Concerns on the coagulation variables, Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT) which are part of coagulation parameters used in assessing haemostatsis in haematology, led to the study of...Concerns on the coagulation variables, Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT) which are part of coagulation parameters used in assessing haemostatsis in haematology, led to the study of the effects of naphthoquinone and chloroquine on the PT and APTT of mice infected with <em>Plasmodium berghei</em>, and treated with graded concentrations of chloroquine and naphthoquinone. Using brain thromboplastin with calcium and rabbit brain cephalosporin ad kaolin respectively the experiment aimed at demonstrating the effect of chloroquine with purity of 99.79% and naphthoquinone with purity of 97.00%, upon a three-day intraperitoneal administration at concentrations of 0.1 mg/kg, 0.5 mg/kg, 1.0 mg/kg and 2.0 mg/kg. Result showed that the APTT and PT of naphthoquinone at 2.0 mg/kg, were 196.67 seconds, and 67.63 seconds respectively, while the APTT and PT of chloroquine were 3.63 seconds and 1.40 seconds respectively for the same concentration. Also, naphthoquinone showed lower APTT but sustained PT at concentrations below 1.50 mg/kg whereas both APTT and PT increased from concentrations above 1.50 mg/kg. On the other hand chloroquine showed a lowered APTT between 0.00 to 0.15 mg/kg while PT was sustained, but both APTT and PT increased from concentration of 0.15 mg/kg gradually. This study conclusively showed that chloroquine has a shorter APTT and PT than naphthoquinones, even though they elicited similar actions. Apart from this, naphthoquinone and chloroquine belonging to the same family, naphthoquinone could be more toxic than chloroquine at the dosages equivalent to 1.50 mg/kg, therefore, any administration of naphthoquinone above this dosage should be closely monitored to avoid any form of danger to the patient.展开更多
This letter to the editor involves the article published in the World Journal of Gastrointestinal Oncology.Bone metastasis(BM)in gastric cancer(GC)is uncommon but can be prevalent in autopsy studies.BM significantly i...This letter to the editor involves the article published in the World Journal of Gastrointestinal Oncology.Bone metastasis(BM)in gastric cancer(GC)is uncommon but can be prevalent in autopsy studies.BM significantly impairs quality of life and is frequently underdiagnosed,as sensitive diagnostic tests are only performed after symptoms occur.Imaging is crucial for the diagnosis of BM but is not routinely used for screening and is expensive.Examining laboratory risk factors for BM in GC patients using multivariate analysis could be a more effective approach.展开更多
