This article focuses on the remote diagnosis and analysis of rail vehicle status based on the data of the Train Control Management System(TCMS).It first expounds on the importance of train diagnostic analysis and desi...This article focuses on the remote diagnosis and analysis of rail vehicle status based on the data of the Train Control Management System(TCMS).It first expounds on the importance of train diagnostic analysis and designs a unified TCMS data frame transmission format.Subsequently,a remote data transmission link using 4G signals and data processing methods is introduced.The advantages of remote diagnosis are analyzed,and common methods such as correlation analysis,fault diagnosis,and fault prediction are explained in detail.Then,challenges such as data security and the balance between diagnostic accuracy and real-time performance are discussed,along with development prospects in technological innovation,algorithm optimization,and application promotion.This research provides ideas for remote analysis and diagnosis based on TCMS data,contributing to the safe and efficient operation of rail vehicles.展开更多
为了将列车数据应用到实际运营工作中,本文设计了一种车辆分析系统。该系统实现了对网络控制系统(Train Control and Management System,TCMS)数据的接收、校验、存储、计算、展示等全生命周期管理,并将数据用于分析统计、故障预警等,...为了将列车数据应用到实际运营工作中,本文设计了一种车辆分析系统。该系统实现了对网络控制系统(Train Control and Management System,TCMS)数据的接收、校验、存储、计算、展示等全生命周期管理,并将数据用于分析统计、故障预警等,为地面运营工作提供辅助决策支撑。展开更多
The protection system for traditional Chinese medicine(TCM)varieties,as an important policy tool to promote the development of TCM,has a long history of over 30 years,from the promulgation of the“Regulations on the P...The protection system for traditional Chinese medicine(TCM)varieties,as an important policy tool to promote the development of TCM,has a long history of over 30 years,from the promulgation of the“Regulations on the Protection of Traditional Chinese Medicine Varieties”in 1992 to the comprehensive revision of the draft for soliciting opinions in 2022.The TCM protection system evolves to meet the needs of innovative development of TCM.This paper reviews the policy developments in TCM varieties protection,collates protection data(1993 to 2024),and analyzes enterprises application strategies amid impending regulatory changes.展开更多
This study examines the digital transformation of traditional Chinese medicine(TCM)education within the context of global standardization,along with the challenges and opportunities of its cross-cultural dissemination...This study examines the digital transformation of traditional Chinese medicine(TCM)education within the context of global standardization,along with the challenges and opportunities of its cross-cultural dissemination.With the rapid advancement of technologies such as artificial intelligence,virtual reality,and blockchain,TCM education is experiencing a significant disruption and innovation of its traditional models.The research develops a“Standard-Technology-Culture”tri-spiral model to analyze how TCM education can achieve a seamless integration of standardization,technological innovation,and cultural preservation during its globalization process.The study finds that standardization provides the foundation for TCM education’s global expansion,while technological innovation drives the transformation of educational methodologies.Simultaneously,cultural preservation ensures the distinctiveness of TCM education.However,the tension between standardization and the unique characteristics of TCM,as well as the balance between technological empowerment and cultural transmission,remain critical challenges in the ongoing transformation.Based on these findings,the study proposes strategies such as the“digital apprenticeship”model and blockchain-based certification systems to advance the globalization and digital transformation of TCM education,providing theoretical support for the creation of a global health community.展开更多
[Objectives]This meta-analysis evaluated the efficacy of Traditional Chinese Medicine(TCM)manual therapies(Tuina,Daoyin,acupotomology)for idiopathic scoliosis(IS),with dual focus on radiographic outcomes(Cobb angle,ve...[Objectives]This meta-analysis evaluated the efficacy of Traditional Chinese Medicine(TCM)manual therapies(Tuina,Daoyin,acupotomology)for idiopathic scoliosis(IS),with dual focus on radiographic outcomes(Cobb angle,vertebral rotation)and patient-centered metrics(pain,disability,quality of life).[Methods]This study systematically searched PubMed,Cochrane Library,EMBASE,Web of Science,CNKI,Wanfang,and VIP databases(from inception to July 2025)for randomized controlled trials(RCTs)comparing TCM manual therapies against controls(bracing,exercise,sham,or no intervention).Two reviewers independently extracted data and assessed methodological quality using the PEDro scale.Meta-analyses employed random-effects models(Stata 18)to calculate Hedges'g with 95%confidence intervals(CI).Heterogeneity was quantified via I 2 statistics,and subgroup analyses examined intervention types(standalone versus combined)and control groups.[Results]Radiographic outcomes:TCM therapies significantly reduced Cobb angle(Hedges'g=-0.93;95%CI:-1.37,-0.49;p<0.001)and vertebral torsion rotation(VTR;g=-0.71;95%CI:-0.91,-0.51;p<0.001)versus controls;patient-centered outcomes:substantial pain reduction(VAS:g=-1.47;95%CI:-2.64,-0.30;p=0.01)and disability improvement(ODI:g=-1.10;95%CI:-1.57,-0.64;p<0.001)were observed.Quality of life(SRS-22)showed non-significant gains(g=2.01;95%CI:-0.43,4.45;p=0.11).[Conclusions]TCM manual therapies significantly improve spinal alignment and reduce pain/disability in IS patients,particularly when integrated with exercise regimens.While results support their role as complementary interventions,standardization of protocols and long-term efficacy studies are needed for clinical implementation.展开更多
