This study describes an automatic berthing system with mooring lines. It is designed to be berthed by using mooring device on the upper deck of a ship. It is to berth once maintaining parallel with the quay by control...This study describes an automatic berthing system with mooring lines. It is designed to be berthed by using mooring device on the upper deck of a ship. It is to berth once maintaining parallel with the quay by controlling both forward and aft breast lines. Berthing method is used through length adjustment of mooring lines connected between ship and quay by controlling the angular velocity and the torque of hydraulic motor in mooring device. The study is conducted under three changing conditions of draft, such as even-keel, rise of the gravity center and trim to stern. Variables affecting berthing stability are determined based on the control performance of each condition. Bond graphs method is used to model the system. Controller is designed as PID control method of reference-model algorithm. The control program is composed of synchronous control system based on the equations derived with the numerical analysis. The tank test is conducted to verify the usefulness of the control program.展开更多
This paper analyzes fender selection process in berth design and focuses on the case of a rigid berth with rubber cone fenders.Fender types and performance comparison methods are studied along with current numerical m...This paper analyzes fender selection process in berth design and focuses on the case of a rigid berth with rubber cone fenders.Fender types and performance comparison methods are studied along with current numerical models.Berth design methods are analyzed with a focus on berthing energy calculation and fender selection.A new approach to determine the required fender capacity is suggested.A finite elements rubber cone model is tested and used in simulations of angular side berthing.Results show that the energy absorbed by the fender can be much higher than what can be calculated with the current berth design method.A new form for the expression of the energy that must be absorbed by the fender during angular berthing impact is suggested.展开更多
Contact reactions of guide surfaces of assembly interfaces lead to the decreasing of theirs lateral and angular misalignments. The focus of this paper is the development of algorithms for computation of guide surfaces...Contact reactions of guide surfaces of assembly interfaces lead to the decreasing of theirs lateral and angular misalignments. The focus of this paper is the development of algorithms for computation of guide surfaces contact forces with acceptable engineering accuracy for real time simulation of assembly operations. Therefore, each complex guide surface is described as a set of contacting elements. Each contacting element for one＇s part can be represented by a finite set of geometric primitives which geometry is described by low order algebraic equations. So contact conditions and geometric parameters for all pairs of primitives are determined by analytical expressions. Math models are developed for two classes of contact interaction. The first class includes all cases when each contacting surface has several degrees of freedom of motion. Therefore, contact reactions introduced into differential equations of motion are calculated by using contacting elements penetrations, stiffness and damping parameters. The second class corresponds to all cases when one of contacting surfaces has insignificant inertia and only one degree of freedom of relative displacement counteracted by a spring. Here contact reactions are calculated from spring tension with any practical accuracy. This is very useful in some practical applications. Presented algorithms provide real time simulation together with some approaches for reduction of redundant comnutations.展开更多
In order to solve the technical problems of autonomous berthing of the Unmanned Surface Vehicle(USV),this research has met the requirements of maneuverability berthing under different conditions by effectively using t...In order to solve the technical problems of autonomous berthing of the Unmanned Surface Vehicle(USV),this research has met the requirements of maneuverability berthing under different conditions by effectively using the bow and stern thrusters,which is a technological breakthrough in actual production and life.Based on the MMG model,the maneuverability mathematical model of the USV with bow and stern thruster was established.And the motion simulation of USV maneuvering was carried out through the numerical simulation calculation.Then the berthing plan was designed based on the maneuverability analysis of the USV low-speed motion,and the simulation of automatic berthing for USV was carried out.The research results of this paper can be of certain practical significance for the USV based on the support of the bow and stern thruster in the berthing.At the same time,it also provides a certain theoretical reference for the handling of the USV automatic berthing.展开更多
When an oil tanker under the combined action of wind, waves and tidal current and is berthed or moored to a platform, the impact forces on the fenders and the tensile force in the mooring lines are important factors i...When an oil tanker under the combined action of wind, waves and tidal current and is berthed or moored to a platform, the impact forces on the fenders and the tensile force in the mooring lines are important factors in the studies of berthing and mooring conditions. Based on the experiment of a berthing and mooring tanker model under the action of wind, wave and tidal current in the same direction, this paper studies the allowable berthing and mooring conditions by considering the tensile forces of mooring lines and impact forces on the fenders, as well as the impact energy on the fenders. And a method has been proposed here for motion amplitude analysis. A successful method to decrease impact forces on the fenders is put forward. Blowing in wind and blowing off wind and different angles between waves and the fenders are considered in the experimental study. In the berthing tests of the tanker model, the impact forces are measured and the impact energy is calculated, then the berthing conditions are determined. In the mooring tests of the tanker model, the mooring line tensile forces and impact forces are measured, and the allowable mooring conditions are given that will be useful to engineering design.展开更多
