The development of sustainable electrode materials for energy storage systems has become very important and porous carbons derived from biomass have become an important candidate because of their tunable pore structur...The development of sustainable electrode materials for energy storage systems has become very important and porous carbons derived from biomass have become an important candidate because of their tunable pore structure,environmental friendliness,and cost-effectiveness.Recent advances in controlling the pore structure of these carbons and its relationship between to is energy storage performance are discussed,emphasizing the critical role of a balanced distribution of micropores,mesopores and macropores in determining electrochemical behavior.Particular attention is given to how the intrinsic components of biomass precursors(lignin,cellulose,and hemicellulose)influence pore formation during carbonization.Carbonization and activation strategies to precisely control the pore structure are introduced.Finally,key challenges in the industrial production of these carbons are outlined,and future research directions are proposed.These include the establishment of a database of biomass intrinsic structures and machine learning-assisted pore structure engineering,aimed at providing guidance for the design of high-performance carbon materials for next-generation energy storage devices.展开更多
Objective Previous studies link lower body mass index(BMI)with increased obsessive-compulsive disorder(OCD)risk,yet other body mass indicators may be more etioloically relevant.We dissected the causal association betw...Objective Previous studies link lower body mass index(BMI)with increased obsessive-compulsive disorder(OCD)risk,yet other body mass indicators may be more etioloically relevant.We dissected the causal association between body fat mass(FM)and OCD.Methods Summary statistics from genome-wide association studies of European ancestry were utilized to conduct two-sample Mendelian randomization analysis.Heterogeneity,horizontal pleiotropy,and sensitivity analyses were performed to assess the robustness.Results The inverse variance weighting method demonstrated that a genetically predicted decrease in FM was causally associated with an increased OCD risk[odds ratio(OR)=0.680,95%confidence interval(CI):0.528–0.875,P=0.003].Similar estimates were obtained using the weighted median approach(OR=0.633,95%CI:0.438–0.915,P=0.015).Each standard deviation increases in genetically predicted body fat percentage corresponded to a reduced OCD risk(OR=0.638,95%CI:0.455–0.896,P=0.009).The sensitivity analysis confirmed the robustness of these findings with no outlier instrument variables identified.Conclusion The negative causal association between FM and the risk of OCD suggests that the prevention or treatment of mental disorders should include not only the control of BMI but also fat distribution and body composition.展开更多
Although traditional gamma-gamma density(GGD)logging technology is widely utilized,its potential environmental risks have prompted the development of more environmentally friendly neutron-gamma density(NGD)logging tec...Although traditional gamma-gamma density(GGD)logging technology is widely utilized,its potential environmental risks have prompted the development of more environmentally friendly neutron-gamma density(NGD)logging technology.However,NGD measurements are influenced by both neutron and gamma radiations.In the logging environment,variations in the formation composition indicate different elemental compositions,which affect the neutron-gamma reaction cross-sections and gamma generation.Compared to traditional gamma sources such as Cs-137,these changes significantly affect the generation and transport of neutron-induced inelastic gamma rays and hinder accurate measurements.To address this,a novel method is proposed that incorporates the mass attenuation coefficient function to account for the effects of various lithologies and pore contents on gamma-ray attenuation,thereby achieving more accurate density measurements by clarifying the transport processes of inelastic gamma rays with varying energies and spatial distributions in varied logging environments.The proposed method avoids the complex correction of neutron transport and is verified through Monte Carlo simulations for its applicability across various lithologies and pore contents,demonstrating absolute density errors that are less than 0.02 g/cm^(3)in clean formations and indicating good accuracy.This study clarifies the NGD mechanism and provides theoretical guidance for the application of NGD logging methods.Further studies will be conducted on extreme environmental conditions and tool calibration.展开更多
Although the effectiveness of a tuned viscous mass damper(TVMD)as an inerter-based device for vibration control in civil structures has been thoroughly investigated,there is a lack of systematic research regarding the...Although the effectiveness of a tuned viscous mass damper(TVMD)as an inerter-based device for vibration control in civil structures has been thoroughly investigated,there is a lack of systematic research regarding the application of TVMDs for seismic response control of industrial buildings coupled with mechanical equipment.Therefore,this study proposes ungrounded and grounded TVMDs to effectively utilize the mass of the mechanical equipment and fully exploit the capabilities of the inerter element.An optimal design methodology is developed by pursuing the maximum effective damping ratio and seeking the most rational TVMD control scheme.Validation of TVMD control performance is conducted through time-history analysis based on 20 real seismic ground motions recommended by ATC-40,and by providing a barrel mixer industrial building as a real-life numerical example.The results show that both an ungrounded and grounded TVMD can effectively mitigate the seismic response of the primary structure.Compared to the traditional tuned mass damper(TMD),TVMDs can obtain improved control performance for a given equipment mass ratio.Moreover,an ungrounded TVMD and a TMD show similar working mechanisms that tend to release the displacement of equipment to keep their optimal state,whereas equipment displacement for a grounded TVMD should be strictly limited to provide sufficient anti-force.展开更多