Cancer pain is one of the most prevalent and debilitating symptoms in patients with advanced malignancies,arising from multifactorial mechanisms involving peripheral,central,and systemic pathways.Conventional analgesi...Cancer pain is one of the most prevalent and debilitating symptoms in patients with advanced malignancies,arising from multifactorial mechanisms involving peripheral,central,and systemic pathways.Conventional analgesics,including opioids and nonsteroidal anti-inflammatory drugs,are often limited by their insufficient efficacy,tolerance,and risk of dependence.Traditional Chinese Medicine(TCM),characterized by its multi-component,multi-target,and systemic regulatory properties,has shown promising potential in cancer pain management.This review provides a comprehensive overview of the clinical classification and underlying mechanisms of cancer pain(including nerve infiltration,dysregulation of inflammatory mediators and ion channels,central sensitization,neuro-immune crosstalk,metabolic reprogramming,and gut-brain axis impairment),as well as the analgesic effects of representative TCM agents in cancer pain management.For example,bioactive components such as tetrahydroberberine,levo-tetrahydropalmatine,and piperine exert analgesic effects,thereby improving the quality of life of patients by inhibiting inflammatory cascades,regulating neurotransmitter systems,and preserving neural integrity.Commonly used preclinical models,including bone cancer pain,pancreatic cancer pain,and chemotherapy-induced peripheral neuropathy models,are summarized for their utility in mechanistic studies and efficacy evaluations.This review also discusses the current limitations of clinical evidence,such as small sample sizes,short follow-up periods,and limited translation from animal models,alongside major challenges in standardization,mechanistic elucidation,and clinical trial design.Future directions should focus on precise pain phenotyping,integrated multi-target interventions,rigorous efficacy safety validation,and innovations in drug delivery to facilitate the standardization and global adoption of TCM in cancer pain management.展开更多
[Objectives]To analyze the clinical characteristics,distribution of traditional Chinese medicine(TCM)syndrome types,spectrum of comorbidities,and complications among inpatients with gout.[Methods]Data from 592 gout pa...[Objectives]To analyze the clinical characteristics,distribution of traditional Chinese medicine(TCM)syndrome types,spectrum of comorbidities,and complications among inpatients with gout.[Methods]Data from 592 gout patients admitted in the Department of Rheumatology at Wuxi Traditional Chinese Medicine Hospital between January 2018 and December 2024 were retrospectively collected.The data collected encompassed patient gender,age,TCM syndrome types,underlying comorbidities,infection status,and major complications,including renal insufficiency,interstitial lung disease,and osteoporosis.Descriptive statistical analyses were subsequently performed.[Results]Among the 592 inpatients,80.75%were male and 19.25%were female.A total of 94.76%patients had at least one underlying condition,with hypertension(80.74%),cerebral infarction(29.59%),heart disease(24.24%),and diabetes(21.56%)being the most prevalent.The primary TCM syndrome types identified were damp-heat obstruction syndrome(63.51%)and phlegm-stasis obstruction syndrome(21.11%).During hospitalization,20.94%of patients experienced concurrent infections,predominantly pulmonary infections(38.10%).The principal complications observed included renal insufficiency(32.09%),interstitial lung disease(18.75%),and osteoporosis(9.29%).[Conclusions]Inpatients diagnosed with gout often present with complex conditions and a high burden of comorbidities,predominantly cardiovascular and cerebrovascular diseases,as well as metabolic disorders.Additionally,there is a high incidence of infections and renal insufficiency within this population.TCM syndrome types in these patients are primarily characterized by damp-heat obstruction.In clinical practice,a comprehensive management approach that incorporates multidisciplinary collaboration is recommended.Alongside the control of uric acid levels and joint inflammation,proactive screening and management of comorbidities and related complications are essential.展开更多
