目的探讨经颅直流电刺激(transcranial direct current stimulation,tDCS)在改善甲基苯丙胺成瘾者的执行功能和降低药物渴求方面的效果。方法以沈阳市6个社区戒毒(康复)中心268例甲基苯丙胺成瘾的戒毒人员为研究对象,采用随机双盲对照法...目的探讨经颅直流电刺激(transcranial direct current stimulation,tDCS)在改善甲基苯丙胺成瘾者的执行功能和降低药物渴求方面的效果。方法以沈阳市6个社区戒毒(康复)中心268例甲基苯丙胺成瘾的戒毒人员为研究对象,采用随机双盲对照法,将268例甲基苯丙胺成瘾者随机分配到干预组和对照组,干预组在5周内接受10次tDCS治疗,对照组采用相同的方法接受假tDCS治疗。在干预前、干预结束时即刻和干预后1个月测量主要执行功能任务(例如工作记忆、抑制控制、认知灵活性和冒险行为)和药物渴求的表现。结果与对照组相比,干预组在干预结束时和干预后1个月观察到对药物的渴求显着降低(P<0.05),同样,干预组在干预结束时和干预后1个月在N-back、Go/No-Go、WCST和BART任务中的表现显著改善(P<0.05);认知控制改善与渴求降低之间的存在显著相关性(P<0.05)。结论认知控制功能的改善与渴求的降低密切相关,tDCS反复刺激背外侧前额叶皮质以提高执行控制能力可能是药物成瘾治疗干预的一种有前景的方法。展开更多
Background: Transcranial direct current stimulation (tDCS) has research evidence that it can reduce symptoms of depression. Flow FL-100 is a transcranial direct current stimulation (tDCS) device self-administered by a...Background: Transcranial direct current stimulation (tDCS) has research evidence that it can reduce symptoms of depression. Flow FL-100 is a transcranial direct current stimulation (tDCS) device self-administered by a patient at home in combination with a software application that delivers wellbeing behaviour therapy training. Purpose/aim: The purpose of this study was to investigate if Flow can be introduced to a Crisis Resolution & Home Treatment (CRT) service and the impact of Flow in treating depression. The study addresses the questions: 1) “what are the depression reliable improvement and remission rates?” and 2) “can Flow significantly reduce depressive symptoms and improve real world functioning (every-day, social and occupational functioning) and health-related quality of life?”. Methods: An open-label patient cohort design with no control group. Pre-intervention and 6-week follow-up intervention assessments using the participant self-report measures: Patient Health Questionnaire (PHQ-9), Work and Social Adjustment Scale (WSAS), and EuroQol five-dimension (EQ-5D-5L). Participants were 49 CRT patients, 19 males and 30 females, with an age range of 20 to 66 years, and average age of 42 years. Results: PHQ-9 reliable improvement and remission rates were 57.1% and 14.3%. PHQ-9 scores significantly improved, from 23.1 (SD 3.44) to 14.8 (SD 6.82) at 6 weeks, with a large effect size. PHQ-9 suicide/self-harm related question significantly improved from 2.51 (SD 0.77) to 1.08 (SD 1.17), with a large effect size. WSAS scores significantly improved, from 33.6 (SD 5.22) to 21.9 (SD 10.82) at 6 weeks, with a large effect size. EQ-5D-5L results showed significant improvements in the health index score, global assessment of health EQ-VAS from 34.2 (22.26) to 51.6 (24.95), and three EQ-5D-5L dimensions (“self-care”, “usual activity”, and “anxiety/depression”). Conclusion: A CRT service effectively integrated Flow tDCS treatment. Flow was beneficial in terms of improving functioning and quality of life and reducing depression symptoms and thoughts of suicide/self-harm. Flow FL100 tDCS and wellbeing behaviour therapy training could be offered through all CRT services to treat depression, reduce thoughts of suicide/self-harm, enable better functioning, and improve quality of life.展开更多
目的:探讨经颅直流电刺激(transcranial direct current stimulation,tDCS)对甲基苯丙胺成瘾者认知功能、焦虑及抑郁的治疗效果。方法:于2018年7-10月,采用分层整群随机抽样的方法,抽取辽宁省3个强制隔离戒毒所264例甲基苯丙胺成瘾戒毒...目的:探讨经颅直流电刺激(transcranial direct current stimulation,tDCS)对甲基苯丙胺成瘾者认知功能、焦虑及抑郁的治疗效果。方法:于2018年7-10月,采用分层整群随机抽样的方法,抽取辽宁省3个强制隔离戒毒所264例甲基苯丙胺成瘾戒毒人员为研究对象,随机分为试验组与对照组,每组各132例患者,试验组采用tDCS治疗,对照组采用假tDCS治疗;采用简易智力状态检查量表(MMSE)、蒙特利尔认知评估量表(MoCA)、汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)评价两组戒毒人员的认知功能、焦虑和抑郁情况。结果:tDCS治疗后试验组MMSE和MoCA得分均较治疗前显著升高(P<0.05);治疗后试验组HAMD和HAMA得分均较治疗前显著降低(P<0.05);试验组治疗后MMSE、MoCA、HAMD和HAMA得分与对照组之间差异有统计学意义(P<0.05)。结论:tDCS治疗可改善甲基苯丙胺成瘾者认知功能,并减轻其焦虑、抑郁症状。展开更多
