Cometary nuclei, the remnant icy bodies of planet formation, located at the outer edge of the solar system, are relatively poorly studied because of their small sizes and thus faintness. Thus far more than a hundred l...Cometary nuclei, the remnant icy bodies of planet formation, located at the outer edge of the solar system, are relatively poorly studied because of their small sizes and thus faintness. Thus far more than a hundred large members (size about 100 km) of this cometary population in the Kuiper belt have been identified. Smaller bodies (10 km) are much too faint to image directly and their number so far can only be extrapolated on theoretical grounds. The Taiwan-America Occultation Survey (TAOS) will conduct a census of the number of Kuiper belt objects down to a few km size by monitoring chance stellar occultations by these cometary nuclei. We will set up an array of small (50cm), wide-field (f/1 9) telescopes, each equipped with a 2K squared CCD camera, along a 7 km baseline in central Taiwan at an elevation above ～ 3000 m. The robot telescopes will operate in a coincidence mode, so the sequence and timing of any candidate occultation event can be recorded and distinguished against a false detection. The Lawrence Livermore National Laboratory, the National Central University, and the Academia Sinica, will each contribute one telescope system. Researchers from an international variety of institutes are also participating in the project. Our experiment provides the only means to study the cometary population in the small-sized end of the distrbution. A great number of scientific byproducts, notably variable stars, will also derive from the huge TAOS database, some 10, 000 giga-bytes worth of photometrical measuremements per year.展开更多
The Taishan Antineutrino Observatory(TAO)is a satellite experiment of the Jiangmen Underground Neutrino Observatory,located near the Taishan nuclear power plant(NPP).The TAO aims to measure the energy spectrum of reac...The Taishan Antineutrino Observatory(TAO)is a satellite experiment of the Jiangmen Underground Neutrino Observatory,located near the Taishan nuclear power plant(NPP).The TAO aims to measure the energy spectrum of reactor antineutrinos with unprecedented precision,which would benefit both reactor neutrino physics and the nuclear database.A detector geometry and event visualization system was developed for the TAO.The software was based on ROOT packages and embedded in the TAO offline software framework.This provided an intuitive tool for visualizing the detector geometry,tuning the reconstruction algorithm,understanding neutrino physics,and monitoring the operation of reactors at NPP.Further applications of the visualization system in the experimental operation of TAO and its future development are discussed.展开更多
The Taishan Antineutrino Observatory(TAO)experiment features a top veto tracker system comprising 160 modules,each constructed from plastic scintillator(PS)strips,embedded wavelength shifting fibers(WLS-fibers),and si...The Taishan Antineutrino Observatory(TAO)experiment features a top veto tracker system comprising 160 modules,each constructed from plastic scintillator(PS)strips,embedded wavelength shifting fibers(WLS-fibers),and silicon photomultipliers.This article reports on the performance of all produced modules,focusing on the production and readout/trigger design,and providing insights into scintillation detectors based on WLS-fibers.Three types of trigger modes and their efficiencies were defined to comprehensively evaluate the performance of this unique design,which was verified through batch production,comprehensive measurement strategies,and quality inspection methods.In“module”mode,the detection(tagging)efficiency of the PS exceeded 99.67%at a 30-photoelectron threshold,and even in“AND”mode,it surpassed 99.60%at a 15-photoelectron threshold.The muon tagging efficiency satisfies the requirements of TAO.The production and performance of PS modules establish a benchmark for other experiments,with optimized optical fiber arrangements that enhance light yield and muon detection efficiency.展开更多
