卵巢衰老分为生理性与病理性两类,表现为卵巢储备功能下降、卵泡数量减少和激素水平紊乱,并与多种慢性疾病风险相关。研究发现,免疫失衡在卵巢衰老中扮演核心角色,尤其是辅助性T细胞17(helper T cell 17,Th17细胞)与调节性T细胞(regulat...卵巢衰老分为生理性与病理性两类,表现为卵巢储备功能下降、卵泡数量减少和激素水平紊乱,并与多种慢性疾病风险相关。研究发现,免疫失衡在卵巢衰老中扮演核心角色,尤其是辅助性T细胞17(helper T cell 17,Th17细胞)与调节性T细胞(regulatory T cell,Treg细胞)的比例失调。Th17/Treg平衡受炎症因子、核因子κB(nuclear factor-κB,NF-κB)通路及哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)通路的精密调控,其失衡会加剧卵巢局部炎症,加速卵泡耗竭。目前,针对Th17/Treg比例失衡的干预策略在自身免疫性疾病的治疗中已取得进展,为卵巢衰老的临床干预提供了新思路。综述Th17/Treg比例失衡在卵巢衰老中的核心作用,为探索延缓卵巢衰老的免疫治疗策略提供了理论依据。展开更多
The year 2025 marks the 120th anniversary of the birth of Chinese filmmaking.From the first film Dingjun Mountain released in 1905,which captured scenes from Peking opera,to the present day where artificial intelligen...The year 2025 marks the 120th anniversary of the birth of Chinese filmmaking.From the first film Dingjun Mountain released in 1905,which captured scenes from Peking opera,to the present day where artificial intelligence(AI)is utilised in film production,the Chinese film industry has been developing for over a century.Data from the China Film Administration shows that China’s 2025 box o"ce revenue topped 51.8 billion yuan($7.4 billion),realising a year-on-year increase of nearly 22 percent.展开更多
目的观察芪参还五胶囊对冠心病患者心功能的改善及对外周血Th17/Treg平衡的影响。方法选择于医院治疗的110例冠心病患者,2021年1月—2022年6月为病例入组时间,分组方式为随机数字表法,西医组55例,给予西医基础治疗;芪参还五胶囊组55例,...目的观察芪参还五胶囊对冠心病患者心功能的改善及对外周血Th17/Treg平衡的影响。方法选择于医院治疗的110例冠心病患者,2021年1月—2022年6月为病例入组时间,分组方式为随机数字表法,西医组55例,给予西医基础治疗;芪参还五胶囊组55例,在西医基础治疗同时给予患者芪参还五胶囊治疗。治疗前、后检测两组患者Th17/Treg细胞比例、血红素加氧酶1(HO-1)、一氧化氮(NO)、白细胞介素-35(IL-35)、脂联素(APN)、白细胞介素-17A(IL-17A)、血管性血友病因子(vWF)、脂蛋白相关磷脂酶A2(Lp-PLA2)水平,检测患者冠状动脉微循环指标:冠状动脉血流储备(CFR)、血流量(Qmean)、平均循环抵抗指数(IMR),检测患者心肌耗氧量、左室射血分数(LVEF)、连续窦性R-R间期标准差(SDNN)、24 h QT离散度(QTd),给予患者动则喘息、胸闷气短、心胸隐痛、胸痛反复发作、倦怠懒言、面色㿠白评价,比较西医组及芪参还五胶囊组临床疗效。结果芪参还五胶囊组患者Th17/Treg、IL-17A含量较西医组明显降低(P<0.05),芪参还五胶囊组HO-1、IL-35含量较西医组升高(P<0.005);芪参还五胶囊组患者Lp-PLA2、vWF含量较西医组明显降低(P<0.05),芪参还五胶囊组患者NO、APN含量较西医组升高(P<0.05);芪参还五胶囊组CFR、Qmean较西医组明显升高(P<0.05),芪参还五胶囊组IMR较西医组明显降低(P<0.05);芪参还五胶囊组患者心肌耗氧量、QTd较西医组明显降低(P<0.05),芪参还五胶囊组LVEF、SDNN较西医组升高(P<0.05);芪参还五胶囊组患者心悸易汗、动则喘息、胸闷气短、心胸隐痛、胸痛反复发作、倦怠懒言、面色㿠白评分较西医组明显降低(P<0.05),芪参还五胶囊组总有效率为98.18%,西医组总有效率为83.64%,芪参还五胶囊组患者总有效率高于西医组(P<0.05)。结论芪参还五胶囊治疗冠心病患者,可调节机体Th17/Treg平衡,抑制机体炎症,减少血管内皮损伤,改善患者心功能、冠状动脉微循环及心电图指标,提升患者临床疗效。展开更多
