Although the search for appropriate radiation countermeasures has been ongoing for decades,there remains a lack of safe and effective radioprotective pharmaceuticals for preventing,mitigating,or treating acute radiati...Although the search for appropriate radiation countermeasures has been ongoing for decades,there remains a lack of safe and effective radioprotective pharmaceuticals for preventing,mitigating,or treating acute radiation syndrome(ARS)and other severe radiation injuries,and only a handful of drugs have been approved for clinical use with various side-effects.It has been increasingly recognized that valuable radiation countermeasures can be derived from Earth-based species exhibiting resistance to extremely high levels of ionizing radiation.In the pursuit of the mechanisms that govern radiosensitivity,a groundbreaking study in Science has delved into the radiation tolerance mechanisms of the tardigrade Hypsibius henanensis sp.nov.,revealing cross-species radiation defense strategies by integrating genomics,transcriptomics,and proteomic.Three key findings emerged:The horizontal transfer of the 4,5-DOPA dioxygenase gene from bacteria enhanced antioxidant production.The tardigrade-specific protein TRID1 was crucial for DNA double-strand break repair through liquid-liquid sepa-ration.The up-regulation of mitochondrial function-related genes accelerated NAD^(+)regeneration for DNA damage repair.This multi-omics approach not only sheds light on the extraordinary survival strategies of radiotolerant species,but also opens a promising avenue for harnessing cross-species radiation tolerance to develop innovative radioprotective compounds.展开更多
Tardigrades,also known as water bears,are microscopic eight-legged animals with an adult body length of 0.1–1.2 mm(Figure 1A).These minute animals are renowned for their resilience against extreme environmental condi...Tardigrades,also known as water bears,are microscopic eight-legged animals with an adult body length of 0.1–1.2 mm(Figure 1A).These minute animals are renowned for their resilience against extreme environmental conditions(Mùbjerg et al.,2011).Despite their small size,and being composed of only ca.展开更多
基金The National Natural Science Foundation of China(82473574 and 82404200)the Sichuan Science and Technology Program(25QNJJ4600),China.
文摘Although the search for appropriate radiation countermeasures has been ongoing for decades,there remains a lack of safe and effective radioprotective pharmaceuticals for preventing,mitigating,or treating acute radiation syndrome(ARS)and other severe radiation injuries,and only a handful of drugs have been approved for clinical use with various side-effects.It has been increasingly recognized that valuable radiation countermeasures can be derived from Earth-based species exhibiting resistance to extremely high levels of ionizing radiation.In the pursuit of the mechanisms that govern radiosensitivity,a groundbreaking study in Science has delved into the radiation tolerance mechanisms of the tardigrade Hypsibius henanensis sp.nov.,revealing cross-species radiation defense strategies by integrating genomics,transcriptomics,and proteomic.Three key findings emerged:The horizontal transfer of the 4,5-DOPA dioxygenase gene from bacteria enhanced antioxidant production.The tardigrade-specific protein TRID1 was crucial for DNA double-strand break repair through liquid-liquid sepa-ration.The up-regulation of mitochondrial function-related genes accelerated NAD^(+)regeneration for DNA damage repair.This multi-omics approach not only sheds light on the extraordinary survival strategies of radiotolerant species,but also opens a promising avenue for harnessing cross-species radiation tolerance to develop innovative radioprotective compounds.
文摘Tardigrades,also known as water bears,are microscopic eight-legged animals with an adult body length of 0.1–1.2 mm(Figure 1A).These minute animals are renowned for their resilience against extreme environmental conditions(Mùbjerg et al.,2011).Despite their small size,and being composed of only ca.