The impedance characteristics of distributed amplifiers are analyzed based on T-type matching networks, and a distributed power amplifier consisting of three gain cells is proposed. Non-uniform T-type matching network...The impedance characteristics of distributed amplifiers are analyzed based on T-type matching networks, and a distributed power amplifier consisting of three gain cells is proposed. Non-uniform T-type matching networks are adopted to make the impedance of artificial transmission lines connected to the gate and drain change stage by stage gradually, which provides good impedance matching and improves the output power and efficiency. The measurement results show that the amplifier gives an average forward gain of 6 dB from 3 to 16. 5 GHz. In the desired band, the input return loss is typically less than - 9. 5 dB, and the output return loss is better than -8.5 dB. The output power at 1-dB gain compression point is from 3.6 to 10. 6 dBm in the band of 2 to 16 GHz while the power added efficiency （PAE） is from 2% to 12. 5% . The power consumption of the amplifier is 81 mW with a supply of 1.8 V, and the chip area is 0.91 mm × 0.45 mm.展开更多
In this paper,the berth scheduling problem is transformed into a special two-dimensional packing problem with some constraints.A nonlinear programming model for the problem is established,and a heuristic algorithm is ...In this paper,the berth scheduling problem is transformed into a special two-dimensional packing problem with some constraints.A nonlinear programming model for the problem is established,and a heuristic algorithm is proposed to solve the model.Simulation results show that the algorithm can improve the utilization of berths on discrete berth scheduling in the container port.展开更多
Regulation of intracellular calcium is an important signaling mechanism for cell proliferation in both normal and cancerous cells. In normal epithelial cells, free calcium concentration is essential for cells to enter...Regulation of intracellular calcium is an important signaling mechanism for cell proliferation in both normal and cancerous cells. In normal epithelial cells, free calcium concentration is essential for cells to enter and accomplish the S phase and the M phase of the cell cycle. In contrast, cancerous cells can pass these phases of the cell cycle with much lower cytoplasmic free calcium concentrations, indicating an alternative mechanism has developed for fulfilling the intracellular calcium requirement for an increased rate of DNA synthesis and mitosis of fast replicating cancerous cells. The detailed mechanism underlying the altered calcium loading pathway remains unclear; however, there is a growing body of evidence that suggests the T-type Ca2+ channel is abnormally expressed in cancerous cells and that blockade of these channels may reduce cell proliferation in addition to inducing apoptosis. Recent studies also show that the expression of T-type Ca2+ channels in breast cancer cells is proliferation state dependent, i.e. the channels are expressed at higher levels during the fast-replication period, and once the cells are in a non-proliferation state, expression of this channel isminimal. Therefore, selectively blocking calcium entry into cancerous cells may be a valuable approach for preventing tumor growth. Since T-type Ca2+ channels are not expressed in epithelial cells, selective T-type Ca2+ channel blockers may be useful in the treatment of certain types of cancers.展开更多
To study a more micro-invasive procedure for patients having pancreatic duct stones(PDS).Till now,there has been no report of laparoscopic pancreatic duct incision and stone removal and T-type tube drainage for PDS in...To study a more micro-invasive procedure for patients having pancreatic duct stones(PDS).Till now,there has been no report of laparoscopic pancreatic duct incision and stone removal and T-type tube drainage for PDS in the English literature.An 82-year-old man suffered from subxiphoid pain associated with a dilated pancreatic duct(7 mm)containing one stone,but without a mass in the head of the pancreas.Laparoscopic pancreatic duct incision,stone removal,and T-type tube drainage were successfully performed without intraoperative or postoperative complications.An uneventful operation was performed with laparoscopically completed procedures in 160 min.The intraoperative loss of blood was around 50 mL.After patient a discharge on day 11,complete relief from the subxiphoid pain was reported at a follow-up visit 15 mo later.Laparoscopic pancreatic duct incision with stone removal and T-type tube drainage is applicable in carefully selected patients and can be effectively and safely used for the treatment of the abdominal pain of chronic pancreatitis.展开更多
Complex tibial plateau fractures can seriously affect quality of life and physical and mental health of patients.The anatomical relationship between the proximal tibial bone and soft tissue is complex,resulting in dif...Complex tibial plateau fractures can seriously affect quality of life and physical and mental health of patients.The anatomical relationship between the proximal tibial bone and soft tissue is complex,resulting in different types of tibial plateau fractures.Violent trauma can lead to displaced fracture,serious soft tissue injury,and potentially,dislocation of the knee joint.Therefore,tibial plateau fractures are extremely unstable.AIM To assess the use of locking compression plate(LCP)+T-type steel plate for postoperative weight bearing and functional recovery of complex tibial plateau fractures.METHODS Ninety-seven patients with complex tibial plateau fractures who underwent surgery at our hospital were selected for retrospective study.Forty-nine patients had been treated with LCP+T-type steel plate limited internal fixation(study group),and 48 patients with bilateral ordinary steel plate support(control group).The operation process index,postoperative rehabilitation related index,Rasmussen score of the knee joint,tibial plateau varus angle(TPA),tibial plateau retroversion angle(PA),and surgical complications of the two groups were compared.RESULTS The operation time and intraoperative bone graft volume in the study group were lower than those in the control group(P<0.05).There were no significant differences in surgical bleeding,anterior external incision length,postoperative drainage,hospital stay duration,and fracture healing time between the groups(P>0.05).There was no significant difference in the TPA and PA angle between the groups immediately and 18 mo after surgery(P>0.05).At 12 mo after surgery,the Rasmussen scale score was higher in the study group than in the control group(P<0.05).There was no significant difference in the Rasmussen scale score at 18 mo after surgery,and the radiology score at 12 and 18 mo after surgery,between the two groups(P>0.05).The postoperative complication rate in the study group(3.77%)was lower than that in the control group(15.09%;P<0.05).CONCLUSION LCP+T-type steel plate internal fixation has advantages in terms of minimizing trauma and enabling early postoperative functional exercise,promoting functional recovery and lower limb weight-bearing,and reducing postoperative complications.展开更多