Radiative cooling systems(RCSs)possess the distinctive capability to dissipate heat energy via solar and thermal radiation,making them suitable for thermal regulation and energy conservation applications,essential for...Radiative cooling systems(RCSs)possess the distinctive capability to dissipate heat energy via solar and thermal radiation,making them suitable for thermal regulation and energy conservation applications,essential for mitigating the energy crisis.A comprehensive review connecting the advancements in engineered radiative cooling systems(ERCSs),encompassing material and structural design as well as thermal and energy-related applications,is currently absent.Herein,this review begins with a concise summary of the essential concepts of ERCSs,followed by an introduction to engineered materials and structures,containing nature-inspired designs,chromatic materials,meta-structural configurations,and multilayered constructions.It subsequently encapsulates the primary applications,including thermal-regulating textiles and energy-saving devices.Next,it highlights the challenges of ERCSs,including maximized thermoregulatory effects,environmental adaptability,scalability and sustainability,and interdisciplinary integration.It seeks to offer direction for forthcoming fundamental research and industrial advancement of radiative cooling systems in real-world applications.展开更多
We investigate the constrained fractional Choquard equation■where m>0,N>2s with s∈(0,1)being the order of the fractional Laplacian operator and I_(α)forα∈(0,N)denotes the Riesz potential.The parameterμ∈ℝa...We investigate the constrained fractional Choquard equation■where m>0,N>2s with s∈(0,1)being the order of the fractional Laplacian operator and I_(α)forα∈(0,N)denotes the Riesz potential.The parameterμ∈ℝappears as a Lagrange multiplier.By imposing general mass-supercritical conditions on F,we confirm the existence of normalized solutions that characterize the global minimizer on the Pohozaev manifold.Our proof does not depend on the assumption that all weak solutions satisfy the Pohozaev identity,a challenge that remains unsolved for this doubly nonlocal equation.展开更多
Background:Diabetic foot,a severe complication of diabetes,is characterized by chronic refractory wounds.Sanhuang Oil,a topical herbal formula,demonstrates significant therapeutic effects including antibacterial,anti-...Background:Diabetic foot,a severe complication of diabetes,is characterized by chronic refractory wounds.Sanhuang Oil,a topical herbal formula,demonstrates significant therapeutic effects including antibacterial,anti-inflammatory,and immunomodulatory activities.However,its active constituents and mechanisms of action against diabetic foot remain to be elucidated.Methods:In this study,the chemical constituents of Sanhuang Oil were identified using UPLC-QE-Orbitrap-MS.Subsequently,the mechanism by which Sanhuang Oil promotes diabetic foot ulcer healing was predicted by integrating network pharmacology and molecular docking.Additionally,diabetic mouse model was established in ICR mice using a combination of a high-fat diet(HFD)and streptozotocin(STZ)chemical induction.A full-thickness skin defect was created on the dorsum of the mice.Wound healing and the healing rate were observed following Sanhuang Oil intervention.The mechanism underlying Sanhuang Oil’s promotion of diabetic ulcer healing was further investigated using transcriptomics and histopathological examination(H&E staining).Results:A total of 97 active ingredients were identified from Sanhuang Oil.Network pharmacology analysis predicted 543 common targets,and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis identified 203 relevant pathways.Molecular docking further confirmed high binding affinity(binding energy≤−5.0 kcal/mol)between specific active components in Sanhuang Oil(e.g.,coptisine,phellodendrine,baicalein)and key targets associated with diabetic foot ulcers(e.g.,EGFR,AKT1,STAT3).In vivo experimental results demonstrated that the wound healing rate was significantly higher in Sanhuang Oil-treated groups compared to the model group(P<0.001).HE staining revealed that the high-dose Sanhuang Oil group exhibited more pronounced epithelial tissue coverage over the wound,reduced inflammatory cell infiltration,and increased collagen deposition and fibroblast proliferation.transcriptomic analysis identified Pdk4,Ttn,Csrp3,Actn2,Myoz2,Tnnc2,Myod1,Myog,Myot,and Myf6 as key regulatory proteins involved in promoting wound healing.Conclusion:Sanhuang Oil promotes wound healing in diabetic ulcer mice,potentially by mitigating inflammation and regulating key targets such as Pdk4 to enhance fibroblast function.These findings provide novel insights into the multi-target,multi-pathway mechanism of Sanhuang Oil for treating diabetic foot ulcers.展开更多
Overweight and obesity has been a major public health problem globally.It was estimated that more than 2.1 billion adults were affected by overweight or obese in 2021 worldwide,about one fifth of whom lived in China^(...Overweight and obesity has been a major public health problem globally.It was estimated that more than 2.1 billion adults were affected by overweight or obese in 2021 worldwide,about one fifth of whom lived in China^([1]).By 2050,the country is forecast to remain the one with the largest population of overweight and obese globally^([1]),if no effective strategies were applied on overweight/obesity control.展开更多
In this manuscript,we consider a non-autonomous dynamical system.Using the Carathéodory structure,we define a BS dimension on an arbitrary subset and obtain a Bowen’s equation that illustrates the relation of th...In this manuscript,we consider a non-autonomous dynamical system.Using the Carathéodory structure,we define a BS dimension on an arbitrary subset and obtain a Bowen’s equation that illustrates the relation of the BS dimension to the Pesin-Pitskel topological pressure given by Nazarian[24].Moreover,we establish a variational principle and an inverse variational principle for the BS dimension of non-autonomous dynamical systems.Finally,we also get an analogue of Billingsley’s theorem for the BS dimension of non-autonomous dynamical systems.展开更多
Each morning at Yangluo Port in Wuhan,Hubei Province,the all-electric cargo vessel Huahang Xinneng No.1 completes a battery swap in under 10 minutes before returning to service with nearly 8,000 kWh of power onboard。
