较大地表沉降的问题,结合武汉市轨道交通12号线越江隧道工程,建立三维有限元模型进行数值模拟,并引入衬砌与土体刚性连接的Tie约束模型模拟盾构工程实际情况,计算分步开挖下的地表横向截面沉降结果,与实际监测沉降数据进行对比。结果表明,盾构隧道开挖边线范围内沉降最多,且在隧道开挖隧道轴线正上方出现最大地表沉降,而tie约束计算结果与普通接触约束计算结果相比与实际监测地表沉降结果更相符。 展开更多
关键词 盾构隧道 地表沉降 有限元分析 数值模拟 tie约束模型
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基于Bow-tie模型的LPG运输全过程风险分析研究 被引量:2
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作者 王一昊 赵焕省 吴策宇 《石油化工自动化》 2025年第2期37-42,95,共7页
近年来,由危化品运输泄漏造成的安全风险引起人们的重视。统计分析了中国近年来发生的危化品运输事故,选取较为常见的液化石油气(LPG)运输事故作为研究对象,运用领结图分析法(Bow-tie)分析LPG装卸及运输的危害因素及事故后果,构建LPG运... 近年来,由危化品运输泄漏造成的安全风险引起人们的重视。统计分析了中国近年来发生的危化品运输事故,选取较为常见的液化石油气(LPG)运输事故作为研究对象,运用领结图分析法(Bow-tie)分析LPG装卸及运输的危害因素及事故后果,构建LPG运输全流程的Bow-tie分析模型,针对关键风险因素提出预防措施和事故后果减缓措施。结果表明,Bow-tie分析方法基于直观的安全结构图表,可以清晰表达LPG运输全流程事故原因、后果及对应预防、控制措施,有利于提升LPG运输安全管理水平。 展开更多
关键词 危险化学品运输 装卸 泄漏事故 Bow-tie模型 减缓措施
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脑电生物反馈联合利培酮对老年精神分裂症患者疗效及血清Hcy、BDNF、Tie-2的影响 被引量:1
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作者 王瀚宇 苗逸晨 +1 位作者 李元林 刘昊 《中南医学科学杂志》 2025年第1期102-105,共4页
目的探讨脑电生物反馈联合利培酮对老年精神分裂症患者疗效及血清同型半胱氨酸(Hcy)、脑源性神经营养因子(BDNF)、人血管生成素受体酪氨酸激酶-2(Tie-2)的影响。方法选取老年精神分裂症患者80例,随机均分为对照组(利培酮)、观察组(脑电... 目的探讨脑电生物反馈联合利培酮对老年精神分裂症患者疗效及血清同型半胱氨酸(Hcy)、脑源性神经营养因子(BDNF)、人血管生成素受体酪氨酸激酶-2(Tie-2)的影响。方法选取老年精神分裂症患者80例,随机均分为对照组(利培酮)、观察组(脑电生物反馈联合利培酮)。比较两组临床疗效、脑电波指标、Hcy、BDNF、Tie-2水平、社会功能及精神状况改善情况。结果治疗后,观察组治疗总有效率高于对照组(P<0.05)。与治疗前比较,治疗后两组SMR波、β波、SSFPI评分、BDNF、Tie-2水平升高,θ波、BPRS评分、Hcy水平降低;且治疗后观察组变化较对照组更为显著(P<0.05)。结论老年精神分裂症采用脑电生物反馈联合利培酮治疗疗效良好,可有效调节脑电波,改善社会功能及精神状况,并调控Hcy、BDNF、Tie-2水平。 展开更多
关键词 脑电生物反馈 利培酮 老年精神分裂症 Hcy BDNF tie-2
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基于Bow-tie模型的大型原油储存基地储罐风险与屏障分析
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作者 桑磊 赵敏 《安全、健康和环境》 2025年第11期20-27,共8页
为有效管控大型原油储存基地(危险源聚集、固有风险高)因规模扩大带来的风险,应用蝴蝶结(Bow-tie)模型,结合95起典型事故案例,以原油(气)泄漏为顶上事件,系统构建了预防与减缓屏障体系。通过某基地实例应用验证了该体系的有效性,能够直... 为有效管控大型原油储存基地(危险源聚集、固有风险高)因规模扩大带来的风险,应用蝴蝶结(Bow-tie)模型,结合95起典型事故案例,以原油(气)泄漏为顶上事件,系统构建了预防与减缓屏障体系。通过某基地实例应用验证了该体系的有效性,能够直观展示风险路径,所提出的控制措施可切断事故链,实现风险受控。研究成果对预防火灾与环境污染事故具有实践意义,可为企业的风险识别与隐患排查提供系统方法与依据。 展开更多
关键词 Bow-tie模型 储罐泄漏 预防屏障 减缓屏障 事故链
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TIE1的泛癌图谱及其在宫颈癌中的潜在作用机制
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作者 韦洪建 王鑫 +3 位作者 刘芯言 林冰洁 王齐心 史永华 《海南医科大学学报》 北大核心 2025年第11期849-862,共14页
目的:探讨TIE1在人体肿瘤组织中的表达谱及其潜在的临床意义。方法:利用TIMER2、GEPIA2、cBioPortal、UALCAN和STRING等在线网站和数据库,分析不同类型癌症中TIE1的表达与预后、遗传改变、肿瘤免疫及甲基化状态之间的关系。在本研究中,... 目的:探讨TIE1在人体肿瘤组织中的表达谱及其潜在的临床意义。方法:利用TIMER2、GEPIA2、cBioPortal、UALCAN和STRING等在线网站和数据库,分析不同类型癌症中TIE1的表达与预后、遗传改变、肿瘤免疫及甲基化状态之间的关系。在本研究中,使用宫颈癌患者的数据集分析了TIE1表达,并通过富集分析研究了TIE1的分子机制。通过划痕及Transwell侵袭实验进行体外研究,以确定TIE1在宫颈癌细胞中的生物学功能。结果:泛癌分析显示,TIE1在某些肿瘤中表达上调,其表达与癌症患者的预后显著相关。经数据库分析发现TIE1在皮肤黑色素瘤患者中的基因改变频率最高。此外,TIE1的表达与某些肿瘤中的免疫细胞浸润密切相关。在某些类型的肿瘤中,TIE1启动子的甲基化水平显示出显著差异。通过KEGG富集分析发现与TIE1相关的基因在Ras、PI3K-Akt、RAP1和MAPK信号通路中有较高的富集程度。在宫颈癌数据集GO富集分析也表明,这些基因在与外部包裹结构组织、含胶原蛋白的细胞外基质以及与糖胺聚糖结合相关的通路中富集。此外,体外实验的结果进一步证实了TIE1在促进宫颈癌细胞迁移和侵袭方面的作用。结论:TIE1的表达水平与临床预后、基因突变以及肿瘤细胞周围的免疫浸润状态之间存在密切的关联性。本研究为深入理解TIE1在肿瘤发生和发展过程中的作用提供了关键基础数据。 展开更多
关键词 tie1 生存分析 免疫浸润分析 甲基化分析 富集分析
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一种基于Bow-tie模型的ADS-B IN应用安全评估方法
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作者 肖阳 王洪 赵子安 《电讯技术》 北大核心 2025年第11期1886-1893,共8页
广播式自动相关空空监视(Automatic Dependent Surveillance-Broadcast IN,ADS-B IN)应用能够在飞行活动中为飞行员提供诸多便利,而安全性是实现ADS-B IN应用优势的前提。针对ADS-B IN应用在实际飞行活动中可能存在的安全性问题,引入了... 广播式自动相关空空监视(Automatic Dependent Surveillance-Broadcast IN,ADS-B IN)应用能够在飞行活动中为飞行员提供诸多便利,而安全性是实现ADS-B IN应用优势的前提。针对ADS-B IN应用在实际飞行活动中可能存在的安全性问题,引入了一种基于Bow-tie模型的安全评估方法。该方法通过对预设危险进行分析,得出危险发生的最大可接受概率,进而推导出为实现这一概率所需的ADS-B设备失效率或通信数据链路完整性等安全要求。在对该方法进行阐述的基础上,给出了一个具体实施案例,对该方法做进一步说明。 展开更多