Rational determination and reduction of local energy loss of oil flow at pipe junctions are of important significance to improve hydraulic pipeline＇s work efficiency, especially for complex hydraulic pipeline connect...Rational determination and reduction of local energy loss of oil flow at pipe junctions are of important significance to improve hydraulic pipeline＇s work efficiency, especially for complex hydraulic pipeline connected by isodiametric T-type ducts with sharp comers to get combined and divided flow. From this point of view, the formulae of resistance loss for combined flow and divided flow through isodiametric T-type duct with sharp comers as well as the correlations of resistance loss coefficients in the branches of the duct are derived using energy method. On this basis, resistance characteristics of hydraulic oil in the duct are obtained by numerical simulation of different flow modes, which are commonly applied in hydraulic pipelines, using computational fluid dynamics （CFD） method, and the reasons for the resistance loss are analyzed based on the pressure change mechanism in the flow field. A part of simulation results was validated with the reference data. The research shows that for combined flows the resistance loss of symmetrical is lower than that of unsymmetrical to obtain low speed in common branch, but to gain high speed is quite the contrary, for divided flows, the symmetrical is always a reasonable choice to reduce resistance loss. These conclusions can be applied to optimize the design of hydraulic pipeline.展开更多
Objective Formaldehyde at high concentrations is a contributor to air pollution. It is also an endogenous metabolic product in cells, and when beyond physiological concentrations, has pathological effects on neurons. ...Objective Formaldehyde at high concentrations is a contributor to air pollution. It is also an endogenous metabolic product in cells, and when beyond physiological concentrations, has pathological effects on neurons. Formaldehyde induces mis-folding and aggregation of neuronal tau protein, hippocampal neuronal apoptosis, cognitive impairment and loss of memory functions, as well as excitation of peripheral nociceptive neurons in cancer pain models. Intracellular calcium （[Ca2＋]i） is an important intracellular messenger, and plays a key role in many pathological processes. The present study aimed to investigate the effect of formaldehyde on [Ca2＋]i and the possible involvement of N-methyl-D-aspartate receptors （NMDARs） and T-type Ca2＋ channels on the cell membrane. Methods Using primary cultured hippocampal neurons as a model, changes of [Ca2＋]i in the presence of formaldehyde at a low concentration were detected by confocal laser scanning microscopy. Results Formaldehyde at 1 mmol/L approximately doubled [Ca2＋]i. （2R）-amino-5-phosphonopentanoate （AP5, 25 μmol/L, an NMDAR antagonist） and mibefradil （MIB, 1 μmol/L, a T-type Ca2＋ channel blocker）, given 5 min after formaldehyde perfusion, each partly inhibited the formaldehyde-induced increase of [Ca：＋]i, and this inhibitory effect was reinforced by combined application of AP5 and MIB. When applied 3 min before formaldehyde perfusion, AP5 （even at 50μmol/L） did not inhibit the formaldehyde-induced increase of [Ca2＋]i, but MIB （1 μmol/L） significantly inhibited this increase by 70%. Conclusion These results suggest that formaldehyde at a low concentration increases [Ca2＋]i in cultured hippocampal neurons; NMDARs and T-type Ca2＋ channels may be involved in this process.展开更多
Tide is a significant factor which interferes with the berthing and departing operations of vessels in tidal ports. It is a preferable way to incorporate this factor into the simultaneous berth allocation and quay cra...Tide is a significant factor which interferes with the berthing and departing operations of vessels in tidal ports. It is a preferable way to incorporate this factor into the simultaneous berth allocation and quay crane( QC) assignment problem( BACAP) in order to facilitate the realistic decision-making process at container terminal. For this purpose,an integrated optimization model is built with tidal time windows as forbidden intervals for berthing or departing. A hind-and-fore adjustment heuristic is proposed and applied under an iterative optimization framework. Numerical experiment shows the satisfying performance of the proposed algorithm.展开更多
This work presents the design of hollow fiber T-type zeolite membrane modules with different geometric configurations. The module performances were evaluated by pervaporation dehydration of ethanol/water mixtures. Str...This work presents the design of hollow fiber T-type zeolite membrane modules with different geometric configurations. The module performances were evaluated by pervaporation dehydration of ethanol/water mixtures. Strong concentration polarization was found for the modules with big membrane bundles. The concentration polarization was enhanced at high temperature due to the higher water permeation flux. The increase of feed flow could improve water permeation flux for the membrane modules with small membrane bundle.Computational fluid dynamics was used to visualize the flow field distribution inside of the modules with different configurations. The membrane module with seven bundles exhibited highest separation efficiency due to the uniform distribution of flow rate. The packing density could be 10 times higher than that of the tubular membrane module. The hollow fiber membrane module exhibited good stability for ethanol dehydration.展开更多
In the current study,we sought to investigate whether T-type Ca^(2+)channels(TCCs)in the brain are involved in generating post-anesthetic hyperexcitatory behaviors(PAHBs).We found that younger rat pups(postnatal days ...In the current study,we sought to investigate whether T-type Ca^(2+)channels(TCCs)in the brain are involved in generating post-anesthetic hyperexcitatory behaviors(PAHBs).We found that younger rat pups(postnatal days 9-11)had a higher incidence of PAHBs and higher PAHB scores than older pups(postnatal days16-18)during emergence from sevoflurane anesthesia.The power spectrum of the theta oscillations(4 Hz-8 Hz)in the prefrontal cortex was significantly enhanced in younger pups when PAHBs occurred,while there were no significant changes in older pups.Both the power of theta oscillations and the level of PAHBs were significantly reduced by the administration of TCC inhibitors.Moreover,the sensitivity of TCCs in the medial dorsal thalamic nucleus to sevoflurane was found to increase with age by investigating the kinetic properties of TCCs in vitro.TCCs were activated by potentiated GABAergic depolarization with a sub-anesthetic dose of sevoflurane(1%).These data suggest that(1)TCCs in the brain contribute to the generation of PAHBs and the concomitant electroencephalographic changes;(2)the stronger inhibitory effect of sevoflurane contributes to the lack of PAHBs in older rats;and(3)the contribution of TCCs to PAHBs is not mediated by a direct effect of sevoflurane on TCCs.展开更多