The neuroinflammatory response mediated by microglial activation plays an important role in the secondary nerve injury of traumatic brain injury.The post-transcriptional modification of N^(6)-methyladenosine is ubiqui...The neuroinflammatory response mediated by microglial activation plays an important role in the secondary nerve injury of traumatic brain injury.The post-transcriptional modification of N^(6)-methyladenosine is ubiquitous in the immune response of the central nervous system.The fat mass and obesity-related protein catalyzes the demethylation of N^(6)-methyladenosine modifications on mRNA and is widely expressed in various tissues,participating in the regulation of multiple diseases’biological processes.However,the role of fat mass and obesity in microglial activation and the subsequent neuroinflammatory response after traumatic brain injury is unclear.In this study,we found that the expression of fat mass and obesity was significantly down-regulated in both lipopolysaccharide-treated BV2 cells and a traumatic brain injury mouse model.After fat mass and obesity interference,BV2 cells exhibited a pro-inflammatory phenotype as shown by the increased proportion of CD11b^(+)/CD86^(+)cells and the secretion of pro-inflammatory cytokines.Fat mass and obesity-mediated N^(6)-methyladenosine demethylation accelerated the degradation of ADAM17 mRNA,while silencing of fat mass and obesity enhanced the stability of ADAM17 mRNA.Therefore,down-regulation of fat mass and obesity expression leads to the abnormally high expression of ADAM17 in microglia.These results indicate that the activation of microglia and neuroinflammatory response regulated by fat mass and obesity-related N^(6)-methyladenosine modification plays an important role in the pro-inflammatory process of secondary injury following traumatic brain injury.展开更多
The human retina,a complex and highly specialized structure,includes multiple cell types that work synergistically to generate and transmit visual signals.However,genetic predisposition or age-related degeneration can...The human retina,a complex and highly specialized structure,includes multiple cell types that work synergistically to generate and transmit visual signals.However,genetic predisposition or age-related degeneration can lead to retinal damage that severely impairs vision or causes blindness.Treatment options for retinal diseases are limited,and there is an urgent need for innovative therapeutic strategies.Cell and gene therapies are promising because of the efficacy of delivery systems that transport therapeutic genes to targeted retinal cells.Gene delivery systems hold great promise for treating retinal diseases by enabling the targeted delivery of therapeutic genes to affected cells or by converting endogenous cells into functional ones to facilitate nerve regeneration,potentially restoring vision.This review focuses on two principal categories of gene delivery vectors used in the treatment of retinal diseases:viral and non-viral systems.Viral vectors,including lentiviruses and adeno-associated viruses,exploit the innate ability of viruses to infiltrate cells,which is followed by the introduction of therapeutic genetic material into target cells for gene correction.Lentiviruses can accommodate exogenous genes up to 8 kb in length,but their mechanism of integration into the host genome presents insertion mutation risks.Conversely,adeno-associated viruses are safer,as they exist as episomes in the nucleus,yet their limited packaging capacity constrains their application to a narrower spectrum of diseases,which necessitates the exploration of alternative delivery methods.In parallel,progress has also occurred in the development of novel non-viral delivery systems,particularly those based on liposomal technology.Manipulation of the ratios of hydrophilic and hydrophobic molecules within liposomes and the development of new lipid formulations have led to the creation of advanced non-viral vectors.These innovative systems include solid lipid nanoparticles,polymer nanoparticles,dendrimers,polymeric micelles,and polymeric nanoparticles.Compared with their viral counterparts,non-viral delivery systems offer markedly enhanced loading capacities that enable the direct delivery of nucleic acids,mRNA,or protein molecules into cells.This bypasses the need for DNA transcription and processing,which significantly enhances therapeutic efficiency.Nevertheless,the immunogenic potential and accumulation toxicity associated with non-viral particulate systems necessitates continued optimization to reduce adverse effects in vivo.This review explores the various delivery systems for retinal therapies and retinal nerve regeneration,and details the characteristics,advantages,limitations,and clinical applications of each vector type.By systematically outlining these factors,our goal is to guide the selection of the optimal delivery tool for a specific retinal disease,which will enhance treatment efficacy and improve patient outcomes while paving the way for more effective and targeted therapeutic interventions.展开更多
The differential equations of motion of a comtlaint system with parameters and variable mass, of a system with variable mass and servo constraints and those for the control problem on the forced motion of constraint s...The differential equations of motion of a comtlaint system with parameters and variable mass, of a system with variable mass and servo constraints and those for the control problem on the forced motion of constraint systems with variable mass are given respectively. Finally, an example is presented.展开更多
By the theory of symmetries and conserved quantities, the exact invariants and adiabatic invariants of nonholonomic variable mass systems are studied. The perturbation problem of symmetries for the nonholonomic variab...By the theory of symmetries and conserved quantities, the exact invariants and adiabatic invariants of nonholonomic variable mass systems are studied. The perturbation problem of symmetries for the nonholonomic variable mass systems under small excitation is discussed. The concept of high order adiabatic invariant is presented, and the form of exact invariants and adiabatic invariants as well as the conditions for their existence are given. Then the corresponding inverse problem is studied.展开更多