关键词 广播式自动相关监视 Bow-tie模型 事件树分析 故障树分析
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Tie‐dye:The blooming“flower”on fabric
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作者 罗丽红 《疯狂英语(新悦读)》 2025年第5期50-51,77,共3页
Tie‑dye is a traditional craft that has been passed down through generations.It is an ancient art form that involves tying and dyeing fabric to create beautiful patterns.This craft is not only a way to make clothes an... Tie‑dye is a traditional craft that has been passed down through generations.It is an ancient art form that involves tying and dyeing fabric to create beautiful patterns.This craft is not only a way to make clothes and textiles more colorful but also a way to express creativity and culture. 展开更多
关键词 tying dyeing fabric FABRIC CULTURE tie dye patterns express creativity culture art form CREATIVITY
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Honoring Ties,Embracing the Future Congratulatory message from the Consul General of Myanmar in Nanning on CAEXPO 2025
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《China Report ASEAN》 2025年第9期21-21,共1页
Mingalarpar!On behalf of the Consulate-General of the Republic of the Union of Myanmar in Nanning,I would like to express my sincerest congratulations to CAEXPO on reaching the remarkable milestone of over 20 years—a... Mingalarpar!On behalf of the Consulate-General of the Republic of the Union of Myanmar in Nanning,I would like to express my sincerest congratulations to CAEXPO on reaching the remarkable milestone of over 20 years—an incredible journey filled with numerous achievements. 展开更多
关键词 consulate general CAEXPO milestone CONGRATULATIONS tieS ACHIEVEMENTS Nanning future
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CURRENTS OF COOPERATION With 89 years of legacy,BOC Singapore Branch continues to drive China-Singapore ties while deepening engagement across ASEAN
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作者 Li Xiaolin 《China Report ASEAN》 2025年第8期62-63,共2页
In Chinese tradition,the term“耄耋”(Mào Dié)refers to those in their nineties,a stage of life associated with wisdom and longevity.As the Bank of China Singapore Branch(BOCSG)approaches its 90th anniversar... In Chinese tradition,the term“耄耋”(Mào Dié)refers to those in their nineties,a stage of life associated with wisdom and longevity.As the Bank of China Singapore Branch(BOCSG)approaches its 90th anniversary,this expression captures the spirit of an institution that has stood the test of time.Since its establishment in Singapore in 1936,the BOCSG has maintained a strong and enduring presence not only in Singapore but across Southeast Asia,serving as a bridge between China and Singapore,and more broadly,between China and the ASEAN region.Its continued growth has been underpinned by the mutual prosperity of both economies and the strength of their longstanding and harmonious ties. 展开更多
关键词 anniversary wisdom longevity ASEAN engagement LEGACY Bank China Singapore Branch COOPERATION China Singapore ties
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China-EU Partnership: Mutual Uplift for a Brighter World——Celebrating the 50th Anniversary of Diplomatic Ties
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作者 CAI RUN 《China Today》 2025年第5期28-31,共4页
A sound and stable partnership between China and the EU will not only propel shared development,but also illuminate a path for the world.