Objective Sepsis patients exhibit diverse immune states,making it crucial to identify subtypes with distinct inflammatory profiles through Th1/Th2 cytokine data for personalized treatment and improved prognosis.Method...Objective Sepsis patients exhibit diverse immune states,making it crucial to identify subtypes with distinct inflammatory profiles through Th1/Th2 cytokine data for personalized treatment and improved prognosis.Methods We retrieved data from sepsis patients who underwent Th1/Th2 cytokine testing in Nanfang Hospital,Southern Medical University from June 1,2020,to February 1,2022.An unsupervised K-means clustering method classified participants based on Th1/Th2 cytokine levels,with the primary outcome being the 7-day mortality rate post-ICU admission.Cox proportional hazards and Restricted Mean Survival Time(RMST)analyses were utilized to explore survival outcomes.Results A total of 321 sepsis patients were included.IL-6(HR 1.69,95%CI:1.22,2.34)and IL-10(HR 1.81,95%CI:1.37,2.40)emerged as independent predictors of 7-day mortality.Unsupervised K-means clustering revealed 3 inflammatory/immune subgroups:Cluster 1(n=166,low inflammatory response),Cluster 2(n=99,moderate inflammatory response with immune suppression),and Cluster 3(n=56,strong inflammatory and immune suppression).Compared to Cluster 1,Clusters 2 and 3 had higher 7-day mortality risks(14.4%vs 23.2%,HR=4.30,95%CI:1.51-12.26;14.4%vs 35.7%,HR=7.32,95%CI:2.57-20.79).Conclusion Septic patients in a protective immune response state(Cluster 1)exhibit better short-term prognoses,suggesting the importance of understanding inflammatory/immune states for precise treatment and improved outcomes.展开更多
文摘卵巢衰老分为生理性与病理性两类,表现为卵巢储备功能下降、卵泡数量减少和激素水平紊乱,并与多种慢性疾病风险相关。研究发现,免疫失衡在卵巢衰老中扮演核心角色,尤其是辅助性T细胞17(helper T cell 17,Th17细胞)与调节性T细胞(regulatory T cell,Treg细胞)的比例失调。Th17/Treg平衡受炎症因子、核因子κB(nuclear factor-κB,NF-κB)通路及哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)通路的精密调控,其失衡会加剧卵巢局部炎症,加速卵泡耗竭。目前,针对Th17/Treg比例失衡的干预策略在自身免疫性疾病的治疗中已取得进展,为卵巢衰老的临床干预提供了新思路。综述Th17/Treg比例失衡在卵巢衰老中的核心作用,为探索延缓卵巢衰老的免疫治疗策略提供了理论依据。
文摘The year 2025 marks the 120th anniversary of the birth of Chinese filmmaking.From the first film Dingjun Mountain released in 1905,which captured scenes from Peking opera,to the present day where artificial intelligence(AI)is utilised in film production,the Chinese film industry has been developing for over a century.Data from the China Film Administration shows that China’s 2025 box o"ce revenue topped 51.8 billion yuan($7.4 billion),realising a year-on-year increase of nearly 22 percent.