Intracellular cAMP and Ca^2＋ are involved in the regulation of steroidogenic activity in Leydig cells, which coordinate responses to luteinizing hormone （LH） and human ehorionic gonadotropin （hCG）. However, the i...Intracellular cAMP and Ca^2＋ are involved in the regulation of steroidogenic activity in Leydig cells, which coordinate responses to luteinizing hormone （LH） and human ehorionic gonadotropin （hCG）. However, the identification of Ca^2＋ entry implicated in Leydig cell steroidogenesis is not well defined. The objective of this study was to identify the type of Ca^2＋ channel that affects Leydig cell steroidogenesis. In vitro steroidogenesis in the freshly dissociated Leydig cells of mice was induced by hCG incubation. The effects of mibefradil （a putative T-type Ca^2＋ channel blocker） on steroidogenesis were assessed using reverse transcription （RT）-polymerase chain reaction analysis for the steroidogenic acute regulatory protein （STAR） mRNA expression and testosterone production using radioimmunoassay. In the presence of 1.0 mmol L-1 extracellular Ca^2＋, hCG at 1 to 100 IU noticeably elevated both StAR mRNA level and testosterone secretion （P 〈 0.05）, and the stimulatory effects of hCG were markedly diminished by mibefradil in a dose-dependent manner （P 〈 0.05）. Moreover; the hCG-induced increase in testosterone production was completely removed when external Ca^2＋ was omitted, implying that Ca entry is needed for hCG-induced steroidogenesis. Furthermore, a patch-clamp study revealed the presence of mibefradil-sensitive Ca^24- currents seen at a concentration range that nearly paralleled those inhibiting steroidogenesis. Collectively, Our data provide evidence that hCG-stimulated steroidogenesis is mediated at least in part by Ca^2＋ entry carried out by the T-type Ca^2＋ channel in the Leydig cells of mice.展开更多
A proposed inductive-phase-compensation ultra wideband CMOS digital T-type attenuator design based on an analysis of minimising phase errors is presented in this letter.In a standard CMOS technology,the proposed atten...A proposed inductive-phase-compensation ultra wideband CMOS digital T-type attenuator design based on an analysis of minimising phase errors is presented in this letter.In a standard CMOS technology,the proposed attenuator is analytically demonstrated to have low phase errors due to the inductive-phase-compensation network.A design equation is inferred and a wide-band 4dB attenuation bit digital attenuator with low phase errors is designed as a test vehicle for the proposed approach.展开更多
To take advantage of merits of higher output-power and efficiency of bolt-clamped transducer,a T-type linear ultrasonic motor was proposed in this paper.The proposed motor contained a horizontal transducer and a verti...To take advantage of merits of higher output-power and efficiency of bolt-clamped transducer,a T-type linear ultrasonic motor was proposed in this paper.The proposed motor contained a horizontal transducer and a vertical transducer.The horizontal transducer included two exponential shape horns,and the vertical transducer contained one exponential shape horn.And the horns intersected at tip ends where a driving foot was located.The longitudinal vibrations of transducers were excited by the stretching vibration of PZT ceramics.Longitudinal vibrations were superimposed in the motor and generated elliptical trajectory at the driving foot.The actuating mechanism of the proposed motor was analyzed.The two working modals of the motor were gained with FEM.The resonant frequencies of two working modals were degenerated by adjusting the structural parameters.The motion trajectory of nodes on the driving foot was gained by transient analysis.The vibration amplitude of node on the driving foot indicates that the proposed motor has potential good output characteristics.The results verify the feasibility of the proposed design and provide instructions for the development of the new ultrasonic motor.展开更多
Nesting is a common problem in industries such as shipbuilding, auto-maker, clothing, shoe-making, and furniture, in which various parts are cut off from a stock or stocks while minimizing the wastes or maximizing the...Nesting is a common problem in industries such as shipbuilding, auto-maker, clothing, shoe-making, and furniture, in which various parts are cut off from a stock or stocks while minimizing the wastes or maximizing the utilization of the stock. Berth allocation at seaside is also considered one form of two dimensional nesting problems, in which a ship is assigned a location for service during a certain time slot. This paper presents an expert system using a heuristic search method for nesting problems. The parts and stocks are represented by pixels with which utility function is used to evaluate current state in search tree. The system is developed in CLIPS, an expert system shell and applied to various example problems with different constraints and to a berth allocation example to illustrate its applicability under different conditions.展开更多
基金financially supported by the Post Innovation Program of the Fisheries Science Institute of Chonnam National University
文摘This study describes an automatic berthing system with mooring lines. It is designed to be berthed by using mooring device on the upper deck of a ship. It is to berth once maintaining parallel with the quay by controlling both forward and aft breast lines. Berthing method is used through length adjustment of mooring lines connected between ship and quay by controlling the angular velocity and the torque of hydraulic motor in mooring device. The study is conducted under three changing conditions of draft, such as even-keel, rise of the gravity center and trim to stern. Variables affecting berthing stability are determined based on the control performance of each condition. Bond graphs method is used to model the system. Controller is designed as PID control method of reference-model algorithm. The control program is composed of synchronous control system based on the equations derived with the numerical analysis. The tank test is conducted to verify the usefulness of the control program.