The global prevalence of metabolic-associated fatty liver disease(MAFLD)is on the rise,seriously threatening human health.Currently,no specific approved drugs are available for its treatment.This paper reviews the pat...The global prevalence of metabolic-associated fatty liver disease(MAFLD)is on the rise,seriously threatening human health.Currently,no specific approved drugs are available for its treatment.This paper reviews the pathogenesis of MAFLD,covering aspects like lipid accumulation and insulin resistance,oxidative stress,endoplasmic reticulum stress(ERS),lipotoxicity-induced hepatocyte damage,and fibrosis.It also elaborates on multiple treatment approaches for MAFLD,including metabolic regulation,improvement of the gut-liver axis interaction,modulation of immune and inflammatory pathways,enhancement of the adipose tissue-liver interaction,alleviation of fibrosis,prevention of hepatocyte injury,and traditional Chinese medicine(TCM)external therapies.Additionally,natural product research advancements,individual Chinese medicine components,and mixed herbal formulas for MAFLD treatment is provided.Many natural products and traditional Chinese medicines exhibit favorable effects in regulating lipid metabolism,anti-inflammation,and anti-oxidation,offering new directions and potential drug options for MAFLD treatment.This is expected to provide a reference for future clinical treatment and drug development.展开更多
Currently,the number of patients with myopia is increasing rapidly across the globe.Traditional Chinese medicine(TCM),with its long history and rich experience,has shown promise in effectively managing and treating th...Currently,the number of patients with myopia is increasing rapidly across the globe.Traditional Chinese medicine(TCM),with its long history and rich experience,has shown promise in effectively managing and treating this condition.Nevertheless,considering the vast amount of research that is currently being conducted,focusing on the utilization of TCM in the management of myopia,there is an urgent requirement for a thorough and comprehensive review.The review would serve to clarify the practical applications of TCM within this specific field,and it would also aim to elucidate the underlying mechanisms that are at play,providing a deeper understanding of how TCM principles can be effectively integrated into modern medical practices.Here,some modern medical pathogenesis of myopia and appropriate TCM techniques studies are summarized in the prevention and treatment of myopia.Further,we discussed the potential mechanisms and the future research directions of TCM against myopia.Identifying these mechanisms is crucial for understanding how TCM can be effectively utilized in this context.The combination of various TCM methods or the combination of traditional Chinese and Western medicine is of great significance for the prevention and control of myopia in the future.展开更多
The development of pattern-based traditional Chinese medicine(TCM)compound preparations constitutes a core domain that represents the principle of pattern differentiation-based treatment,a hallmark of TCM.However,the ...The development of pattern-based traditional Chinese medicine(TCM)compound preparations constitutes a core domain that represents the principle of pattern differentiation-based treatment,a hallmark of TCM.However,the field has long been constrained by scientific and regulatory challenges in animal modeling,efficacy evaluation,and clinical positioning.This article proposes a new research and development(R&D)paradigm strategically based on human use experience(HUE)and centered on the patient as the key to overcoming these bottlenecks and achieving high-quality progress.We systematically dissect the traditional problems in this field and demonstrate the pivotal role of high-quality HUE in enabling precise clinical positioning and optimizing R&D pathways(e.g.,applying for exemptions from non-clinical studies).HUE guides the implementation of the“pattern-symptom integration”model.Furthermore,we detail the implementation of the patient-centered concept throughout the process of clinical trial design,collection of patients’experience data,clinical outcome assessment,and benefit-risk assessment.The integrative application of artificial intelligence in the R&D of pattern-based TCM drugs is also specifically explored.By synthesizing the“TCM theory,HUE,and clinical trials”evidence system,this article aims to provide a systematic strategic framework for establishing an R&D pathway that adheres to the intrinsic principles of TCM while simultaneously meeting modern scientific standards.展开更多
