Enamines, promoted by the samarium/samarium diiodide mixed reagent, were synthesized via the cross-coupling of thioamides and diarylketones in good yields.
Introduction Reductive desulfurization of thioamides to amines is one of the methods to prepare amines and is generally achieved by a) Zn in acid, b) sodium or aluminum amal- gams, c) lithium alumminium hydride, d) Ra...Introduction Reductive desulfurization of thioamides to amines is one of the methods to prepare amines and is generally achieved by a) Zn in acid, b) sodium or aluminum amal- gams, c) lithium alumminium hydride, d) Raney Ni and e) electrolytic reduction. These methods are not very convenient to be operated and some need more complex instrument. Here is reported the reductive desulfurization of thioamides to amines by catalytic hydrogen transfer reaction(CHT).展开更多
We present here an efficient green process for the synthesis of 1,2,4-thiadiazoles via iodine-catalyzed,oxidative dimerization of thioamides in water using molecular oxygen as a terminal oxidant. Under the optimized r...We present here an efficient green process for the synthesis of 1,2,4-thiadiazoles via iodine-catalyzed,oxidative dimerization of thioamides in water using molecular oxygen as a terminal oxidant. Under the optimized reaction conditions, aryl thioamides produced 3,5-diaryl-1,2,4-thiadiazoles in good to excellent yields. Alkyl thioamides and substituted thioureas could also provide corresponding 1,2,4-thiadiazole products.展开更多
Ketones smoothly reacted with NBS in the presence of a catalytic amount of ptoluenesulfonic acid to give α-bromoketones in good yields in typical ionic liquids, such as [bmim]PF6 and [bmpy]Tf2N, and the ionic liquids...Ketones smoothly reacted with NBS in the presence of a catalytic amount of ptoluenesulfonic acid to give α-bromoketones in good yields in typical ionic liquids, such as [bmim]PF6 and [bmpy]Tf2N, and the ionic liquids could be repeatedly used for the same reaction after the extraction of the α-bromoketones. Then, the one-pot conversion of ketones into thiazoles by the treatment with NBS, and subsequently with thioamides could be also carried out in [bmim]PF6 and [bmpy]Tf2N, respectively Thus, [bmim]PF6 and [bmpy]Tf2N could be used as recyclable reaction media for the preparation α-bromoketones and thiazoles from ketones.展开更多
The efficient dehydrosulfurization of thioamides to nitriles was carried out using indium(III) triflate as a catalyst. Based on the results of the initial study, the optimal reaction conditions required 5 mol% of indi...The efficient dehydrosulfurization of thioamides to nitriles was carried out using indium(III) triflate as a catalyst. Based on the results of the initial study, the optimal reaction conditions required 5 mol% of indium(III) triflate with toluene as the practical solvent. Various thioamides were successfully converted to nitriles in high yields.展开更多
A facile and efficient approach to the synthesis of secondary thioamides from ketoximes via Beckmann rearrangement has been established, using phosphorus pentasulfide as a dehydrating and thiating agent. It is also ef...A facile and efficient approach to the synthesis of secondary thioamides from ketoximes via Beckmann rearrangement has been established, using phosphorus pentasulfide as a dehydrating and thiating agent. It is also efficient for the preparation of primary thiobenzamide from benzaldoxime. This approach features simple-operation, easy-control and good to excellent yields.展开更多
Two thioamino acids and four fiuorinated amino acids were employed to substitute either partially or entirely the Ile_(2),Ser_(3),Ile_(6),and Ser_(7) residues of Leu_(10)-teixobactin to prepare ten analogues and the b...Two thioamino acids and four fiuorinated amino acids were employed to substitute either partially or entirely the Ile_(2),Ser_(3),Ile_(6),and Ser_(7) residues of Leu_(10)-teixobactin to prepare ten analogues and the bioactivity of them was investigated.The SAR studies revealed that Ile_(6) was tolerable for both thioamidation and fiuoridation,while Ser_(7) was identified as the most tolerable site for thioamidation.Analogue 1a demonstrated comparable or slightly improved antibacterial activity,superior protease stability compared to Leu_(10)-teixobactin,while not exhibiting obvious cytotoxicity against mammalian cells.展开更多