The stability of rock slopes is considered crucial to public safety in highways passing through rock cuts, as well as to personnel and equipment safety in open pit mines. Slope instability and failures occur due to ma...The stability of rock slopes is considered crucial to public safety in highways passing through rock cuts, as well as to personnel and equipment safety in open pit mines. Slope instability and failures occur due to many factors such as adverse slope geometries, geological discontinuities, weak or weathered slope materials as well as severe weather conditions. External loads like heavy precipitation and seismicity could play a significant role in slope failure. In this paper, several rock mass classification systems developed for rock slope stability assessment are evaluated against known rock slope conditions in a region of Saudi Arabia, where slopes located in rugged terrains with complex geometry serve as highway road cuts. Selected empirical methods have been applied to 22 rock cuts that are selected based on their failure mechanisms and slope materials. The stability conditions are identified, and the results of each rock slope classification system are compared. The paper also highlights the limitations of the empirical classification methods used in the study and proposes future research directions.展开更多
Based on the total time derivative along the trajectory of the system the definition and the criterion for a unified symmetry of nonholonomic mechanical system with variable mass are presented in this paper. A new con...Based on the total time derivative along the trajectory of the system the definition and the criterion for a unified symmetry of nonholonomic mechanical system with variable mass are presented in this paper. A new conserved quantity, as well as the Noether conserved quantity and the Hojman conserved quantity, deduced from the unified symmetry, are also obtained, An example is given to illustrate the application of the results.展开更多
The novel method to analyze metallic structure corrosion status was proposed in the presence of stray current in DC mass transit systems. Firstly, the characteristic parameter and the influence parameters for the corr...The novel method to analyze metallic structure corrosion status was proposed in the presence of stray current in DC mass transit systems. Firstly, the characteristic parameter and the influence parameters for the corrosion status were determined. Secondly, an experimental system was established for simulating the corrosion process within the stray current interference. Then, a predictive model for the corrosion status was built, using a support vector machine(SVM) method and experimental data. The data were divided into two sets, including training set and testing set. The training set was used to generate the SVM model and the testing set was used to evaluate the predictive performance of the SVM model. The results show that the relationship between the characteristic parameter and the influence parameters is nonlinear and the SVM model is suitable for predicting the corrosion status.展开更多
This study deals with the comparative investigation on various classification/characterization systems for sedimentary rocks in two parts,40 kmlong of the Zagros tunnel,west of Iran.The results of extensive geotechnic...This study deals with the comparative investigation on various classification/characterization systems for sedimentary rocks in two parts,40 kmlong of the Zagros tunnel,west of Iran.The results of extensive geotechnical explorations and field measurements were applied to obtain the rock mass classification/characterization systems such as Rock Mass Rating(RMR),Rock Condition Rating(RCR),Q-system(Q),Rock Mass Number(QN),Rock Mass index(RMi),Rock Structure Rating(RSR),and Geological Strength Index(GSI)for a wide range of sedimentary rocks.A set of systems inter-relationship is proposed.Some of these correlation relations such as RMR-Q,RMR-RMi,RMi-Q,RCR,GSI-GSI(Cai)are similar to the one or more relations proposed in the previous studies,however,some of them such as RSR-RMR,RSR-Q,RCR-QN and GSI-RMR are not similar to the previous works.Joint set orientation and joint set number are more important parameters that cause weak correlation coefficients where both side classifications are not similar in considering them in calculating values.So it is proposed to find relations between any pairs of systems that both of them consider or not consider these parameters.The relations are proposed for a wide range of sedimentary rocks and can be applied for similar geological environments.展开更多
For a one-dimensional conservative system with position depending mass, one deduces consistently a constant of motion, a Lagrangian, and a Hamiltonian for the nonrelativistic case. With these functions, one shows the ...For a one-dimensional conservative system with position depending mass, one deduces consistently a constant of motion, a Lagrangian, and a Hamiltonian for the nonrelativistic case. With these functions, one shows the trajectories on the spaces (x,v) and (x,p) for a linear position depending mass. For the relativistic case, the Lagrangian and Hamiltonian cannot be given explicitly in general. However, we study the particular system with constant force and mass linear dependence on the position where the Lagrangian can be found explicitly, but the Hamiltonian remains implicit in the constant of motion.展开更多
文摘The development of sustainable electrode materials for energy storage systems has become very important and porous carbons derived from biomass have become an important candidate because of their tunable pore structure,environmental friendliness,and cost-effectiveness.Recent advances in controlling the pore structure of these carbons and its relationship between to is energy storage performance are discussed,emphasizing the critical role of a balanced distribution of micropores,mesopores and macropores in determining electrochemical behavior.Particular attention is given to how the intrinsic components of biomass precursors(lignin,cellulose,and hemicellulose)influence pore formation during carbonization.Carbonization and activation strategies to precisely control the pore structure are introduced.Finally,key challenges in the industrial production of these carbons are outlined,and future research directions are proposed.These include the establishment of a database of biomass intrinsic structures and machine learning-assisted pore structure engineering,aimed at providing guidance for the design of high-performance carbon materials for next-generation energy storage devices.