The prevalence of neuropsychiatric disorders,such as Alzheimer’s disease and major depressive disorder,has been rising annually,imposing a significant burden on social and economic development.Although current therap...The prevalence of neuropsychiatric disorders,such as Alzheimer’s disease and major depressive disorder,has been rising annually,imposing a significant burden on social and economic development.Although current therapeutic interventions can mitigate symptoms,a comprehensive understanding of the complex etiologies underlying these disorders remains elusive.This suggests that exploring the mechanisms of these disorders from a holistic perspective may lead to more effective therapeutic strategies.Traditional Chinese medicine(TCM)is primarily composed of natural compounds,often associated with fewer side effects,and its holistic treatment philosophy.These advantages have led to its widespread use in alleviating neuropsychiatric disorders.However,the specific mechanisms through which orally administered TCM interacts with the nervous system to exert therapeutic effects remain undefined.Numerous studies have suggested that these effects may be linked to gastrointestinal absorption and metabolism,particularly the interactions between TCM and gut microbiota.On one hand,TCM can regulate the balance of the gut microbiome,which plays a critical role in the progression of many neuropsychiatric diseases.On the other hand,TCM is metabolized by gut microbiota into key bioactive molecules,which then exert their alleviating effects on neuropsychiatric disorders through specific signaling pathways.This review will elucidate the interactions between the microbiota-gut-brain axis and neuropsychiatric disorders through the perspectives of neurological,immune,and endocrine-metabolic pathways.Furthermore,it will summarize the current clinical applications and therapeutic potentials of single TCM herbs,herbal formulas,and bioactive compounds,based on the microbiota-gut-brain axis theory,in alleviating major neuropsychiatric conditions.展开更多
Objective:To investigate the distribution of Traditional Chinese Medicine(TCM)constitution among night-shift nurses at a public tertiary-level Class A hospital,thereby identifying new approaches for developing effecti...Objective:To investigate the distribution of Traditional Chinese Medicine(TCM)constitution among night-shift nurses at a public tertiary-level Class A hospital,thereby identifying new approaches for developing effective interventions to enhance their health status.Methods:A total of 601 nurses employed at a public tertiary-level Class A hospital from August 2024 to August 2025 participated in the survey.Analysis was conducted using the Traditional Chinese Medicine Constitution Questionnaire.Results:The most prevalent TCM constitution types among night-shift nurses were Yang Deficiency Constitution(50.4%),Yin Deficiency Constitution(49.8%),Qi Deficiency Constitution(45.4%),and Phlegm-Dampness Constitution(45.1%).Conclusion:A high proportion of clinical night-shift nursing staff exhibit imbalanced constitution types,severely impacting their physical and mental health.Nursing administrators should implement targeted TCM constitution-based health maintenance and regulation to improve the health status of nursing personnel.展开更多
Based on Liu Shaowu’s “Exterior Region” theory in the “Three Regions and Six Diseases” doctrine, combined with Zhang Zhongjing’s therapeutic principle of “diaphoresis method”, this paper explores the TCM patho...Based on Liu Shaowu’s “Exterior Region” theory in the “Three Regions and Six Diseases” doctrine, combined with Zhang Zhongjing’s therapeutic principle of “diaphoresis method”, this paper explores the TCM pathogenesis and treatment methods of cold-damp type allergic rhinitis. It points out that the core pathogenesis of the disease is the invasion of wind-cold-damp pathogens into the exterior region, leading to stagnation of defensive Yang and obstruction of orifices and collaterals. Through three typical clinical cases (involving symptoms such as nasal itching, nasopharyngeal tube obstruction, nasal congestion with headache), modified ephedra-based formulas such as Mahuang Decoction, Maxing Shigan Decoction, and Xiaoqinglong Decoction are used, combined with drugs for inducing resuscitation, resolving dampness, and promoting blood circulation, to expel pathogens through diaphoresis. Clinical observations show that expelling pathogens with the “diaphoresis method” can effectively relieve symptoms with significant curative effect. This study provides new ideas and methods for expanding the application of the “diaphoresis method” in the treatment of sinusitis.展开更多
Background:The historical trajectory of TCM appropriate technologies spans from their primordial origins in daily life practices,through the systematization of classical theoretical frameworks,to modern scientific val...Background:The historical trajectory of TCM appropriate technologies spans from their primordial origins in daily life practices,through the systematization of classical theoretical frameworks,to modern scientific validation and health management applications.Methods:Employing literature review and historical analysis methodologies,this study systematically traces and synthesizes the entire developmental pathway of TCM appropriate technologies.Results:The analysis reveals the intrinsic developmental patterns of these technologies and underscores their practical significance in“preventive treatment”and chronic condition management.A key exemplar of modern innovation is presented:the Hand Twelve Jing-Well Points Exercise.This non-invasive technique adapts the classical Jing-Well Points(jǐng xué)theory,extending its traditional functions in emergency care and brain health from a focus on“treating established diseases”to the paradigm of“preventive treatment.”Conclusion:This research provides a comprehensive case study for the systematic investigation of TCM appropriate technologies.It elucidates a model of inheritance and innovation within modern healthcare systems and offers a theoretical foundation for the promotion and cultural dissemination of these practices.展开更多
