Objective: To explore the correlation of TI-RADS grading with oncogene and invasion molecule expression in thyroid cancer lesions. Methods: Patients who were diagnosed with thyroid cancer in this hospital between Janu...Objective: To explore the correlation of TI-RADS grading with oncogene and invasion molecule expression in thyroid cancer lesions. Methods: Patients who were diagnosed with thyroid cancer in this hospital between January 2017 and January 2018 were divided into TI-RADS grade 4 group (n=54) and TI-RADS grade 5 group (n=56) according to TI-RADS grading. 50 patients who underwent surgery and were diagnosed with thyroid adenoma in this hospital during the same period were chosen as benign thyroid group. The differences in the expression of oncogenes and invasion molecules in lesion tissues were compared among the three groups. Results: Proto-oncogenes c-myc, c-erbB-2, RET and TRK mRNA expression in lesions of TI-RADS grade 4 group and TI-RADS grade 5 group were higher than those of benign thyroid group whereas tumor suppressor genes DPC4, p53, PTEN and HBB mRNA expression were lower than those of benign thyroid group;invasion molecules BCORL1, BRD4, STAT3, CD151, SATB1 and CXCR4 mRNA expression were higher than those of benign thyroid group whereas ST7L mRNA expression were lower than that of thyroid benign group. With the increase of TI-RADS grading, the changes in the expression of oncogenes and invasion molecules were aggravated. Conclusion: The changes in oncogene and invasion molecule expression were aggravated with the increase of TI-RADS grading of thyroid cancer, and the specific TI-RADS grading was positively correlated with tumor malignancy.展开更多
目的:拟采用超微血管成像技术(superb microvascular imaging,SMI)和超声造影(contrast-enhanced ultrasound,CEUS)相结合的方法,对甲状腺4a及4b级结节进行TI-RADS(thyroid imaging reporting and data system)分级。方法:对27例超声造...目的:拟采用超微血管成像技术(superb microvascular imaging,SMI)和超声造影(contrast-enhanced ultrasound,CEUS)相结合的方法,对甲状腺4a及4b级结节进行TI-RADS(thyroid imaging reporting and data system)分级。方法:对27例超声造影证实的甲状腺结节进行回顾性分析,术前分别行2 D灰阶超声、超微血管显像和超声造影,并对其进行分组、定量计分,得到各组的工作特性曲线(receiver operating characteristic,ROC)。结果:(1)27例行超声造影检查的甲状腺结节中:TI-RADS分级联合超微血管成像与TI-RADS分级联合超声造影曲线下面积相比较(Z=-0.206,P=0.175),诊断效能差异无统计学意义(P>0.05),表明SMI与CEUS诊断效能近似;(2)27例行超声造影检查的甲状腺结节中:TI-RADS分级联合超微血管成像和超声造影与TI-RADS分级曲线下面积相比较(Z=-1.242,P=0.011),诊断效能差异有统计学意义(P<0.05)。结论:TI-RADS分级联合超微血管成像结合超声造影能够提高甲状腺结节诊断的准确性,能够为临床诊治提供较为准确指导;超微血管成像与超声造影在鉴别诊断甲状腺结节良恶性方面具有较高一致性。展开更多
文摘Objective: To explore the correlation of TI-RADS grading with oncogene and invasion molecule expression in thyroid cancer lesions. Methods: Patients who were diagnosed with thyroid cancer in this hospital between January 2017 and January 2018 were divided into TI-RADS grade 4 group (n=54) and TI-RADS grade 5 group (n=56) according to TI-RADS grading. 50 patients who underwent surgery and were diagnosed with thyroid adenoma in this hospital during the same period were chosen as benign thyroid group. The differences in the expression of oncogenes and invasion molecules in lesion tissues were compared among the three groups. Results: Proto-oncogenes c-myc, c-erbB-2, RET and TRK mRNA expression in lesions of TI-RADS grade 4 group and TI-RADS grade 5 group were higher than those of benign thyroid group whereas tumor suppressor genes DPC4, p53, PTEN and HBB mRNA expression were lower than those of benign thyroid group;invasion molecules BCORL1, BRD4, STAT3, CD151, SATB1 and CXCR4 mRNA expression were higher than those of benign thyroid group whereas ST7L mRNA expression were lower than that of thyroid benign group. With the increase of TI-RADS grading, the changes in the expression of oncogenes and invasion molecules were aggravated. Conclusion: The changes in oncogene and invasion molecule expression were aggravated with the increase of TI-RADS grading of thyroid cancer, and the specific TI-RADS grading was positively correlated with tumor malignancy.