文摘目的探讨经颅直流电刺激(transcranial direct current stimulation,tDCS)在改善甲基苯丙胺成瘾者的执行功能和降低药物渴求方面的效果。方法以沈阳市6个社区戒毒(康复)中心268例甲基苯丙胺成瘾的戒毒人员为研究对象,采用随机双盲对照法,将268例甲基苯丙胺成瘾者随机分配到干预组和对照组,干预组在5周内接受10次tDCS治疗,对照组采用相同的方法接受假tDCS治疗。在干预前、干预结束时即刻和干预后1个月测量主要执行功能任务(例如工作记忆、抑制控制、认知灵活性和冒险行为)和药物渴求的表现。结果与对照组相比,干预组在干预结束时和干预后1个月观察到对药物的渴求显着降低(P<0.05),同样,干预组在干预结束时和干预后1个月在N-back、Go/No-Go、WCST和BART任务中的表现显著改善(P<0.05);认知控制改善与渴求降低之间的存在显著相关性(P<0.05)。结论认知控制功能的改善与渴求的降低密切相关,tDCS反复刺激背外侧前额叶皮质以提高执行控制能力可能是药物成瘾治疗干预的一种有前景的方法。
文摘Background: Transcranial direct current stimulation (tDCS) has research evidence that it can reduce symptoms of depression. Flow FL-100 is a transcranial direct current stimulation (tDCS) device self-administered by a patient at home in combination with a software application that delivers wellbeing behaviour therapy training. Purpose/aim: The purpose of this study was to investigate if Flow can be introduced to a Crisis Resolution & Home Treatment (CRT) service and the impact of Flow in treating depression. The study addresses the questions: 1) “what are the depression reliable improvement and remission rates?” and 2) “can Flow significantly reduce depressive symptoms and improve real world functioning (every-day, social and occupational functioning) and health-related quality of life?”. Methods: An open-label patient cohort design with no control group. Pre-intervention and 6-week follow-up intervention assessments using the participant self-report measures: Patient Health Questionnaire (PHQ-9), Work and Social Adjustment Scale (WSAS), and EuroQol five-dimension (EQ-5D-5L). Participants were 49 CRT patients, 19 males and 30 females, with an age range of 20 to 66 years, and average age of 42 years. Results: PHQ-9 reliable improvement and remission rates were 57.1% and 14.3%. PHQ-9 scores significantly improved, from 23.1 (SD 3.44) to 14.8 (SD 6.82) at 6 weeks, with a large effect size. PHQ-9 suicide/self-harm related question significantly improved from 2.51 (SD 0.77) to 1.08 (SD 1.17), with a large effect size. WSAS scores significantly improved, from 33.6 (SD 5.22) to 21.9 (SD 10.82) at 6 weeks, with a large effect size. EQ-5D-5L results showed significant improvements in the health index score, global assessment of health EQ-VAS from 34.2 (22.26) to 51.6 (24.95), and three EQ-5D-5L dimensions (“self-care”, “usual activity”, and “anxiety/depression”). Conclusion: A CRT service effectively integrated Flow tDCS treatment. Flow was beneficial in terms of improving functioning and quality of life and reducing depression symptoms and thoughts of suicide/self-harm. Flow FL100 tDCS and wellbeing behaviour therapy training could be offered through all CRT services to treat depression, reduce thoughts of suicide/self-harm, enable better functioning, and improve quality of life.
文摘目的:探讨经颅直流电刺激(transcranial direct current stimulation,tDCS)对甲基苯丙胺成瘾者认知功能、焦虑及抑郁的治疗效果。方法:于2018年7-10月,采用分层整群随机抽样的方法,抽取辽宁省3个强制隔离戒毒所264例甲基苯丙胺成瘾戒毒人员为研究对象,随机分为试验组与对照组,每组各132例患者,试验组采用tDCS治疗,对照组采用假tDCS治疗;采用简易智力状态检查量表(MMSE)、蒙特利尔认知评估量表(MoCA)、汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)评价两组戒毒人员的认知功能、焦虑和抑郁情况。结果:tDCS治疗后试验组MMSE和MoCA得分均较治疗前显著升高(P<0.05);治疗后试验组HAMD和HAMA得分均较治疗前显著降低(P<0.05);试验组治疗后MMSE、MoCA、HAMD和HAMA得分与对照组之间差异有统计学意义(P<0.05)。结论:tDCS治疗可改善甲基苯丙胺成瘾者认知功能,并减轻其焦虑、抑郁症状。
