以前谈到过物联网（Internet of Things）和物连网（Networks of Things）的区别，目前的许多物联网应用其实大部分都是以“物连网”的形态存在，这是由“物”的“所有权”性质决定的。例如公安系统的消防和安防物联网主要存在于内网（I...以前谈到过物联网（Internet of Things）和物连网（Networks of Things）的区别，目前的许多物联网应用其实大部分都是以“物连网”的形态存在，这是由“物”的“所有权”性质决定的。例如公安系统的消防和安防物联网主要存在于内网（Intranet）和专网（Extranet）中，展开更多
In 1929,Weyl H.proposed that the massless solution of the Dirac equation represents a pair of a new type of particles,the so-called Weyl fermions[1].However,their existence as a fundamental particle remains evasive af...In 1929,Weyl H.proposed that the massless solution of the Dirac equation represents a pair of a new type of particles,the so-called Weyl fermions[1].However,their existence as a fundamental particle remains evasive after more than eight decades.Neutrinos were once considered to be Weyl fermions until its mass was found.Recently,it was proposed that Weyl fermions can be hosted in a class of exotic condensed matter,so called Weyl semimetal(WSM),展开更多
Thoracic aortic aneurysm(TAA)significantly endangers the lives of individuals with Marfan syndrome(MFS),yet the intricacies of their biomechanical origins remain elusive.Our investigation delves into the pivotal role ...Thoracic aortic aneurysm(TAA)significantly endangers the lives of individuals with Marfan syndrome(MFS),yet the intricacies of their biomechanical origins remain elusive.Our investigation delves into the pivotal role of hemodynamic disturbance in the pathogenesis of TAA,with a particular emphasis on the mechanistic contributions of the mammalian target of rapamycin(mTOR)signaling cascade.We uncovered that activation of the mTOR complex 1(mTORC1)within smooth muscle cells,instigated by the oscillatory wall shear stress(OSS)that stems from disturbed flow(DF),is a catalyst for TAA progression.This revelation was corroborated through both an MFS mouse model(Fbn1+/C1039G)and clinical MFS specimens.Crucially,our research demonstrates a direct linkage between the activation of the mTORC1 pathway and the intensity in OSS.Therapeutic administration of rapamycin suppresses mTORC1 activity,leading to the attenuation of aberrant SMC behavior,reduced inflammatory infiltration,and restoration of extracellular matrix integrity—collectively decelerating TAA advancement in our mouse model.These insights posit the mTORC1 axis as a strategic target for intervention,offering a novel approach to manage TAAs in MFS and potentially pave insights for current treatment paradigms.展开更多
文摘以前谈到过物联网（Internet of Things）和物连网（Networks of Things）的区别，目前的许多物联网应用其实大部分都是以“物连网”的形态存在，这是由“物”的“所有权”性质决定的。例如公安系统的消防和安防物联网主要存在于内网（Intranet）和专网（Extranet）中，
文摘In 1929,Weyl H.proposed that the massless solution of the Dirac equation represents a pair of a new type of particles,the so-called Weyl fermions[1].However,their existence as a fundamental particle remains evasive after more than eight decades.Neutrinos were once considered to be Weyl fermions until its mass was found.Recently,it was proposed that Weyl fermions can be hosted in a class of exotic condensed matter,so called Weyl semimetal(WSM),
基金supported by the National Natural Science Foundation of China(Grant Nos.:82000429 and 81470574)Young Elite Scientists Sponsorship Program by CAST,China(Program No.:YESS20230395/2023QNRC001)+4 种基金Beijing Nova Program,China(Program No.:20230484308)Youth Elite Program of Beijing Friendship Hospital,China(Program No.:YYQCJH2022-9)Young Elite Scientists Sponsorship Program by BAST,China(Program No.:BYESS2024045)Capital's Funds for Health Improvement and Research,China(Grant No.:CFH2022-4-20217)Chinese Institutes for Medical Research,Beijing(CIMR)Organized Research Project,China(Project No.:CX23YQ07)。
文摘Thoracic aortic aneurysm(TAA)significantly endangers the lives of individuals with Marfan syndrome(MFS),yet the intricacies of their biomechanical origins remain elusive.Our investigation delves into the pivotal role of hemodynamic disturbance in the pathogenesis of TAA,with a particular emphasis on the mechanistic contributions of the mammalian target of rapamycin(mTOR)signaling cascade.We uncovered that activation of the mTOR complex 1(mTORC1)within smooth muscle cells,instigated by the oscillatory wall shear stress(OSS)that stems from disturbed flow(DF),is a catalyst for TAA progression.This revelation was corroborated through both an MFS mouse model(Fbn1+/C1039G)and clinical MFS specimens.Crucially,our research demonstrates a direct linkage between the activation of the mTORC1 pathway and the intensity in OSS.Therapeutic administration of rapamycin suppresses mTORC1 activity,leading to the attenuation of aberrant SMC behavior,reduced inflammatory infiltration,and restoration of extracellular matrix integrity—collectively decelerating TAA advancement in our mouse model.These insights posit the mTORC1 axis as a strategic target for intervention,offering a novel approach to manage TAAs in MFS and potentially pave insights for current treatment paradigms.