基金the National Natural Science Foundation of China(Nos.41172251 and 41330633)
文摘This paper analyzes fender selection process in berth design and focuses on the case of a rigid berth with rubber cone fenders.Fender types and performance comparison methods are studied along with current numerical models.Berth design methods are analyzed with a focus on berthing energy calculation and fender selection.A new approach to determine the required fender capacity is suggested.A finite elements rubber cone model is tested and used in simulations of angular side berthing.Results show that the energy absorbed by the fender can be much higher than what can be calculated with the current berth design method.A new form for the expression of the energy that must be absorbed by the fender during angular berthing impact is suggested.
文摘Contact reactions of guide surfaces of assembly interfaces lead to the decreasing of theirs lateral and angular misalignments. The focus of this paper is the development of algorithms for computation of guide surfaces contact forces with acceptable engineering accuracy for real time simulation of assembly operations. Therefore, each complex guide surface is described as a set of contacting elements. Each contacting element for one＇s part can be represented by a finite set of geometric primitives which geometry is described by low order algebraic equations. So contact conditions and geometric parameters for all pairs of primitives are determined by analytical expressions. Math models are developed for two classes of contact interaction. The first class includes all cases when each contacting surface has several degrees of freedom of motion. Therefore, contact reactions introduced into differential equations of motion are calculated by using contacting elements penetrations, stiffness and damping parameters. The second class corresponds to all cases when one of contacting surfaces has insignificant inertia and only one degree of freedom of relative displacement counteracted by a spring. Here contact reactions are calculated from spring tension with any practical accuracy. This is very useful in some practical applications. Presented algorithms provide real time simulation together with some approaches for reduction of redundant comnutations.
基金This research was funded by National Natural Science Foundation of China(No.51309148).
文摘In order to solve the technical problems of autonomous berthing of the Unmanned Surface Vehicle(USV),this research has met the requirements of maneuverability berthing under different conditions by effectively using the bow and stern thrusters,which is a technological breakthrough in actual production and life.Based on the MMG model,the maneuverability mathematical model of the USV with bow and stern thruster was established.And the motion simulation of USV maneuvering was carried out through the numerical simulation calculation.Then the berthing plan was designed based on the maneuverability analysis of the USV low-speed motion,and the simulation of automatic berthing for USV was carried out.The research results of this paper can be of certain practical significance for the USV based on the support of the bow and stern thruster in the berthing.At the same time,it also provides a certain theoretical reference for the handling of the USV automatic berthing.
文摘When an oil tanker under the combined action of wind, waves and tidal current and is berthed or moored to a platform, the impact forces on the fenders and the tensile force in the mooring lines are important factors in the studies of berthing and mooring conditions. Based on the experiment of a berthing and mooring tanker model under the action of wind, wave and tidal current in the same direction, this paper studies the allowable berthing and mooring conditions by considering the tensile forces of mooring lines and impact forces on the fenders, as well as the impact energy on the fenders. And a method has been proposed here for motion amplitude analysis. A successful method to decrease impact forces on the fenders is put forward. Blowing in wind and blowing off wind and different angles between waves and the fenders are considered in the experimental study. In the berthing tests of the tanker model, the impact forces are measured and the impact energy is calculated, then the berthing conditions are determined. In the mooring tests of the tanker model, the mooring line tensile forces and impact forces are measured, and the allowable mooring conditions are given that will be useful to engineering design.
