TCCA(Tutor of“Channels,Collaterals and Acupuncture)是一个基于微型机的中医“经络腧穴学”智能教学系统。它面向高级、中级和普及型三类学生及教学专家,采用统一的泛概念网知识描述结构以及灵活的教学策略,利用个别辅导、会话和模...TCCA(Tutor of“Channels,Collaterals and Acupuncture)是一个基于微型机的中医“经络腧穴学”智能教学系统。它面向高级、中级和普及型三类学生及教学专家,采用统一的泛概念网知识描述结构以及灵活的教学策略,利用个别辅导、会话和模拟相结合的教学模式进行教授。本文介绍系统功能、设计思想和实现结构。展开更多
2-Isoxazolines and 2-pyrazolines have been derived from oxime and hydrazone derivatives reacted with <span style="font-family:Verdana;">N<span style="font-family:Verdana;">-chlorosuccin...2-Isoxazolines and 2-pyrazolines have been derived from oxime and hydrazone derivatives reacted with <span style="font-family:Verdana;">N<span style="font-family:Verdana;">-chlorosuccinimide (NCS) and trichloroisocyanuric acid (TCCA). Cyclization strategy is developed for the reaction of <span style="font-family:Verdana;">β<span style="font-family:Verdana;">, <span style="font-family:Verdana;">γ<span style="font-family:Verdana;">-unsaturated hydrazones with the TCCA to drive 2-pyrazolines and the reaction of <span style="font-family:Verdana;">β<span style="font-family:Verdana;">, <span style="font-family:Verdana;">γ<span style="font-family:Verdana;">-unsaturated oximes with NCS to derive 2-isoxalzolines. Structures of all new 2-isoxazolines and 2-pyrazolines have been elucidated by microanalyses, <sup></sup><sup><span style="font-family:Verdana;">1</sup><span style="font-family:Verdana;">H, <sup></sup><sup><span style="font-family:Verdana;">13</sup><span style="font-family:Verdana;">C NMR and Mass spectroscopies.展开更多
3-Thiocyanated chromones was conveniently synthesized from alkynyl aryl ketones using commercially available,inexpensive trichloroisocyanuric acid(TCCA)as oxidant and NH_(4)SCN as thiocyanato(SCN)source.This metalfree...3-Thiocyanated chromones was conveniently synthesized from alkynyl aryl ketones using commercially available,inexpensive trichloroisocyanuric acid(TCCA)as oxidant and NH_(4)SCN as thiocyanato(SCN)source.This metalfree approach is postulated to first in situ generate thiocyanogen chloride(Cl-SCN)from the reaction of TCCA and NH_(4)SCN,followed by a rare efficient electrophilic thiocyano oxyfunctionalization of alkynes enabled by the reactive electrophilic species generated thereof.展开更多
文摘TCCA(Tutor of“Channels,Collaterals and Acupuncture)是一个基于微型机的中医“经络腧穴学”智能教学系统。它面向高级、中级和普及型三类学生及教学专家,采用统一的泛概念网知识描述结构以及灵活的教学策略,利用个别辅导、会话和模拟相结合的教学模式进行教授。本文介绍系统功能、设计思想和实现结构。
文摘2-Isoxazolines and 2-pyrazolines have been derived from oxime and hydrazone derivatives reacted with <span style="font-family:Verdana;">N<span style="font-family:Verdana;">-chlorosuccinimide (NCS) and trichloroisocyanuric acid (TCCA). Cyclization strategy is developed for the reaction of <span style="font-family:Verdana;">β<span style="font-family:Verdana;">, <span style="font-family:Verdana;">γ<span style="font-family:Verdana;">-unsaturated hydrazones with the TCCA to drive 2-pyrazolines and the reaction of <span style="font-family:Verdana;">β<span style="font-family:Verdana;">, <span style="font-family:Verdana;">γ<span style="font-family:Verdana;">-unsaturated oximes with NCS to derive 2-isoxalzolines. Structures of all new 2-isoxazolines and 2-pyrazolines have been elucidated by microanalyses, <sup></sup><sup><span style="font-family:Verdana;">1</sup><span style="font-family:Verdana;">H, <sup></sup><sup><span style="font-family:Verdana;">13</sup><span style="font-family:Verdana;">C NMR and Mass spectroscopies.
基金We acknowledge the National Natural Science Foundation of China(No.22071175)for financial supportX.B.Wang thanks the financial support from the National Natural Science Foundation of China(Nos.21908018,22078174),and Qi Lu Young Scholar Start-up Foundation of Shandong University.
文摘3-Thiocyanated chromones was conveniently synthesized from alkynyl aryl ketones using commercially available,inexpensive trichloroisocyanuric acid(TCCA)as oxidant and NH_(4)SCN as thiocyanato(SCN)source.This metalfree approach is postulated to first in situ generate thiocyanogen chloride(Cl-SCN)from the reaction of TCCA and NH_(4)SCN,followed by a rare efficient electrophilic thiocyano oxyfunctionalization of alkynes enabled by the reactive electrophilic species generated thereof.