Antimony（III） complexes of thioamides [thioamides=thiourea （Tu）, N,N＇dimethylthiourea （Dmtu）, tetramethylthiourea （Tmtu）, imidazolidine-2-thione （Imt） and diazinane-2-thione （Diaz）] with the general formu...Antimony（III） complexes of thioamides [thioamides=thiourea （Tu）, N,N＇dimethylthiourea （Dmtu）, tetramethylthiourea （Tmtu）, imidazolidine-2-thione （Imt） and diazinane-2-thione （Diaz）] with the general formulae, Sb（thione）nCl3 （n= 1, 2, 2.5, 3） were prepared and characterized by elemental analysis, IR and NMR （1H, 13C） spectroscopic methods. The spectral data of the complexes are consistent with the coordination of the thiones to antimony（III）. The crystal structure of one of them, {[Sb（Imt）2Cl2]2（u2-Imt）}Cl2 （1）, was determined by X-ray crystallography, which shows that the complex is dinuclear consisting of two [Sb（Imt）2Cl2] units bridged by an Imt molecule. In 1, the antimony atom is bonded to two chlorine atoms, two sulfur atoms of coordinated Imt molecules and one sulfur atom of a bridging Imt molecule. The antimony environment can be considered to be distorted octahedral with one Cl- ion weakly bound to antimony.展开更多
Thioviridamide-like compounds are a unique subfamily of ribosomally synthesized and post-translationally modified peptides and contain characteristic thioamide bonds and S-[(Z)-2-aminovinyI]-Dcysteine(AviCys). Members...Thioviridamide-like compounds are a unique subfamily of ribosomally synthesized and post-translationally modified peptides and contain characteristic thioamide bonds and S-[(Z)-2-aminovinyI]-Dcysteine(AviCys). Members of this family are active against a number of cancer cell lines. The distribution, biosynthetic machinery and the mode of action of thioviridamide-like compounds remain largely unknown. In this review, we outlined recent advances in the discovery of thioviridamide-like peptide natural products and the effort in the elucidation of their biosynthetic origin.展开更多
The title compound （C30H27NO3） was synthesized via a one-pot procedure starting from fl-benzoylthioacetanilide, benzaldehyde and 5,5-dimethyl-1,3-cyclohexanedione, and its structure was determined by single-crystal ...The title compound （C30H27NO3） was synthesized via a one-pot procedure starting from fl-benzoylthioacetanilide, benzaldehyde and 5,5-dimethyl-1,3-cyclohexanedione, and its structure was determined by single-crystal X-ray diffraction analysis. The crystal belongs to triclinic system, space group PI, with a = 6.325（2）, b = 11.243（3）, c = 17.553（4） A, a = 87.306（4）, β = 80.822（4）, γ = 77.798（4）°, V= 1204.2（5） A^3, Z = 2, Mr= 449.53, Dc= 1.240 g/cm^3, p = 0.080 mm^-1, F（000） = 476, the final R = 0.0459 and wR = 0.0970 for 2301 observed reflections with I 〉 2σ（I）.展开更多
Based on an umpolung strategy, a series of novel full substituted, optically active dihydrothiophenes, which contain several functional groups, such as amine, ester and oxime groups, were obtained via an efficient org...Based on an umpolung strategy, a series of novel full substituted, optically active dihydrothiophenes, which contain several functional groups, such as amine, ester and oxime groups, were obtained via an efficient organocatalytic asymmetric a formal thio[3 ＋ 2]-cyclization of acyclic thioamides with （E）- α-nitrostyrenes.展开更多
（E） -2- （ 1H-Benzo [ d ] [ 1,2,3 ] trlazol-1-yl） -3- （4-chlorophenyl） -3 -hydroxy-N-phenylprop-2 -enethioamide （ compound 1 ） and （E） -2- （ 1H-benzo [ d ] [ 1,2,3 ] trlazol-1-yl ） -3 -hydroxy-N, 3 -dipheny...（E） -2- （ 1H-Benzo [ d ] [ 1,2,3 ] trlazol-1-yl） -3- （4-chlorophenyl） -3 -hydroxy-N-phenylprop-2 -enethioamide （ compound 1 ） and （E） -2- （ 1H-benzo [ d ] [ 1,2,3 ] trlazol-1-yl ） -3 -hydroxy-N, 3 -diphenylprop-2-enethioamide （ compound 2） were synthesized and their structures were confirmed by means of IR, MS, ^1H NMR, and elemental analysis. The structure of compound 1 was determined with single-crystal X-ray diffraction analysis. The results of the biological test show that the two compounds have a certain antifungal activity.展开更多
The Beckmann rearrangement has been predominantly studied for the synthesis of amide and lactam.By strategically using the in situ generated Appel’s salt or Mitsunobu’s zwitterionic adduct as the de-hydrating agent,...The Beckmann rearrangement has been predominantly studied for the synthesis of amide and lactam.By strategically using the in situ generated Appel’s salt or Mitsunobu’s zwitterionic adduct as the de-hydrating agent,a series of Beckmann rearrangement and following cascade reactions have been devel-oped herein.The protocol allows the conversion of various ketoximes into amide,thioamide,tetrazole and imide products in modular procedures.The generality and tolerance of functionalities of this method have been demonstrated.展开更多
The title compound, 2-(methoxybenzoyl)-N-phenyl-2-(1,2,4-triazol-1-yl)thioacetamide was synthesized by several reactions from 4-methoxyacetophenone, triazole and phenyl isothiocyanate. The structure was identified by ...The title compound, 2-(methoxybenzoyl)-N-phenyl-2-(1,2,4-triazol-1-yl)thioacetamide was synthesized by several reactions from 4-methoxyacetophenone, triazole and phenyl isothiocyanate. The structure was identified by elemental analysis, ~ 1H NMR, MS and IR. The single crystal structure of 2-(methoxybenzoyl)-N-phenyl-2-(1,2,4-triazol-1-yl)thioacetamide was determined with X-ray diffraction. The preliminary bioassays show that the title compound exhibits weak antifungal activities and plant-growth regulatory activity.展开更多