文摘This article focuses on the remote diagnosis and analysis of rail vehicle status based on the data of the Train Control Management System(TCMS).It first expounds on the importance of train diagnostic analysis and designs a unified TCMS data frame transmission format.Subsequently,a remote data transmission link using 4G signals and data processing methods is introduced.The advantages of remote diagnosis are analyzed,and common methods such as correlation analysis,fault diagnosis,and fault prediction are explained in detail.Then,challenges such as data security and the balance between diagnostic accuracy and real-time performance are discussed,along with development prospects in technological innovation,algorithm optimization,and application promotion.This research provides ideas for remote analysis and diagnosis based on TCMS data,contributing to the safe and efficient operation of rail vehicles.
文摘The protection system for traditional Chinese medicine(TCM)varieties,as an important policy tool to promote the development of TCM,has a long history of over 30 years,from the promulgation of the“Regulations on the Protection of Traditional Chinese Medicine Varieties”in 1992 to the comprehensive revision of the draft for soliciting opinions in 2022.The TCM protection system evolves to meet the needs of innovative development of TCM.This paper reviews the policy developments in TCM varieties protection,collates protection data(1993 to 2024),and analyzes enterprises application strategies amid impending regulatory changes.
文摘This study examines the digital transformation of traditional Chinese medicine(TCM)education within the context of global standardization,along with the challenges and opportunities of its cross-cultural dissemination.With the rapid advancement of technologies such as artificial intelligence,virtual reality,and blockchain,TCM education is experiencing a significant disruption and innovation of its traditional models.The research develops a“Standard-Technology-Culture”tri-spiral model to analyze how TCM education can achieve a seamless integration of standardization,technological innovation,and cultural preservation during its globalization process.The study finds that standardization provides the foundation for TCM education’s global expansion,while technological innovation drives the transformation of educational methodologies.Simultaneously,cultural preservation ensures the distinctiveness of TCM education.However,the tension between standardization and the unique characteristics of TCM,as well as the balance between technological empowerment and cultural transmission,remain critical challenges in the ongoing transformation.Based on these findings,the study proposes strategies such as the“digital apprenticeship”model and blockchain-based certification systems to advance the globalization and digital transformation of TCM education,providing theoretical support for the creation of a global health community.
文摘[Objectives]This meta-analysis evaluated the efficacy of Traditional Chinese Medicine(TCM)manual therapies(Tuina,Daoyin,acupotomology)for idiopathic scoliosis(IS),with dual focus on radiographic outcomes(Cobb angle,vertebral rotation)and patient-centered metrics(pain,disability,quality of life).[Methods]This study systematically searched PubMed,Cochrane Library,EMBASE,Web of Science,CNKI,Wanfang,and VIP databases(from inception to July 2025)for randomized controlled trials(RCTs)comparing TCM manual therapies against controls(bracing,exercise,sham,or no intervention).Two reviewers independently extracted data and assessed methodological quality using the PEDro scale.Meta-analyses employed random-effects models(Stata 18)to calculate Hedges'g with 95%confidence intervals(CI).Heterogeneity was quantified via I 2 statistics,and subgroup analyses examined intervention types(standalone versus combined)and control groups.[Results]Radiographic outcomes:TCM therapies significantly reduced Cobb angle(Hedges'g=-0.93;95%CI:-1.37,-0.49;p<0.001)and vertebral torsion rotation(VTR;g=-0.71;95%CI:-0.91,-0.51;p<0.001)versus controls;patient-centered outcomes:substantial pain reduction(VAS:g=-1.47;95%CI:-2.64,-0.30;p=0.01)and disability improvement(ODI:g=-1.10;95%CI:-1.57,-0.64;p<0.001)were observed.Quality of life(SRS-22)showed non-significant gains(g=2.01;95%CI:-0.43,4.45;p=0.11).[Conclusions]TCM manual therapies significantly improve spinal alignment and reduce pain/disability in IS patients,particularly when integrated with exercise regimens.While results support their role as complementary interventions,standardization of protocols and long-term efficacy studies are needed for clinical implementation.