关键词 EU stable partnership global path China diplomatic ties shared development mutual uplift
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China-Indonesia Economic and Trade Cooperation:Current situation,challenges and opportunities
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作者 Karim Akmal Fouad Abdelhamid Soliman 《China's Foreign Trade》 2025年第4期44-46,共3页
Since the early 2000s,economic ties between China and Indonesia have grown into one of the most important bilateral partnerships in Asia.Recent developments have strengthened this relationship,as Indonesia became Chin... Since the early 2000s,economic ties between China and Indonesia have grown into one of the most important bilateral partnerships in Asia.Recent developments have strengthened this relationship,as Indonesia became China’s largest trading partner for the ninth repeated year,with bilateral trade surpassing USD 147 billion in 2024. 展开更多
关键词 bilateral partnership trade relations indonesia china bilateral trade economic ties bilateral partnerships trade volume
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Upgrading Economic Ties
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作者 HE WENPING 《ChinAfrica》 2025年第7期28-30,共3页
New agreements and projects expand the scope of China-Africa cooperation across all sectors This year marks the 25th anniversary of the founding of the Forum on China-Africa Cooperation(FOCAC).It is also the inau-gura... New agreements and projects expand the scope of China-Africa cooperation across all sectors This year marks the 25th anniversary of the founding of the Forum on China-Africa Cooperation(FOCAC).It is also the inau-gural year for implementing the outcomes of the 2024 FOCAC Summit in Beijing.In June,Changsha,Hunan Province,hosted a series of China-Africa engagements poised to deepen their ties further. 展开更多
关键词 focac th anniversary china africa cooperation forum china africa cooperation SECTORS projects economic ties new agreements
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50 Years of EU-China Ties:Spain Hails China as a Key EU Partner
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作者 AUGUSTO SOTO 《China Today》 2025年第7期20-21,共2页
Reaffirming its commitment to strengthening ties with China,Spain underscores its role as a bridge between Europe and China in a shifting global landscape.JUST days before Spanish Prime Minister Pedro Sánchez emb... Reaffirming its commitment to strengthening ties with China,Spain underscores its role as a bridge between Europe and China in a shifting global landscape.JUST days before Spanish Prime Minister Pedro Sánchez embarked on his third official visit to Beijing in April in less than three years,the Spanish government hosted a high-level meeting at the Moncloa Palace in Madrid with five prominent Spanish China experts specializing in bilateral relations and continental ties with Beijing.I was honored to join this select group for a three-hour exchange of views with Prime Minister Sánchez and his team-a conversation marked by candor and strategic vision. 展开更多
关键词 bilateral relations EU China ties China spanish china experts global landscape strategic vision Spain
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A Taste of Trade Burundian co%ee exports to China fulfil a historic agreement, deepening bilateral trade ties
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作者 《ChinAfrica》 2025年第11期44-45,共2页