Transition-metal-catalyzed asymmetric C-H functionalization has developed into a powerful method for the facile synthesis of planar chiral ferrocene derivatives in recent decades.However,a large array of reactions in ...Transition-metal-catalyzed asymmetric C-H functionalization has developed into a powerful method for the facile synthesis of planar chiral ferrocene derivatives in recent decades.However,a large array of reactions in this category has been focused on enantioselective incorporation of an sp2 hybridized carbon-based functionality to the ferrocene backbone;meanwhile,successful examples on transition-metalcatalyzed asymmetric ferrocene C-H alkylation remain quite limited.Herein,we report an efficient synthesis of planar chiral ferrocene derivatives via Co-catalyzed C(sp^(2))-C(sp^(3))bond formation.Enabled by a binaphthyl-based chiral Cpx Co catalyst,ferrocene thioamides were readily coupled with allyl carbonates,delivering the corresponding planar chiral allylation products in up to 81%yield with 95%ee.Comprehensive mechanistic studies allowed the depiction of the kinetic profile,energy landscape of the reaction,the characterization of key Cpx Co complexes,and the establishment of the stereochemical model.The synthetic potential of this reaction was demonstrated by diverse transformations of the products and the preparation of new phosphine-olefin ligands for asymmetric(conjugated)addition reactions.展开更多
Thioamide was straightforwardly constructed via a chemoselective one-pot synthesis,employing acylsilanes in conjunction with diverse amines and elemental sulfur.The driving force of thioamidation stemmed from silane m...Thioamide was straightforwardly constructed via a chemoselective one-pot synthesis,employing acylsilanes in conjunction with diverse amines and elemental sulfur.The driving force of thioamidation stemmed from silane migration,a synergy process of lone pair electron attack from amine and more stable Si-O bond formation,followed by the nucleophilic activation of elemental sulfur via carbanion intermediate.The leaving trend of trimethylsilanolate and nucleophilicity of linear polysulfur facilitated the cleavage of the S-S bond affording thioamide.A variety of sensitive functional groups,including unprotected hydroxyl,carboxyl and difluoride substitution moieties,are well tolerated under the reaction conditions.Site-selective introduction of thioamide was further demonstrated for the biologically active molecule linkage,displaying the advantages compared with the conventional Lawesson's reagent.展开更多
Objective To assess the efficacy and safety of thioamide as a maintenance therapy for peripheral T-cell lymphoma(PTCL).Methods This study retrospectively analyzed the data from 58 patients with PTCL who were treated i...Objective To assess the efficacy and safety of thioamide as a maintenance therapy for peripheral T-cell lymphoma(PTCL).Methods This study retrospectively analyzed the data from 58 patients with PTCL who were treated in the Department of Hematology at the First Affiliated Hospital of Nanjing Medical University from January 2015to July2022.Chidamidewas orally administered as a maintenance therapy after first-line or salvage treatment.Progression-free survival(PFS),overall survival(OS),and safety were analyzed.Results Among the 58 patients with PTCL,43 were males and 15 were females,and the median age was 66(range 29-83)years.Thirty-nine patients received thioamide as first-line maintenance therapy,and 19 patients received thioamide as maintenance therapyafter salvage treatment.The median maintenance therapy duration was 16 months(range 1-72 months),with a median PFS time of 33(2-74)months,and the median OS time had not tbeen reached.Patients who received first-line maintenance therapy withtthioamidedemonstrated superior PFS and OS outcomes compared with patients who received thioamide maintenance therapy after salvage treatment(median PFS time:not reached vs 7 months,P<0.001;median 0S time:not reached us 67 months,P=0.009).The most prevalent adverse reaction was a hematologic adverse reaction(77.6%).Twelve(20.7%)patients underwent a dose reduction and three patients discontinued treatment.Conclusion Patients receiving thioamide maintenance therapy demonstrate a promising PFS and OS with a manageable safety profile,especially as the first-line maintenance therapy.展开更多
基金the National Natural Science Foundation of China(Project No.20072033)Specialized Research Fund for the Doctoral Program of Higher Education of China.