基金supported by the National Natural Science Foundation of China(No.82360238,82071245)。
文摘Cancer pain is one of the most prevalent and debilitating symptoms in patients with advanced malignancies,arising from multifactorial mechanisms involving peripheral,central,and systemic pathways.Conventional analgesics,including opioids and nonsteroidal anti-inflammatory drugs,are often limited by their insufficient efficacy,tolerance,and risk of dependence.Traditional Chinese Medicine(TCM),characterized by its multi-component,multi-target,and systemic regulatory properties,has shown promising potential in cancer pain management.This review provides a comprehensive overview of the clinical classification and underlying mechanisms of cancer pain(including nerve infiltration,dysregulation of inflammatory mediators and ion channels,central sensitization,neuro-immune crosstalk,metabolic reprogramming,and gut-brain axis impairment),as well as the analgesic effects of representative TCM agents in cancer pain management.For example,bioactive components such as tetrahydroberberine,levo-tetrahydropalmatine,and piperine exert analgesic effects,thereby improving the quality of life of patients by inhibiting inflammatory cascades,regulating neurotransmitter systems,and preserving neural integrity.Commonly used preclinical models,including bone cancer pain,pancreatic cancer pain,and chemotherapy-induced peripheral neuropathy models,are summarized for their utility in mechanistic studies and efficacy evaluations.This review also discusses the current limitations of clinical evidence,such as small sample sizes,short follow-up periods,and limited translation from animal models,alongside major challenges in standardization,mechanistic elucidation,and clinical trial design.Future directions should focus on precise pain phenotyping,integrated multi-target interventions,rigorous efficacy safety validation,and innovations in drug delivery to facilitate the standardization and global adoption of TCM in cancer pain management.
基金Supported by Wuxi Taihu Talent Program(202101)Project of Wu Jieping Medical Foundation(320.6750.2023-03-33).
文摘[Objectives]To analyze the clinical characteristics,distribution of traditional Chinese medicine(TCM)syndrome types,spectrum of comorbidities,and complications among inpatients with gout.[Methods]Data from 592 gout patients admitted in the Department of Rheumatology at Wuxi Traditional Chinese Medicine Hospital between January 2018 and December 2024 were retrospectively collected.The data collected encompassed patient gender,age,TCM syndrome types,underlying comorbidities,infection status,and major complications,including renal insufficiency,interstitial lung disease,and osteoporosis.Descriptive statistical analyses were subsequently performed.[Results]Among the 592 inpatients,80.75%were male and 19.25%were female.A total of 94.76%patients had at least one underlying condition,with hypertension(80.74%),cerebral infarction(29.59%),heart disease(24.24%),and diabetes(21.56%)being the most prevalent.The primary TCM syndrome types identified were damp-heat obstruction syndrome(63.51%)and phlegm-stasis obstruction syndrome(21.11%).During hospitalization,20.94%of patients experienced concurrent infections,predominantly pulmonary infections(38.10%).The principal complications observed included renal insufficiency(32.09%),interstitial lung disease(18.75%),and osteoporosis(9.29%).[Conclusions]Inpatients diagnosed with gout often present with complex conditions and a high burden of comorbidities,predominantly cardiovascular and cerebrovascular diseases,as well as metabolic disorders.Additionally,there is a high incidence of infections and renal insufficiency within this population.TCM syndrome types in these patients are primarily characterized by damp-heat obstruction.In clinical practice,a comprehensive management approach that incorporates multidisciplinary collaboration is recommended.Alongside the control of uric acid levels and joint inflammation,proactive screening and management of comorbidities and related complications are essential.
基金supported by the National Natural Science Foundation of China(82574477)the Jiangsu Provincial Traditional Chinese Medicine Science and Technology Development Plan(QN202426)+5 种基金Jiangsu Province“333 High-level Talents Training Project”((2024)3-0189)Youth Talent Support Project of the Jiangsu Association for Science and Technology(TJ-2023-053)Shanxi Provincial Department-Municipal Key Laboratory Cultivation Base for Quality Enhancement and Utilization of Shangdang Chinese Medicinal Materials(KF202401)Fundamental Research Program of Shanxi Province(202403021221211)the research project supported by the Shanxi Scholarship Council of China(No.2023-158)Open Project of Key Laboratory of Tibetan Medicine Basic Research,Ministry of Education.
