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Tc-MDP对类风湿关节炎患者CR1、CIC和RF表达的影响及其临床意义 被引量:2
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作者 陆东明 李琰君 赵书平 《青海医学院学报》 CAS 2008年第1期58-59,63,共3页
目的探讨锝亚甲基二磷酸盐(Tc-MDP)治疗类风湿性关节炎(RA)时,对红细胞膜补体受体-1(CR1)、循环免疫复合物(CIC)和类风湿因子(RF)表达的影响及临床意义。方法将54例RA患者随机分为治疗组和对照组。对照组(26例)常规采用非甾体抗炎药物... 目的探讨锝亚甲基二磷酸盐(Tc-MDP)治疗类风湿性关节炎(RA)时,对红细胞膜补体受体-1(CR1)、循环免疫复合物(CIC)和类风湿因子(RF)表达的影响及临床意义。方法将54例RA患者随机分为治疗组和对照组。对照组(26例)常规采用非甾体抗炎药物双氯酚酸治疗,治疗组(28例)在服用双氯酚酸的同时静注Tc-MDP(5mg/d)。40d后获取两组静脉抗凝血(3m l),分离出红细胞与血浆。采用酶联免疫吸附实验(ELISA)法测定红细胞膜CR1(405nm)和RF(450nm)OD值,通过聚乙二醇(PEG)比浊法测定CIC。结果治疗组CR1的OD值显著高于对照组(P<0.01),CIC和RF水平在治疗组中的降低程度具有统计学意义(P<0.01)。结论CR1、CIC、RF的联合检测可作为RA疗效检测指标;Tc-MDP对CR1表达低下的自身免疫性疾病有一定治疗作用。 展开更多
关键词 锝亚甲基二磷酸盐 类风湿性关节炎 补体受体-1 循环免疫复合物类风湿因子
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Treatment of Supraventricular Arrhythmias by Transcatheter Radiofrequency Ablation: The Experience of the Electrophysiology Unit of the University Hospital
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作者 Zecchin Massimo Porto Andrea +2 位作者 Bianco Elisabetta Gianfranco Sinagra Stroili Manuela 《Journal of Pharmacy and Pharmacology》 2017年第1期5-8,共4页
TC-RF (transcatheter radiofrequency) ablation has an important role in the treatment ofSVA (supraventricular arrhythmias). The indication to TC-RF ablation is usually made to improve the patient's quality of life... TC-RF (transcatheter radiofrequency) ablation has an important role in the treatment ofSVA (supraventricular arrhythmias). The indication to TC-RF ablation is usually made to improve the patient's quality of life through the elimination of the arrhythmic substrate. The objective of this study is to make a brief review of the literature and to report the Electrophysiology Unit experience of the Cardiovascular Department of the University Hospital of Trieste. From the study, it can be found that about one thousand of patients are visited annually in the Cardiovascular Department of the University Hospital of Trieste (1,019 ± 71/year over the past five years). The acute success rate of atrial fibrillation and flutter ablation procedures was respectively 93.9% and 97.9% with a relapse rate of 30% and 10% at 12 month. Accessory pathways and nodal atrio ventricular re-entry tachycardia ablation procedures had an acute success rate of respectively 91.1% and 96.6% with a relapse rate of 10% at 12 months. The overall complication rate was 5%. Catheter ablation is an effective therapy for SVA treatment. It can often be definitive, and it is generally superior to drug therapy, with a low complication rate. The improvement in patients' quality of life is associated with a reduced need for access to health services. 展开更多
关键词 tc-rf (transcatheter radiofrequency) ablation SVA (supraventricular arrhythmias) atrial fibrillation atrial flutter atrio-ventricular re-entry tachycardia atrio-ventricular nodal re-entry tachycardia technology assessment.
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