TDP-43 proteinopathies and cryptic exons:Transactive response DNA binding protein of 43 kDa(TDP-43)is a ubiquitously expressed RNA/DNA binding protein crucial for coding and non-coding RNA metabolism including transcr...TDP-43 proteinopathies and cryptic exons:Transactive response DNA binding protein of 43 kDa(TDP-43)is a ubiquitously expressed RNA/DNA binding protein crucial for coding and non-coding RNA metabolism including transcription,splicing,transport,translation,and turnover.TDP-43 shuttles between the nucleus and cytoplasm,but is predominantly localized in the nucleus.Neurodegenerative diseases(NDs)may be accompanied by nuclear loss and possible cytoplasmic accumulation and aggregation of TDP-43 in vulnerable neurons and beyond.This neuropathology is the hallmark of most individuals suffering from amyotrophic lateral sclerosis(ALS),frontotemporal dementia(FTD)with TDP-43-immunoreactive pathology(FTD-TDP),limbic-predominant age-related TDP-43 encephalopathy(LATE)and Perry syndrome,but also coexists with the primary pathology in subsets of patients suffering from other NDs,such as Alzheimer’s disease,Lewy body dementias,or Huntington’s disease.Variants in the gene encoding TDP-43(TARDBP)are the cause of ALS and/or FTD in some rare cases substantiating the importance of this protein in aging neurons.It is still controversial if loss of nuclear,or increased cytoplasmic and/or aggregating TDP-43 is more harmful to neurons(Nag and Schneider,2023).Recently,the role of nuclear TDP-43 in repressing the inclusion of intronic sequences,named cryptic exons(CEs),into mature mRNAs gained much attention.展开更多
目的:分析TDP联合电脑中频并功能锻炼治疗护理慢性腰肌劳损的疗效。方法:从2023年10月~2024年9月,选取100例患有慢性腰肌劳损的疗养人员作为研究样本,进行随机分组,对照组50例进行功能锻炼结合常规指导,观察组50例在对照组的基础上使用...目的:分析TDP联合电脑中频并功能锻炼治疗护理慢性腰肌劳损的疗效。方法:从2023年10月~2024年9月,选取100例患有慢性腰肌劳损的疗养人员作为研究样本,进行随机分组,对照组50例进行功能锻炼结合常规指导,观察组50例在对照组的基础上使用TDP联合电脑中频并功能锻炼治疗与康复指导,对比两组相关指标。结果:观察组治疗总有效率高于对照组,治疗后1个疗程,观察组VAS评分低于对照组(P Objective: To analyze the efficacy of TDP combined with computerized intermediate frequency and functional exercise in the treatment of chronic lumbar muscle strain. Methods: From October 2023 to September 2024, 100 convalescents with chronic lumbar muscle strain were selected as research samples and randomized, 50 cases in the control group were treated with functional exercise combined with conventional guidance, and 50 cases in the observation group were treated with TDP combined with computer intermediate frequency and functional exercise treatment and rehabilitation guidance on the basis of the control group, and the relevant indexes of the two groups were compared. Results: The total effective rate of treatment in the observation group was higher than that in the control group, and the VAS score in the observation group was lower than that in the control group (P < 0.01) after one course of treatment, and the serum inflammatory factor level in the observation group was lower than that in the control group (P < 0.01). Conclusion: The application of TDP combined with computer intermediate frequency and functional exercise therapy and nursing for convalescents has obvious effects, which can effectively reduce pain and control the level of inflammation, which is worthy of promotion.展开更多
基金supported by the Deutsche Forschungsgemeinschaft(DFGgrant#521487152)(to AF)。
文摘TDP-43 proteinopathies and cryptic exons:Transactive response DNA binding protein of 43 kDa(TDP-43)is a ubiquitously expressed RNA/DNA binding protein crucial for coding and non-coding RNA metabolism including transcription,splicing,transport,translation,and turnover.TDP-43 shuttles between the nucleus and cytoplasm,but is predominantly localized in the nucleus.Neurodegenerative diseases(NDs)may be accompanied by nuclear loss and possible cytoplasmic accumulation and aggregation of TDP-43 in vulnerable neurons and beyond.This neuropathology is the hallmark of most individuals suffering from amyotrophic lateral sclerosis(ALS),frontotemporal dementia(FTD)with TDP-43-immunoreactive pathology(FTD-TDP),limbic-predominant age-related TDP-43 encephalopathy(LATE)and Perry syndrome,but also coexists with the primary pathology in subsets of patients suffering from other NDs,such as Alzheimer’s disease,Lewy body dementias,or Huntington’s disease.Variants in the gene encoding TDP-43(TARDBP)are the cause of ALS and/or FTD in some rare cases substantiating the importance of this protein in aging neurons.It is still controversial if loss of nuclear,or increased cytoplasmic and/or aggregating TDP-43 is more harmful to neurons(Nag and Schneider,2023).Recently,the role of nuclear TDP-43 in repressing the inclusion of intronic sequences,named cryptic exons(CEs),into mature mRNAs gained much attention.
文摘目的:分析TDP联合电脑中频并功能锻炼治疗护理慢性腰肌劳损的疗效。方法:从2023年10月~2024年9月,选取100例患有慢性腰肌劳损的疗养人员作为研究样本,进行随机分组,对照组50例进行功能锻炼结合常规指导,观察组50例在对照组的基础上使用TDP联合电脑中频并功能锻炼治疗与康复指导,对比两组相关指标。结果:观察组治疗总有效率高于对照组,治疗后1个疗程,观察组VAS评分低于对照组(P Objective: To analyze the efficacy of TDP combined with computerized intermediate frequency and functional exercise in the treatment of chronic lumbar muscle strain. Methods: From October 2023 to September 2024, 100 convalescents with chronic lumbar muscle strain were selected as research samples and randomized, 50 cases in the control group were treated with functional exercise combined with conventional guidance, and 50 cases in the observation group were treated with TDP combined with computer intermediate frequency and functional exercise treatment and rehabilitation guidance on the basis of the control group, and the relevant indexes of the two groups were compared. Results: The total effective rate of treatment in the observation group was higher than that in the control group, and the VAS score in the observation group was lower than that in the control group (P < 0.01) after one course of treatment, and the serum inflammatory factor level in the observation group was lower than that in the control group (P < 0.01). Conclusion: The application of TDP combined with computer intermediate frequency and functional exercise therapy and nursing for convalescents has obvious effects, which can effectively reduce pain and control the level of inflammation, which is worthy of promotion.