The theory of"Life and Practice"education was developed based on Tao Xingzhi's theory of life education from the early 20th century.Tao Xingzhi's theory of life education continues to profoundly infl...The theory of"Life and Practice"education was developed based on Tao Xingzhi's theory of life education from the early 20th century.Tao Xingzhi's theory of life education continues to profoundly influence contemporary and future educational reforms.The 21st century is an era of information and artificial intelligence,with the third major transformation undergoing in the field of education.Compared to the era in which Tao Xingzhi lived,China has experienced tremendous changes in its social structure and educational system.Therefore,to adapt to the requirements of this new era,the theory of"Life and Practiceeducation has emerged by inheriting and developing Tao Xingzhi's theory of life education.The core goal of"Life and Practice"education is to address the disconnect between education and life,school and society,and teaching and practice.展开更多
Dear Editor,Thyroid-associated ophthalmopathy(TAO),or Graves’ophthalmopathy(GO),is a complex autoimmune condition characterized by eye symptoms such as proptosis,lid retraction,and periorbital swelling,often associat...Dear Editor,Thyroid-associated ophthalmopathy(TAO),or Graves’ophthalmopathy(GO),is a complex autoimmune condition characterized by eye symptoms such as proptosis,lid retraction,and periorbital swelling,often associated with thyroid dysfunction[1].Current drug treatments primarily include glucocorticoids,traditional immunosuppressants,and novel biologics such as Teprotumumab.While able to alleviate symptoms,they often do not adequately address irreversible conditions such as visual impairment and fi brosis,and it is diffi cult to avoid long-term medication side eff ects.In this context,exploring new therapeutic avenues for TAO to improve patients’prognosis and quality of life is meaningful.We proposed chimeric antigen receptor(CAR)-based therapy as a novel treatment orientation.展开更多
THE tremendous impact of large models represented by ChatGPT[1]-[3]makes it necessary to con-sider the practical applications of such models[4].However,for an artificial intelligence(AI)to truly evolve,it needs to pos...THE tremendous impact of large models represented by ChatGPT[1]-[3]makes it necessary to con-sider the practical applications of such models[4].However,for an artificial intelligence(AI)to truly evolve,it needs to possess a physical“body”to transition from the virtual world to the real world and evolve through interaction with the real environments.In this context,“embodied intelligence”has sparked a new wave of research and technology,leading AI beyond the digital realm into a new paradigm that can actively act and perceive in a physical environment through tangible entities such as robots and automated devices[5].展开更多
BACKGROUND Lung cancer(LC)combined with chronic obstructive pulmonary disease(COPD)is a common combination of comorbidities.Anti-inflammation and modulation of oxidative/antioxidative imbalance may prevent COPD-induce...BACKGROUND Lung cancer(LC)combined with chronic obstructive pulmonary disease(COPD)is a common combination of comorbidities.Anti-inflammation and modulation of oxidative/antioxidative imbalance may prevent COPD-induced LC,and are also crucial to the treatment of LC combined with COPD.Modern studies have shown that Tao Hong Si Wu Tang(THSW)has vasodilatory,anti-inflammatory,anti-fatigue,anti-shock,immunoregulatory,lipid-reducing,micronutrient-supplementing,and anti-allergy effects.AIM To observe the effects of THSW on COPD and LC in mice.METHODS A total of 100 specific pathogen-free C57/BL6 mice were randomly divided into five groups:Blank control group(group A),model control group(group B),THSW group(group C),IL-6 group(group D),and THSW+IL-6 group(group E),with 20 mice in each group.A COPD mouse model was established using fumigation plus lipopolysaccharide intra-airway drip,and an LC model was replicated by in situ inoculation using the Lewis cell method.RESULTS The blank control group exhibited a clear alveolar structure.The model control and IL-6 groups had thickened alveolar walls,with