In what is a great news for those engage in the co!ee sector,the government of Burundi and the Chinese embassy in Bujumbura recently announced the commencement of exports of Burundian co!ee to China.The first consignm... In what is a great news for those engage in the co!ee sector,the government of Burundi and the Chinese embassy in Bujumbura recently announced the commencement of exports of Burundian co!ee to China.The first consignment of 38 tonnes of green co!ee has already been shipped to China.This will further strengthen the economic and trade relations between the two countries.China Henan International Cooperation Group(CHICO)will be responsible for selling Burundian co!ee in China. 展开更多
关键词 economic trade relations economic relations trade relations TRADE Burundian coffee bilateral trade ties Chinese embassy China
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Educational Endeavors The Nanyang Institute of Management is strengthening people-to-people ties between China and Singapore
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作者 Huang Jiangqin 《China Report ASEAN》 2025年第8期47-47,共1页
The Nanyang Institute of Management(NIM)was established as a private university in Singapore in 2001.The institute consists of eight schools,including a School of Business,School of Logistics,School of Art,School of T... The Nanyang Institute of Management(NIM)was established as a private university in Singapore in 2001.The institute consists of eight schools,including a School of Business,School of Logistics,School of Art,School of Tourism&Hospitality,School of Language,and School of Information Technology,serving approximately 1,000 international students from 22 countries.At present,NIM maintains its Southeast Asian presence mostly in Singapore,Malaysia,and Thailand.The students at the institute mainly hail from the 10 ASEAN member states,China,and India.In terms of major selection,the traditional popular majors such as business administration,finance,and hotel management remain in high demand.In recent years,with the development of big data,the number of students choosing to major in artificial intelligence and art has increased,leading to a trend of diversification.An increasing number of students have begun to follow their personal interests in major selection. 展开更多
关键词 educational endeavors SINGAPORE people people ties China private university Southeast Asian presence ASEAN Nanyang Institute Management
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Stronger Ties,Greater Markets Congratulatory message from the Consul General of the Lao PDR in Nanning on the 22nd CAEXPO
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《China Report ASEAN》 2025年第9期19-20,共2页
Since 2004,China has been dedicated to expanding economic integration with ASEAN countries,designating Guangxi Zhuang Autonomous Region as a hub to attract ASEAN member countries for greater coordination and economic ... Since 2004,China has been dedicated to expanding economic integration with ASEAN countries,designating Guangxi Zhuang Autonomous Region as a hub to attract ASEAN member countries for greater coordination and economic cooperation.Each year,Guangxi hosts the China-ASEAN Expo(CAEXPO)and related activities,providing a platform for strategic economic partners to meet,discuss,and explore ways to strengthen trade and investment cooperation. 展开更多
关键词 expanding economic integration asean countriesdesignating Nanning economic integration Lao PDR coordination economic cooperationeach consul general CAEXPO stronger ties
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