基金the National Natural Science Foundation of China(No.51109186)Zhejiang Provincial Natural Science Foundation(Nos:LY16E090004,LY17E090002,LQ17E090003)+1 种基金the Doctoral Scientific Research Foundation of Zhejiang Ocean University Projectthe Open Foundation from Key Laboratory of Offshore Engineering Technology of Zhejiang
基金The National Natural Science Foundation of China(No.61106021)the Postdoctoral Science Foundation of China(No.2015M582541)+1 种基金the Natural Science Foundation of Higher Education Institutions of Jiangsu Province(No.15KJB510020)the Research Fund of Nanjing University of Posts and Telecommunications(No.NY215140,No.NY215167)
文摘The impedance characteristics of distributed amplifiers are analyzed based on T-type matching networks, and a distributed power amplifier consisting of three gain cells is proposed. Non-uniform T-type matching networks are adopted to make the impedance of artificial transmission lines connected to the gate and drain change stage by stage gradually, which provides good impedance matching and improves the output power and efficiency. The measurement results show that the amplifier gives an average forward gain of 6 dB from 3 to 16. 5 GHz. In the desired band, the input return loss is typically less than - 9. 5 dB, and the output return loss is better than -8.5 dB. The output power at 1-dB gain compression point is from 3.6 to 10. 6 dBm in the band of 2 to 16 GHz while the power added efficiency （PAE） is from 2% to 12. 5% . The power consumption of the amplifier is 81 mW with a supply of 1.8 V, and the chip area is 0.91 mm × 0.45 mm.
文摘In this paper,the berth scheduling problem is transformed into a special two-dimensional packing problem with some constraints.A nonlinear programming model for the problem is established,and a heuristic algorithm is proposed to solve the model.Simulation results show that the algorithm can improve the utilization of berths on discrete berth scheduling in the container port.
文摘Regulation of intracellular calcium is an important signaling mechanism for cell proliferation in both normal and cancerous cells. In normal epithelial cells, free calcium concentration is essential for cells to enter and accomplish the S phase and the M phase of the cell cycle. In contrast, cancerous cells can pass these phases of the cell cycle with much lower cytoplasmic free calcium concentrations, indicating an alternative mechanism has developed for fulfilling the intracellular calcium requirement for an increased rate of DNA synthesis and mitosis of fast replicating cancerous cells. The detailed mechanism underlying the altered calcium loading pathway remains unclear; however, there is a growing body of evidence that suggests the T-type Ca2+ channel is abnormally expressed in cancerous cells and that blockade of these channels may reduce cell proliferation in addition to inducing apoptosis. Recent studies also show that the expression of T-type Ca2+ channels in breast cancer cells is proliferation state dependent, i.e. the channels are expressed at higher levels during the fast-replication period, and once the cells are in a non-proliferation state, expression of this channel isminimal. Therefore, selectively blocking calcium entry into cancerous cells may be a valuable approach for preventing tumor growth. Since T-type Ca2+ channels are not expressed in epithelial cells, selective T-type Ca2+ channel blockers may be useful in the treatment of certain types of cancers.
基金Supported by Foundation of Department of Science and Technology of Jinhua,No.2015-3-0012015-3-012
文摘To study a more micro-invasive procedure for patients having pancreatic duct stones(PDS).Till now,there has been no report of laparoscopic pancreatic duct incision and stone removal and T-type tube drainage for PDS in the English literature.An 82-year-old man suffered from subxiphoid pain associated with a dilated pancreatic duct(7 mm)containing one stone,but without a mass in the head of the pancreas.Laparoscopic pancreatic duct incision,stone removal,and T-type tube drainage were successfully performed without intraoperative or postoperative complications.An uneventful operation was performed with laparoscopically completed procedures in 160 min.The intraoperative loss of blood was around 50 mL.After patient a discharge on day 11,complete relief from the subxiphoid pain was reported at a follow-up visit 15 mo later.Laparoscopic pancreatic duct incision with stone removal and T-type tube drainage is applicable in carefully selected patients and can be effectively and safely used for the treatment of the abdominal pain of chronic pancreatitis.
文摘Complex tibial plateau fractures can seriously affect quality of life and physical and mental health of patients.The anatomical relationship between the proximal tibial bone and soft tissue is complex,resulting in different types of tibial plateau fractures.Violent trauma can lead to displaced fracture,serious soft tissue injury,and potentially,dislocation of the knee joint.Therefore,tibial plateau fractures are extremely unstable.AIM To assess the use of locking compression plate(LCP)+T-type steel plate for postoperative weight bearing and functional recovery of complex tibial plateau fractures.METHODS Ninety-seven patients with complex tibial plateau fractures who underwent surgery at our hospital were selected for retrospective study.Forty-nine patients had been treated with LCP+T-type steel plate limited internal fixation(study group),and 48 patients with bilateral ordinary steel plate support(control group).The operation process index,postoperative rehabilitation related index,Rasmussen score of the knee joint,tibial plateau varus angle(TPA),tibial plateau retroversion angle(PA),and surgical complications of the two groups were compared.RESULTS The operation time and intraoperative bone graft volume in the study group were lower than those in the control group(P<0.05).There were no significant differences in surgical bleeding,anterior external incision length,postoperative drainage,hospital stay duration,and fracture healing time between the groups(P>0.05).There was no significant difference in the TPA and PA angle between the groups immediately and 18 mo after surgery(P>0.05).At 12 mo after surgery,the Rasmussen scale score was higher in the study group than in the control group(P<0.05).There was no significant difference in the Rasmussen scale score at 18 mo after surgery,and the radiology score at 12 and 18 mo after surgery,between the two groups(P>0.05).The postoperative complication rate in the study group(3.77%)was lower than that in the control group(15.09%;P<0.05).CONCLUSION LCP+T-type steel plate internal fixation has advantages in terms of minimizing trauma and enabling early postoperative functional exercise,promoting functional recovery and lower limb weight-bearing,and reducing postoperative complications.