smaller alveolar lumens,interstitial edema,and several inflammatory infiltrating cells.Histopathological changes in the lungs of the THSW and THSW+IL-6 groups were less than those of the model control group.The serum IL-1β,IL-6,and TNF-αlevels and IL-6R,JAK,p-JAK,STAT1/3,p-STAT1/3,FOXO,p-FOXO,and IL-7R expression levels in lung tissues of mice in the rest of the groups were significantly higher than those of the blank control group(P<0.01).Compared with the model control group,the IL-6 group demonstrated significantly higher levels for the abovementioned proteins in the serum and lung tissues(P<0.01),and the THSW group had significantly higher serum IL-1β,IL-6,and TNF-αlevels and IL-7R expression levels in lung tissues(P<0.01)but significantly decreased IL-6R,JAK,p-JAK,STAT1/3,p-STAT1/3,FOXO,p-FOXO,and IL-7R levels(P<0.01).CONCLUSION THSW reduces the serum IL-1β,IL-6,and TNF-αlevels in the mouse model with anti-inflammatory effects.Its antiinflammatory mechanism lies in inhibiting the overactivation of the JAK/STAT1/3 signaling pathway.展开更多
The exact dating of Laozi and his work has long been a topic of scholarly interest.Since the 1920s,traditional views on Laozi’s dating have been widely questioned in both Chinese and Western academia.In the latter ha...The exact dating of Laozi and his work has long been a topic of scholarly interest.Since the 1920s,traditional views on Laozi’s dating have been widely questioned in both Chinese and Western academia.In the latter half of the 20th century,as the“Trust Antiquity”trend gradually emerged in Chinese academia,the view that“Laozi did not exist”became the most influential mainstream perspective in Western academia.This paper first reviews the process of unification and differentiation of opinions between Chinese and Western academia.Then,by analyzing and comparing representative papers from Chinese and Western scholars,it explores the reasons for the differences in mainstream opinions.Additionally,it briefly discusses the implications of these differences to provide insights for future research.展开更多
利用美国国家浮标数据中心NDBC和热带大气海洋计划TAO浮标的海表面温度数据,对Wind Sat 2004年—2013年近10年的海表面温度产品进行了验证。结果表明,在美国沿岸海域,Wind Sat反演得到的海表面温度的平均偏差为0.10°C,标准偏差为0....利用美国国家浮标数据中心NDBC和热带大气海洋计划TAO浮标的海表面温度数据,对Wind Sat 2004年—2013年近10年的海表面温度产品进行了验证。结果表明,在美国沿岸海域,Wind Sat反演得到的海表面温度的平均偏差为0.10°C,标准偏差为0.59°C;在近赤道太平洋海域,反演得到的海表面温度的平均偏差为–0.15°C,标准偏差为0.33°C。Wind Sat海表面温度在夏季相对浮标实测值有正偏差增大和负偏差缩小的趋势,在美国东海岸以及墨西哥湾区域部分站点反演得到的海表面温度的标准偏差较大,其标准偏差超过1°C。在5–10 m/s风速段,Wind Sat海表面温度反演效果比较理想,平均偏差和标准偏差相对恒定。当风速大于12 m/s时,Wind Sat海表面温度反演的不确定性明显增加。与AMSR-E月平均海表面温度产品对比发现,夏季,Wind Sat SST较AMSRE偏低;冬季,Wind Sat SST较AMSR-E偏高。展开更多
文摘Cometary nuclei, the remnant icy bodies of planet formation, located at the outer edge of the solar system, are relatively poorly studied because of their small sizes and thus faintness. Thus far more than a hundred large members (size about 100 km) of this cometary population in the Kuiper belt have been identified. Smaller bodies (10 km) are much too faint to image directly and their number so far can only be extrapolated on theoretical grounds. The Taiwan-America Occultation Survey (TAOS) will conduct a census of the number of Kuiper belt objects down to a few km size by monitoring chance stellar occultations by these cometary nuclei. We will set up an array of small (50cm), wide-field (f/1 9) telescopes, each equipped with a 2K squared CCD camera, along a 7 km baseline in central Taiwan at an elevation above ～ 3000 m. The robot telescopes will operate in a coincidence mode, so the sequence and timing of any candidate occultation event can be recorded and distinguished against a false detection. The Lawrence Livermore National Laboratory, the National Central University, and the Academia Sinica, will each contribute one telescope system. Researchers from an international variety of institutes are also participating in the project. Our experiment provides the only means to study the cometary population in the small-sized end of the distrbution. A great number of scientific byproducts, notably variable stars, will also derive from the huge TAOS database, some 10, 000 giga-bytes worth of photometrical measuremements per year.
