Heart failure(HF)is a disease in which the heart fails to efficiently pump blood due to diminished cardiac function,which seriously affects the quality of life and prognosis of patients.In recent years,traditional Chi...Heart failure(HF)is a disease in which the heart fails to efficiently pump blood due to diminished cardiac function,which seriously affects the quality of life and prognosis of patients.In recent years,traditional Chinese medicine(TCM),as a national treasure of China,has been shown to regulate cardiac energy metabolism and has been widely used in the treatment of HF.This article summarised commonly used TCMs for the treatment of HF,mainly from the perspective of improving energy metabolism.The results showed that TCMs can enhance the cardiac energy supply and improve cardiac function by altering the heart's preference for metabolic substrates,regulating the activity of key metabolic enzymes and the expression of related proteins,and attenuating impaired mitochondrial function.Among them,Astragali Radix(Huangqi in Chinese),Ginseng Radix et Rhizoma(Renshen in Chinese),Salviae Miltiorrhizae Radix et Rhizoma(Danshen in Chinese),and their extracts can exert significant cardioprotective effects.In addition,some TCM herbal formulas,such as Shengmai San and Zhenwu Tang,have been widely used in the treatment of HF.The application of these herbal extracts and formulas provides an effective option for the treatment of HF,but further studies are needed to clarify their mechanisms of action and clinical applications.展开更多
基金funded by the Natural Science Foundation of Gansu Province project(No.22JR5RA610)。
文摘Heart failure(HF)is a disease in which the heart fails to efficiently pump blood due to diminished cardiac function,which seriously affects the quality of life and prognosis of patients.In recent years,traditional Chinese medicine(TCM),as a national treasure of China,has been shown to regulate cardiac energy metabolism and has been widely used in the treatment of HF.This article summarised commonly used TCMs for the treatment of HF,mainly from the perspective of improving energy metabolism.The results showed that TCMs can enhance the cardiac energy supply and improve cardiac function by altering the heart's preference for metabolic substrates,regulating the activity of key metabolic enzymes and the expression of related proteins,and attenuating impaired mitochondrial function.Among them,Astragali Radix(Huangqi in Chinese),Ginseng Radix et Rhizoma(Renshen in Chinese),Salviae Miltiorrhizae Radix et Rhizoma(Danshen in Chinese),and their extracts can exert significant cardioprotective effects.In addition,some TCM herbal formulas,such as Shengmai San and Zhenwu Tang,have been widely used in the treatment of HF.The application of these herbal extracts and formulas provides an effective option for the treatment of HF,but further studies are needed to clarify their mechanisms of action and clinical applications.