文摘目的观察芪参还五胶囊对冠心病患者心功能的改善及对外周血Th17/Treg平衡的影响。方法选择于医院治疗的110例冠心病患者,2021年1月—2022年6月为病例入组时间,分组方式为随机数字表法,西医组55例,给予西医基础治疗;芪参还五胶囊组55例,在西医基础治疗同时给予患者芪参还五胶囊治疗。治疗前、后检测两组患者Th17/Treg细胞比例、血红素加氧酶1(HO-1)、一氧化氮(NO)、白细胞介素-35(IL-35)、脂联素(APN)、白细胞介素-17A(IL-17A)、血管性血友病因子(vWF)、脂蛋白相关磷脂酶A2(Lp-PLA2)水平,检测患者冠状动脉微循环指标:冠状动脉血流储备(CFR)、血流量(Qmean)、平均循环抵抗指数(IMR),检测患者心肌耗氧量、左室射血分数(LVEF)、连续窦性R-R间期标准差(SDNN)、24 h QT离散度(QTd),给予患者动则喘息、胸闷气短、心胸隐痛、胸痛反复发作、倦怠懒言、面色㿠白评价,比较西医组及芪参还五胶囊组临床疗效。结果芪参还五胶囊组患者Th17/Treg、IL-17A含量较西医组明显降低(P<0.05),芪参还五胶囊组HO-1、IL-35含量较西医组升高(P<0.005);芪参还五胶囊组患者Lp-PLA2、vWF含量较西医组明显降低(P<0.05),芪参还五胶囊组患者NO、APN含量较西医组升高(P<0.05);芪参还五胶囊组CFR、Qmean较西医组明显升高(P<0.05),芪参还五胶囊组IMR较西医组明显降低(P<0.05);芪参还五胶囊组患者心肌耗氧量、QTd较西医组明显降低(P<0.05),芪参还五胶囊组LVEF、SDNN较西医组升高(P<0.05);芪参还五胶囊组患者心悸易汗、动则喘息、胸闷气短、心胸隐痛、胸痛反复发作、倦怠懒言、面色㿠白评分较西医组明显降低(P<0.05),芪参还五胶囊组总有效率为98.18%,西医组总有效率为83.64%,芪参还五胶囊组患者总有效率高于西医组(P<0.05)。结论芪参还五胶囊治疗冠心病患者,可调节机体Th17/Treg平衡,抑制机体炎症,减少血管内皮损伤,改善患者心功能、冠状动脉微循环及心电图指标,提升患者临床疗效。
文摘Objective Sepsis patients exhibit diverse immune states,making it crucial to identify subtypes with distinct inflammatory profiles through Th1/Th2 cytokine data for personalized treatment and improved prognosis.Methods We retrieved data from sepsis patients who underwent Th1/Th2 cytokine testing in Nanfang Hospital,Southern Medical University from June 1,2020,to February 1,2022.An unsupervised K-means clustering method classified participants based on Th1/Th2 cytokine levels,with the primary outcome being the 7-day mortality rate post-ICU admission.Cox proportional hazards and Restricted Mean Survival Time(RMST)analyses were utilized to explore survival outcomes.Results A total of 321 sepsis patients were included.IL-6(HR 1.69,95%CI:1.22,2.34)and IL-10(HR 1.81,95%CI:1.37,2.40)emerged as independent predictors of 7-day mortality.Unsupervised K-means clustering revealed 3 inflammatory/immune subgroups:Cluster 1(n=166,low inflammatory response),Cluster 2(n=99,moderate inflammatory response with immune suppression),and Cluster 3(n=56,strong inflammatory and immune suppression).Compared to Cluster 1,Clusters 2 and 3 had higher 7-day mortality risks(14.4%vs 23.2%,HR=4.30,95%CI:1.51-12.26;14.4%vs 35.7%,HR=7.32,95%CI:2.57-20.79).Conclusion Septic patients in a protective immune response state(Cluster 1)exhibit better short-term prognoses,suggesting the importance of understanding inflammatory/immune states for precise treatment and improved outcomes.