文摘The global prevalence of metabolic-associated fatty liver disease(MAFLD)is on the rise,seriously threatening human health.Currently,no specific approved drugs are available for its treatment.This paper reviews the pathogenesis of MAFLD,covering aspects like lipid accumulation and insulin resistance,oxidative stress,endoplasmic reticulum stress(ERS),lipotoxicity-induced hepatocyte damage,and fibrosis.It also elaborates on multiple treatment approaches for MAFLD,including metabolic regulation,improvement of the gut-liver axis interaction,modulation of immune and inflammatory pathways,enhancement of the adipose tissue-liver interaction,alleviation of fibrosis,prevention of hepatocyte injury,and traditional Chinese medicine(TCM)external therapies.Additionally,natural product research advancements,individual Chinese medicine components,and mixed herbal formulas for MAFLD treatment is provided.Many natural products and traditional Chinese medicines exhibit favorable effects in regulating lipid metabolism,anti-inflammation,and anti-oxidation,offering new directions and potential drug options for MAFLD treatment.This is expected to provide a reference for future clinical treatment and drug development.
基金supported by Healthy China initiative of Traditional Chinese Medicine(No.889042).
文摘Currently,the number of patients with myopia is increasing rapidly across the globe.Traditional Chinese medicine(TCM),with its long history and rich experience,has shown promise in effectively managing and treating this condition.Nevertheless,considering the vast amount of research that is currently being conducted,focusing on the utilization of TCM in the management of myopia,there is an urgent requirement for a thorough and comprehensive review.The review would serve to clarify the practical applications of TCM within this specific field,and it would also aim to elucidate the underlying mechanisms that are at play,providing a deeper understanding of how TCM principles can be effectively integrated into modern medical practices.Here,some modern medical pathogenesis of myopia and appropriate TCM techniques studies are summarized in the prevention and treatment of myopia.Further,we discussed the potential mechanisms and the future research directions of TCM against myopia.Identifying these mechanisms is crucial for understanding how TCM can be effectively utilized in this context.The combination of various TCM methods or the combination of traditional Chinese and Western medicine is of great significance for the prevention and control of myopia in the future.
基金supported by the Key Laboratory of Clinical Evaluation Technology for Human Experience with Chinese Medicine,Science and Technology Innovation Project of Guangdong Provincial Medical Products Administration(2022ZDB06)the Jointly Funded Project by Guangzhou Science and Technology Bureau,Research Institutes and Enterprises(2024A03j0355)+1 种基金the State Key Laboratory of Traditional Chinese Medicine Syndrome"Unveiling the List and Taking on Leadership"Project(SKLKY2025C0013)the National Key Research and Development Program of China(2025YFC3507902).
文摘The development of pattern-based traditional Chinese medicine(TCM)compound preparations constitutes a core domain that represents the principle of pattern differentiation-based treatment,a hallmark of TCM.However,the field has long been constrained by scientific and regulatory challenges in animal modeling,efficacy evaluation,and clinical positioning.This article proposes a new research and development(R&D)paradigm strategically based on human use experience(HUE)and centered on the patient as the key to overcoming these bottlenecks and achieving high-quality progress.We systematically dissect the traditional problems in this field and demonstrate the pivotal role of high-quality HUE in enabling precise clinical positioning and optimizing R&D pathways(e.g.,applying for exemptions from non-clinical studies).HUE guides the implementation of the“pattern-symptom integration”model.Furthermore,we detail the implementation of the patient-centered concept throughout the process of clinical trial design,collection of patients’experience data,clinical outcome assessment,and benefit-risk assessment.The integrative application of artificial intelligence in the R&D of pattern-based TCM drugs is also specifically explored.By synthesizing the“TCM theory,HUE,and clinical trials”evidence system,this article aims to provide a systematic strategic framework for establishing an R&D pathway that adheres to the intrinsic principles of TCM while simultaneously meeting modern scientific standards.
基金supported by Henan Provincial Medical Science and Technology Research Project(LHGJ20240430).
