This study investigates the adoption of carbon footprint tracking apps(CFAs)among Thai millennials,a critical element in addressing climate change.CFAs have yet to gain significant traction among users despite offerin...This study investigates the adoption of carbon footprint tracking apps(CFAs)among Thai millennials,a critical element in addressing climate change.CFAs have yet to gain significant traction among users despite offering personalized missions.Employing an extended Technology Acceptance Model(TAM)framework,we examine factors influencing CFA adoption intentions based on a sample of 30 environmentally conscious Thai millennials.Our findings indicate that perceived ease of use and enjoyment are crucial drivers of CFA adoption.Trust significantly impacts perceived usefulness,while enjoyment influences perceived ease of use.The study underscores the importance of user experience(UX)and enjoyment in driving adoption,highlighting the need for intuitive interfaces and engaging features.This research provides comprehensive insights into CFA adoption in Thailand by integrating TAM with external trust and perceived enjoyment factors.These findings offer valuable guidance for app developers,policymakers,and marketers,emphasizing the critical role of user experience and fun in fostering widespread CFA adoption.We discuss implications for stakeholders and suggest directions for future research,including larger-scale studies and cross-cultural comparisons within Southeast Asia.This research contributes to SDG 13(Climate Action)and SDG 12(Responsible Consumption and Production).展开更多
Melanoma is a malignant neoplasm with a high propensity to metastasize,arising from melanocytes and contributing significantly to global morbidity and mortality.Despite the demonstrated efficacy of many immunotherapy ap...Melanoma is a malignant neoplasm with a high propensity to metastasize,arising from melanocytes and contributing significantly to global morbidity and mortality.Despite the demonstrated efficacy of many immunotherapy approaches,these methods rely on direct destruction of tumor cells with minimal impact on the aggregate of nearby non-tumor cells,the extracellular matrix,and blood vessels that form the tumor microenvironment(TME).The TME is known to be heterogeneous and dynamic,exerting both antitumor and pro-tumor effects depending on the specific features and stage of carcinogenesis.TME has been shown in several studies to promote malignancy,angiogenesis,and metastasis in tumors in general and melanoma in particular.Consequently,a significant number of studies in thefield of melanoma therapy have been redirected to investigate the effects of individual TME constituents,their prognostic significance for patients,and the potential of therapeutic intervention to improve overall patient survival.This review highlights novel therapeutic approaches targeting two key resident cell types in the melanoma microenvironment:tumor-associated macrophages(TAMs)and cancer-associatedfibroblasts(CAFs).The review discusses their role in disease progression and summarizes the results of preclinical and clinical trials of targeted therapies against these cell types in the melanoma TME.展开更多
文摘This study investigates the adoption of carbon footprint tracking apps(CFAs)among Thai millennials,a critical element in addressing climate change.CFAs have yet to gain significant traction among users despite offering personalized missions.Employing an extended Technology Acceptance Model(TAM)framework,we examine factors influencing CFA adoption intentions based on a sample of 30 environmentally conscious Thai millennials.Our findings indicate that perceived ease of use and enjoyment are crucial drivers of CFA adoption.Trust significantly impacts perceived usefulness,while enjoyment influences perceived ease of use.The study underscores the importance of user experience(UX)and enjoyment in driving adoption,highlighting the need for intuitive interfaces and engaging features.This research provides comprehensive insights into CFA adoption in Thailand by integrating TAM with external trust and perceived enjoyment factors.These findings offer valuable guidance for app developers,policymakers,and marketers,emphasizing the critical role of user experience and fun in fostering widespread CFA adoption.We discuss implications for stakeholders and suggest directions for future research,including larger-scale studies and cross-cultural comparisons within Southeast Asia.This research contributes to SDG 13(Climate Action)and SDG 12(Responsible Consumption and Production).
基金performed at the expense of the subsidy allocated to Kazan Federal University for the fulfillment of the stated task in the field of scientific activity,No.FZSM-2023-0011.
文摘Melanoma is a malignant neoplasm with a high propensity to metastasize,arising from melanocytes and contributing significantly to global morbidity and mortality.Despite the demonstrated efficacy of many immunotherapy approaches,these methods rely on direct destruction of tumor cells with minimal impact on the aggregate of nearby non-tumor cells,the extracellular matrix,and blood vessels that form the tumor microenvironment(TME).The TME is known to be heterogeneous and dynamic,exerting both antitumor and pro-tumor effects depending on the specific features and stage of carcinogenesis.TME has been shown in several studies to promote malignancy,angiogenesis,and metastasis in tumors in general and melanoma in particular.Consequently,a significant number of studies in thefield of melanoma therapy have been redirected to investigate the effects of individual TME constituents,their prognostic significance for patients,and the potential of therapeutic intervention to improve overall patient survival.This review highlights novel therapeutic approaches targeting two key resident cell types in the melanoma microenvironment:tumor-associated macrophages(TAMs)and cancer-associatedfibroblasts(CAFs).The review discusses their role in disease progression and summarizes the results of preclinical and clinical trials of targeted therapies against these cell types in the melanoma TME.