基金supported by the Yanzhao Gold Talent Project of Hebei Province(NO.HJZD202506)。
文摘Objective Previous studies link lower body mass index(BMI)with increased obsessive-compulsive disorder(OCD)risk,yet other body mass indicators may be more etioloically relevant.We dissected the causal association between body fat mass(FM)and OCD.Methods Summary statistics from genome-wide association studies of European ancestry were utilized to conduct two-sample Mendelian randomization analysis.Heterogeneity,horizontal pleiotropy,and sensitivity analyses were performed to assess the robustness.Results The inverse variance weighting method demonstrated that a genetically predicted decrease in FM was causally associated with an increased OCD risk[odds ratio(OR)=0.680,95%confidence interval(CI):0.528–0.875,P=0.003].Similar estimates were obtained using the weighted median approach(OR=0.633,95%CI:0.438–0.915,P=0.015).Each standard deviation increases in genetically predicted body fat percentage corresponded to a reduced OCD risk(OR=0.638,95%CI:0.455–0.896,P=0.009).The sensitivity analysis confirmed the robustness of these findings with no outlier instrument variables identified.Conclusion The negative causal association between FM and the risk of OCD suggests that the prevention or treatment of mental disorders should include not only the control of BMI but also fat distribution and body composition.
基金supported by the National Natural Science Foundation of China(U23B20151 and 52171253).
文摘Although traditional gamma-gamma density(GGD)logging technology is widely utilized,its potential environmental risks have prompted the development of more environmentally friendly neutron-gamma density(NGD)logging technology.However,NGD measurements are influenced by both neutron and gamma radiations.In the logging environment,variations in the formation composition indicate different elemental compositions,which affect the neutron-gamma reaction cross-sections and gamma generation.Compared to traditional gamma sources such as Cs-137,these changes significantly affect the generation and transport of neutron-induced inelastic gamma rays and hinder accurate measurements.To address this,a novel method is proposed that incorporates the mass attenuation coefficient function to account for the effects of various lithologies and pore contents on gamma-ray attenuation,thereby achieving more accurate density measurements by clarifying the transport processes of inelastic gamma rays with varying energies and spatial distributions in varied logging environments.The proposed method avoids the complex correction of neutron transport and is verified through Monte Carlo simulations for its applicability across various lithologies and pore contents,demonstrating absolute density errors that are less than 0.02 g/cm^(3)in clean formations and indicating good accuracy.This study clarifies the NGD mechanism and provides theoretical guidance for the application of NGD logging methods.Further studies will be conducted on extreme environmental conditions and tool calibration.
基金National Natural Science Foundation of China under Grant Nos.52408327 and 52278306Key Research and Development Program of Hunan Province,China under Grant No.2022SK2096+3 种基金Science and Technology Progress and Innovation Project of the Department of Transportation of Hunan Province,China under Grant No.201912Natural Science Foundation of Hunan Province,China under Grant No.2024JJ6198Scientific Research Project of the Education Department of Hunan Province,China under Grant No.25A0645Emergency Management Science and Technology Project of the Emergency Management Department of Hunan Province,China under Grant No.yjtkjxm_202406。
文摘Although the effectiveness of a tuned viscous mass damper(TVMD)as an inerter-based device for vibration control in civil structures has been thoroughly investigated,there is a lack of systematic research regarding the application of TVMDs for seismic response control of industrial buildings coupled with mechanical equipment.Therefore,this study proposes ungrounded and grounded TVMDs to effectively utilize the mass of the mechanical equipment and fully exploit the capabilities of the inerter element.An optimal design methodology is developed by pursuing the maximum effective damping ratio and seeking the most rational TVMD control scheme.Validation of TVMD control performance is conducted through time-history analysis based on 20 real seismic ground motions recommended by ATC-40,and by providing a barrel mixer industrial building as a real-life numerical example.The results show that both an ungrounded and grounded TVMD can effectively mitigate the seismic response of the primary structure.Compared to the traditional tuned mass damper(TMD),TVMDs can obtain improved control performance for a given equipment mass ratio.Moreover,an ungrounded TVMD and a TMD show similar working mechanisms that tend to release the displacement of equipment to keep their optimal state,whereas equipment displacement for a grounded TVMD should be strictly limited to provide sufficient anti-force.