基金supported by Hebei Provincial Natural Science Foundation of China (Grant No. 503292)
文摘Rational determination and reduction of local energy loss of oil flow at pipe junctions are of important significance to improve hydraulic pipeline＇s work efficiency, especially for complex hydraulic pipeline connected by isodiametric T-type ducts with sharp comers to get combined and divided flow. From this point of view, the formulae of resistance loss for combined flow and divided flow through isodiametric T-type duct with sharp comers as well as the correlations of resistance loss coefficients in the branches of the duct are derived using energy method. On this basis, resistance characteristics of hydraulic oil in the duct are obtained by numerical simulation of different flow modes, which are commonly applied in hydraulic pipelines, using computational fluid dynamics （CFD） method, and the reasons for the resistance loss are analyzed based on the pressure change mechanism in the flow field. A part of simulation results was validated with the reference data. The research shows that for combined flows the resistance loss of symmetrical is lower than that of unsymmetrical to obtain low speed in common branch, but to gain high speed is quite the contrary, for divided flows, the symmetrical is always a reasonable choice to reduce resistance loss. These conclusions can be applied to optimize the design of hydraulic pipeline.
基金supported by grants from the National Natural Science Foundation of China (81171042,81070893 and 81221002)the Beijing Outstanding Ph.D.Program Mentor Grantthe Specialized Research Fund for Doctoral Programs of Higher Education, China(20110001110058)
文摘Objective Formaldehyde at high concentrations is a contributor to air pollution. It is also an endogenous metabolic product in cells, and when beyond physiological concentrations, has pathological effects on neurons. Formaldehyde induces mis-folding and aggregation of neuronal tau protein, hippocampal neuronal apoptosis, cognitive impairment and loss of memory functions, as well as excitation of peripheral nociceptive neurons in cancer pain models. Intracellular calcium （[Ca2＋]i） is an important intracellular messenger, and plays a key role in many pathological processes. The present study aimed to investigate the effect of formaldehyde on [Ca2＋]i and the possible involvement of N-methyl-D-aspartate receptors （NMDARs） and T-type Ca2＋ channels on the cell membrane. Methods Using primary cultured hippocampal neurons as a model, changes of [Ca2＋]i in the presence of formaldehyde at a low concentration were detected by confocal laser scanning microscopy. Results Formaldehyde at 1 mmol/L approximately doubled [Ca2＋]i. （2R）-amino-5-phosphonopentanoate （AP5, 25 μmol/L, an NMDAR antagonist） and mibefradil （MIB, 1 μmol/L, a T-type Ca2＋ channel blocker）, given 5 min after formaldehyde perfusion, each partly inhibited the formaldehyde-induced increase of [Ca：＋]i, and this inhibitory effect was reinforced by combined application of AP5 and MIB. When applied 3 min before formaldehyde perfusion, AP5 （even at 50μmol/L） did not inhibit the formaldehyde-induced increase of [Ca2＋]i, but MIB （1 μmol/L） significantly inhibited this increase by 70%. Conclusion These results suggest that formaldehyde at a low concentration increases [Ca2＋]i in cultured hippocampal neurons; NMDARs and T-type Ca2＋ channels may be involved in this process.
基金National Natural Science Foundations of China(Nos.70771065,71171130,61473211,71502129)
文摘Tide is a significant factor which interferes with the berthing and departing operations of vessels in tidal ports. It is a preferable way to incorporate this factor into the simultaneous berth allocation and quay crane( QC) assignment problem( BACAP) in order to facilitate the realistic decision-making process at container terminal. For this purpose,an integrated optimization model is built with tidal time windows as forbidden intervals for berthing or departing. A hind-and-fore adjustment heuristic is proposed and applied under an iterative optimization framework. Numerical experiment shows the satisfying performance of the proposed algorithm.
基金Supported by the National Natural Science Foundation of China(21222602,21490585 and 21176117)National High-tech R&D Program of China(2015AA03A602)+4 种基金the Key Project of Chinese Ministry of Education(212060)the Outstanding Young Fund of Jiangsu Province(BK2012040)Young Fund of Jiangsu Province(BK20130915)the "Six Top Talents" and "333 Talent Project" of Jiangsu Province,a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)the Innovation Project for Graduate Student of Jiangsu Province(KYLX15-0790)
文摘This work presents the design of hollow fiber T-type zeolite membrane modules with different geometric configurations. The module performances were evaluated by pervaporation dehydration of ethanol/water mixtures. Strong concentration polarization was found for the modules with big membrane bundles. The concentration polarization was enhanced at high temperature due to the higher water permeation flux. The increase of feed flow could improve water permeation flux for the membrane modules with small membrane bundle.Computational fluid dynamics was used to visualize the flow field distribution inside of the modules with different configurations. The membrane module with seven bundles exhibited highest separation efficiency due to the uniform distribution of flow rate. The packing density could be 10 times higher than that of the tubular membrane module. The hollow fiber membrane module exhibited good stability for ethanol dehydration.