基金supported by the National Natural Science Foundation of China(Nos.12175321,11975021,and 11675275)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDA10010900)。
文摘The Taishan Antineutrino Observatory(TAO)is a satellite experiment of the Jiangmen Underground Neutrino Observatory,located near the Taishan nuclear power plant(NPP).The TAO aims to measure the energy spectrum of reactor antineutrinos with unprecedented precision,which would benefit both reactor neutrino physics and the nuclear database.A detector geometry and event visualization system was developed for the TAO.The software was based on ROOT packages and embedded in the TAO offline software framework.This provided an intuitive tool for visualizing the detector geometry,tuning the reconstruction algorithm,understanding neutrino physics,and monitoring the operation of reactors at NPP.Further applications of the visualization system in the experimental operation of TAO and its future development are discussed.
基金supported by the General Program of the National Natural Science Foundation of China(No.12075087)National Key Research and Development Program of China(No.2022YFA1602002)+1 种基金Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDA10011102)support from the Guangdong Provincial Key Laboratory of Advanced Particle Detection Technology。
文摘The Taishan Antineutrino Observatory(TAO)experiment features a top veto tracker system comprising 160 modules,each constructed from plastic scintillator(PS)strips,embedded wavelength shifting fibers(WLS-fibers),and silicon photomultipliers.This article reports on the performance of all produced modules,focusing on the production and readout/trigger design,and providing insights into scintillation detectors based on WLS-fibers.Three types of trigger modes and their efficiencies were defined to comprehensively evaluate the performance of this unique design,which was verified through batch production,comprehensive measurement strategies,and quality inspection methods.In“module”mode,the detection(tagging)efficiency of the PS exceeded 99.67%at a 30-photoelectron threshold,and even in“AND”mode,it surpassed 99.60%at a 15-photoelectron threshold.The muon tagging efficiency satisfies the requirements of TAO.The production and performance of PS modules establish a benchmark for other experiments,with optimized optical fiber arrangements that enhance light yield and muon detection efficiency.
文摘The theory of"Life and Practice"education was developed based on Tao Xingzhi's theory of life education from the early 20th century.Tao Xingzhi's theory of life education continues to profoundly influence contemporary and future educational reforms.The 21st century is an era of information and artificial intelligence,with the third major transformation undergoing in the field of education.Compared to the era in which Tao Xingzhi lived,China has experienced tremendous changes in its social structure and educational system.Therefore,to adapt to the requirements of this new era,the theory of"Life and Practiceeducation has emerged by inheriting and developing Tao Xingzhi's theory of life education.The core goal of"Life and Practice"education is to address the disconnect between education and life,school and society,and teaching and practice.
基金supported by the Distinguished Young Scholars of the National Defense Biotechnology Foundation(01-SWKJYCJJ11).
文摘Dear Editor,Thyroid-associated ophthalmopathy(TAO),or Graves’ophthalmopathy(GO),is a complex autoimmune condition characterized by eye symptoms such as proptosis,lid retraction,and periorbital swelling,often associated with thyroid dysfunction[1].Current drug treatments primarily include glucocorticoids,traditional immunosuppressants,and novel biologics such as Teprotumumab.While able to alleviate symptoms,they often do not adequately address irreversible conditions such as visual impairment and fi brosis,and it is diffi cult to avoid long-term medication side eff ects.In this context,exploring new therapeutic avenues for TAO to improve patients’prognosis and quality of life is meaningful.We proposed chimeric antigen receptor(CAR)-based therapy as a novel treatment orientation.
基金supported by the National Natural Science Foundation of China(62302047,62203250)the Science and Technology Development Fund of Macao SAR(0093/2023/RIA2,0050/2020/A1).
文摘THE tremendous impact of large models represented by ChatGPT[1]-[3]makes it necessary to con-sider the practical applications of such models[4].However,for an artificial intelligence(AI)to truly evolve,it needs to possess a physical“body”to transition from the virtual world to the real world and evolve through interaction with the real environments.In this context,“embodied intelligence”has sparked a new wave of research and technology,leading AI beyond the digital realm into a new paradigm that can actively act and perceive in a physical environment through tangible entities such as robots and automated devices[5].