基金support from the Contract Research(“Development of Breathable Fabrics with Nano-Electrospun Membrane”,CityU ref.:9231419“Research and application of antibacterial and healing-promoting smart nanofiber dressing for children’s burn wounds”,CityU ref:PJ9240111)+1 种基金the National Natural Science Foundation of China(“Study of Multi-Responsive Shape Memory Polyurethane Nanocomposites Inspired by Natural Fibers”,Grant No.51673162)Startup Grant of CityU(“Laboratory of Wearable Materials for Healthcare”,Grant No.9380116).
文摘Radiative cooling systems(RCSs)possess the distinctive capability to dissipate heat energy via solar and thermal radiation,making them suitable for thermal regulation and energy conservation applications,essential for mitigating the energy crisis.A comprehensive review connecting the advancements in engineered radiative cooling systems(ERCSs),encompassing material and structural design as well as thermal and energy-related applications,is currently absent.Herein,this review begins with a concise summary of the essential concepts of ERCSs,followed by an introduction to engineered materials and structures,containing nature-inspired designs,chromatic materials,meta-structural configurations,and multilayered constructions.It subsequently encapsulates the primary applications,including thermal-regulating textiles and energy-saving devices.Next,it highlights the challenges of ERCSs,including maximized thermoregulatory effects,environmental adaptability,scalability and sustainability,and interdisciplinary integration.It seeks to offer direction for forthcoming fundamental research and industrial advancement of radiative cooling systems in real-world applications.
基金supported by the Guangdong Basic and Applied Basic Research Foundation(2022A1515012138)the NSFC(12271436,12371119)supported by the Natural Science Basic Research Program of Shaanxi(2022JC-04).
文摘We investigate the constrained fractional Choquard equation■where m>0,N>2s with s∈(0,1)being the order of the fractional Laplacian operator and I_(α)forα∈(0,N)denotes the Riesz potential.The parameterμ∈ℝappears as a Lagrange multiplier.By imposing general mass-supercritical conditions on F,we confirm the existence of normalized solutions that characterize the global minimizer on the Pohozaev manifold.Our proof does not depend on the assumption that all weak solutions satisfy the Pohozaev identity,a challenge that remains unsolved for this doubly nonlocal equation.
基金supported by the Natural Science Foundation of Hubei Provincial Department of Education(D20232101)Shandong Second Medical University 2024 Affiliated Hospital(Teaching Hospital)Scientific Research Development Fund Project(2024FYQ026)+3 种基金the innovative Research Programme of Xiangyang No.1 People’s Hospital(XYY2023ZY01)Faculty Development Grants of Xiangyang No.1 People’s Hospital Affiliated to Hubei University of Medicine(XYY2023D05)Joint supported by Hubei Provincial Natural Science Foundation and Xiangyang of China(2025AFD091)Traditional Chinese Medicine Scientific Research Project of Hubei Provincial Administration of Traditional Chinese Medicine(ZY2025D019).
文摘Background:Diabetic foot,a severe complication of diabetes,is characterized by chronic refractory wounds.Sanhuang Oil,a topical herbal formula,demonstrates significant therapeutic effects including antibacterial,anti-inflammatory,and immunomodulatory activities.However,its active constituents and mechanisms of action against diabetic foot remain to be elucidated.Methods:In this study,the chemical constituents of Sanhuang Oil were identified using UPLC-QE-Orbitrap-MS.Subsequently,the mechanism by which Sanhuang Oil promotes diabetic foot ulcer healing was predicted by integrating network pharmacology and molecular docking.Additionally,diabetic mouse model was established in ICR mice using a combination of a high-fat diet(HFD)and streptozotocin(STZ)chemical induction.A full-thickness skin defect was created on the dorsum of the mice.Wound healing and the healing rate were observed following Sanhuang Oil intervention.The mechanism underlying Sanhuang Oil’s promotion of diabetic ulcer healing was further investigated using transcriptomics and histopathological examination(H&E staining).Results:A total of 97 active ingredients were identified from Sanhuang Oil.Network pharmacology analysis predicted 543 common targets,and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis identified 203 relevant pathways.Molecular docking further confirmed high binding affinity(binding energy≤−5.0 kcal/mol)between specific active components in Sanhuang Oil(e.g.,coptisine,phellodendrine,baicalein)and key targets associated with diabetic foot ulcers(e.g.,EGFR,AKT1,STAT3).In vivo experimental results demonstrated that the wound healing rate was significantly higher in Sanhuang Oil-treated groups compared to the model group(P<0.001).HE staining revealed that the high-dose Sanhuang Oil group exhibited more pronounced epithelial tissue coverage over the wound,reduced inflammatory cell infiltration,and increased collagen deposition and fibroblast proliferation.transcriptomic analysis identified Pdk4,Ttn,Csrp3,Actn2,Myoz2,Tnnc2,Myod1,Myog,Myot,and Myf6 as key regulatory proteins involved in promoting wound healing.Conclusion:Sanhuang Oil promotes wound healing in diabetic ulcer mice,potentially by mitigating inflammation and regulating key targets such as Pdk4 to enhance fibroblast function.These findings provide novel insights into the multi-target,multi-pathway mechanism of Sanhuang Oil for treating diabetic foot ulcers.
