The simultaneous achievement of wide band gap and strong nonlinear optical(NLO)effect poses a challenging task in the development of infrared(IR)NLO materials.The coupling strategy of polyhedral building blocks has be...The simultaneous achievement of wide band gap and strong nonlinear optical(NLO)effect poses a challenging task in the development of infrared(IR)NLO materials.The coupling strategy of polyhedral building blocks has been demonstrated to be one of the effective approaches for constructing superior optical materials with well-balanced performance.Here,a new family of IR NLO materials A^(I)_(2)Mg_(3)Ga_(12)S_(22)(AI=K,Rb)that first contain[MgS_(6)]octahedra and T2-type supertetrahedra was designed and synthesized.K_(2)Mg_(3)Ga_(12)S_(22) exhibits a wide band gap of 3.34 eV,and a moderate second-harmonic generation response intensity of 0.4 times that of AgGaS2 under 2µm Q-switched laser radiation.Furthermore,the birefringence of K_(2)Mg_(3)Ga_(12)S_(22) is calculated to be 0.028@1064 nm,resulting in favorable phase-matching behavior in IR region.These characteristics suggest that K_(2)Mg_(3)Ga_(12)S_(22) could be a promising material for nonlinear frequency conversion applications and it provides new ideas into the design of novel compounds with outstanding IR NLO performances.展开更多
目的:探讨T2-mapping成像技术定量评价2型糖尿病(T2DM)患者心功能的临床价值。方法:按纳入标准前瞻性搜集92例T2MD患者为T2DM组,根据纽约心脏病协会(NYHA)心功能分级将T2DM组分为NYHAⅠ级组26例,NYHAⅡ级组28例,NYHAⅢ级组25例,NYHAⅣ级...目的:探讨T2-mapping成像技术定量评价2型糖尿病(T2DM)患者心功能的临床价值。方法:按纳入标准前瞻性搜集92例T2MD患者为T2DM组,根据纽约心脏病协会(NYHA)心功能分级将T2DM组分为NYHAⅠ级组26例,NYHAⅡ级组28例,NYHAⅢ级组25例,NYHAⅣ级组13例,选取年龄、性别、BMI匹配的健康成人30例为对照组,所有受检者均行心脏T2-mapping成像,T2DM组同期行钆对比剂延迟增强扫描(LGE),分别测量17段心肌的T2值。对比T2DM组与对照组左心室心肌T2值的差异;分析T2DM组左心室非强化心肌T2值与心功能(NYHA分级)、血清甘油三酯(TG)、空腹血糖(FPG)、糖化血红蛋白(HbA1c)及糖尿病病程的相关性。结果:T2DM组各组及对照组左心室各节段非强化心肌的平均T2值之间差异具有统计学意义(对照组<NYHAⅠ级组<NYHAⅡ级组<NYHAⅢ级组<NYHAⅣ级组,P均<0.01)。左心室延迟强化心肌的平均T2值与对照组无统计学差异(57.80±3.82 ms vs.56.67±3.06ms,t=-1.671,P=0.095)。T2DM组左心室各节段非强化心肌的平均T2值与心功能(NYHA分级)呈正相关(P均<0.01),与TG含量呈弱相关(除3段T2值外,P均<0.05),与FPG、HbA1c的含量及糖尿病病程无相关性(P均>0.05),但FPG、HbA1c平均值均高于正常值。结论:T2-mapping可以定量评价心功能(NYHA分级),T2值越高,T2DM合并心功能不全的可能性越大。同时,T2-mapping可以间接评估T2DM心肌损伤的程度,早期预测糖尿病心肌损害,为临床定量评价T2DM心功能提供了新的影像学方法。展开更多
基金supported by the Natural Science Foundation of the Xinjiang Uygur Autonomous Region(2023D01A04 and 2022D01B206)the Shanghai Cooperation Organization Science and Technology Partnership Program(2023E01001)+1 种基金the National Natural Science Foundation of China(22335007,22361132544,62305382,and 52302011)the support from Tianchi Doctor Plan of Xinjiang Uygur Autonomous Region。
文摘The simultaneous achievement of wide band gap and strong nonlinear optical(NLO)effect poses a challenging task in the development of infrared(IR)NLO materials.The coupling strategy of polyhedral building blocks has been demonstrated to be one of the effective approaches for constructing superior optical materials with well-balanced performance.Here,a new family of IR NLO materials A^(I)_(2)Mg_(3)Ga_(12)S_(22)(AI=K,Rb)that first contain[MgS_(6)]octahedra and T2-type supertetrahedra was designed and synthesized.K_(2)Mg_(3)Ga_(12)S_(22) exhibits a wide band gap of 3.34 eV,and a moderate second-harmonic generation response intensity of 0.4 times that of AgGaS2 under 2µm Q-switched laser radiation.Furthermore,the birefringence of K_(2)Mg_(3)Ga_(12)S_(22) is calculated to be 0.028@1064 nm,resulting in favorable phase-matching behavior in IR region.These characteristics suggest that K_(2)Mg_(3)Ga_(12)S_(22) could be a promising material for nonlinear frequency conversion applications and it provides new ideas into the design of novel compounds with outstanding IR NLO performances.
文摘目的:探讨T2-mapping成像技术定量评价2型糖尿病(T2DM)患者心功能的临床价值。方法:按纳入标准前瞻性搜集92例T2MD患者为T2DM组,根据纽约心脏病协会(NYHA)心功能分级将T2DM组分为NYHAⅠ级组26例,NYHAⅡ级组28例,NYHAⅢ级组25例,NYHAⅣ级组13例,选取年龄、性别、BMI匹配的健康成人30例为对照组,所有受检者均行心脏T2-mapping成像,T2DM组同期行钆对比剂延迟增强扫描(LGE),分别测量17段心肌的T2值。对比T2DM组与对照组左心室心肌T2值的差异;分析T2DM组左心室非强化心肌T2值与心功能(NYHA分级)、血清甘油三酯(TG)、空腹血糖(FPG)、糖化血红蛋白(HbA1c)及糖尿病病程的相关性。结果:T2DM组各组及对照组左心室各节段非强化心肌的平均T2值之间差异具有统计学意义(对照组<NYHAⅠ级组<NYHAⅡ级组<NYHAⅢ级组<NYHAⅣ级组,P均<0.01)。左心室延迟强化心肌的平均T2值与对照组无统计学差异(57.80±3.82 ms vs.56.67±3.06ms,t=-1.671,P=0.095)。T2DM组左心室各节段非强化心肌的平均T2值与心功能(NYHA分级)呈正相关(P均<0.01),与TG含量呈弱相关(除3段T2值外,P均<0.05),与FPG、HbA1c的含量及糖尿病病程无相关性(P均>0.05),但FPG、HbA1c平均值均高于正常值。结论:T2-mapping可以定量评价心功能(NYHA分级),T2值越高,T2DM合并心功能不全的可能性越大。同时,T2-mapping可以间接评估T2DM心肌损伤的程度,早期预测糖尿病心肌损害,为临床定量评价T2DM心功能提供了新的影像学方法。