文摘Enamines, promoted by the samarium/samarium diiodide mixed reagent, were synthesized via the cross-coupling of thioamides and diarylketones in good yields.
文摘Introduction Reductive desulfurization of thioamides to amines is one of the methods to prepare amines and is generally achieved by a) Zn in acid, b) sodium or aluminum amal- gams, c) lithium alumminium hydride, d) Raney Ni and e) electrolytic reduction. These methods are not very convenient to be operated and some need more complex instrument. Here is reported the reductive desulfurization of thioamides to amines by catalytic hydrogen transfer reaction(CHT).
基金Guangdong Medical College(No.XK1110)for financial support
文摘We present here an efficient green process for the synthesis of 1,2,4-thiadiazoles via iodine-catalyzed,oxidative dimerization of thioamides in water using molecular oxygen as a terminal oxidant. Under the optimized reaction conditions, aryl thioamides produced 3,5-diaryl-1,2,4-thiadiazoles in good to excellent yields. Alkyl thioamides and substituted thioureas could also provide corresponding 1,2,4-thiadiazole products.
文摘Ketones smoothly reacted with NBS in the presence of a catalytic amount of ptoluenesulfonic acid to give α-bromoketones in good yields in typical ionic liquids, such as [bmim]PF6 and [bmpy]Tf2N, and the ionic liquids could be repeatedly used for the same reaction after the extraction of the α-bromoketones. Then, the one-pot conversion of ketones into thiazoles by the treatment with NBS, and subsequently with thioamides could be also carried out in [bmim]PF6 and [bmpy]Tf2N, respectively Thus, [bmim]PF6 and [bmpy]Tf2N could be used as recyclable reaction media for the preparation α-bromoketones and thiazoles from ketones.
文摘The efficient dehydrosulfurization of thioamides to nitriles was carried out using indium(III) triflate as a catalyst. Based on the results of the initial study, the optimal reaction conditions required 5 mol% of indium(III) triflate with toluene as the practical solvent. Various thioamides were successfully converted to nitriles in high yields.
文摘A facile and efficient approach to the synthesis of secondary thioamides from ketoximes via Beckmann rearrangement has been established, using phosphorus pentasulfide as a dehydrating and thiating agent. It is also efficient for the preparation of primary thiobenzamide from benzaldoxime. This approach features simple-operation, easy-control and good to excellent yields.
基金supported by the National Natural Science Foundation of China(No.21977111)the Natural Science Foundation of Guangdong Province(No.2023A1515011765)Shenzhen Science and Technology Program(Nos.JCYJ20220818101404010,JCYJ20220818100412028)。
文摘Two thioamino acids and four fiuorinated amino acids were employed to substitute either partially or entirely the Ile_(2),Ser_(3),Ile_(6),and Ser_(7) residues of Leu_(10)-teixobactin to prepare ten analogues and the bioactivity of them was investigated.The SAR studies revealed that Ile_(6) was tolerable for both thioamidation and fiuoridation,while Ser_(7) was identified as the most tolerable site for thioamidation.Analogue 1a demonstrated comparable or slightly improved antibacterial activity,superior protease stability compared to Leu_(10)-teixobactin,while not exhibiting obvious cytotoxicity against mammalian cells.