文摘Overweight and obesity has been a major public health problem globally.It was estimated that more than 2.1 billion adults were affected by overweight or obese in 2021 worldwide,about one fifth of whom lived in China^([1]).By 2050,the country is forecast to remain the one with the largest population of overweight and obese globally^([1]),if no effective strategies were applied on overweight/obesity control.
基金supported by the NSFC(12461012)and the NSF of Chongqing(CSTB2024NSCQ-MSX1246).
文摘In this manuscript,we consider a non-autonomous dynamical system.Using the Carathéodory structure,we define a BS dimension on an arbitrary subset and obtain a Bowen’s equation that illustrates the relation of the BS dimension to the Pesin-Pitskel topological pressure given by Nazarian[24].Moreover,we establish a variational principle and an inverse variational principle for the BS dimension of non-autonomous dynamical systems.Finally,we also get an analogue of Billingsley’s theorem for the BS dimension of non-autonomous dynamical systems.
文摘Each morning at Yangluo Port in Wuhan,Hubei Province,the all-electric cargo vessel Huahang Xinneng No.1 completes a battery swap in under 10 minutes before returning to service with nearly 8,000 kWh of power onboard。
基金supported by grants from the Major Projects of Health Science Research Foundation for Middle-Aged and Young Scientist of Fujian Province,China,No.2022ZQNZD01010010the National Natural Science Foundation of China,No.82371390Fujian Province Scientific Foundation,No.2023J01725(all to XC).
文摘The neuroinflammatory response mediated by microglial activation plays an important role in the secondary nerve injury of traumatic brain injury.The post-transcriptional modification of N^(6)-methyladenosine is ubiquitous in the immune response of the central nervous system.The fat mass and obesity-related protein catalyzes the demethylation of N^(6)-methyladenosine modifications on mRNA and is widely expressed in various tissues,participating in the regulation of multiple diseases’biological processes.However,the role of fat mass and obesity in microglial activation and the subsequent neuroinflammatory response after traumatic brain injury is unclear.In this study,we found that the expression of fat mass and obesity was significantly down-regulated in both lipopolysaccharide-treated BV2 cells and a traumatic brain injury mouse model.After fat mass and obesity interference,BV2 cells exhibited a pro-inflammatory phenotype as shown by the increased proportion of CD11b^(+)/CD86^(+)cells and the secretion of pro-inflammatory cytokines.Fat mass and obesity-mediated N^(6)-methyladenosine demethylation accelerated the degradation of ADAM17 mRNA,while silencing of fat mass and obesity enhanced the stability of ADAM17 mRNA.Therefore,down-regulation of fat mass and obesity expression leads to the abnormally high expression of ADAM17 in microglia.These results indicate that the activation of microglia and neuroinflammatory response regulated by fat mass and obesity-related N^(6)-methyladenosine modification plays an important role in the pro-inflammatory process of secondary injury following traumatic brain injury.
基金Hongguang Wu,Both authors contributed equally to this work and share first authorshipLing Dong,Both authors contributed equally to this work and share first authorship。
文摘The human retina,a complex and highly specialized structure,includes multiple cell types that work synergistically to generate and transmit visual signals.However,genetic predisposition or age-related degeneration can lead to retinal damage that severely impairs vision or causes blindness.Treatment options for retinal diseases are limited,and there is an urgent need for innovative therapeutic strategies.Cell and gene therapies are promising because of the efficacy of delivery systems that transport therapeutic genes to targeted retinal cells.Gene delivery systems hold great promise for treating retinal diseases by enabling the targeted delivery of therapeutic genes to affected cells or by converting endogenous cells into functional ones to facilitate nerve regeneration,potentially restoring vision.This review focuses on two principal categories of gene delivery vectors used in the treatment of retinal diseases:viral and non-viral systems.Viral vectors,including lentiviruses and adeno-associated viruses,exploit the innate ability of viruses to infiltrate cells,which is followed by the introduction of therapeutic genetic material into target cells for gene correction.Lentiviruses can accommodate exogenous genes up to 8 kb in length,but their mechanism of integration into the host genome presents insertion mutation risks.Conversely,adeno-associated viruses are safer,as they exist as episomes in the nucleus,yet their limited packaging capacity constrains their application to a narrower spectrum of diseases,which necessitates the exploration of alternative delivery methods.In parallel,progress has also occurred in the development of novel non-viral delivery systems,particularly those based on liposomal technology.Manipulation of the ratios of hydrophilic and hydrophobic molecules within liposomes and the development of new lipid formulations have led to the creation of advanced non-viral vectors.These innovative systems include solid lipid nanoparticles,polymer nanoparticles,dendrimers,polymeric micelles,and polymeric nanoparticles.Compared with their viral counterparts,non-viral delivery systems offer markedly enhanced loading capacities that enable the direct delivery of nucleic acids,mRNA,or protein molecules into cells.This bypasses the need for DNA transcription and processing,which significantly enhances therapeutic efficiency.Nevertheless,the immunogenic potential and accumulation toxicity associated with non-viral particulate systems necessitates continued optimization to reduce adverse effects in vivo.This review explores the various delivery systems for retinal therapies and retinal nerve regeneration,and details the characteristics,advantages,limitations,and clinical applications of each vector type.By systematically outlining these factors,our goal is to guide the selection of the optimal delivery tool for a specific retinal disease,which will enhance treatment efficacy and improve patient outcomes while paving the way for more effective and targeted therapeutic interventions.