基金Supported by Liaoning Province“Xingliao Talent Program”Project,No.XLYC2007019.
文摘BACKGROUND Lung cancer(LC)combined with chronic obstructive pulmonary disease(COPD)is a common combination of comorbidities.Anti-inflammation and modulation of oxidative/antioxidative imbalance may prevent COPD-induced LC,and are also crucial to the treatment of LC combined with COPD.Modern studies have shown that Tao Hong Si Wu Tang(THSW)has vasodilatory,anti-inflammatory,anti-fatigue,anti-shock,immunoregulatory,lipid-reducing,micronutrient-supplementing,and anti-allergy effects.AIM To observe the effects of THSW on COPD and LC in mice.METHODS A total of 100 specific pathogen-free C57/BL6 mice were randomly divided into five groups:Blank control group(group A),model control group(group B),THSW group(group C),IL-6 group(group D),and THSW+IL-6 group(group E),with 20 mice in each group.A COPD mouse model was established using fumigation plus lipopolysaccharide intra-airway drip,and an LC model was replicated by in situ inoculation using the Lewis cell method.RESULTS The blank control group exhibited a clear alveolar structure.The model control and IL-6 groups had thickened alveolar walls,with smaller alveolar lumens,interstitial edema,and several inflammatory infiltrating cells.Histopathological changes in the lungs of the THSW and THSW+IL-6 groups were less than those of the model control group.The serum IL-1β,IL-6,and TNF-αlevels and IL-6R,JAK,p-JAK,STAT1/3,p-STAT1/3,FOXO,p-FOXO,and IL-7R expression levels in lung tissues of mice in the rest of the groups were significantly higher than those of the blank control group(P<0.01).Compared with the model control group,the IL-6 group demonstrated significantly higher levels for the abovementioned proteins in the serum and lung tissues(P<0.01),and the THSW group had significantly higher serum IL-1β,IL-6,and TNF-αlevels and IL-7R expression levels in lung tissues(P<0.01)but significantly decreased IL-6R,JAK,p-JAK,STAT1/3,p-STAT1/3,FOXO,p-FOXO,and IL-7R levels(P<0.01).CONCLUSION THSW reduces the serum IL-1β,IL-6,and TNF-αlevels in the mouse model with anti-inflammatory effects.Its antiinflammatory mechanism lies in inhibiting the overactivation of the JAK/STAT1/3 signaling pathway.
文摘The exact dating of Laozi and his work has long been a topic of scholarly interest.Since the 1920s,traditional views on Laozi’s dating have been widely questioned in both Chinese and Western academia.In the latter half of the 20th century,as the“Trust Antiquity”trend gradually emerged in Chinese academia,the view that“Laozi did not exist”became the most influential mainstream perspective in Western academia.This paper first reviews the process of unification and differentiation of opinions between Chinese and Western academia.Then,by analyzing and comparing representative papers from Chinese and Western scholars,it explores the reasons for the differences in mainstream opinions.Additionally,it briefly discusses the implications of these differences to provide insights for future research.
文摘利用美国国家浮标数据中心NDBC和热带大气海洋计划TAO浮标的海表面温度数据,对Wind Sat 2004年—2013年近10年的海表面温度产品进行了验证。结果表明,在美国沿岸海域,Wind Sat反演得到的海表面温度的平均偏差为0.10°C,标准偏差为0.59°C;在近赤道太平洋海域,反演得到的海表面温度的平均偏差为–0.15°C,标准偏差为0.33°C。Wind Sat海表面温度在夏季相对浮标实测值有正偏差增大和负偏差缩小的趋势,在美国东海岸以及墨西哥湾区域部分站点反演得到的海表面温度的标准偏差较大,其标准偏差超过1°C。在5–10 m/s风速段,Wind Sat海表面温度反演效果比较理想,平均偏差和标准偏差相对恒定。当风速大于12 m/s时,Wind Sat海表面温度反演的不确定性明显增加。与AMSR-E月平均海表面温度产品对比发现,夏季,Wind Sat SST较AMSRE偏低;冬季,Wind Sat SST较AMSR-E偏高。