目的探讨不同孕前体重指数(body mass index,BMI)孕妇孕早期凝血及纤溶功能与妊娠期糖尿病(gestational diabetes,GDM)发生的相关性。方法选取2023年9月至2024年2月到昆明医科大学第二附属医院产检的290例孕妇,收集孕前BMI、年龄、家族...目的探讨不同孕前体重指数(body mass index,BMI)孕妇孕早期凝血及纤溶功能与妊娠期糖尿病(gestational diabetes,GDM)发生的相关性。方法选取2023年9月至2024年2月到昆明医科大学第二附属医院产检的290例孕妇,收集孕前BMI、年龄、家族遗传史、孕次、产次及孕早期凝血及纤溶功能检查结果。根据是否发生GDM分为GDM组(n=72)及非GDM组(n=218),根据孕前BMI分为低体重GDM组(n=8)、低体重非GDM组(n=29)、正常体重GDM组(n=39)、正常体重非GDM组(n=145)、超重/肥胖GDM组(n=25)、超重/肥胖非GDM组(n=44),定量资料采用独立样本t检验或Mann-WhitneyU检验,定性资料采用χ^(2)检验或Fisher确切概率法,采用多因素Logistic回归校正影响因素。结果总人群中校正年龄、家族史以及孕前BMI后活化部分凝血活酶时间(APTT)与GDM发生呈负相关(P<0.05,OR=0.840),纤维蛋白原(FIB)与GDM呈正相关(P<0.01,OR=2.598)。在低体重组,APTT与GDM呈负相关(P<0.05,OR=0.483)、FIB与GDM呈正相关(P<0.05,OR=82.501),而校正年龄、家族史、孕前BMI后APTT、FIB与GDM无明显相关性;在正常体重组,APTT与GDM呈负相关(P<0.01,OR=0.786)、FIB与GDM呈正相关(P<0.05,OR=2.413),而校正年龄、家族史、孕前BMI后APTT与GDM仍呈负相关(P<0.05,OR=0.812)、FIB与GDM仍呈正相关(P<0.05,OR=2.391);在超重/肥胖组中,凝血酶时间(TT)与GDM呈负相关(P<0.05,OR=0.510),校正年龄、家族史、孕前BMI后TT与GDM无明显相关性。结论在正常体重人群中,APTT与GDM发生呈负相关,FIB与GDM发生呈正相关;在低体重与超重/肥胖人群中,凝血及纤溶相关指标受BMI影响较大,与GDM发生无明显相关性。展开更多
目的探讨极低出生体重儿(VLBWI)发生肺出血的高危因素并建立预测模型。方法回顾性分析2016年10月至2023年10月安徽医科大学第一附属医院收治的142例VLBWI的临床资料,按照新生儿肺出血诊断标准分为肺出血组(63例)和无肺出血组(79例)。收...目的探讨极低出生体重儿(VLBWI)发生肺出血的高危因素并建立预测模型。方法回顾性分析2016年10月至2023年10月安徽医科大学第一附属医院收治的142例VLBWI的临床资料,按照新生儿肺出血诊断标准分为肺出血组(63例)和无肺出血组(79例)。收集两组临床特征、凝血指标、血气分析指标等,先进行单因素分析,再纳入多因素logistic回归分析高危因素,构建预测模型,通过受试者工作特征(ROC)曲线、校准曲线及决策曲线对VLBWI肺出血预测模型进行评估。结果肺出血组和无肺出血组性别、剖宫产、羊水量异常、羊水污染、胎盘异常、脐带异常、人工授精、气管插管等比较,差异无统计学意义(P>0.05);两组出生体重、胎龄、肺表面活性物质(PS)使用、胎膜早破>18 h、产前糖皮质激素使用、低白蛋白血症、1 min Apgar评分、5 min Apgar评分、凝血酶原时间、凝血酶原活动度、国际标准化比值、活化部分凝血活酶时间(APTT)、纤维蛋白原、二氧化碳分压、HCO^(3-)、二氧化碳总量、游离钙(i Ca)比较,差异均有统计学意义(P<0.05)。多因素logistic分析显示,产前糖皮质激素使用、iCa是VLBWI肺出血发生的保护因素,PS使用、APTT是VLBWI肺出血发生的独立危险因素(P<0.05)。4个独立因素纳入最终模型,该模型的ROC曲线下面积为0.811。结论VLBWI肺出血的发生与产妇产前糖皮质激素使用、新生儿出生后PS使用、APTT延长及低iCa相关,利用这些因素构建的预测模型可帮助临床医生早期识别肺出血高危人群,为临床诊疗提供重要的参考信息,对发生肺出血有一定的预测作用。展开更多
文摘Concerns on the coagulation variables, Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT) which are part of coagulation parameters used in assessing haemostatsis in haematology, led to the study of the effects of naphthoquinone and chloroquine on the PT and APTT of mice infected with <em>Plasmodium berghei</em>, and treated with graded concentrations of chloroquine and naphthoquinone. Using brain thromboplastin with calcium and rabbit brain cephalosporin ad kaolin respectively the experiment aimed at demonstrating the effect of chloroquine with purity of 99.79% and naphthoquinone with purity of 97.00%, upon a three-day intraperitoneal administration at concentrations of 0.1 mg/kg, 0.5 mg/kg, 1.0 mg/kg and 2.0 mg/kg. Result showed that the APTT and PT of naphthoquinone at 2.0 mg/kg, were 196.67 seconds, and 67.63 seconds respectively, while the APTT and PT of chloroquine were 3.63 seconds and 1.40 seconds respectively for the same concentration. Also, naphthoquinone showed lower APTT but sustained PT at concentrations below 1.50 mg/kg whereas both APTT and PT increased from concentrations above 1.50 mg/kg. On the other hand chloroquine showed a lowered APTT between 0.00 to 0.15 mg/kg while PT was sustained, but both APTT and PT increased from concentration of 0.15 mg/kg gradually. This study conclusively showed that chloroquine has a shorter APTT and PT than naphthoquinones, even though they elicited similar actions. Apart from this, naphthoquinone and chloroquine belonging to the same family, naphthoquinone could be more toxic than chloroquine at the dosages equivalent to 1.50 mg/kg, therefore, any administration of naphthoquinone above this dosage should be closely monitored to avoid any form of danger to the patient.