基金supported by the National Natural Science Foundation,Beijing,People’s Republic of China(81671058 and 81730031 to YW and 81401089 to MD)the National Research Foundation of Korea grants funded by the Republic of Korea(2019R1I1A1A01057744 to YK)the Foundation of Shanghai Municipal Science and Technology Commission(19ZR1407500 to FS)。
文摘In the current study,we sought to investigate whether T-type Ca^(2+)channels(TCCs)in the brain are involved in generating post-anesthetic hyperexcitatory behaviors(PAHBs).We found that younger rat pups(postnatal days 9-11)had a higher incidence of PAHBs and higher PAHB scores than older pups(postnatal days16-18)during emergence from sevoflurane anesthesia.The power spectrum of the theta oscillations(4 Hz-8 Hz)in the prefrontal cortex was significantly enhanced in younger pups when PAHBs occurred,while there were no significant changes in older pups.Both the power of theta oscillations and the level of PAHBs were significantly reduced by the administration of TCC inhibitors.Moreover,the sensitivity of TCCs in the medial dorsal thalamic nucleus to sevoflurane was found to increase with age by investigating the kinetic properties of TCCs in vitro.TCCs were activated by potentiated GABAergic depolarization with a sub-anesthetic dose of sevoflurane(1%).These data suggest that(1)TCCs in the brain contribute to the generation of PAHBs and the concomitant electroencephalographic changes;(2)the stronger inhibitory effect of sevoflurane contributes to the lack of PAHBs in older rats;and(3)the contribution of TCCs to PAHBs is not mediated by a direct effect of sevoflurane on TCCs.
文摘Intracellular cAMP and Ca^2＋ are involved in the regulation of steroidogenic activity in Leydig cells, which coordinate responses to luteinizing hormone （LH） and human ehorionic gonadotropin （hCG）. However, the identification of Ca^2＋ entry implicated in Leydig cell steroidogenesis is not well defined. The objective of this study was to identify the type of Ca^2＋ channel that affects Leydig cell steroidogenesis. In vitro steroidogenesis in the freshly dissociated Leydig cells of mice was induced by hCG incubation. The effects of mibefradil （a putative T-type Ca^2＋ channel blocker） on steroidogenesis were assessed using reverse transcription （RT）-polymerase chain reaction analysis for the steroidogenic acute regulatory protein （STAR） mRNA expression and testosterone production using radioimmunoassay. In the presence of 1.0 mmol L-1 extracellular Ca^2＋, hCG at 1 to 100 IU noticeably elevated both StAR mRNA level and testosterone secretion （P 〈 0.05）, and the stimulatory effects of hCG were markedly diminished by mibefradil in a dose-dependent manner （P 〈 0.05）. Moreover; the hCG-induced increase in testosterone production was completely removed when external Ca^2＋ was omitted, implying that Ca entry is needed for hCG-induced steroidogenesis. Furthermore, a patch-clamp study revealed the presence of mibefradil-sensitive Ca^24- currents seen at a concentration range that nearly paralleled those inhibiting steroidogenesis. Collectively, Our data provide evidence that hCG-stimulated steroidogenesis is mediated at least in part by Ca^2＋ entry carried out by the T-type Ca^2＋ channel in the Leydig cells of mice.
文摘A proposed inductive-phase-compensation ultra wideband CMOS digital T-type attenuator design based on an analysis of minimising phase errors is presented in this letter.In a standard CMOS technology,the proposed attenuator is analytically demonstrated to have low phase errors due to the inductive-phase-compensation network.A design equation is inferred and a wide-band 4dB attenuation bit digital attenuator with low phase errors is designed as a test vehicle for the proposed approach.
基金Sponsored by the National Natural Science Foundation of China(Grant No. 50875057 and 51075082)the State Key Laboratory of Robotics and Systems(HIT No. SKLRS200901A04)
文摘To take advantage of merits of higher output-power and efficiency of bolt-clamped transducer,a T-type linear ultrasonic motor was proposed in this paper.The proposed motor contained a horizontal transducer and a vertical transducer.The horizontal transducer included two exponential shape horns,and the vertical transducer contained one exponential shape horn.And the horns intersected at tip ends where a driving foot was located.The longitudinal vibrations of transducers were excited by the stretching vibration of PZT ceramics.Longitudinal vibrations were superimposed in the motor and generated elliptical trajectory at the driving foot.The actuating mechanism of the proposed motor was analyzed.The two working modals of the motor were gained with FEM.The resonant frequencies of two working modals were degenerated by adjusting the structural parameters.The motion trajectory of nodes on the driving foot was gained by transient analysis.The vibration amplitude of node on the driving foot indicates that the proposed motor has potential good output characteristics.The results verify the feasibility of the proposed design and provide instructions for the development of the new ultrasonic motor.
文摘Nesting is a common problem in industries such as shipbuilding, auto-maker, clothing, shoe-making, and furniture, in which various parts are cut off from a stock or stocks while minimizing the wastes or maximizing the utilization of the stock. Berth allocation at seaside is also considered one form of two dimensional nesting problems, in which a ship is assigned a location for service during a certain time slot. This paper presents an expert system using a heuristic search method for nesting problems. The parts and stocks are represented by pixels with which utility function is used to evaluate current state in search tree. The system is developed in CLIPS, an expert system shell and applied to various example problems with different constraints and to a berth allocation example to illustrate its applicability under different conditions.