文摘The prevalence of neuropsychiatric disorders,such as Alzheimer’s disease and major depressive disorder,has been rising annually,imposing a significant burden on social and economic development.Although current therapeutic interventions can mitigate symptoms,a comprehensive understanding of the complex etiologies underlying these disorders remains elusive.This suggests that exploring the mechanisms of these disorders from a holistic perspective may lead to more effective therapeutic strategies.Traditional Chinese medicine(TCM)is primarily composed of natural compounds,often associated with fewer side effects,and its holistic treatment philosophy.These advantages have led to its widespread use in alleviating neuropsychiatric disorders.However,the specific mechanisms through which orally administered TCM interacts with the nervous system to exert therapeutic effects remain undefined.Numerous studies have suggested that these effects may be linked to gastrointestinal absorption and metabolism,particularly the interactions between TCM and gut microbiota.On one hand,TCM can regulate the balance of the gut microbiome,which plays a critical role in the progression of many neuropsychiatric diseases.On the other hand,TCM is metabolized by gut microbiota into key bioactive molecules,which then exert their alleviating effects on neuropsychiatric disorders through specific signaling pathways.This review will elucidate the interactions between the microbiota-gut-brain axis and neuropsychiatric disorders through the perspectives of neurological,immune,and endocrine-metabolic pathways.Furthermore,it will summarize the current clinical applications and therapeutic potentials of single TCM herbs,herbal formulas,and bioactive compounds,based on the microbiota-gut-brain axis theory,in alleviating major neuropsychiatric conditions.
文摘Objective:To investigate the distribution of Traditional Chinese Medicine(TCM)constitution among night-shift nurses at a public tertiary-level Class A hospital,thereby identifying new approaches for developing effective interventions to enhance their health status.Methods:A total of 601 nurses employed at a public tertiary-level Class A hospital from August 2024 to August 2025 participated in the survey.Analysis was conducted using the Traditional Chinese Medicine Constitution Questionnaire.Results:The most prevalent TCM constitution types among night-shift nurses were Yang Deficiency Constitution(50.4%),Yin Deficiency Constitution(49.8%),Qi Deficiency Constitution(45.4%),and Phlegm-Dampness Constitution(45.1%).Conclusion:A high proportion of clinical night-shift nursing staff exhibit imbalanced constitution types,severely impacting their physical and mental health.Nursing administrators should implement targeted TCM constitution-based health maintenance and regulation to improve the health status of nursing personnel.
文摘Based on Liu Shaowu’s “Exterior Region” theory in the “Three Regions and Six Diseases” doctrine, combined with Zhang Zhongjing’s therapeutic principle of “diaphoresis method”, this paper explores the TCM pathogenesis and treatment methods of cold-damp type allergic rhinitis. It points out that the core pathogenesis of the disease is the invasion of wind-cold-damp pathogens into the exterior region, leading to stagnation of defensive Yang and obstruction of orifices and collaterals. Through three typical clinical cases (involving symptoms such as nasal itching, nasopharyngeal tube obstruction, nasal congestion with headache), modified ephedra-based formulas such as Mahuang Decoction, Maxing Shigan Decoction, and Xiaoqinglong Decoction are used, combined with drugs for inducing resuscitation, resolving dampness, and promoting blood circulation, to expel pathogens through diaphoresis. Clinical observations show that expelling pathogens with the “diaphoresis method” can effectively relieve symptoms with significant curative effect. This study provides new ideas and methods for expanding the application of the “diaphoresis method” in the treatment of sinusitis.
基金supported by the Tianjin Municipal Education Commission Scientific Research Plan Project(Grant No.2022ZD042).
文摘Background:The historical trajectory of TCM appropriate technologies spans from their primordial origins in daily life practices,through the systematization of classical theoretical frameworks,to modern scientific validation and health management applications.Methods:Employing literature review and historical analysis methodologies,this study systematically traces and synthesizes the entire developmental pathway of TCM appropriate technologies.Results:The analysis reveals the intrinsic developmental patterns of these technologies and underscores their practical significance in“preventive treatment”and chronic condition management.A key exemplar of modern innovation is presented:the Hand Twelve Jing-Well Points Exercise.This non-invasive technique adapts the classical Jing-Well Points(jǐng xué)theory,extending its traditional functions in emergency care and brain health from a focus on“treating established diseases”to the paradigm of“preventive treatment.”Conclusion:This research provides a comprehensive case study for the systematic investigation of TCM appropriate technologies.It elucidates a model of inheritance and innovation within modern healthcare systems and offers a theoretical foundation for the promotion and cultural dissemination of these practices.