文摘This letter to the editor involves the article published in the World Journal of Gastrointestinal Oncology.Bone metastasis(BM)in gastric cancer(GC)is uncommon but can be prevalent in autopsy studies.BM significantly impairs quality of life and is frequently underdiagnosed,as sensitive diagnostic tests are only performed after symptoms occur.Imaging is crucial for the diagnosis of BM but is not routinely used for screening and is expensive.Examining laboratory risk factors for BM in GC patients using multivariate analysis could be a more effective approach.
文摘目的探讨不同孕前体重指数(body mass index,BMI)孕妇孕早期凝血及纤溶功能与妊娠期糖尿病(gestational diabetes,GDM)发生的相关性。方法选取2023年9月至2024年2月到昆明医科大学第二附属医院产检的290例孕妇,收集孕前BMI、年龄、家族遗传史、孕次、产次及孕早期凝血及纤溶功能检查结果。根据是否发生GDM分为GDM组(n=72)及非GDM组(n=218),根据孕前BMI分为低体重GDM组(n=8)、低体重非GDM组(n=29)、正常体重GDM组(n=39)、正常体重非GDM组(n=145)、超重/肥胖GDM组(n=25)、超重/肥胖非GDM组(n=44),定量资料采用独立样本t检验或Mann-WhitneyU检验,定性资料采用χ^(2)检验或Fisher确切概率法,采用多因素Logistic回归校正影响因素。结果总人群中校正年龄、家族史以及孕前BMI后活化部分凝血活酶时间(APTT)与GDM发生呈负相关(P<0.05,OR=0.840),纤维蛋白原(FIB)与GDM呈正相关(P<0.01,OR=2.598)。在低体重组,APTT与GDM呈负相关(P<0.05,OR=0.483)、FIB与GDM呈正相关(P<0.05,OR=82.501),而校正年龄、家族史、孕前BMI后APTT、FIB与GDM无明显相关性;在正常体重组,APTT与GDM呈负相关(P<0.01,OR=0.786)、FIB与GDM呈正相关(P<0.05,OR=2.413),而校正年龄、家族史、孕前BMI后APTT与GDM仍呈负相关(P<0.05,OR=0.812)、FIB与GDM仍呈正相关(P<0.05,OR=2.391);在超重/肥胖组中,凝血酶时间(TT)与GDM呈负相关(P<0.05,OR=0.510),校正年龄、家族史、孕前BMI后TT与GDM无明显相关性。结论在正常体重人群中,APTT与GDM发生呈负相关,FIB与GDM发生呈正相关;在低体重与超重/肥胖人群中,凝血及纤溶相关指标受BMI影响较大,与GDM发生无明显相关性。
文摘目的探讨极低出生体重儿(VLBWI)发生肺出血的高危因素并建立预测模型。方法回顾性分析2016年10月至2023年10月安徽医科大学第一附属医院收治的142例VLBWI的临床资料,按照新生儿肺出血诊断标准分为肺出血组(63例)和无肺出血组(79例)。收集两组临床特征、凝血指标、血气分析指标等,先进行单因素分析,再纳入多因素logistic回归分析高危因素,构建预测模型,通过受试者工作特征(ROC)曲线、校准曲线及决策曲线对VLBWI肺出血预测模型进行评估。结果肺出血组和无肺出血组性别、剖宫产、羊水量异常、羊水污染、胎盘异常、脐带异常、人工授精、气管插管等比较,差异无统计学意义(P>0.05);两组出生体重、胎龄、肺表面活性物质(PS)使用、胎膜早破>18 h、产前糖皮质激素使用、低白蛋白血症、1 min Apgar评分、5 min Apgar评分、凝血酶原时间、凝血酶原活动度、国际标准化比值、活化部分凝血活酶时间(APTT)、纤维蛋白原、二氧化碳分压、HCO^(3-)、二氧化碳总量、游离钙(i Ca)比较,差异均有统计学意义(P<0.05)。多因素logistic分析显示,产前糖皮质激素使用、iCa是VLBWI肺出血发生的保护因素,PS使用、APTT是VLBWI肺出血发生的独立危险因素(P<0.05)。4个独立因素纳入最终模型,该模型的ROC曲线下面积为0.811。结论VLBWI肺出血的发生与产妇产前糖皮质激素使用、新生儿出生后PS使用、APTT延长及低iCa相关,利用这些因素构建的预测模型可帮助临床医生早期识别肺出血高危人群,为临床诊疗提供重要的参考信息,对发生肺出血有一定的预测作用。