文摘Antimony（III） complexes of thioamides [thioamides=thiourea （Tu）, N,N＇dimethylthiourea （Dmtu）, tetramethylthiourea （Tmtu）, imidazolidine-2-thione （Imt） and diazinane-2-thione （Diaz）] with the general formulae, Sb（thione）nCl3 （n= 1, 2, 2.5, 3） were prepared and characterized by elemental analysis, IR and NMR （1H, 13C） spectroscopic methods. The spectral data of the complexes are consistent with the coordination of the thiones to antimony（III）. The crystal structure of one of them, {[Sb（Imt）2Cl2]2（u2-Imt）}Cl2 （1）, was determined by X-ray crystallography, which shows that the complex is dinuclear consisting of two [Sb（Imt）2Cl2] units bridged by an Imt molecule. In 1, the antimony atom is bonded to two chlorine atoms, two sulfur atoms of coordinated Imt molecules and one sulfur atom of a bridging Imt molecule. The antimony environment can be considered to be distorted octahedral with one Cl- ion weakly bound to antimony.
基金supported by the 1000-Youth Talents Plan, NSF of China (No. 21778030)Natural Science Foundation of Jiangsu Province (No. BK20160640)the Fundamental Research Funds for the Central Universities
文摘Thioviridamide-like compounds are a unique subfamily of ribosomally synthesized and post-translationally modified peptides and contain characteristic thioamide bonds and S-[(Z)-2-aminovinyI]-Dcysteine(AviCys). Members of this family are active against a number of cancer cell lines. The distribution, biosynthetic machinery and the mode of action of thioviridamide-like compounds remain largely unknown. In this review, we outlined recent advances in the discovery of thioviridamide-like peptide natural products and the effort in the elucidation of their biosynthetic origin.
基金This project was supported by the N N S Foundation of China (No. 20572057) N S Foundation of Shandong province (Y2006B11)
文摘The title compound （C30H27NO3） was synthesized via a one-pot procedure starting from fl-benzoylthioacetanilide, benzaldehyde and 5,5-dimethyl-1,3-cyclohexanedione, and its structure was determined by single-crystal X-ray diffraction analysis. The crystal belongs to triclinic system, space group PI, with a = 6.325（2）, b = 11.243（3）, c = 17.553（4） A, a = 87.306（4）, β = 80.822（4）, γ = 77.798（4）°, V= 1204.2（5） A^3, Z = 2, Mr= 449.53, Dc= 1.240 g/cm^3, p = 0.080 mm^-1, F（000） = 476, the final R = 0.0459 and wR = 0.0970 for 2301 observed reflections with I 〉 2σ（I）.
基金provided by National Natural Science Foundation of China(No. 21272214)
文摘Based on an umpolung strategy, a series of novel full substituted, optically active dihydrothiophenes, which contain several functional groups, such as amine, ester and oxime groups, were obtained via an efficient organocatalytic asymmetric a formal thio[3 ＋ 2]-cyclization of acyclic thioamides with （E）- α-nitrostyrenes.
文摘（E） -2- （ 1H-Benzo [ d ] [ 1,2,3 ] trlazol-1-yl） -3- （4-chlorophenyl） -3 -hydroxy-N-phenylprop-2 -enethioamide （ compound 1 ） and （E） -2- （ 1H-benzo [ d ] [ 1,2,3 ] trlazol-1-yl ） -3 -hydroxy-N, 3 -diphenylprop-2-enethioamide （ compound 2） were synthesized and their structures were confirmed by means of IR, MS, ^1H NMR, and elemental analysis. The structure of compound 1 was determined with single-crystal X-ray diffraction analysis. The results of the biological test show that the two compounds have a certain antifungal activity.
基金supported by National Key Research and Development Project (No. 2021YFC2100100)National Natural Science Foundation of China (No. 21901123)+1 种基金Natural Science Foundation of Jiangsu Province (No. BK20190694)Jiangsu Specially Appointed Professor Plan
文摘The Beckmann rearrangement has been predominantly studied for the synthesis of amide and lactam.By strategically using the in situ generated Appel’s salt or Mitsunobu’s zwitterionic adduct as the de-hydrating agent,a series of Beckmann rearrangement and following cascade reactions have been devel-oped herein.The protocol allows the conversion of various ketoximes into amide,thioamide,tetrazole and imide products in modular procedures.The generality and tolerance of functionalities of this method have been demonstrated.
文摘The title compound, 2-(methoxybenzoyl)-N-phenyl-2-(1,2,4-triazol-1-yl)thioacetamide was synthesized by several reactions from 4-methoxyacetophenone, triazole and phenyl isothiocyanate. The structure was identified by elemental analysis, ~ 1H NMR, MS and IR. The single crystal structure of 2-(methoxybenzoyl)-N-phenyl-2-(1,2,4-triazol-1-yl)thioacetamide was determined with X-ray diffraction. The preliminary bioassays show that the title compound exhibits weak antifungal activities and plant-growth regulatory activity.
