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多肽T9sP对胶质瘤细胞抗肿瘤活性的研究 被引量:1
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作者 王榕 李博文 +2 位作者 邵耐远 彭亚 支枫 《临床神经外科杂志》 2022年第4期396-401,共6页
目的研究来源于E3泛素连接酶TRIM9分子短亚型TRIM9s蛋白的多肽片段T9sP对胶质瘤细胞U87的增殖、迁移和凋亡的影响。方法采用CCK-8法检测T9sP对U87细胞增殖的影响;划痕实验检测多肽对U87细胞迁移的影响;Trans-well实验检测多肽对U87细胞... 目的研究来源于E3泛素连接酶TRIM9分子短亚型TRIM9s蛋白的多肽片段T9sP对胶质瘤细胞U87的增殖、迁移和凋亡的影响。方法采用CCK-8法检测T9sP对U87细胞增殖的影响;划痕实验检测多肽对U87细胞迁移的影响;Trans-well实验检测多肽对U87细胞侵袭的影响;Annexin V-FITC/PI双染后使用流式细胞仪检测多肽对U87细胞凋亡的影响。Western Blot法检测多肽对关键信号通路蛋白表达的影响。结果穿膜肽TAT可以促进多肽T9sP进入肿瘤细胞。与对照组相比,多肽T9sP可以显著抑制U87细胞的增殖、迁移和侵袭,促进U87细胞凋亡,T9sP可以显著激活p38信号通路。结论多肽T9sP具有发展为新型抗肿瘤多肽的潜力。 展开更多
关键词 t9sp 胶质瘤 迁移 凋亡 P38
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GaAs pHEMT multi-band/multi-mode SP9T switch for quad-band GSM and UMTS handsets applications 被引量:1
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作者 Xiao-ying WANG Wen-ting GUO Yang-yang PENG Wen-quan SUI 《Journal of Zhejiang University-Science C(Computers and Electronics)》 SCIE EI 2011年第4期317-322,共6页
A multi-band/multi-mode single-pole nine-throw (SP9T) switch for GSM/UMTS (global system for mobile communications/universal mobile telecommunication system) systems is demonstrated.The switch consists of a GaAs 0.5μ... A multi-band/multi-mode single-pole nine-throw (SP9T) switch for GSM/UMTS (global system for mobile communications/universal mobile telecommunication system) systems is demonstrated.The switch consists of a GaAs 0.5μm pseudomorphic high-electron mobility transistor (pHEMT) radio frequency (RF) switches module and Si complementary metal-oxide-semiconductor (COMS) digital module with an encoder and a DC boost circuit.High isolation and high linearity are achieved by a series-shunt switch structure and the DC boost circuit,respectively.The switch shows a measured insertion loss of 0.4 dB at 0.8 GHz for GSM transmit arms,0.7 dB at 0.9 GHz and 0.9 dB at 1.8 GHz for GSM receive arms,and 0.6 dB at 1.8 GHz for UMTS arms.The switch introduces 2nd and 3rd harmonic suppression levels less than 64 dBc at 37 dBm input power.Isolations between transmit and receive terminals are more than 48 dB when one transmit arm is activated.The size of the RF switches module is 1.5 mm×1.1 mm,and the size of the digital module is 1.3 mm×0.63 mm with gold bonding wires connecting these two modules. 展开更多
关键词 GSM UMTS Single-pole nine-throw (SP9T) PHEMT Encoder DC boost
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