文摘The differential equations of motion of a comtlaint system with parameters and variable mass, of a system with variable mass and servo constraints and those for the control problem on the forced motion of constraint systems with variable mass are given respectively. Finally, an example is presented.
文摘By the theory of symmetries and conserved quantities, the exact invariants and adiabatic invariants of nonholonomic variable mass systems are studied. The perturbation problem of symmetries for the nonholonomic variable mass systems under small excitation is discussed. The concept of high order adiabatic invariant is presented, and the form of exact invariants and adiabatic invariants as well as the conditions for their existence are given. Then the corresponding inverse problem is studied.
基金financially supported by the Saudi Geological Survey through a doctoral fellowship at McGill University
文摘The stability of rock slopes is considered crucial to public safety in highways passing through rock cuts, as well as to personnel and equipment safety in open pit mines. Slope instability and failures occur due to many factors such as adverse slope geometries, geological discontinuities, weak or weathered slope materials as well as severe weather conditions. External loads like heavy precipitation and seismicity could play a significant role in slope failure. In this paper, several rock mass classification systems developed for rock slope stability assessment are evaluated against known rock slope conditions in a region of Saudi Arabia, where slopes located in rugged terrains with complex geometry serve as highway road cuts. Selected empirical methods have been applied to 22 rock cuts that are selected based on their failure mechanisms and slope materials. The stability conditions are identified, and the results of each rock slope classification system are compared. The paper also highlights the limitations of the empirical classification methods used in the study and proposes future research directions.
文摘Based on the total time derivative along the trajectory of the system the definition and the criterion for a unified symmetry of nonholonomic mechanical system with variable mass are presented in this paper. A new conserved quantity, as well as the Noether conserved quantity and the Hojman conserved quantity, deduced from the unified symmetry, are also obtained, An example is given to illustrate the application of the results.
基金Project(BE2010043) supported by the Technology Support Program of Jiangsu Province,ChinaProject(CXZZ13_0928) supported by the Graduate Education Innovation Project of Jiangsu Province,China
文摘The novel method to analyze metallic structure corrosion status was proposed in the presence of stray current in DC mass transit systems. Firstly, the characteristic parameter and the influence parameters for the corrosion status were determined. Secondly, an experimental system was established for simulating the corrosion process within the stray current interference. Then, a predictive model for the corrosion status was built, using a support vector machine(SVM) method and experimental data. The data were divided into two sets, including training set and testing set. The training set was used to generate the SVM model and the testing set was used to evaluate the predictive performance of the SVM model. The results show that the relationship between the characteristic parameter and the influence parameters is nonlinear and the SVM model is suitable for predicting the corrosion status.
文摘This study deals with the comparative investigation on various classification/characterization systems for sedimentary rocks in two parts,40 kmlong of the Zagros tunnel,west of Iran.The results of extensive geotechnical explorations and field measurements were applied to obtain the rock mass classification/characterization systems such as Rock Mass Rating(RMR),Rock Condition Rating(RCR),Q-system(Q),Rock Mass Number(QN),Rock Mass index(RMi),Rock Structure Rating(RSR),and Geological Strength Index(GSI)for a wide range of sedimentary rocks.A set of systems inter-relationship is proposed.Some of these correlation relations such as RMR-Q,RMR-RMi,RMi-Q,RCR,GSI-GSI(Cai)are similar to the one or more relations proposed in the previous studies,however,some of them such as RSR-RMR,RSR-Q,RCR-QN and GSI-RMR are not similar to the previous works.Joint set orientation and joint set number are more important parameters that cause weak correlation coefficients where both side classifications are not similar in considering them in calculating values.So it is proposed to find relations between any pairs of systems that both of them consider or not consider these parameters.The relations are proposed for a wide range of sedimentary rocks and can be applied for similar geological environments.
文摘For a one-dimensional conservative system with position depending mass, one deduces consistently a constant of motion, a Lagrangian, and a Hamiltonian for the nonrelativistic case. With these functions, one shows the trajectories on the spaces (x,v) and (x,p) for a linear position depending mass. For the relativistic case, the Lagrangian and Hamiltonian cannot be given explicitly in general. However, we study the particular system with constant force and mass linear dependence on the position where the Lagrangian can be found explicitly, but the Hamiltonian remains implicit in the constant of motion.