基金support for this study was received from the National Key Research&Development Program of China(grant no.2021YFA1500100)the National Natural Science Foundation of China(NSFC,grant nos.21821002,92256302,22322111,and 22393893)+6 种基金the Science and Technology Commission of Shanghai Municipality,China(grant no.23JC1404500)the Strategic Priority Research Program of the Chinese Academy of Sciences(CASgrant no.XDB0610000)Youth Innovation Promotion Association,CAS(grant no.Y2021075)support from the New Cornerstone Science Foundation,China.Y.Z.thanks to the China Postdoctoral Science Foundation(grant no.2021M693279)the China Postdoctoral Science Foundation(grant nos.2022M723286 and 2023T160665)Shanghai Postdoctoral Excellent Program,China(grant no.2022717).
文摘Transition-metal-catalyzed asymmetric C-H functionalization has developed into a powerful method for the facile synthesis of planar chiral ferrocene derivatives in recent decades.However,a large array of reactions in this category has been focused on enantioselective incorporation of an sp2 hybridized carbon-based functionality to the ferrocene backbone;meanwhile,successful examples on transition-metalcatalyzed asymmetric ferrocene C-H alkylation remain quite limited.Herein,we report an efficient synthesis of planar chiral ferrocene derivatives via Co-catalyzed C(sp^(2))-C(sp^(3))bond formation.Enabled by a binaphthyl-based chiral Cpx Co catalyst,ferrocene thioamides were readily coupled with allyl carbonates,delivering the corresponding planar chiral allylation products in up to 81%yield with 95%ee.Comprehensive mechanistic studies allowed the depiction of the kinetic profile,energy landscape of the reaction,the characterization of key Cpx Co complexes,and the establishment of the stereochemical model.The synthetic potential of this reaction was demonstrated by diverse transformations of the products and the preparation of new phosphine-olefin ligands for asymmetric(conjugated)addition reactions.
基金supported by the National Natural Science Foundation of China(No.22125103)Science and Technology Commission of Shanghai Municipality(No.22JC1401000).
文摘Thioamide was straightforwardly constructed via a chemoselective one-pot synthesis,employing acylsilanes in conjunction with diverse amines and elemental sulfur.The driving force of thioamidation stemmed from silane migration,a synergy process of lone pair electron attack from amine and more stable Si-O bond formation,followed by the nucleophilic activation of elemental sulfur via carbanion intermediate.The leaving trend of trimethylsilanolate and nucleophilicity of linear polysulfur facilitated the cleavage of the S-S bond affording thioamide.A variety of sensitive functional groups,including unprotected hydroxyl,carboxyl and difluoride substitution moieties,are well tolerated under the reaction conditions.Site-selective introduction of thioamide was further demonstrated for the biologically active molecule linkage,displaying the advantages compared with the conventional Lawesson's reagent.
文摘Objective To assess the efficacy and safety of thioamide as a maintenance therapy for peripheral T-cell lymphoma(PTCL).Methods This study retrospectively analyzed the data from 58 patients with PTCL who were treated in the Department of Hematology at the First Affiliated Hospital of Nanjing Medical University from January 2015to July2022.Chidamidewas orally administered as a maintenance therapy after first-line or salvage treatment.Progression-free survival(PFS),overall survival(OS),and safety were analyzed.Results Among the 58 patients with PTCL,43 were males and 15 were females,and the median age was 66(range 29-83)years.Thirty-nine patients received thioamide as first-line maintenance therapy,and 19 patients received thioamide as maintenance therapyafter salvage treatment.The median maintenance therapy duration was 16 months(range 1-72 months),with a median PFS time of 33(2-74)months,and the median OS time had not tbeen reached.Patients who received first-line maintenance therapy withtthioamidedemonstrated superior PFS and OS outcomes compared with patients who received thioamide maintenance therapy after salvage treatment(median PFS time:not reached vs 7 months,P<0.001;median 0S time:not reached us 67 months,P=0.009).The most prevalent adverse reaction was a hematologic adverse reaction(77.6%).Twelve(20.7%)patients underwent a dose reduction and three patients discontinued treatment.Conclusion Patients receiving thioamide maintenance therapy demonstrate a promising PFS and OS with a manageable safety profile,especially as the first-line maintenance therapy.
